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Matti Narkia

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth... - 0 views

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    Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. Li Y, Liu L, Tollefsbol TO. FASEB J. 2009 Dec 17. [Epub ahead of print] PMID: 20019239 doi: 10.1096/fj.09-149328 Cancer cells metabolize glucose at elevated rates and have a higher sensitivity to glucose reduction. However, the precise molecular mechanisms leading to different responses to glucose restriction between normal and cancer cells are not fully understood. We analyzed normal WI-38 and immortalized WI-38/S fetal lung fibroblasts and found that glucose restriction resulted in growth inhibition and apoptosis in WI-38/S cells, whereas it induced lifespan extension in WI-38 cells. Moreover, in WI-38/S cells glucose restriction decreased expression of hTERT (human telomerase reverse transcriptase) and increased expression of p16(INK4a). Opposite effects were found in the gene expression of hTERT and p16 in WI-38 cells in response to glucose restriction. The altered gene expression was partly due to glucose restriction-induced DNA methylation changes and chromatin remodeling of the hTERT and p16 promoters in normal and immortalized WI-38 cells. Furthermore, glucose restriction resulted in altered hTERT and p16 expression in response to epigenetic regulators in WI-38 rather than WI-38/S cells, suggesting that energy stress-induced differential epigenetic regulation may lead to different cellular fates in normal and precancerous cells. Collectively, these results provide new insights into the epigenetic mechanisms of a nutrient control strategy that may contribute to cancer therapy as well as antiaging approaches.
Matti Narkia

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adipo... - 0 views

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    Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ. J Clin Invest. 2009 May;119(5):1322-34. Epub 2009 Apr 20. PMID: 19381015 doi: 10.1172/JCI37385. Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.
Matti Narkia

Calorie restriction: Scientists take important step toward 'fountain of youth' - 0 views

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    "ScienceDaily (Dec. 26, 2009) - Going back for a second dessert after your holiday meal might not be the best strategy for living a long, cancer-free life say researchers from the University of Alabama at Birmingham. That's because they've shown exactly how restricted calorie diets -- specifically in the form of restricted glucose -- help human cells live longer. They found that the normal cells lived longer, and many of the precancerous cells died, when given less glucose. Gene activity was also measured under these same conditions. The reduced glucose caused normal cells to have a higher activity of the gene that dictates the level of telomerase, an enzyme that extends their lifespan and lower activity of a gene (p16) that slows their growth. Epigenetic effects (effects not due to gene mutations) were found to be a major cause in changing the activity of these genes as they reacted to decreased glucose levels. "Western science is on the cusp of developing a pharmaceutical fountain of youth" said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study confirms that we are on the path to persuading human cells to let us to live longer, and perhaps cancer-free, lives.""
Matti Narkia

Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood gluc... - 0 views

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    Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and ghrelin concentrations in healthy subjects. Hlebowicz J, Hlebowicz A, Lindstedt S, Björgell O, Höglund P, Holst JJ, Darwiche G, Almér LO. Am J Clin Nutr. 2009 Jan 21. [Epub ahead of print] PMID: 19158209 doi:10.3945/ajcn.2008.26807
Matti Narkia

Vitamin D Status and Glucose Homeostasis in the 1958 British Birth Cohort - Diabetes Care - 0 views

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    Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Hyppönen E, Power C. Diabetes Care. 2006 Oct;29(10):2244-6. PMID: 17003300 doi: 10.2337/dc06-0946 CONCLUSIONS-Body size was a strong determinant for 25(OH)D, with concentrations being suboptimal in most obese participants. Randomized controlled trials [using dosages sufficient to improve 25(OH)D also for the obese] are required to determine whether clinically relevant improvements in glucose metabolism can be obtained by vitamin D supplementation.
Matti Narkia

Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in... - 0 views

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    Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in Pediatric Outpatients. Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S. J Pediatr. 2009 Nov 17. [Epub ahead of print] PMID: 19926097 Conclusions Low 25(OH) D levels in children and adolescents are associated with higher plasma glucose and lower HDL concentrations.
Matti Narkia

