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Matti Narkia

VitaminD3 - Ted Hutchinson's blog - 0 views

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    "Thursday, 17 December 2009
    This blog is in response to Dr Briffa's post here. as I keep having problems commenting on his blogs.

    While 44ng/ml is sufficient to not only maximize uptake of calcium (>32ng/ml) and ensure maximum bone mineral density (>42ng/ml), pregnant and nursing mothers should be aware that in order to maximize the amount of vitamin D3 in human breast milk 6400iu/daily was found to be necessary to raise (>58ng/ml) at latitude 32.
    This is detailed in the Taylor, Wagner and Hollis paper.
    Vitamin D supplementation during lactation to support infant and mother.
    Although 4000iu/daily met the mothers daily needs in full it left babies being born with lower 25(OH)D status than required for optimum calcium absorption

    They also found DAILY use of supplements was required by pregnant and nursing mothers to ensure an even daily Vitamin D3 supply to the foetus & baby.
    It makes virtually no measurable difference for everyone else if you supplement daily or weekly.

    While Dr Briffa will not be lactating he may be interested seeing in the
    Grassrootshealth chart showing disease incidence by 25(OH)D status.
    this may encourage him to go just another 10ng/ml higher and a bit nearer to the natural level at which human breast milk flows replete with D3."
Matti Narkia

Vitamin D, nervous system and aging. - Tuohimaa et al. - Psychoneuroendocrinology Volum... - 0 views

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    Vitamin D, nervous system and aging.
    P. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. .
    Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286
    NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION
    doi:10.1016/j.psyneuen.2009.07.003

    This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
Matti Narkia

Vitamin D and Disease Incidence Prevention | Free The Animal - 0 views

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    "For what reason I don't know, but this January 2009 editorial by William Faloon of the Life Extension Foundation is making the rounds. Perhaps it just came available on the web.

    It's a good read, particularly in light of the billions and trillions of dollars the thieves & thugs in DC are about to flush down the crapper on your behalf. Some notable excerpts.

    A large number of new vitamin D studies have appeared in the scientific literature since I wrote my plea to the federal government. These studies don't just confirm what we knew 16 months ago-they show that optimizing vitamin D intake will save even more lives than what we projected.

    For instance, a study published in June 2008 showed that men with low vitamin D levels suffer 2.42 times more heart attacks. Now look what this means in actual body counts.

    Each year, about 157,000 Americans die from coronary artery disease-related heart attacks. Based on this most recent study, if every American optimized their vitamin D status, the number of deaths prevented from this kind of heart attack would be 92,500.

    To put the number of lives saved in context, tens of millions of dollars are being spent to advertise that Lipitor® reduces heart attacks by 37%. This is certainly a decent number, but not when compared with how many lives could be saved by vitamin D. According to the latest study, men with the higher vitamin D levels had a 142% reduction in heart attacks."
Matti Narkia

Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-b... - 0 views

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    Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-based therapy in genotype 1 chronic hepatitis C
    Salvatore Petta et al.
    Hepatology, Volume 9999 Issue 999A, Page NA. Published Online: 4 Dec 2009
    DOI: 10.1002/hep.23489

    Conclusions:
    G1 CHC patients had low 25(OH)D serum levels, possibly due to reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on IFN-based therapy. (HEPATOLOGY 2010.)
Matti Narkia

Dietary Cod Protein Reduces Plasma C-Reactive Protein in Insulin-Resistant Men and Wome... - 0 views

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    Dietary cod protein reduces plasma C-reactive protein in insulin-resistant men and women.
    Ouellet V, Weisnagel SJ, Marois J, Bergeron J, Julien P, Gougeon R, Tchernof A, Holub BJ, Jacques H.
    J Nutr. 2008 Dec;138(12):2386-91.
    PMID: 19022962

    Therefore, these results show that CP can lower hsCRP, a marker of inflammation associated with insulin resistance and type 2 diabetes.
Matti Narkia

Can a Treatment for Sarcoidosis be Helpful for CFS or Fibromyalgia? - 0 views

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    Is the MP Treatment for Sarcoidosis Helpful for Other Chronic Diseases?
    MP's Vitamin D Theories Are Not Supported by Lab Studies.
    Updated July 2, 2008

    "The MP treatment plan was originally designed to treat an inflammatory condition known as sarcoidosis. The treatment consists of using the drug Benicar, combined with the avoidance of all sources of vitamin D, and eventually adding various antibiotics, especially minocycline. After being used by sarcoidosis patients for some years, it was then theorized and claimed that the treatment could treat other inflammatory conditions. Eventually it was also claimed that it could treat fibromyalgia and CFS, conditions which are not recognized by the medical literature as being inflammatory in nature. "
Matti Narkia

Voices of reason in the vitamin D debate - 0 views

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    "Maybe vitamin D isn't the answer after all.

