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Matti Narkia

Lipoxin - Wikipedia, the free encyclopedia - 0 views

en.wikipedia.org/Lipoxin

lipoxin lipoxins info reference wikipedia eicosanoids inflammation resolution omega-6 arachidonic_acid AA lipoxin_A4 LXA4 lipoxin_B4 LXB4 NF-KappaB anti-inflammatory mediators lipid_mediators nutrition A4 B4

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    Lipoxins are a series of anti-inflammatory mediators. Lipoxins are short lived endogenously produced nonclassic eicosanoids whose appearance in inflammation signals the resolution of inflammation. They are abbreviated as LX, an acronym for lipoxygenase (LO) interaction products. At present two lipoxins have been identified; lipoxin A4 (LXA4) and lipoxin B4 (LXB4)
Matti Narkia

Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. - Bentham Science Publi... - 0 views

www.benthamdirect.org/...content.php

2006 April study review lipxins lipoxin 15-Epi-Lipoxins aspirin-triggered aspirin lipd_mediators ATL inflammation resolution 12-LOX 5-LOX COX-2 LOX metabolism omega-6 AA nutrition medline eicosanoids

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    Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. Romano M. Inflamm Allergy Drug Targets. 2006 Apr;5(2):81-90. Review. PMID: 16613567
Matti Narkia

Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 depend... - 0 views

www.nature.com/...nm1355.html

2006 March nature study research in_vivo lipoxins lipoxin A4 lipoxin_A4 LXA4 aspirin anti-inflammatory actions SOCS-2 IL-12 dendritic_cells nutrition medline omega-6 AA

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    Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, Aliberti J. Nat Med. 2006 Mar;12(3):330-4. Epub 2006 Jan 15. PMID: 16415877 doi:10.1038/nm1355\n
Matti Narkia

15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acut... - 0 views

jem.rupress.org/...69

2004 July study research in_vivo animal_study leukocytes resolution NSAID NSAIDs epi-lipoxins endothelium aspirin anti_inflammatory_lipid_mediators 15-epi-lipoxin_A4 lipoxin lipoxins NO nitric_oxide nutrition medline omega-6 AA

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    15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, Cooper D, Gilroy DW. J Exp Med. 2004 Jul 5;200(1):69-78. PMID: 15238606
Matti Narkia

Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a rando... - 0 views

www.pnas.org/...15178.long

2004 October PNAS study research clinical_trial rct humans lipoxins lipoxin 15-epi-lipoxin A4 15-epi-lipoxin_A4 aspirin triggers anti-inflammatory thromboxane ATL TXB2 TX inhibition inhibits COX-2 lipoxin_A4 LXA4 nutrition medline ASA

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    Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CN. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15178-83. Epub 2004 Oct 7. PMID: 15471991 doi: 10.1073/pnas.0405445101
Matti Narkia

Lipoxins and resolvins in inflammatory bowel disease. - Inflamm Bowel Dis. 2007 Jun - 0 views

www3.interscience.wiley.com/...HTMLSTART

2007 June study review inflammatory_bowel_disease IBS lipoxins lipoxin resolvins resolvin inflammation immunology dendritic_cells omega-3 omega-6 T-regs Tregs T_cells nutrition medline anti-inflammatory lipid_mediators immune system immune_system

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    Lipoxins and resolvins in inflammatory bowel disease. Weylandt KH, Kang JX, Wiedenmann B, Baumgart DC. Inflamm Bowel Dis. 2007 Jun;13(6):797-9. Review. PMID: 17262807
Matti Narkia

Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels. ... - 0 views

www.sciencedirect.com/science

2005 study research epidemilogical humans lipoxins lipoxin A4 lipoxin_A4 LXA4 levels aging anti-inflammatory inflammation leukotrienes resolution old older elderly chronic low-grade low-grade_inflammation age-related_diseases nutrition medline

