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Nathan Goodyear

JAMA Network | JAMA | Estrogen Plus Progestin and the Incidence of Dementia a... - 0 views

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    Estrogen with progestin worsens cognitive decline in women >65.  Little can be taken from this study other than, medroxyprogesterone acetate is a bad drug and should not be given to women for any purpose, especially in those >65.  One wonders if bioidentical, physiologic hormone replacement would have the same effect?  I doubt it.  The likely negative impact of hormones on the brain in women >65 is due to the negative effects of MPA, the change in inflammatory cytokines, and the change in receptors.
Nathan Goodyear

JAMA Network | JAMA | Conjugated Equine Estrogens and Incidence of Probable D... - 0 views

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    This was the WHI review of data as it pertains to dementia and cognitive decline in women.  The take home here is that the data provides little evidence for premarin with or without medroxyprogesterone acetate in > 65 for prevention of dementia.  However, this is in women > 65 and studies show that younger women do indeed receive benefit, especially in those with early ovary removal.  Another point here, MPA (medroxyprogesterone acetate) increases cognitive decline.  Just don't take MPA, it is a bad drug all the way around!
Nathan Goodyear

Immunosuppressive Biological Mechanisms Support Reassessment of Use of the Injectable C... - 0 views

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    Injectable medroxyprogesterone acetate for contraception provides immune suppression through glucocorticoid receptors.
Nathan Goodyear

Effect of Medroxyprogesterone Acetate on Endothelium-Dependent Vasodilation in Postmeno... - 0 views

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    medroxyprogsterone acetate (synthetic progestin) increase vascular function in postmenopausal women
Nathan Goodyear

Effect of Medroxyprogesterone Acetate on Endothelium-Dependent Vasodilation in Postmeno... - 0 views

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    synthetic progestin (MPA) off sets beneficial estrogen heart benefits
Nathan Goodyear

Informa Healthcare - Climacteric - 6(3):221 - Summary - 0 views

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    Progesterone reduce breast growth and Medroxyprogesterone acetate increases breast growth
Nathan Goodyear

Medroxyprogesterone acetate induces cell prolifera... [Endocrinology. 2005] - PubMed re... - 0 views

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    MedroxyProgesterone Acetate increases breast cell growht
Nathan Goodyear

ScienceDirect - European Journal of Cancer and Clinical Oncology : Actions of a progest... - 0 views

  • at both progestogen and glucocorticoid receptors may mediate the effects of high-dose MPA therapy in breast cancer. The possible stimulation of the growth of some cell types by MPA requires further investigation.
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    Provera provides stimulation of breast issue; likely increasing risk of breast cancer
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