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Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. Volvert ML, Seyen S, Piette M, Evrard B, Gangolf M, Plumier JC, Bettendorff L. BMC Pharmacol. 2008 Jun 12;8:10. PMID: 18549472 doi:10.1186/1471-2210-8-10 Conclusion Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. This would explain why beneficial effects of benfotiamine have only been observed in peripheral tissues, while sulbutiamine, a lipid-soluble thiamine disulfide derivative, that increases thiamine derivatives in the brain as well as in cultured cells, acts as a central nervous system drug. We propose that benfotiamine only penetrates the cells after dephosphorylation by intestinal alkaline phosphatases. It then enters the bloodstream as S-benzoylthiamine that is converted to thiamine in erythrocytes and in the liver. Benfotiamine, an S-acyl derivative practically insoluble in organic solvents, should therefore be differentiated from truly lipid-soluble thiamine disulfide derivatives (allithiamine and the synthetic sulbutiamine and fursultiamine) with a different mechanism of absorption and different pharmacological properties.

Sulbutiamine (brand name: Arcalion) is a precursor to thiamine (i.e., vitamin B1). As a dimer of two structurally modified thiamine residues, sulbutiamine retains many of the features of thiamine. However, the thiazole rings are open, the alcohol groups are esterified, and a disulfide bridge connects the two thiamine analogues. Sulbutiamine is indicated for the treatment of asthenia.[1] Its ability to reduce fatigue is also considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. In one study of chronic fatigue patients, sulbutiamine did not demonstrate sustained benefits over the placebo, which raises doubts about its clinical efficacy.[2] However, the authors of that study suggest that additional research is needed to evalulate the potential usefulness of sulbutiamine in the treatment of chronic fatigue. Sulbutiamine may be beneficial for cognition. Indeed, the demonstrated ability of sulbutiamine to improve memory in rats[3] and patients of schizophrenia[3] suggests that it is a nootropic. Recent research also shows support for the use of sulbutiamine in the treatment of erectile dysfunction

This site was established to provide visitors with comprehensive information about benfotiamine, a synthetic derivative of thiamine (vitamin B-1) which shows promise in treating a number of neurological and vascular conditions. Benfotiamine also appears to have beneficial anti-aging qualities, protecting human cells from harmful metabolic end products. Benfotiamine is not just for diabetics. Any population suffering from conditions brought about by unknown or inadvertent thiamine deficiencies should respond well to benfotiamine. Benfotiamine is emerging as the most effective of the thiamine compounds.

Benfotiamine (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamine B1). After absorption, benfotiamine can be dephosphorylated by cells bearing an ecto-alkaline phosphatase to the lipid-soluble S-benzoylthiamine. The primary use of this antioxidant is as an "anti-AGE" supplement.[3] In a trial, benfotiamine lowered AGE by 40%.[4] However, in Germany doctors have been known to combine benfotiamine with pyridoxine hydrochloride and use it to treat patients with nerve damage and nerve pain such as sciatica. At high doses, benfotiamine was shown to be effective for the treatment of diabetic retinopathy, neuropathy, and nephropathy. I

Wheat germ boosts the immune system of the body and prevents cardiovascular disease and cancer. It is full of protein and fiber and is packed vitamins B, folate, vitamin B1 (thiamin) and vitamin B6. Vitamin B is important for the heart, brain and cardiovascular health.

Wheat germ boosts the immune system of the body and prevents cardiovascular disease and cancer. It is full of protein and fiber and is packed vitamins B, folate, vitamin B1 (thiamin) and vitamin B6. Vitamin B is important for the heart, brain and cardiovascular health.

Benefits of apple juice are one too many, enriching your body right from almost all types of vitamins (vitamin A, vitamin C, Vitamin E, vitamin K, B6, thiamine and riboflavin) to essential minerals like iron, copper, phosphorous, and potassium. But there are more valuable benefits of drinking apple juice. Recent studies have demonstrated that apple products boost memory, increase lipid metabolism, protect the heart, prevent colon cancer, prevent atherosclerosis, reduce wheezing among children. Read the full article and try THE SMOOTHIE RECIPE!