Powerful Advances in Natural Cancer Prevention - Life Extension - 0 views

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    Scientists have known that cruciferous vegetables contain a host of chemopreventive agents that act in many different ways to block cancer development.2 Key among these products are indole-3-carbinol (I3C) and sulforaphane.1,3 Cancer cells need a brisk blood supply to support their rampant growth and reproduction. Preliminary studies in vitro and in vivo have found that apigenin inhibits blood vessel growth (angiogenesis) in human ovarian cancer cells, blocking production of two main signaling molecules required to stimulate vessel growth.20,21 Scientists confirmed this effect in ovarian cancer cells, also finding that apigenin strongly inhibits cell proliferation.22 Apigenin and BITC: Complementary Cancer Protection Cancer cells also need energy to support their frenetic reproductive activity. Researchers applied apigenin to human pancreatic cancer cells in culture and studied the cells' uptake of glucose.14 Astonishingly, they found that apigenin deprived energy-hungry cancer cells of glucose to support their voracious appetites and aggressive growth. It did this by down-regulating vital glucose-transporting proteins in cancer cells. This approach could effectively starve deadly cancer cells and stop them in their tracks. Another cruciferous vegetable component receiving rave reviews is the sulfur-containing molecule benzyl isothiocyanate, or BITC (pronounced "bitsy"). As with apigenin, population studies have shown that higher intakes of BITC correlate with reduced risk of cancers of the lung, breast, and colon30 while blocking cancer development in a host of different ways. BITC induces breast cancer cell death by apoptosis (programmed cell death), interfering with cancer cells' energy utilization and causing them to die off before they can contribute to tumor growth.31,32 In human ovarian cancer cells, BITC induces apoptosis by a different mechanism. It stimulates "signaling" molecules that tell cancer cells it's time to close up shop.
Matti Narkia

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing ... - 0 views

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    Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Zhang H, Wei J, Xue R, Wu JD, Zhao W, Wang ZZ, Wang SK, Zhou ZX, Song DQ, Wang YM, Pan HN, Kong WJ, Jiang JD. Metabolism. 2009 Sep 3 doi:10.1016/j.metabol.2009.07.029 Liver function was improved greatly in these patients by showing reduction of liver enzymes. Our results confirmed the activity of BBR on InsR in humans and its relationship with the glucose-lowering effect. Together with our previous report, we strongly suggest BBR as an ideal medicine for T2DM with a mechanism different from metformin and rosiglitazone.
Matti Narkia

Whole Health Source: paleolithic diet - 0 views

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    Dr. Staffan Lindeberg has published a new study using the "paleolithic diet" to treat type II diabetics (free full text). Type II diabetes, formerly known as late-onset diabetes until it began appearing in children, is typically thought to develop as a result of insulin resistance (a lowered tissue response to the glucose-clearing function of insulin). This is often followed by a decrease in insulin secretion due to degeneration of the insulin-secreting pancreatic beta cells. After Dr. Lindeberg's wild success treating patients with type II diabetes or glucose intolerance, in which he normalized the glucose tolerance of all 14 of his volunteers in 12 weeks, he set out to replicate the experiment. This time, he began with 13 men and women who had been diagnosed with type II diabetes for an average of 9 years.
Matti Narkia

A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in i... - 0 views

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    A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Lindeberg S, Jönsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjöström K, Ahrén B. Diabetologia. 2007 Sep;50(9):1795-807. Epub 2007 Jun 22. PMID: 17583796 DOI: 10.1007/s00125-007-0716-y Conclusions/interpretation A Palaeolithic diet may improve glucose tolerance independently of decreased waist circumference.
Matti Narkia