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    Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels. Gangemi S, Pescara L, D'Urbano E, Basile G, Nicita-Mauro V, Davì G, Romano M. Exp Gerontol. 2005 Jul;40(7):612-4. PMID: 15935589 doi:10.1016/j.exger.2005.04.004
Matti Narkia

Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in end... - 0 views

www.schattauer.de/index.php

2007 January study research lipoxins lipoxin A4 lipoxin_A4 LXA4 omega-6 AA aspirin-triggered aspirin ATL CVD angiotensin ROS generation ROS_generation novel antioxidative mechanism nutrition medline

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    Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism. Nascimento-Silva V, Arruda MA, Barja-Fidalgo C, Fierro IM. Thromb Haemost. 2007 Jan;97(1):88-98. PMID: 17200775 DOI: 10.1160/TH06-06-0315
Matti Narkia

Lipoxin A4 levels in asthma: relation with disease severity and aspirin sensitivity. - ... - 0 views

www3.interscience.wiley.com/...abstract

2007 October study research epidemiolgical humans lipoxins lipoxin A4 lipoxin_A4 LXA4 anti-inflammatory eicosanoid omega-6 AA asthma severity aspirin inflammation low levels low_levels nutrition medline 15-epi-LXA4 AERD

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    Lipoxin A4 levels in asthma: relation with disease severity and aspirin sensitivity. Celik GE, Erkekol FO, Misirligil Z, Melli M. Clin Exp Allergy. 2007 Oct;37(10):1494-501. PMID: 17883729 DOI: 10.1111/j.1365-2222.2007.02806.x
Matti Narkia

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal d... - 0 views

jem.rupress.org/...1077

2008 May study research in_vivo lipoxins lipoxin native aspirin-triggered aspirin innate immunity innate_immunity TRAF6 SOCS-2 nutrition medline omega-6 AA anti-inflammatory LXA4 ATL ASA

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    Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. Machado FS, Esper L, Dias A, Madan R, Gu Y, Hildeman D, Serhan CN, Karp CL, Aliberti J. J Exp Med. 2008 May 12;205(5):1077-86. Epub 2008 Apr 14. PMID: 18411340 doi:10.1084/jem.20072416
Matti Narkia

Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. - J Immu... - 0 views

www.jimmunol.org/...3819

2009 March study research in_vitro in_vivo lipoxins lipoxin A4 lipoxin_A4 LXA4 anti-inflammatory anti-angiogenic antiangiogenic endothelial_cells aspirin VEGF IL-6 TNF-alpha IFN-gamma IL-8 LTD4 angiogenesis nutrition medline

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    Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. Baker N, O'Meara SJ, Scannell M, Maderna P, Godson C. J Immunol. 2009 Mar 15;182(6):3819-26. PMID: 19265161 doi:10.4049/jimmunol.0803175
Matti Narkia

Targeting lipoxygenases with care. - ScienceDirect - Chemistry & Biology 2006 Nov - 0 views

www.sciencedirect.com/science

2006 November study research fish_oil omega-3 EPA resolvin E2 resolvins resolvin_E2 RvE2 5-LOX LOX lipoxins lipoxin omega-6 AA lipoxin_A4 LXA4 lipoxin_B4 LXB4 aspirin COX-2 12-LOX 15R-HETE 5S-HEPE nutrition medline COX RvE1

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    Targeting lipoxygenases with care. de Souza PM, Newson J, Gilroy DW. Chem Biol. 2006 Nov;13(11):1121-2. PMID: 17113992 doi:10.1016/j.chembiol.2006.11.002  
Matti Narkia

Modulation of inflammation in brain: a matter of fat. - J Neurochem. 2007 May - 0 views

www3.interscience.wiley.com/...HTMLSTART

2007 May study review inflammation brain modulation fat omega-6 AA lipoxins lipoxin omega-3 DHA eicosanoids docosanoids cytokines resolvins neuroprotectins neurodegenerative diseases neurodegenerative_diseases nutrition medline neuroinflammation NF-kappaB

