Skip to main content

Home/ Nutrition/ Group items tagged IL-6

Rss Feed Group items tagged

Matti Narkia

Low Vitamin D Status, High Bone Turnover, and Bone Fractures in Centenarians -- Passeri... - 0 views

  •  
    Low vitamin D status, high bone turnover, and bone fractures in centenarians.
    Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C.
    J Clin Endocrinol Metab. 2003 Nov;88(11):5109-15.
    PMID: 14602735

    We conclude that the extreme decades of life are characterized by a pathophysiological sequence of events linking vitamin D deficiency, low serum calcium, and secondary hyperparathyroidism with an increase in bone resorption and severe osteopenia. These data offer a rationale for the possible prevention of elevated bone turnover, bone loss, and consequently the reduction of osteoporotic fractures and fracture-induced disability in the oldest olds through the supplementation with calcium and vitamin D.
Matti Narkia

Conjugated Linoleic Acid Promotes Human Adipocyte Insulin Resistance through ... - 0 views

  •  
    Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production.
    Chung S, Brown JM, Provo JN, Hopkins R, McIntosh MK.
    J Biol Chem. 2005 Nov 18;280(46):38445-56. Epub 2005 Sep 9.
    PMID: 16155293
    doi: 10.1074/jbc.M508159200

    Collectively, these data demonstrate for the first time that trans-10, cis-12 CLA promotes NFkappaB activation and subsequent induction of IL-6, which are at least in part responsible for trans-10, cis-12 CLA-mediated suppression of peroxisome proliferator-activated receptor gamma target gene expression and insulin sensitivity in mature human adipocytes.

    In summary, our in vitro data demonstrate that a physiological level of trans-10, cis-12 CLA activates NFκB- and ERK1/2-dependent cytokine production, which together suppress PPARγ and Glut4 levels and lead to impaired glucose uptake. Studies are currently under way examining 1) how CLA regulates PPARγ and the expression of its target genes, 2) the specific signaling role of SV cells and adipocytes in mediating the TG-lowering actions of CLA, and 3) the CLA-induced, upstream signal that activates NFκB and ERK1/2.
Matti Narkia

Omega-3 fatty acids enter plaque, resulting in increased stability and less inflammatio... - 0 views

  •  
    "June 21, 2006 | Michael O'Riordan

    Rome, Italy - One of the possible ways in which long-chain omega-3 fatty acids play a role in decreasing cardiovascular events is by entering advanced atherosclerotic plaques. According to the results of a new study, investigators were able to show that the incorporation of eicosapentaenoic acid (EPA) into advanced plaque was associated with a decreased expression of various matrix metalloproteinases (MMPs) involved in causing plaque instability, as well as with decreased plaque inflammation.

    These are results of the Omacor Carotid Endarterectomy Intervention (OCEAN) study, presented here this week at the International Symposium on Atherosclerosis by Dr Philip Calder (University of Southampton, UK).

    "By increasing the availability of omega-3 fatty acids, they appear in advanced atherosclerotic plaques, indicated in this study by the carotid artery, and this results in lower numbers of macrophages, foam cells, and T cells, as well as the lower expression of inflammatory markers," said Calder. "Histologically, this results in a plaque that appears to be less inflamed and more stable. This may contribute to reduced mortality in patients consuming omega-3 fatty acids, for example, in the GISSI Prevenzione trial.""
Matti Narkia

VITAMIN D LOWERS C-REACTIVE PROTEIN (CRP) - 1 views

  •  
    VITAMIN D LOWERS C-REACTIVE PROTEIN (CRP)
    Van den Berghe and colleagues at the University of Leuven in Belgium appear to be the first to show that simple, natural and cheap vitamin D (cholecalciferol) lowers CRP in critically ill patients. Even small amounts of cholecalciferol (500 IU) lowered CRP by more than 25% in a small group of critically ill patients. Another marker of inflammation (IL-6) was reduced even more. The researchers also found that critically ill patients were profoundly deficient in vitamin D.
Matti Narkia

Immunologic effects of national cholesterol education panel step-2 diets with and witho... - 0 views

  •  
    Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived N-3 fatty acid enrichment.
    Meydani SN, Lichtenstein AH, Cornwall S, Meydani M, Goldin BR, Rasmussen H, Dinarello CA, Schaefer EJ.
    J Clin Invest. 1993 Jul;92(1):105-13.
    PMID: 8325975
    doi:10.1172/JCI116537

    the low-fat, high-fish diet significantly decreased the percentage of helper T cells whereas the percentage of suppressor T cells increased
Matti Narkia

Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the e... - 0 views

  •  
    Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation.
    Schambach F, Schupp M, Lazar MA, Reiner SL.
    Eur J Immunol. 2007 Sep;37(9):2396-9.
    PMID: 17694576
    DOI: 10.1002/eji.200737621
Matti Narkia

Are Omega-3 Fatty Acids Effective in Enhancing Tumoricidal Cell Activity? - Are Omega-3... - 0 views

  •  
    K. L. Fritsche
    Are Omega-3 Fatty Acids Effective in Enhancing Tumoricidal Cell Activity?
    J. Nutr., December 1, 2005; 135(12): 2916S - 2917S.
Matti Narkia

Fish oil and treatment of cancer cachexia - Genes Nutr. 2008 Apr. - 0 views

  •  
    Fish oil and treatment of cancer cachexia.
    Giacosa A, Rondanelli M.
    Genes Nutr. 2008 Apr;3(1):25-8.
    PMID: 18850196
Matti Narkia

Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in pa... - 0 views

  •  
    Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial.
    Read JA, Beale PJ, Volker DH, Smith N, Childs A, Clarke SJ.
    Support Care Cancer. 2007 Mar;15(3):301-7. Epub 2006 Oct 5.
    PMID: 17021855
    Doi: 10.1007/s00520-006-0153-3
Matti Narkia

Comparison of the effects of linseed oil and different doses of fish oil on mononuclear... - 0 views

  •  
    Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects.
    Wallace FA, Miles EA, Calder PC.
    Br J Nutr. 2003 May;89(5):679-89.
    PMID: 12720588

Matti Narkia

Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty aci... - 0 views

  •  
    Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids.
    Ohman M, Akerfeldt T, Nilsson I, Rosen C, Hansson LO, Carlsson M, Larsson A.
    Ups J Med Sci. 2008;113(3):315-23.
    PMID: 18991244

    Addition of one regular egg per day to the normal diet had no negative impact on blood lipids or inflammation markers. Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose. These effects have been associated in previous studies with a reduced risk for cardiovascular mortality and diabetes.

Matti Narkia

Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization i... - 0 views

  •  
    Eicosapentaenoic acid is anti-inflammatory in preventing choroidal
    neovascularization in mice.
    Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S,
    Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S.
    Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4328-34.
    PMID: 17724224
    DOI:  10.1167/iovs.06-1148
Matti Narkia

Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimula... - 0 views

  •  
    Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid.
    Weldon SM, Mullen AC, Loscher CE, Hurley LA, Roche HM.
    J Nutr Biochem. 2007 Apr;18(4):250-8. Epub 2006 Jun 16.
    PMID: 16781858
    doi:10.1016/j.jnutbio.2006.04.003
Matti Narkia

Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. - J Immu... - 0 views

  •  
    Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells.
    Baker N, O'Meara SJ, Scannell M, Maderna P, Godson C.
    J Immunol. 2009 Mar 15;182(6):3819-26.
    PMID: 19265161
    doi:10.4049/jimmunol.0803175
1 - 14 of 14
Showing 20 items per page