Dr. Goodyear

T3 may promote cancer cell proliferation says study.  Triiodothyronine was found to enhance the MCF-7 and T47-D breast cancer cell lines.  The conclusion of the abstract discusses a role of T3 in breast cancer development and progression.  This likely has more to do with progression than development through increased metabolism of the cell lines.

Article points to potential chemosensitizing effect of T3 in cancer treatment.  Chemotherapy with increased metabolic demand with T3 may improve cancer kill rate.

T3 may have effects similar to Estradiol in breast cell proliferation.  This may be, but what about the effects on increased metabolism and resultant fat loss which leads to reduce inflammation...I believe this is all about context of the environment in the individual and the importance of customizing therapy.

No decrease or trend for lower inflammatory markers seen in Testosterone therapy in men > 65.  These men had levels of T < 475 ng/dl, which brings into question this studies results as most studies point to 300 or 250 as the mark.

Finnish study found no association between free Testosterone and Total Testosterone, and ED.

really interesting abstract.  Bisphenol A (BPA)  is a xenoestrogen.  This animal study finds that BPA down regulated ER-beta in the brains of male rats.  It also blocked the production of GABA(A)alpha 2 receptor.  These long term effects were evident in anxiety and depression in adult mice. Pregnancy exposure would set up an ER-alpha dominance in the male brain increasing risk of continuous ER alpha stim.

Low bioavailable Testosterone associated with increased IL-1beta and TNF-alpha in men with CHF.

low Total Testosterone and bioavailable Testosterone is associated with increased IL-1beta and IL-10.  This points to low T having a more direct link to increased systemic inflammation in men.

low Free testosterone found to be associated with muscle mass loss in women when compared to high free Testosterone levels.

Study finds low free Testosterone and low calculated free Testosterone was associated with sarcopenia in Japanese men.  This association was not found with Total Testosterone.

animal study finds Testosterone reversed age associated sarcopenia.

Good discussion of sarcopenia.  They article looked at the evidence of Testosterone and found the evidence pointed to improved lean muscle mass; but not a direct cause effect of low T and sarcopenia.

I love these review articles that highlight the metabolic differences of hormones in women versus men.  The medical community as a whole doesn't seem to get this at all.  The marketing-based medical community doesn't either.

I love this abstract.  I am going to try and find the full print.  As it relates to metabolic dysfunction, elevated Testosterone provides a similar functional picture in women as low Testosterone does in men.

Bioidentical progesterone used in IVF.  This is not new, the SQ administration is.  So, physicians cry against BHRT, yet bioidentical progesterone has been used for years in the treatment of infertility.

I like this review of a ketogenic diet.  This article discusses the use and benefits in neurodegenerative disease.

review on metabolic syndrome.

Insulin and it's various roles in metabolic syndrome.

Interesting, yet not surprising.  TNF-alpha has strong correlation with IR in pregnancy.  This follows metabolic endotoxemia pathophysiology.  I believe this could be used to assess risk for PIH...

good review of Cushing's syndrome and Cushing's disease