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Nathan Goodyear

Arch Intern Med -- Abstract: Dietary Supplements and Mortality Rate in Older Women: The Iowa Women's Health Study, October 10, 2011, Mursu et al. 171 (18): 1625 - 0 views

archinte.ama-assn.org/...1625

dietary supplements junk science health study

shared by Nathan Goodyear on 12 Oct 11 - No Cached
  • Nathan Goodyear on 12 Oct 11
     
    Terrible study published in medical journal that provides no scientific valuable information
Nathan Goodyear

The android woman - a risky condition - BJÖRNTORP - 2003 - Journal of Internal Medicine - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

hyperandrogenism women elevated androgens male hormones DHEA DHEAS tesosterone androstenedione overweight obese weight gain HTN IR insulin resistance CVC

shared by Nathan Goodyear on 28 Oct 11 - No Cached
  • Nathan Goodyear on 28 Oct 11
     
    women with elevated androgens (testosterone, DHT, androstenedione, DHEA...) are shown to have more HTN, insulin resistance, overweight issues, and CVD
Nathan Goodyear

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition - Ose - International Journal of Cancer - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...FD615B31CBA2A30EB588D93.f01t03

ovarian cancer SHBG androgens women female

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    prospective study finds that increasing endogenous androgens is associated with low grade epithelial ovarian cancer and inversely associated with high-grade.
Nathan Goodyear

Association of androgen-deprivation therapy with excess cardiac-specific mortality in men with prostate cancer - Ziehr - 2014 - BJU International - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...1FB6E68961FAD6E8D59FE72.f04t04

androgen deprivation therapy ADT CVD cardiovascular disease men male hormone hormones prostate cancer

shared by Nathan Goodyear on 05 Nov 14 - No Cached
  • Nathan Goodyear on 05 Nov 14
     
    Androgen Deprivation Therapy, ADT,  is associated with increased cardiovascular mortality in men with pre-existing CVD.  This has also been shown to be the case with IR, Diabetes, weight gain...What man 40+ with prostate cancer doesn't have some degree of CVD??
Nathan Goodyear

Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: a large multi-institutional study - Mir - 2010 - BJU International - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

bladder cancer bladder cancer androgen receptor androgen receptors androgen receptor

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    multi-center study finds no association between androgen receptor expression and invasive bladder cancer.  There was also no difference between male and female in androgen receptor expression.
Nathan Goodyear

Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder - Miyamoto - 2012 - BJU International - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

AR androgen receptor androgen receptors androgen receptor ER alpha ER-alpha bladder cancer bladder cancer ER-beta ER beta hormone hormones

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    Study finds that loss of AR and ER-alpha is associated with high grade bladder cancer and ER-beta was positively associated. This has been contradicted by other studies.
Nathan Goodyear

Associations between apolipoprotein B, apolipop... [J Intern Med. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16629854

Apo B:Apo A1 apo B apo A1 Apolipoprotein B Apolipoprotien A1 lipoproteins cardiovascular disease risk

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Meta-analysis finds "strong association" between Apo A1, Apo B and the ratio Apo B:A1 and cardiovascular risk.
Nathan Goodyear

International Journal of Impotence Research - Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit? - 0 views

www.nature.com/...3900981a.html

low T Testosterone ED erectile dysfunction climid

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    Nice study that looked at climid to restore HPA function and increase Testosterone stimulation and production.  This study also does a good job of reviewing the mechanisms of low T.  Low T is really a biomarker of poor health in men.
Nathan Goodyear

:: International Braz J Urol :: - 0 views

brazjurol.com.br/...DaRos_512_518.htm

climid low T Testosterone men male hormone hormones hypogonadism

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    small study of men with low T and symptoms of hypogonadism found to improve with clomid.  Testosterone levels were found to increase by 115% and quality of life measures improved as well.  
Nathan Goodyear

International braz j urol - Age-related testosterone decline in a Brazilian cohort of healthy military men - 0 views

www.scielo.br/scielo.php

Testosterone men male hormone hormones aging low T low Testosterone low T

shared by Nathan Goodyear on 11 Aug 14 - No Cached
  • Nathan Goodyear on 11 Aug 14
     
    Study of military men in Brazil finds a decline in Serum Total Testosterone levels with aging.
Nathan Goodyear

