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Nathan Goodyear

Association Between Plasma Vitamin C Concentrations and Blood Pressure in the European Prospective Investigation Into Cancer-Norfolk Population-Based Study | Hypertension - 0 views

hyper.ahajournals.org/...372.long

vitamin C blood pressure hypertension

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    study of almost 21,000 women finds patients with the highest serum vitamin c was associated with the lowest blood pressure.  "We found a strong linear association between plasma vitamin C concentrations and systolic blood pressure.
Nathan Goodyear

Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes - European Journal of Sport Science | Taylor & Francis Online - 0 views

www.tandfonline.com/...17461391.2014.949310

fish oil omega 3 omega-3 n-3 cycling athletes NO endurance sports endurance athletes endurance exercise

shared by Nathan Goodyear on 06 Jul 16 - No Cached
  • Nathan Goodyear on 06 Jul 16
     
    supplementation of 2.6 grams of n-3 found to increase NO and VO2max in elite cycling athletes.  This has applications for all endurance athletes.  
Nathan Goodyear

Dietary patterns and the risk of major adverse cardiovascular events in a global study of high-risk patients with stable coronary heart disease | European Heart Journal - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehw125

mediterranean diet nutrition CAD coronary artery disease CVD cardiovascular disease heart disease heart

shared by Nathan Goodyear on 02 May 16 - No Cached
  • Nathan Goodyear on 02 May 16
     
    Mediterranean diet reduces major cardiovascular event incidence in those individuals with coronary artery disease.
wheelchairindia9

Tynor Foot Drop Splint Right-Left - 0 views

www.wheelchairindia.com/...or-Foot-Drop-Splint-Right-Left

Ankle Splint and Foot Drop Splint Stabilize Ankle Joint uphold the ankle joint easily fits into the feet foot drop splint flexible reduces the pressure on the ankle proper cushioning to the ankles Enhances comfort and walking pleasure

shared by wheelchairindia9 on 17 Mar 16 - No Cached
  • wheelchairindia9 on 17 Mar 16
     
    Tynor Foot Drop Splint Right/Left Applications Prevention and correction of foot drop. Peripheral nerve paralysis. Nerve/Muscle damage. Ankle or Plantar flexion contracture. Functional Alignment of the foot. Post operative care. Burn patients. Tynor Foot Drop Splint Right/Left Features Effective foot lift. Strong leaf spring action. Customizable. Thin walled, worn in a shoe. Tynor Foot Drop Splint Right/Left Measurements Measure shoe size Size Chart - Sizes European American Small 34-36 2.8-4.4 Medium 37-39 5.3-6.8 Large 40-42 7.5-9.0
Nathan Goodyear

Reproductive Hormone Levels in Men Exposed to Persistent Organohalogen Pollutants: A Study of Inuit and Three European Cohorts - 0 views

www.ncbi.nlm.nih.gov/...PMC1570059

POP organochlorides endocrine disruptors persistent organohalogen men pollutants DDE DDT low T testosterone hormone male hormones

shared by Nathan Goodyear on 21 May 12 - No Cached
  • Nathan Goodyear on 21 May 12
     
    Review finds endocrine disruption from Organocholrides, also called persistent organohalogen pollutants. Common POP, would be DDE, DDT... This is a review of several cohorts, but this follows the rest of the literature that these environmental toxicants are endocrine disruptors.
Nathan Goodyear

Dietary glycemic index and glycemic load and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) - 0 views

www.ajcn.org/...ajcn.111.026724.abstract

dietary glycemic index nutrition breast cancer breast cancer women postmenopausal carbohydrates high ER PR

shared by Nathan Goodyear on 11 Jul 12 - No Cached
  • Nathan Goodyear on 11 Jul 12
     
    high carbohydrate intake associated with increased risk of ER/PR negative breast cancer in Postmenopausal women.
Nathan Goodyear

SpringerLink - European Journal of Applied Physiology, Volume 111, Number 8 - 0 views

www.springerlink.com/...an5p2161l8252904

saliva salivary testing hormone evaluation estradiol E2 BHRT

shared by Nathan Goodyear on 26 Nov 11 - No Cached
  • Nathan Goodyear on 26 Nov 11
     
    salivary estradiol evaluation validated.  Interesting, that alot of the research these days has moved beyond the use of saliva testing as experimental.  The only industry that hasn't is the insurance industry.  Of course, because they don't want to pay for anything.
Nathan Goodyear

