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Matti Narkia

Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pa... - 0 views

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    Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology.
    Peterlik M, Cross HS.
    Eur J Clin Nutr. 2009 Dec;63(12):1377-86. Epub 2009 Sep 2.
    PMID: 19724293
    doi:10.1038/ejcn.2009.105

    A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely encountered in European and North American countries, independent of age or gender. Both conditions are linked to the pathogenesis of many degenerative, malignant, inflammatory and metabolic diseases. Studies on tissue-specific expression and activity of vitamin D metabolizing enzymes, 25-(OH)D-1alpha-hydroxylase and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing receptor (CaR) have led to the understanding of how, in non-renal tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation, differentiation and function. Impairment of cooperative signalling from the 1,25-(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide.
Matti Narkia

Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabe... - 0 views

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    Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans.
    Pani MA, Knapp M, Donner H, Braun J, Baur MP, Usadel KH, Badenhoop K.
    Diabetes. 2000 Mar;49(3):504-7.
    PubMed PMID: 10868975.
    doi: 10.2337/diabetes.49.3.504
Matti Narkia

Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes melli... - 0 views

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    Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes mellitus in the Taiwanese population.
    Chang TJ, Lei HH, Yeh JI, Chiu KC, Lee KC, Chen MC, Tai TY, Chuang LM.
    Clin Endocrinol (Oxf). 2000 May;52(5):575-80.
    PMID: 10792336
    DOI: 10.1046/j.1365-2265.2000.00985.x

    CONCLUSIONS

    Vitamin D receptor gene polymorphisms were associated with type 1 diabetes in a Taiwanese population. However, functional studies are needed to establish the role of the vitamin D receptor in the pathogenesis of type 1 diabetes mellitus.
Matti Narkia

Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabete... - 0 views

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    Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group.
    [No authors listed]
    Diabetologia. 1999 Jan;42(1):51-4.
    PMID: 10027578
    DOI: 10.1007/s001250051112

    In conclusion, this large multicentre trial covering many different European settings consistently showed a protective effect of vitamin D supplementation in infancy. The findings indicate that activated vitamin D might contribute to immune modulation and thereby protect or arrest an ongoing immune process initiated in susceptible people by early environmental
    exposures.
Matti Narkia

(VIDEO) Shedding light on the vitamin D deficiency 'crisis' - thebahamasweekly.com - 1 views

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    (VIDEO) Shedding light on the vitamin D deficiency 'crisis'
    By GrassRootsHealth.com
    Oct 11, 2009 - 4:49:39 PM

    San Diego, CA - Can vitamin D prevent 80% of the incidence of breast cancer? What is its affect on colon cancer and other major illnesses? These questions and more will be addressed when some of the most prominent vitamin D researchers in North America participate in the " Diagnosis & Treatment of Vitamin D Deficiency" seminar presented by GrassrootsHealth at the University of Toronto on Tuesday, November 3 from 8 a.m. - 5 p.m.

    GrassrootsHealth is the founder of D*action, an international public health project whose goal is to solve the vitamin D deficiency epidemic. GrassrootsHealth and D*action work with over 30 scientists, institutions and individuals committed to educate, test, and study vitamin D levels worldwide.

    At the conference, a group of physicians and researchers in the vitamin D field will discuss vitamin D's role in the potential prevention of many diseases, including breast cancer, colon cancer, type 1 diabetes and multiple sclerosis, the ultimate reduction in the incidence of infectious diseases and the economic impact of such action
Matti Narkia

Use of cod liver oil during the first year of life is associated with lower risk of chi... - 0 views

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    Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study.
    Stene LC, Joner G; Norwegian Childhood Diabetes Study Group.
    Am J Clin Nutr. 2003 Dec;78(6):1128-34.
    PMID: 14668274

    Conclusion: Cod liver oil may reduce the risk of type 1 diabetes, perhaps through the antiinflammatory effects of long-chain n-3 fatty acids.
Matti Narkia

Vitamin D and diabetes: Improvement of glycemic control with vitamin D3 repletion -- Sc... - 0 views

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    Vitamin D and diabetes: improvement of glycemic control with vitamin D3 repletion.
    Schwalfenberg G.
    Can Fam Physician. 2008 Jun;54(6):864-6.
    PMID: 18556494

    Conclusion

    These cases support information that is already known about VTD and its effect on the islet cell. As discussed above, this might be true only for vitamin D3 and not vitamin D2, although vitamin D2 has been shown to improve bone health. Vitamin D insufficiency or deficiency is common, and repletion might improve glycemic control early in type 2 diabetes. Diabetes is one of the fastest growing chronic diseases worldwide. Vitamin D3 is inexpensive and readily available. Well-designed clinical studies are required to ascertain if improving 25(OH)D levels from an insufficiency or deficiency to sufficiency improves glycemic control in diabetes. These studies need to be properly designed: a randomized controlled trial with VTD deficiency or insufficiency identified in diabetic patients of various ethnic
Matti Narkia

YouTube - Vitamin D and Diabetes-Can We Prevent it? - 0 views

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    Frank Garland
Matti Narkia

Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study : The Lancet - 0 views