    Not only does the above statement ring true, it's also the title of a recent post on "Dr. Len's Cancer Blog" - a website written by Dr. Len Lichtenfeld, Deputy Chief Medical Officer for the national office of the American Cancer Society, in order to facilitate communication with the public on important issues related to cancer. "
Matti Narkia

Vitamin D, nervous system and aging - ScienceDirect - Psychoneuroendocrinology - 0 views

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    Vitamin D, nervous system and aging.
    Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A.
    Psychoneuroendocrinology. 2009 Aug 4. [Epub ahead of print]
    PMID: 19660871
Matti Narkia

Vitamin D metabolites as clinical markers in autoimmune and chronic disease. - Ann N Y ... - 0 views

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    Vitamin D metabolites as clinical markers in autoimmune and chronic disease.
    Blaney GP, Albert PJ, Proal AD.
    Ann N Y Acad Sci. 2009 Sep;1173:384-90.
    PMID: 19758177
    DOI: 10.1111/j.1749-6632.2009.04875.x
Matti Narkia

Vitamin D for Pain - 0 views

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    According to peer-reviewed clinical research, inadequacies of vitamin D have been linked to chronic musculoskeletal pain of various types, muscle weakness or fatigue, fibromyalgia syndrome, rheumatic disorders, osteoarthritis, hyperesthesia, migraine headaches, and other somatic complaints. It also has been implicated in the mood disturbances of chronic fatigue syndrome and seasonal affective disorder.

    Current best evidence demonstrates that supplemental vitamin D can help to resolve or alleviate chronic pain and fatigue syndromes in many patients who have been unresponsive to other therapies. Vitamin D therapy is easy for patients to self-administer, is well tolerated, and is very economical. The documents on this page provide detailed background information and practice recommendations.
Matti Narkia

RANK ligand and TNF-{alpha} mediate acid-induced bone calcium efflux in vitro -- Frick ... - 0 views

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    Frick KK, LaPlante K, Bushinsky DA.
    RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro.
    Am J Physiol Renal Physiol. 2005 Nov;289(5):F1005-11. Epub 2005 Jun 21.
    PMID: 15972386 [PubMed - indexed for MEDLINE
Matti Narkia

Evidence-based decision making on micronutrients and chronic disease: long-term randomi... - 0 views

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    Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough.
    Ames BN, McCann JC, Stampfer MJ, Willett WC.
    Am J Clin Nutr. 2007 Aug;86(2):522-3; author reply 523-4.
    PMID: 17684228
Matti Narkia

Causes of disturbances in acid-base balance - Acid-base balance, dentinogenesis and den... - 0 views

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    The most common imbalance in the acid-base balance in the industrialized countries is mild chronic metabolic acidosis caused by the diet rich in the animal protein. Proteins are metabolized to organic acids. The typical American diet produces after metabolism approximately 100 meq of acid every day (Barzel 1995). This kind of a diet has been proved to cause aciduria and calciuria as a consequence of acidosis and thus a loss of total calcium of the body (Breslau et al. 1988, Schuette et al. 1980, Licata et al. 1981). Cola drinks that contain phosphoric acid are another acidosis-inducing ingredient of diet, especially among young people (Barzel 1995).
Matti Narkia

Nutrition, chronic disease, and the problem of proof -- Heaney 84 (3): 471 -- American ... - 0 views

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    Nutrition, chronic disease, and the problem of proof.
    Heaney RP.
    Am J Clin Nutr. 2006 Sep;84(3):471-2. No abstract available.
    PMID: 16960157
Matti Narkia

Chronic Sunscreen Use Decreases Circulating Concentrations of 25-Hydroxyvitamin D: A Pr... - 0 views

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    Matsuoka, L. Y., Wortsman, J., Hanifan, N. & Holick, M. F. (1988)
    Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D: a preliminary study.
    Arch. Dermatol. 124:1802-1804
Matti Narkia

Long-latency deficiency disease: insights from calcium and vitamin D -- Heaney 78 (5): ... - 0 views

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    Long-latency deficiency disease: insights from calcium and vitamin D.
    Heaney RP.
    Am J Clin Nutr. 2003 Nov;78(5):912-9. Review.
    PMID: 14594776
Matti Narkia

Vitamin D in preventive medicine: are we ignoring the evidence? - 0 views

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    Vitamin D in preventive medicine: are we ignoring the evidence?
    Zittermann A.
    Br J Nutr. 2003 May;89(5):552-72. Review.
    PMID: 12720576

    Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. European children and young adults often have circulating 25(OH)D levels in the insufficiency range during wintertime. Elderly subjects have mean 25(OH)D levels in the insufficiency range throughout the year. In institutionalized subjects 25(OH)D levels are often in the deficiency range. There is now general agreement that a low vitamin D status is involved in the pathogenesis of osteoporosis. Moreover, vitamin D insufficiency can lead to a disturbed muscle function. Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer. Some intervention trials have demonstrated that supplementation with vitamin D or its metabolites is able: (i) to reduce blood pressure in hypertensive patients; (ii) to improve blood glucose levels in diabetics; (iii) to improve symptoms of rheumatoid arthritis and multiple sclerosis. The oral dose necessary to achieve adequate serum 25(OH)D levels is probably much higher than the current recommendations of 5-15 microg/d.
Matti Narkia

YouTube - Vitamin D and Prevention of Chronic Diseases - 0 views

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    Vitamin D and Prevention of Chronic Diseases. A presentation by professor Michael F. Holick
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