Testosterone restores insulin sensitivity in patients with diabetes and hypogonadism | ... - 0 views
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Nathan Goodyear on 19 May 14This is the abstract from oral presentation at AACE in Las Vegas from May. Small study finds reduction in fat mass, increase in muscle mass, increase in insulin sensitivity, and reduction in inflammation signaling with Testosterone therapy in men with low Testosterone. These men were type 2 diabetics. This is consistent with prior published literature. However, men without diabetes, this association is hard to reproduce. The degree of glucose control also effects the response to Testosterone therapy i.e. the worse the glucose control, the more the response from Testosterone. Also of note, those men with hypogonatrophic hypogonadism had decreased insulin receptor expression, decreased insulin sensitivity, and decreased GLUT-4 expression versus eugonadal men. Remember from prior studies, it is the conversion of Testosterone to DHT that increases GLUT-4 transcription, translocation, and expression.