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Conditions, Diseases,Chronic Passive Congestion,Chronic ,Passive ,Congestion

"THURSDAY, Dec. 3 (HealthDay News) -- New research points to the possibility of a genetic link between vitamin D and heart disease. People with high blood pressure who had a gene variant that reduces vitamin D activation in the body were found to be twice as likely as those without the variant to have congestive heart failure, the study found. The finding may lead to a way to identify people at increased risk for heart disease, according to Robert U. Simpson, an assistant professor of pharmacology at the University of Michigan Medical School and his research colleagues. They analyzed the genetic profiles of 617 people. One-third had hypertension, one-third had hypertension and congestive heart failure, and the remaining third served as healthy controls. The researchers found that a variant in the CYP27B1 gene was associated with congestive heart failure in people with hypertension. The study is in the November issue of Pharmacogenomics."

Zittermann A, Schleithoff SS, Koerfer R. Vitamin D insufficiency in congestive heart failure: why and what to do about it? Heart Fail Rev. 2006 Mar;11(1):25-33. PMID: 16819575 [PubMed - in process]

Zittermann A, Schleithoff SS, Tenderich G, Berthold HK, Korfer R, Stehle P. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol. 2003 Jan 1;41(1):105-12. PMID: 12570952 [PubMed - indexed for M

Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.Am J Clin Nutr. 2006 Apr;

Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Zeng XH, Zeng XJ, Li YY. Am J Cardiol. 2003 Jul 15;92(2):173-6. PMID: 12860219 doi:10.1016/S0002-9149(03)00533-2 Thus, berberine improved quality of life and decreased VPCs and mortality in patients with CHF.

Coenzyme Q10. Bonakdar RA, Guarneri E. Am Fam Physician. 2005 Sep 15;72(6):1065-70. Review. PMID: 16190504 Coenzyme Q10 is a vitamin-like substance used in the treatment of a variety of disorders primarily related to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of coenzyme Q10 appear most promising for neurodegenerative disorders such as Parkinson's disease and certain encephalomyopathies for which coenzyme Q10 has gained orphan drug status. Results in other areas of research, including treatment of congestive heart failure and diabetes, appear to be contradictory or need further clarification before proceeding with recommendations. Coenzyme Q10 appears to be a safe supplement with minimal side effects and low drug interaction potential.

Side Effects and Warnings Berberine has been reported to cause nausea, vomiting, hypertension (high blood pressure), respiratory failure and paresthesias (abnormal sensations such as numbness or tingling); however, clinical evidence of such adverse effects is not prominent in the literature. Rare adverse effects including headache, skin irritation, facial flushing, headache, bradycardia (slowed heart rate) have also been reported with the use of berberine. Use cautiously when taking berberine for longer than eight weeks due to theoretical changes in bacterial gut flora. Use cautiously in individuals with diabetes, as both human and animal studies indicate that berberine may decrease blood sugar levels. Also use cautiously in individuals with hypotension (low blood pressure), as berberine may have antihypertensive effects. Patients with cardiovascular disease should also use caution as berberine has been associated with the development of ventricular arrhythmias in subjects with congestive heart failure. Although not well studied in humans, berberine may also theoretically cause delays in small intestinal transit time or increase the risk of bleeding. Berberine may cause abortion, eye or kidney irritation, nephritis (inflamed kidneys), dyspnea (difficulty breathing), flu-like symptoms, giddiness, lethargy, or liver toxicity. Patients with leukopenia (abnormally low white blood cell count) should use cautiously due to the potential for development of leukopenia symptoms. When injected under the skin, berberine may cause hyperpigmentation in the arm. Use berberine cautiously in individuals with high exposure to sunlight or artificial light due to potential for adverse phototoxic reactions. Avoid in newborns due to potential for increase in free bilirubin, jaundice, and development of kernicterus (brain damage caused by severe newborn jaundice). Use berberine cautiously in children due to a lack of safety information. Pregnancy and Breastfeeding Berberine is not recomme

