Group items tagged

PCOS with associated hyperandrogenism, is associated with increased risk of NAFLD versus PCOS without hyperandrogenism.

Very insightful study.  Study looked at hyperadrogenism and inflammation in women on the orders of PCOS.  The study subjects did not have PCOS, but hyperandrogenism via 130 mg DHEA was associated with an increase in TNF-alpha in these lean o/w healthy women.  We know this is due to hyperandrogenism as elevated Testosterone, DHEA, and androstenedione were documented with treatment. Take home:  androgens promote inflammation in women.  I believe this has serious negative implications about the massive Testosterone doping that is occurring in women today.

Study finds that increasing body fat and associated insulin resistance in women with PCOS is associated with an increase in CRP. These women with PCOS are hyperandrogenic. It makes absolutely no sense to give these women more Testosterone.

D-chiro-inositol deficiency and its role in PCOS, insulin resistance, and hyperandrogenism

This study shows that induced hyperandrogenism in women causes insulin resistance.  This should be taken well note of by many physicians and patient.  Many women are prescribed massive amounts of testosterone through pills or injections, which is likely contributing to weight increase.  

Interesting study finds hyperandrogenism stimulates excessive inflammatory response to glucose intake.  This study was done in otherwise healthy women not in women with PCOS.  The inflammatory cytokine production was via NF-KappaB activation.  Again, this has negative implications in women being doped with Testosterone.

Women with PCOS will have hyperandrogenism. This study finds an association between this increased androgen levels and hyperhomocysteinemia.

Another study that finds hyperandrogenism in women is associated with increased Metabolic Syndrome.  This study found obesity was associated with increased hyperandrogegism and Metabolic Syndrome irregardless of PCOS diagnosis or not.

Mean Platelet Volume (MPV) is associated with increased cardiovascular disease in some studies.  Hyperandrogenism is associated with increased CVD in women with PCOS. This study found that elevated androgen levels in non obese women with/without PCOS was associated with lower MPV values.  This stands in contrast to other studies. 

Study points to inflammation causing hyperandrogenism via ovarian theca stimulation.

Cochran review of 6 studies of only 164 women found lifestyle interventions improved body composition, mostly fat loss, decreased the hyperandrogen status and improved insulin resistance in women with PCOS.

Increasing Free androgen index is associated with worsening metabolic syndrome parameters in women.  Paticularily increasing insulin and poor glucose control was found.

Progesterone deficiency and elevated male hormones in women increase premenopausal breast cancer

PCOS is not a birth control pill deficiency, but a complex hormonal imbalance

D-chiro-inositol reduced insulin levels and associated male hormone production in lean women with PCOS

salivary testosterone is a reliable way to evaluate free testosterone

women with elevated androgens (testosterone, DHT, androstenedione, DHEA...) are shown to have more HTN, insulin resistance, overweight issues, and CVD

Elevated androgens are associated increasing insulin, insulin resistance, and inflammation (as measured by CRP).