A popular vitamin supplement is being advertised with claims that are demonstrably untrue, as revealed by research published in the open access journal BMC Pharmacology. Benfotiamine is a synthetic derivative of thiamine (vitamin B1). It is marketed heavily as a dietary supplement using a selection of unsubstantiated, 'not-quite-medical' claims that tend to characterize this field. A large part of this campaign has been built around the belief that benfotiamine is lipid-soluble and, therefore, more physiologically active. Scientific research led by Dr Lucien Bettendorff of the Center for Cellular and Molecular Neurobiology at the University of Liège, Belgium, has entirely disproved these claims.

Vitamin B refers to a group of 8 vitamins. They are vitamin B1 (Thiamine), Vitamin B2 (Riboflavin), Vitamin B3 (Niacin), vitamin B5 (Pantothenic acid), vitamin B6 (Pyridoxine), vitamin B7 (Biotin), vitamin B8 (myo-inositol), vitamin B9 (Folic acid) and vitamin B12 (Cobalamin).

Litchi is a fruit with amazing health benefits belongs to Sapindaceae family. It is grown in the tropical and subtropical regions of the world and found abundantly in the summer season. It was first originated in the Chinese regions of Guangdong and Fujian and has been started cultivating in the various countries of the world (India, Vietnam, Sri Lanka, Thailand, Taiwan, Japan, Bangladesh, Nepal, Australia, Pakistan, Malaysia, Vietnam, Mexico, Southern Africa and etc). It is very delicate and attractive smelling fruit which is usually eaten fresh. It is found in many types such as emperor lychee or biggest lychee, ohia lychee or litchi with little seed, Brewster lychee and etc. Benefits of Litchi (Lychee) Fruit Juice It is loaded with numerous healthy nutrients including vitamins, minerals, antioxidants, fatty acids and so many. It protects from various diseases, infections and skin problems by enhancing the immunity power. It contains polyphenols which helps in fighting with weight problems, liver damage and type-2 diabetes. Some of its amazing health benefits are mentioned below: Benefits of Litchi for Heart Benefits of Litchi for Cancer Benefits of Litchi for Digestive System Benefits of Litchi for Bones, Teeth and Joints Benefits of Litchi for Hair Benefits of Litchi for Weight Loss Benefits of Litchi for Aging Benefits of Litchi for Women during Pregnancy Benefits of Litchi for Kids Benefits of Litchi for Men Benefits of Litchi Seeds Benefits of Litchi Juice of Skin Nutrition Facts of Litchi Dash per 100 ml Energy: 60 Kcal Fat: 0 gm Carbohydrate: 14.8 gm Protein: 0 gm Sugar: 12.5 g Vitamins Thiamine: 0.011 mg Riboflavin: 0.065 mg Niacin: 0.603 mg Choline: 7.1 mg Pyridoxine: 0.100 mg Folates: 14 µg Vitamin C: 71.5 mg Vitamin E: 0.07 mg Vitamin K: 0.4 µg Minerals Calcium: 5 mg Copper: 0.148 mg Iron: 0.31 mg Magnesium: 10 mg Manganese: 0.055 mg Phosphorus: 31 mg Selenium: 0.6 µg Zinc: 0.07 mg

Mango is one of the delicious tropical seasonal fruit and believed to be originated in the sub-Himalayan plains of Indian subcontinent.It is Maintains cancers, Blood Pressure and heart conditions and more.

Mango juice contains the vital nutrient, potassium that assists your muscles, heart and nerves' functions. This advantageous mineral also regulates the balance of fluids in your body and your blood pressure.

Mangoes is a seasonal fruit has been a regular part of human diet for about four thousand years, thanks to its unique flavour, taste and fragrance. You would also have relished this fruit but do you know the benefits of mango?

Mangoes have an impressive vitamin content that assures overall health. They are rich in potassium (4% in 156 mg) and magnesium (2% in 9 mg), and mango juice are great natural remedies for high blood pressure patients. They also contain selenium, calcium, iron and phosphorus. Mangoes are said to be vitamin powerhouses as they are rich in riboflavin, vitamin B6, A, C, E, K, niacin, folate, thiamin and panthothenic acid. These components help you to avoid a host of diseases that can come from deficiencies of these vitamins and minerals. The vitamin E content in mangoes can even help to boost your sex life by triggering the activity of your sex hormones.