Mechanisms of berberine (natural yellow 18)-induced mitochondrial dysfunction: interaction with the adenine nucleotide translocator. Pereira CV, Machado NG, Oliveira PJ. Toxicol Sci. 2008 Oct;105(2):408-17. Epub 2008 Jul 3. PMID: 18599498 doi: 10.1124/jpet.107.128017 The data from the present work appear to show that berberine also presents some degree of toxicity to "nontumor" systems, which should be carefully understood. ANT inhibition in nontumor cells by berberine would be responsible for a decrease in energy production and could also result in MPT induction. To the best of our knowledge, no full toxicity assessment exists for berberine in humans, although its use in several commercially available supplements suggests that the compound may present a relatively wide safety interval. In fact, a study with patients with congestive heart failure treated with 1.2 g/day of oral berberine revealed low toxicity and resulted into an average plasma concentration of 0.11 mg/l which would translate into 0.3µM (Zeng and Zeng, 1999Go). Repeated cumulative treatments, alternative forms of formulation (e.g., topical application vs. injection) or more importantly, active mitochondrial accumulation due to its positive charge would be expected to increase its concentration in cells into the range of concentrations used in this study. Empirical data from nontraditional medicines plus the use of extensive clinical assays would allow the use of berberine as a promising antimelanoma agent while maintaining its safety for humans. In radial/vertical forms of melanoma, a possible topical application of berberine would also be possible, thus minimizing side effects on other organs. In conclusion, the present work identifies the ANT as an important target for berberine, with clear relevance for its proposed antitumor effects.

Mango juice Summary of the Health benefits Mango Fruit Juice are rich in iron, thus patients with anemia and pregnant women are advised to consume it regularly. Phenols are presents in Mango Juice and Mango drinks this compound phenol has strong antioxidant and anticancer capacities. mangoes and it's Juice helps in relieving congested pores of the skin. Patients suffering from acidity and weak digestion can benefit from the consumption of mango juice. It is a fruit which is low in carbohydrates and is an rich antioxidant. The rich source of vitamin A (beta-carotene), E and Selenium present in Mangoes helps in protection from heart diseases and other problems. Mango Juice is rich in pre-biotic dietary fiber, vitamins, minerals, and poly-phenolic flavonoid antioxidant compounds. According to new research study, mango fruit juice has been found to protect against colon, breast, leukemia and prostate cancers. Several trial studies suggest that polyphenolic anti-oxidant compounds in mango are known to offer protection against breast and colon cancers. Mango Juice is an excellent source of Vitamin-A and flavonoids like beta-carotene, alpha-carotene,and beta-cryptoxanthin. 100 g of fresh Mango juice provides 765 mg or 25% of recommended daily levels of vitamin A. Together these compounds are known to have antioxidant properties and are essential for vision. Vitamin A is also required for maintaining healthy mucus membranes and skin. Consumption of natural fruits rich in carotenes is known to protect body from lung and oral cavity cancers. Fresh mango Juice is a very rich source of potassium. Potassium is an important component of cell and body fluids that helps controlling heart rate and blood pressure. mango juice is also a very good source of vitamin-B6 (pyridoxine), vitamin-C and vitamin-E. Consumption of foods rich in vitamin C helps body develop resistance against infectious agents and scavenge harmful oxygen free radicals. Vitamin B-6 o

Readers and consumers can better evaluate the versatility and multi-fold action of turmeric night cream given as follows: 1. Use It As An Eye Cream Combined with the potent antioxidant vitamin C, turmeric eye cream possesses beneficial properties that can combat dark circles under the eyes effectively. Turmeric's skin lightening and soothing traits can enhance circulation, thereby reducing under-eye puffiness and discoloration caused by inadequate blood flow. Further, its anti-inflammatory features, as well as its ability to lighten skin and increase microcirculation, make turmeric vitamin C eye cream an ideal ingredient in this case. 2. Turmeric Cream for Skin Whitening Turmeric is a sun-drenched tropical spice that has a wide range of skin-friendly benefits. It can help reduce oxidative stress and address skin conditions like dullness and dehydration. Turmeric cream can enhance the skin's radiance thanks to its healing, antioxidant, and anti-inflammatory properties that effectively cleanse and revitalize congested, inflamed, or impaired skin. Adding more turmeric to your skincare routine may enhance the skin's microcirculation, resulting in a firmer and more supple complexion. 3. Use Turmeric Cream For Hyperpigmentation Since turmeric inhibits the production of melanin, the utilization of vitamin C can effectively diminish hyperpigmentation. Hyperpigmentation is a skin problem in which some parts of the skin produce excessive melanin, resulting in blemishes such as sunspots, age spots, and melasma. It can possibly emerge in areas where the acne has been treated and healed previously. Turmeric can prevent the production of melanin responsible for dark spots and hyperpigmentation. Applying a product like a turmeric skin cream consistently can help reduce imperfections and provide a smoother, more even complexion.

Hypocalcemia as a Cause of Reversible Cardiomyopathy with Ventricular Tachycardia Chandrakant B. Chavan, MD, DNB; Kalavakolanu Sharada, MD, DM; Hygriv B. Rao, MD, DM; and Calambur Narsimhan, MD, DM, AB Annals of Internal Medicine, 3 April 2007, Volume