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    Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study.
    Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM.
    Lancet. 2001 Nov 3;358(9292):1500-3.
    PMID: 11705562
    doi:10.1016/S0140-6736(01)06580-1

    INTERPRETATION: Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes. Ensuring adequate vitamin D supplementation for infants could help to reverse the increasing trend in the incidence of type 1 diabetes.
Matti Narkia

GrassrootsHealth | Vitamin D Action - Seminar - December 2008 - 0 views

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    Diagnosis and Treatment of Vitamin D Deficiency Seminar

    December 2, 2008
Matti Narkia

Diagnosis & Treatment of Vitamin D Deficiency - Seminar Presentations (PDF Slides) - Un... - 0 views

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    Diagnosis & Treatment of Vitamin D Deficiency

    Wednesday, April 9, 2008 * 12:30pm - 6:00pm
    Garren Auditorium, University of California, San Diego

    Seminar Presentations
Matti Narkia

Response -- Schwalfenberg 53 (9): 1435 -- Canadian Family Physician - 0 views

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    Vitamin D supplementation.
    Eveleigh B.
    Can Fam Physician. 2007 Sep;53(9):1435; author reply 1435.
    PMID: 17872869

    My concern regarding vitamin D2 is that it is a synthetic analogue and might interact with the vitamin D receptor differently in various cell systems. It has been reported that vitamin D3 might improve glycemic control.7 Vitamin D2 has been reported to cause worsening of glycemic control in people of East Indian descent.8 Is this because of vitamin D receptor polymorphism, or because of enhanced 24-hydroxylase enzyme activation, or is it due to how vitamin D2 interacts with the receptor? Until this has been sorted out, I feel safest using vitamin D3. There are about 2000 synthetic analogues of vitamin D. The search is on for one that can cross the blood-brain barrier to treat certain types of brain cancers without causing hypercalcemia.9 But then again, what other effects would this compound have? There are still so many unknowns
Matti Narkia

Not enough vitamin D: Health consequences for Canadians -- Schwalfenberg 53 (5): 841 --... - 0 views

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    Not enough vitamin D: health consequences for Canadians.
    Schwalfenberg G.
    Can Fam Physician. 2007 May;53(5):841-54. Review
    PMID: 17872747

    Conclusion

    Low levels of VTD are considered a major public health problem in Canada, especially during the winter. Those with risk factors should be screened for low 25(OH)D levels and repletion therapy instituted if needed. Researchers have estimated that the oral dose of vitamin D3 to attain and maintain 25(OH)D levels >80 nmol/L is 2200 IU/d if baseline levels are 20 to 40 nmol/L, 1800 IU/d if levels are 40 to 60 nmol/L, and 1160 IU/d if levels are between 60 and 80 nmol/L.64

    We need to ensure that patients have healthy blood levels of 25(OH)D to prevent levels of parathyroid hormone from rising and to maximize absorption of calcium, magnesium, and phosphate. Positive effects on bone are marginal at best unless patients consume at least 800 IU/d of VTD. The emerging and exciting role of the VTD receptor and the actions of VTD in maintaining health in other cell types have become more apparent during the last decade.
Matti Narkia

YouTube - Vitamin D and Diabetes-Can We Prevent it? - 0 views

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    Vitamin D and Diabetes-Can We Prevent it? Frank C. Garland
Matti Narkia

Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vascul... - 0 views

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    Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.
    Nascimento NR, Lessa LM, Kerntopf MR, Sousa CM, Alves RS, Queiroz MG, Price J, Heimark DB, Larner J, Du X, Brownlee M, Gow A, Davis C, Fonteles MC.
    Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):218-23. Epub 2005 Dec 22.
    PMID: 16373499
    doi: 10.1073/pnas.0509779103
Matti Narkia

The Pathobiology of Diabetic Complications: a unifying mechanism. - Diabetes - 0 views

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    The pathobiology of diabetic complications: a unifying mechanism.
    Brownlee M.
    Diabetes. 2005 Jun;54(6):1615-25.
    PMID: 15919781
    doi: 10.2337/diabetes.54.6.1615
Matti Narkia

Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes - 0 views

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    Indian herbs and herbal drugs used for the treatment of diabetes.\nModak M, Dixit P, Londhe J, Ghaskadbi S, Paul A Devasagayam T.\nJ Clin Biochem Nutr. 2007 May;40(3):163-73.\nPMID: 18398493 \ndoi: 10.3164/jcbn.40.163
Matti Narkia

Four times current vitamin D doses needed for winter levels: Study - 0 views

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    Maintaining adequate levels of vitamin D during winter months requires a daily dose of 20 micrograms, four times the current recommended dose, says a new study.
    The study, led by Susan Sullivan from the University of Maine, has important implications for ongoing consultations on vitamin D recommendations, with the current level of five micrograms (200 International Units) seen by many as insufficient.
Matti Narkia

A comparison of vitamin d levels in nondiabetic and diabetic patient populations. - J ... - 0 views

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    A comparison of vitamin d levels in nondiabetic and diabetic patient populations.\nYoho RM, Frerichs J, Dodson NB, Greenhagan R, Geletta S.\nJ Am Podiatr Med Assoc. 2009 Jan-Feb;99(1):35-41.\nPMID: 19141720
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