Dr. Goodyear

Cochrane review for Testosterone therapy for women points to lacking data.  The lengths of study reached a maximum of 2 years with the average at 6 months.  Improvement in sexual function was found in post-menopausal women, but safety and long-term data is lacking.

Only abstract available.  Meta-analysis of Testosterone therapy in post-menopausal women finds significant bias, some improvement in sexual function and cholesterol levels, yet safety and long-term data is significantly lacking.  Take this with studies on endogenous Testosterone in women, significant caution needs to be followed with Testosterone in women. Only abstract available here.

Supporting evidence for DHEA improvement for women is mixed and minimal.  Full article is not available so the question as whether a need was indicated based on testing is not available.  Side effects were seen with DHEA--primarily acne.  

Black Spanish radish found to up regulate phase I/II liver detoxification with tylenol exposure.  Now, this was sponsored by a maker of a herbal product so that would include some potential bias.

Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.

Time that physicians start following the science.  Study using data from the Multi-ethnic Study of Atherosclerosis was used to assess hormones and fatty liver in men and women.  Increasing bioavailable Testosterone levels in women was found to be associated with increasing fatty liver in post-menopausal women.  The opposite was found to be true in men.  Higher Estradiol levels were found to be associated with increased fatty liver in both sexes.  However, the statistical significance was higher with men.  Higher SHBG was associated with lower fatty liver incidence in men.  

Again, what is the evidence on androgens in women.  The majority of data is points to negative metabolic effects.  This study looked at men and women and found inverse relationships between Testosterone and DHEA in the sexes.  In women, higher bioavailable Testosterone and DHEA was associated with visceral and subcutaneous fat in women, where as the opposite is true in men.  In both men and women, higher SHBG was associated with lower fat.

Meta-analysis finds that Testosterone therapy in men over 60 increased lean mass and decreased fat mass.

Testosterone reduced the vascular benefits of Estrogen (conjugated equine Estrogen) in female rat model.  Testosterone is seeing widespread use in women with very little positive data.  In fact, the majority of data points to poor metabolic effects and poor outcomes.

Study finds that declining Testosterone levels and increasing TNF-alpha and CRP are associated with shorter end-stage cancer survival.  Testosterone is not the same in men and women.  The effects on inflammatory cytokines are different.  This study should be divided into women and men to better differentiate these effects.

Metabolic Syndrome increases the risk of prostate cancer in men.  No surprise here as low T and hyperinsulinemia are both implicated in development of high grade prostate cancer.

Low T found in young combat veteran with PTSD and SI.  This is no surpass as there is significant HPA dysfunction in these men/women.  The overwhelming cortisol response and resultant PTSD will shut down endogenous Testosterone production.  I have seen this in several combat veterans.

Men with lower Testosterone levels are associated with increased odds (72%) of Metabolic Syndrome.  This was independent from SHBG and BMI.

review of gout and purine metabolism

study identifies 15 Endocrine Disrupting Chemicals that lead to earlier Menopause.  Maybe we should change it to Chemopause.

low Estradiol and high Total Testosterone associated with high risk of ischemic heart disease.  This study looked at endogenous levels in women.  This data as well as others really brings into question the massive prescription Testosterone push in women.

Bioavailable Testosterone is positively associated with Visceral adipose tissue and to a lesser degree subcutaneous fat in women.  

Oral contraceptives shown to reduce Testosterone and DHEA in women, but no effect on cortisol was seen.

nice read on the chelation of Mercury with DMSA, DMPS, vitamin C, and glutathione.

Hashimoto's hypothyroidism is associated with a 44% increase in Heart disease in women under the age o 49.  A non-significant change was seen in men.  This study found that T4 therapy reduced this risk.  A better study would have been if T4 was compared to T4 + T3.