Mediterranean Diet, Lifestyle Factors, and 10-Year Mortality in Elderly European Men and Women, September 22/29, 2004, Knoops et al. 292 (12): 1433 - JAMA - 0 views

jama.ama-assn.org/...1433.short

mediterranean diet lifestyle mortality

shared by Nathan Goodyear on 14 Jan 12 - No Cached
  • Nathan Goodyear on 14 Jan 12
     
    Mediterranean diet shown to reduce all cause mortality in elderly adults by > 50%.
Nathan Goodyear

Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study - 0 views

www.eje-online.org/...445

low T Testosterone SHBG lifestyle changes weight loss obesity overweight male men hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Nathan Goodyear on 04 Feb 14
     
    Lifestyle changes that result in weight loss can increase Total Testosterone, free Testosterone, and SHBG.
Nathan Goodyear

Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study: The Journal of Clinical Endocrinology & Metabolism: Vol 95, No 4 - 0 views

press.endocrine.org/...jc.2009-1796

low T Testosterone obesity overweight men male hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Older men were more likely to have primary [relative risk ratio (RRR) = 3.04; P < 0.001] and compensated (RRR = 2.41; P < 0.001) hypogonadism. Body mass index of 30 kg/m2 or higher was associated with secondary hypogonadism (RRR = 8.74; P < 0.001)
  • Nathan Goodyear on 04 Feb 14
     
    The prevalence of low T varies significantly between lean versus overweight men.  This suggests a significant contribution of obesity and its biologic effects as a cause of low T.  The difference is 30%.
Nathan Goodyear

Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk Within the European Prospective Investigation into Cancer and Nutrition (EPIC) - 0 views

jnci.oxfordjournals.org/...755.long

serum hormone hormones Testosterone progesterone estrogen estradiol breast cancer women female

shared by Nathan Goodyear on 21 Mar 14 - No Cached
  • Nathan Goodyear on 21 Mar 14
     
    Study finds that elevated serum Testosterone and androstenedione is associated with an increase risk of breast cancer.  This EPIC study looked at serum hormones in premenopausal women.  This study also found an association with increased breast cancer and low serum progesterone in women.  This was also found in the ORDET study.  This study did not find a link with estrogen.  These are endogenous levels.  Does this translate to exogenous? This theory of elevated androgens and breast cancer was first proposed by Grattarola.
Nathan Goodyear

The Evolving Role of Oestrogens and Their Receptors in the Development and Progression of Prostate Cancer - European Urology - 0 views

www.europeanurology.com/...S0302-2838(08)01301-8

Estrogen Estradiol aromatase aromatase activity prostate cancer prostate cancer ER ER alpha

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Nathan Goodyear on 21 Aug 13
     
    This study points out, that it is not the androgens, but the high aromatase activity and resultant Estradiol production that promotes prostate disease.  Take this together with high ER alpha dominance and one has a recipe for disease.
Nathan Goodyear

Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation - European Journal of Cancer - 0 views

www.ejcancer.com/...abstract

ER estrogen receptor estrogen receptors ER beta ER-beta colon colorectal cancer estrogen receptor beta women hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    ER beta expression is dominantly expressed in normal, healthy colon cells/tissue.  However, like in breast and prostate cancer, ER beta expression is lost in the dedifferentiation of colorectal transformation.
Nathan Goodyear

Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma - Chytrova - 2007 - European Journal of Neuroscience - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...20C0683F07B011D946D0062.f04t01

BDNF TBI traumatic brain injury exercise

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    exercise aids repair after TBI through BDNF.
Nathan Goodyear

Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men | European Heart Journal - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehv346

low T low Testosterone men Testosterone mortality stroke MI CVD cardiovascular disease hormones male

shared by Nathan Goodyear on 11 Aug 15 - No Cached
  • Normalized-TRT group had significantly fewer deaths than no-TRT
  • Mortality was also significantly lower in the non-normalized-TRT group compared with those in no-TRT group
  • the normalized-TRT group was associated with significantly increased all-cause mortality-free survival (log-rank, P < 0.05) compared with the non-normalized-TRT or no-TRT groups
  • ...10 more annotations...
  • normalized-TRT group showed lower risk of MI than non-normalized-TRT (HR: 0.82, CI 0.71–0.95, P = 0.008) and no-TRT
  • normalized-TRT group had significantly lower stroke events compared with non-normalized-TRT (HR: 0.70, CI 0.51–0.96, P = 0.028) and no-TRT
  • study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes
  • retrospective study
  • the first study to demonstrate that significant benefit is observed only if the dose is adequate to normalize the TT levels
  • Patients who failed to achieve the therapeutic range after TRT did not see a reduction in MI or stroke and had significantly less benefit on mortality
  • selected patients without any previous history of MI or stroke prior to initiation of TRT to reduce bias related to CV outcomes
  • currently only half of the men on TRT had been diagnosed with hypogonadism.
  • 25% of users did not have their T concentrations tested prior to initiating therapy, and 21% of those prescribed TRT did not have their levels tested at any time during treatment.
  • men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
  • Nathan Goodyear on 11 Aug 15
     
    Testosterone therapy in men with low T found to reduce all cause mortality, stroke and MI.
Nathan Goodyear

European Journal of Clinical Nutrition - Table 1 for article: Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database - 0 views

www.nature.com/...ejcn2010221t1.html

polyphenols nutrition antioxidants

shared by Nathan Goodyear on 29 Sep 15 - No Cached
  • Nathan Goodyear on 29 Sep 15
     
    top food sources for polyphenols
Nathan Goodyear

Elderly men over 65 years of age with late-onset hypogonadism benefit as much from testosterone treatment as do younger men - 0 views

www.ncbi.nlm.nih.gov/...PMC4392031

low T low Testosterone Testosterone men male hormone hormones late onset hypogonadism hypogonadism

shared by Nathan Goodyear on 21 May 15 - No Cached
  • The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
  • obesity, but also impaired general health, are the more common causes of low testosterone in aging men
  • Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
  • ...30 more annotations...
  • advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
  • Diabetes mellitus was correlated with hypogonadism in most studies
  • coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
  • LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
    • Nathan Goodyear
      Nathan Goodyear on 27 May 15
       
      the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.  
  • Mean weight decreased
  • Waist circumference decreased
  • Total cholesterol decreased
  • Low-density lipoprotein decreased
  • Triglycerides decreased
  • High-density lipoprotein (HDL) increased
  • ratio of total cholesterol to HDL improved
  • Prostate volume increased
  • PSA increased
  • The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
  • weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
  • Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
  • observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
  • the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
  • The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
  • it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
  • Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
  • Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
  • These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
  • The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
  • Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
  • This apparent paradox is explained by the "saturation model,"
  • Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
  • In the present observational study, no cases of major adverse cardiovascular events occurred.
  • the benefits of testosterone therapy are fully achieved only by long-term treatment
  • To achieve maximal benefits, good patient adherence is a prerequisite
  • Nathan Goodyear on 21 May 15
     
    Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.
Nathan Goodyear

ScienceDirect - European Journal of Cancer and Clinical Oncology : Actions of a progestogen on human breast cancer cells: Mechanisms of growth stimulation and inhibition - 0 views

www.sciencedirect.com/science

breast cancer Provera Medroxyprogesterone acetate MPA HRT and

shared by Nathan Goodyear on 05 Nov 10 - No Cached
  • at both progestogen and glucocorticoid receptors may mediate the effects of high-dose MPA therapy in breast cancer. The possible stimulation of the growth of some cell types by MPA requires further investigation.
  • Nathan Goodyear on 05 Nov 10
     
    Provera provides stimulation of breast issue; likely increasing risk of breast cancer
Nathan Goodyear

The Prevalence of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women: An Epidemiological Study of Women in Four European Countries - Graziottin - 2009 - The Journal of Sexual Medicine - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

low libido sexual dysfunction hormones

shared by Nathan Goodyear on 11 Jan 11 - No Cached
  • Nathan Goodyear on 11 Jan 11
     
    Low Hormones, post-ovary removal, linked to low libido
Nathan Goodyear

The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study -- Åsvold et al. 156 (2): 181 -- European Journal of Endocrinology - 0 views

www.eje-online.org/...181

thyroid TSH cholesterol lipids

shared by Nathan Goodyear on 31 Jan 11 - No Cached
  • Nathan Goodyear on 31 Jan 11
     
    good thyroid function has positive effect on cholesterol
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