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    Modulation of inflammation in brain: a matter of fat. Farooqui AA, Horrocks LA, Farooqui T. J Neurochem. 2007 May;101(3):577-99. Epub 2007 Jan 25. Review. PMID: 17257165 DOI: 10.1111/j.1471-4159.2006.04371.x
Matti Narkia

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators : Abs... - 0 views

www.nature.com/...nri2294.html

2008 May study review anti-inflammatory pro-resolution resolution resolving inflammation lipid mediators lipid_mediators resolvins resolvin protectins lipoxins lipoxin nutrition medline omega-3 EPA DHA omega-6 AA eicosanoids

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    Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Serhan CN, Chiang N, Van Dyke TE. Nat Rev Immunol. 2008 May;8(5):349-61. Review. PMID: 18437155 doi:10.1038/nri2294
Matti Narkia

Novel omega -- 3-derived local mediators in anti-inflammation and resolution. - Science... - 0 views

www.sciencedirect.com/science

2005 January study review anti-inflammatory lipid_mediators omega-3 EPA DHA fish_oil leukocytes eicosanoids aspirin inflammation resolution lipoxin lipoxins omega-6 AA resolvins resolvin docosatrienes neuroprotectins neuroprotectin nutrition medline

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    Novel omega -- 3-derived local mediators in anti-inflammation and resolution. Serhan CN. Pharmacol Ther. 2005 Jan;105(1):7-21. Review. PMID: 15626453 doi:10.1016/j.pharmthera.2004.09.002
Matti Narkia

RvE1 protects from local inflammation and osteoclast-mediated bone destruction in perio... - 0 views

www.fasebj.org/...05-4724fjev1

2006 February FASEB study research in_vitro neutrophil_tissue CVD inflammatory_diseases inflammation periodontitis resolvins resolvin E1 resolvin_E1 RvE1 bone health bone_health omega-3 EPA nutrition medline aspirin lipoxin lipoxins

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    RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE. FASEB J. 2006 Feb;20(2):401-3. Epub 2005 Dec 22. PMID: 16373400 doi:10.1096/fj.05-4724fje
Matti Narkia

Fatty acid facts, part III: Cardiovascular disease, or, a fish diet is noy fishy. - [Dr... - 0 views

www.ncbi.nlm.nih.gov/...19221636

2008 December study review omega-3 EPA DHA lipoxins resolvins protectins CVD anti-inflammatory lipid_mediators COX-2 expression COX-2_expression cardioprotective fish_oil fish diabetes prevention resolvin protectin lipoxin nutrition medline

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    Fatty acid facts, part III: Cardiovascular disease, or, a fish diet is noy fishy. Pauwels EK, Kostkiewicz M. Drug News Perspect. 2008 Dec;21(10):552-61. PMID: 19221636
Matti Narkia

New endogenous anti-inflammatory and proresolving lipid mediators: implications for rhe... - 0 views

www.ncbi.nlm.nih.gov/...17906612

2007 October study review anti-inflammatory proresolving pro-resolving lipid mediators lipid_mediators resolvins resolvin protectins protectin lipoxin rheumatic diseases chronic inflammatory nutrition medline omega-3 EPA DHA

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    New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. Yacoubian S, Serhan CN. Nat Clin Pract Rheumatol. 2007 Oct;3(10):570-9; quiz 1 p following 589. Review. PMID: 17906612
Matti Narkia

Essential fatty acids and their metabolites could function as endogenous HMG-CoA reduct... - 0 views

www.lipidworld.com/37

2008 October study review EFA EFAs metabolites HMG-CoA_reductase ACE inhibitors inhibitor funtion anti-arrhythmic anti-hypertensive anti-atherosclerotic cytoprotective cardioprotective CVD nutrition lipoxins resolvins protectins AA EPA DHA omega-3 omega-6

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    Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules.\nDas UN.\nLipids Health Dis. 2008 Oct 15;7:37. Review.\nPMID: 18922179 \ndoi:10.1186/1476-511X-7-37
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