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Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial.\nLucas M, Asselin G, Mérette C, Poulin MJ, Dodin S.\nAm J Clin Nutr. 2009 Feb;89(2):641-51. Epub 2008 Dec 30.\nPMID: 19116322 \ndoi:10.3945/ajcn.2008.26749

Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.Am J Clin Nutr. 2006 Apr;

A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention. Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C. J Bone Miner Res. 2006 Jun;21(6):836-44. PMID: 16753014 doi: 10.1359/jbmr.060302 We conclude that the current vitamin D recommendation for adolescent girls, at least in the northern latitudes, is too low to ensure sufficient vitamin D status during winter. Intake of vitamin D at rates of 10-15 μg/day aids to maintain stable S-25(OH)D concentrations during winter. Vitamin D induced BMC augmentation by decreasing bone resorption, but not affecting bone formation, which was reflected by the biochemical markers of bone turnover. Optimizing bone mineral gain in adolescence is crucial to the prevention of osteoporosis later in life. Increasing vitamin D intake to 10-15 μg/day aids in attaining this goal.

Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. Trivedi DP, Doll R, Khaw KT. BMJ. 2003 Mar 1;326(7387):469. PMID: 12609940 CONCLUSION: Four monthly supplementation with 100 000 IU oral vitamin D may prevent fractures without adverse effects in men and women living in the general community.

Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. Terakawa N, Matsui Y, Satoi S, Yanagimoto H, Takahashi K, Yamamoto T, Yamao J, Takai S, Kwon AH, Kamiyama Y. Nutr Cancer. 2008;60(5):643-51. PMID: 18791928

Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure-double blind, randomized, placebo controlled clinical trial. Peguet-Navarro J, Dezutter-Dambuyant C, Buetler T, Leclaire J, Smola H, Blum S, Bastien P, Breton L, Gueniche A. Eur J Dermatol. 2008 Sep-Oct;18(5):504-11. Epub 2008 Aug 8. PMID: 18693151

Lin PY, Su KP. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry. 2007 Jul;68(7):1056-61. PMID: 17685742 [PubMed - in process]

Hallahan B, Hibbeln JR, Davis JM, Garland MR. Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial. Br J Psychiatry. 2007 Feb;190:118-22. PMID: 17267927 [PubMed - indexed for M

L-arginine may help in the treatment and prevention of diabetes since many disease complications, including poor circulation and blindness are vascula in nature.

Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. Jorde R, Sneve M, Figenschau Y, Svartberg J, Waterloo K. J Intern Med. 2008 Dec;264(6):599-609. Epub 2008 Sep 10. PMID: 18793245 Conclusions. It appears to be a relation between serum levels of 25(OH)D and symptoms of depression. Supplementation with high doses of vitamin D seems to ameliorate these symptoms indicating a possible causal relationship.

Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. Trivedi DP, Doll R, Khaw KT. BMJ. 2003 Mar 1;326(7387):469. PMID: 12609940 Conclusion: Four monthly supplementation with 100 000 IU oral vitamin D may prevent fractures without adverse effects in men and women living in the general community.

Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K; Japan EPA lipid intervention study (JELIS) Investigators. Lancet. 2007 Mar 31;369(9567):1090-8. Erratum in: Lancet. 2007 Jul 21;370(9583):220. PMID: 17398308 doi:10.1016/S0140-6736(07)60527-3 Interpretation EPA is a promising treatment for prevention of major coronary events, and especially non-fatal coronary events, in Japanese hypercholesterolaemic patients

Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Su KP, Huang SY, Chiu CC, Shen WW. Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71. Erratum in: Eur Neuropsychopharmacol. 2004 Mar;14(2):173. PMID: 12888186 From the preliminary findings in this study, omega-3 PUFAs could improve the short-term course of illness and were well tolerated in patients in major depressive disorder.

Ageless Male is made with a standardized extract called Testofen®, which is a natural and clinically-tested ingredient derived from the fenugreek herb. A double-blind, randomized, placebo-controlled human clinical study on Testofen® has shown it can significantly help boost free testosterone in men within safe, healthy levels.Ageless Male includes vitamin B6, which supports healthy energy metabolism in the body. Instead of an unnatural "jolt" like you'd get from caffeine, your daily intake of this vitamin will promote your body's natural ability to provide energy for your life.

Turner B, Molgaard C, Marckmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2004 Oct;92(4):70

ScienceDaily (Mar. 24, 2009) - Individuals who took a dietary supplement called "factor D", which included selenium, vitamin E, and beta-carotene, continued to have lower gastric cancer and overall mortality 10 years after supplementation ceased compared with individuals who did not take the supplements, according to long-term follow-up data from the randomized, double-blind General Population Nutrition Intervention Trial in Linxian, China.

A recently published study in Nutrition and Cancer (60(5), 643-651) by researchers at Kansai Medical University in Osaka, Japan has shown that AHCC (Active Hexose Correlated Compound) enhances immune function by increasing the number of dendritic cells (DCs). DCs are a key part of the immune system responsible for presenting foreign substances to other immune system cells. The study was conducted in a double-blind randomized fashion where twenty-one healthy subjects received a placebo or AHCC at 3.0 g/day for 4 weeks. Blood samples were obtained and measured at baseline and at 4 weeks. The number of circulating types of DCs was measured which included CD 11c+ DCs (myeloid DC population; DC1) and CD11c- DCs (lymphoid DC population; DC2). Other parameters measured included mixed-leukocyte reaction (MLR), natural killer (NK) cell activity, the proliferative response of T lymphocytes toward mitogen (phytohemagglutinin [PHA]) and cytokine production of interleukin (IL)-2, IL-4, IL-6, IL-10, interferon gamma-gamma, and (alpha)-tumor necrosis factor.

Hallahan B, Hibbeln JR, Davis JM, Garland MR. Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial. Br J Psychiatry. 2007 Feb;190:118-22. PMID: 17267927 [PubMed - indexed for M

The material presented on this site comes from individuals with years of hard-won experience either practicing alternative diets or observing those who do. As you'll find, no two writers will necessarily agree on all topics. A unifying theme, however, is the intent to squarely acknowledge and discuss the sometimes serious problems that can occur on alternative diets but often go unreported, and to go beyond the simplistic dogmas readily available elsewhere--in fact almost everywhere--to "explain them away." A sense of admirable idealism is often a motivating factor encouraging people to take responsibility for their own health and to explore different diets. However, the development of emotional attachments to philosophies underlying such diets can often end up becoming far more important for some individuals than the results they obtain--or fail to. One result has been widespread refusal in the alternative diet community to face health and behavioral problems that may arise on these diets. A common thread in what you'll read here is that a kind of subjective, "blinded naturalism" has become more or less endemic in the vegetarian, raw-food, and alternative diet movements, which can lead to serious health troubles.

"Despite its dubious beginnings, fad-dieting gained mass appeal in the 19th century. In 1829, Presbyterian minister Sylvester Graham touted the Graham Diet - centered on caffeine-free drinks and vegetarian cuisine, and supplemented by the eponymous Graham Cracker - as a cure for not just obesity but masturbation (and the subsequent blindness it was thought to cause.) The diet became so popular that the students of Oberlin College were forced onto it for a brief period in the 1830s before they successfully rebelled through mass dissent in 1841. Thirty-five years later, an English casketmaker named William Banting became famous by pioneering the concept of a low-carbohydrate diet, which helped him lose 50 lbs. He published his results in the 1864 "Letter on Corpulance," and the plan became so popular that "banting" became a synonym for dieting across Britain. "