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Matti Narkia

AMP-activated protein kinase - Wikipedia, the free encyclopedia - 0 views

    "5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans. It is expressed in a number of tissues, including the liver, brain, and skeletal muscle. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation and ketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells.[1]

    It should not be confused with cyclic AMP-activated protein kinase (protein kinase A), which, although being of similar nature, may have opposite effects.[2]"
Matti Narkia

Vitamin D metabolites as clinical markers in autoimmune and chronic disease. - Ann N Y ... - 0 views

    Vitamin D metabolites as clinical markers in autoimmune and chronic disease.
    Blaney GP, Albert PJ, Proal AD.
    Ann N Y Acad Sci. 2009 Sep;1173:384-90.
    PMID: 19758177
    DOI: 10.1111/j.1749-6632.2009.04875.x
Matti Narkia

Advanced Renal Cell Carcinoma drug, Temsirolimus, gets fast track status from FDA - 0 views

    Wyeth Pharmaceuticals announced today that the U.S. Food and Drug Administration (FDA) has granted a new "fast track" designation for temsirolimus (CCI-779), an investigational mTOR kinase inhibitor, in the first-line treatment of poor-prognosis patients
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