Hyperlipid: Physiological insulin resistance and palmitic acid again - 0 views

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    "I like palmitic acid. It causes insulin resistance. Thank goodness. Ted sent me this link. It's depressing. I'm going to discuss a thought drug. I'm going to call it Palmitofake, and it can be developed by Pfizer, no, Fort Dodge. I particularly dislike FD for anaesthesia related reasons. So what does Palmitofake do? BTW, if you didn't need any other hint you can tell this drug is going to bomb as there is neither an x, y or z in its name. Trust FD to screw up (in my mind). Palmitofake is a fluoride substituted analogue of palmitic acid which irreversibly binds to the acyl-CoA interaction site of JNK1 and so inhibits the pathway by which palmitic acid keeps GLUT4 transporters off of the cell surface membrane, whole body-wide. The logic to this is that the lipotoxin, palmitic acid (nature's second biggest mistake, the biggest was obviously cholesterol) can no longer keep glucose out of cells and metabolism can run, unimpaired by fat, for ever on glucose. Woo hoo bring on the glucose."
Matti Narkia

Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty aci... - 0 views

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    Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids. Ohman M, Akerfeldt T, Nilsson I, Rosen C, Hansson LO, Carlsson M, Larsson A. Ups J Med Sci. 2008;113(3):315-23.P MID: 18991244 Today, eggs with an increased content of -3 fatty acids are available but there are few publications on the effects of consumption of such eggs on the lipoproteins and acute phase markers in humans. The aim of the present study was to evaluate the effects of consumption of standard eggs and -3 enriched eggs on lipoproteins, glucose and inflammation markers. Nineteen healthy volunteers consumed one extra egg per day of either standard eggs or omega-3 enriched eggs in a double-blind, cross-over study. The duration of each period was 1 month. The effects of the different egg diets on apolipoprotein A1 and B (Apo A1 and B), lipoprotein (a), creatinine, cystatin C, C-reactive protein, serum amyloid protein A, interleukin 6, triglycerides, glucose, total-, high-density lipoprotein and low-density lipo-protein cholesterol concentrations were analyzed. Addition of one regular egg per day to the normal diet had no negative impact on blood lipids or inflammation markers. Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose. These effects have been associated in previous studies with a reduced risk for cardiovascular mortality and diabetes.
Mango Dash india

Health And Fitness Benefits of Mango Fruit Juice - 0 views

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    Mangoes are the richest source of most important vitamins (A, C, B, E, K), minerals, dietary fibbers, electrolytes and iron which are mostly required by the for better growth and development as well as being healthy and live life without any diseases and infections. It is liked by all people due to its nice color, taste, flavor and quality health aspects. I have mentioned below the few beneficial aspects of the mangoes which you must know to enhance your interest while eating mangoes: Benefits of Mango juice for Cancer Prevention Mango fruit has antioxidant compounds (such as quercetin, fisetin, astragalin, gallic acid, isoquercitrin, methyl gallate and etc) and lots of enzymes which help in protecting against various body organs cancers like colon, leukemia, breast, stomach, prostate, lungs, cervical, oral cavity cancers and etc. These compounds include, as well as the abundant. Polyphenols found in it acts as an anti inflammatory agent and restricts the growth of cancerous cells. The soluble dietary fibers, pectin found in it has property of decreasing the action of protein (galectin) found in the cancerous cells. Benefits of Mango juice for Heart health It contains highest level of soluble dietary fibers (pectin) and vitamin C which involves in lowering the bad serum cholesterol levels means Low-Density Lipoproteins as well as enhancing the good serum cholesterol levels means High-Density Lipoproteins thus keeps the heart healthy by keeping all the heart problems away. It is the rich source of potassium which involves in controlling the blood pressure thus heart rate. Benefits of Mango juice for Skin It is beneficial for the skin in both ways whether it is eaten or applied externally on the skin. It India juice has antioxidants which make the skin healthy, smooth, glowing and wrinkles free. It clear out the blocked pores and provides solution to get free from the pimples if applied on the face. It makes the skin glowing by reducing the dark spot
Matti Narkia

Supplementation with cholecalciferol does not improve glycaemic control in diabetic sub... - 0 views

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    Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. Jorde R, Figenschau Y. Eur J Nutr. 2009 Apr 16. [Epub ahead of print] PMID: 19370371 10.1007/s00394-009-0020-3 Conclusions We were not able to demonstrate that vitamin D supplementation had a significant effect on glucose metabolism in subjects with type 2 diabetes but without vitamin D deficiency. Further studies are needed in larger groups of subjects with type 2 diabetes or impaired glucose tolerance, who also exhibit low serum 25-hydroxyvitamin D levels.
Matti Narkia