Research and studies published at Comprehensive Reviews in Food Science and Food Safety have demonstrated that dietary fiber has a positive effect on eliminating degenerative diseases, including certain cancers,Blood Pressure and heart conditions. Now you have even more reasons to include this delicious fruit in your daily diet. The more you participate in strenuous activities,the more bodily potassium you lose, which is yet another helpful side effects of mangoes - high potassium content!

The litchi benefits have been tried and proven in countries such as China and India and have also been well documented in ancient Chinese books. They contain many nutrients and vitamins that help to fight against various diseases as well as being a treatment for skin care, child growth and strengthening the body.
Tetra Pak Juice of Litchi fruit contains 66 calories per 100 g, comparable to that in the table-grapes. It has no saturated fats or cholesterol, but composes of good amounts of dietary fiber, vitamins, and antioxidants.
Oligonol is a low molecular weight polyphenol found abundantly in litchi fruit. Oligonol has several anti-oxidant and anti-influenza virus actions. It also helps to improve blood circulation, reduces weight and protects the skin from harmful UVA rays.
Litchi, like citrus fruits, is an excellent source of vitamin C; 100 g fresh fruits provide 71.5 mg or 119% of daily-recommended value. Studies suggest that consumption of fruits rich in vitamin C helps the human body develop resistance against infectious agents and scavenge harmful, pro-inflammatory free radicals.
Litchi is a very good source of B-complex vitamins such as thiamin, niacin, and folates. These vitamins are essential since they function by acting as co-factors to help the body metabolize carbohydrates, protein, and fats.
Litchi also carries a very good amount of minerals like potassium and copper. Potassium is an important component of cell and body fluids help control heart rate and blood pressure; thus, it offers protection against stroke and coronary heart diseases. Copper is required in the production of red blood cells.some Health Benefits Of Litchi are
Cancer, Heart Disease, Aids digestion, Maintains healthy bones, Vitamin C, Oligonol, Vitamin B, Weight loss, Improves skin conditions.

Simultaneously Blocking Glycolysis and Fat Metabolism Can the use of DCA and a fatty acid metabolism blocker together force more cancer cells into using aerobic metabolism? Tim McGough used green tea extract, which contains EGCG, in his fantastic response. DCA works by reactivating mitochondria and shifts metabolism from glycolysis to glucose oxidation. Hopefully the cancer cell will then undergo apoptosis. However, cancer cells have an alternate energy source: fat metabolism. This page explores to possibility of blocking fat metabolism to help force the cell into apoptosis. Oral squamous cell carcinoma is a cancer that does not respond well to DCA. This study, Head and Neck Cancer Cell Lines Are Resistant to Mitochondrial-Depolarization-Induced Apoptosis states: "Results: ΔΨm in head and neck cell lines started to show slight loss of ΔΨm, while HL-60 showed significant loss of ΔΨm after 30 min of treatment. All cell lines demonstrated complete mitochondrial depolarization within 24 h, however, only the control cell line HL-60 underwent apoptosis. In addition, HNSCC cell lines did not demonstrate cytoplasmic cytochrome c release despite significant mitochondrial membrane depolarization, while HL-60 cell initiated apoptosis and cytochcrome c release after 24 h of treatment. Conclusions: Head and neck cancer cell lines exhibit defects in mitochondrial-membrane-depolarization-induced apoptosis as well as impaired release of cytochrome c despite significant mitochondrial membrane depolarization. Proximal defects in the mitochondrial apoptosis pathway are a feature of HNSCC.(head and neck squamous cell carcinoma)" Note that although the cell lines were depolarized, apoptosis did not occur. So I checked to see if fatty acid metabolism is used by squamous cell carcinoma.

Sulbutiamine is a centrally acting cholinergic vitamin B analogue. One study shows sulbutiamine improve memory in rats. At this time I prefer using a combination of several B vitamins rather than relying on one vitamin B analogue. For more information on B vitamins or to purchase Vitamin B Coenzyme. Even better is to take a multivitamin that has a combination of the B vitamins along with a couple of dozen vitamins and nutrients. In most cases I think it is better to take a small amount of a number of different nutrients as opposed to a large amount of just one. Consider a very popular product that I have formulated called MultiVit-Rx.