MedWire News - Diabetes - Very low HbA1c values may be as harmful as very high values - 2 views

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    "Lancet 2010; Advance online publication MedWire News: There is a U-shaped relationship between glycated hemoglobin (HbA1c) levels and mortality in people with diabetes, say researchers, meaning that intensive glucose-lowering therapy could be as harmful as uncontrolled hyperglycemia. Writing in The Lancet, Craig Currie (Cardiff University, UK) and team say that if their findings are confirmed then diabetes guidelines may need to be revised to include a lower as well as an upper HbA1c threshold. Currie's team used the UK General Practice Research Database from November 1986 to November 2008 to obtain data on two cohorts of patients aged 50 years and older with Type 2 diabetes. The patients comprised 27,965 individuals whose treatment had been intensified from oral monotherapy to combination therapy with oral blood-glucose lowering agents, and 20,005 who had changed to insulin-containing regimens."
Matti Narkia

The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of In... - 0 views

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    Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Non-diabetic Adults. Diabetes Care. 2007 Feb 2; [Epub ahead of print] PMID: 17277040 [PubMed - as sup
Matti Narkia

The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of In... - 0 views

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    Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007 Apr;30(4):980-6. Epub 2007 Feb 2. PMID: 17277040 [PubMed - in
Matti Narkia

NephroPal: Omega 3 Fatty Acid and Adiponectin Levels - 0 views

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    "Friday, December 18, 2009 Omega 3 Fatty Acid and Adiponectin Levels Today my wife was watching the Oprah show. A commercial came on and I looked up. It was a Christmas special on liposuction in the local area. Considering that the fat tissue (adipose tissue) is now viewed as an endocrine organ and not just a collection of fat cells, I have always thought that sucking out the fat cells maybe a bad idea. Yet, I have never seen proof of this. But, the science of the adipose tissue as an endocrine organ is relatively new. It seems that in the medical literature adiponectin is receiving the most attention from all of the other adipose hormones - or also referred to as adipokines. This is for good reason. As stated before, adiponectin has the following effects: * reduces liver glucose production * increases glucose uptake in the muscles and adipose tissues * causes oxidation of fats which leads to less lipid production * has anti-inflammatory properties * protects the heart against ischemia and reduces myocardial infarct size * acts as an anti-clotting factor * increases nitric oxide production in the vasculature leading to a greater dilation of the vessels"
Matti Narkia

Effects of chili consumption on postprandial glucose, insulin, and energy metabolism --... - 0 views

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    Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Ahuja KD, Robertson IK, Geraghty DP, Ball MJ. Am J Clin Nutr. 2006 Jul;84(1):63-9. PMID: 16825682
Matti Narkia

Animal Pharm: Palmitic Acid+ CARBS = Mouse Skeletal Muscle IR - 0 views

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    "Peter at Hyperlipid and Stephan at Whole Health have dispelled yet again myths regarding the indictment of the 16:0 long-chained saturated fatty acid Palmitic Acid as the prime instigator of insulin resistance (IR). Researchers are always wrong -- it's... HIGH CARBS PLUS Palmitic acid. Their brilliant posts discuss below: --Sportzaid (FRUCTOSE) + Palmitate = IR RETARDNESS --High Carb Lab Chow + Palmitate = IR in the brain Yes. Such inferences applied to low carbers (LCers) is pure ridiculousness. Non-applicable. Low/no carb + Palmitic Acid = GOOD THING. All the low-carb/high saturated fat (palmitic acid) and ketosis trials by Hays JH, Volek JS, and Krauss RM have shown reductions in blood insulin, blood glucoses (BG) and peripheral tissue insulin resistance (IR). Directly contrary to the high carb animal or human studies. Palmitic acid has a special evolutionary, adaptive role in mammalian metabolism. Stephan showed that it likely 'fills in' when blood glucose starts to decline. "
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