Low free testosterone levels predict disease reclassification in men with prostate cancer undergoing active surveillance - San Francisco - 2014 - BJU International - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...FD84CC276320B0418C0A839.f04t03

free Testosterone free Testosterone prostate cancer disease men male hormone hormones

shared by Nathan Goodyear on 08 Sep 14 - No Cached
  • Nathan Goodyear on 08 Sep 14
     
    low free Testosterone was shown to be associated with higher reclassification rates in men with prostate Cancer.  Low free Testosterone has been associated with increased prostate cancer incidence via previous studies.
Nathan Goodyear

National Institutes of Health Pathways to Prevention Workshop: The Role of Opioids in the Treatment of Chronic PainThe Role of Opioids in the Treatment of Chronic Pain | Annals of Internal Medicine - 0 views

annals.org/article.aspx

NIH opioids chronic pain pain health

shared by Nathan Goodyear on 16 Jan 15 - No Cached
  • Nathan Goodyear on 16 Jan 15
     
    NIH panel review finds little empirical evidence to support the use of opioids in chronic pain.
Nathan Goodyear

International Journal of Impotence Research - Obesity, low testosterone levels and erectile dysfunction - 0 views

www.nature.com/...ijir200842a.html

low T low Testosterone men male hormone hormones ED erectile dysfunction Testosterone diabetes metabolic syndrome obesity

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
  • testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
  • In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
  • ...12 more annotations...
  • In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
  • testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
  • Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
  • testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
  • Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
  • available data clearly show a relationship between obesity, low testosterone levels and ED
  • Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
  • Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
  • The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
  • Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
  • Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
  • epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    Obesity is associated with low Testosterone and ED in men.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Vegetarian Dietary Patterns and the Risk of Colorectal Cancers - 0 views

archinte.jamanetwork.com/article.aspx

cancer diet nutrition vegetarian colon cancer colorectal cancer rectal cancer

shared by Nathan Goodyear on 16 Mar 15 - No Cached
  • Nathan Goodyear on 16 Mar 15
     
    Vegeterian diet found to reduce colon, colorectal, and rectal cancer when compared to non-vegetarian diets.
Nathan Goodyear

Peripheral neuropathy: an underdiagnosed cause of erectile dysfunction - Valles-Antuña - 2011 - BJU International - Wiley Online Library - 1 views

onlinelibrary.wiley.com/...abstract

ED erectile dysfunction polyneuropathy neuropathy men men's health male health

shared by Nathan Goodyear on 16 Mar 15 - No Cached
  • Nathan Goodyear on 16 Mar 15
     
    Peripheral neuropathy involved in/associated with the pathogenesis of ED proposed by this study.
Nathan Goodyear

Testosterone deficiency and quality of life in ... [Intern Med J. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25081047

Testosterone quality of life QOL Testicular cancer low T men male hormone hormones

shared by Nathan Goodyear on 04 Aug 14 - No Cached
  • Nathan Goodyear on 04 Aug 14
     
    Small study in men s/p Testicular cancer found no association between Testosterone levels and quality of life measures.
Nathan Goodyear

Low free testosterone is associated with loss of appendicular muscle mass in Japanese community-dwelling women - Yuki - 2014 - Geriatrics & Gerontology International - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

free Testosterone Testosterone women female hormone hormones muscle mass muscle loss

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    low Free testosterone found to be associated with muscle mass loss in women when compared to high free Testosterone levels.
Nathan Goodyear

Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort - Lindqvist - 2014 - Journal of Internal Medicine - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

vitamin D sun exposure mortality

shared by Nathan Goodyear on 16 Nov 14 - No Cached
  • Nathan Goodyear on 16 Nov 14
     
    Swedish Cohort finds low sun exposure is associated with increased mortality.
Nathan Goodyear

Testosterone and benign prostatic hyperplasia Jarvis TR, Chughtai B, Kaplan SA, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

Testosterone BPH low T low Testosterone prostate cancer men male hormone hormones

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • The prevalence of hypogonadism (often defined as serum testosterone < 300 ng dl−1 ) ranges from 6% [10] to as high as 38%
  • The process of BPH, however, continues as men age and despite the fact their serum testosterone decreases
  • Liu et al. [12] demonstrated that in a group of older males (mean age 59.8 years) that there was not a significant correlation of serum testosterone levels (total, free or bioavailable) with either prostate volume or International Prostate Symptom Score (IPSS)
  • ...11 more annotations...
  • in eugonadal men, studies have demonstrated that the prostate can increase in volume by approximately 12%
  • There seems to be little doubt that the treatment with testosterone of a young hypogonadal male leads to significant growth of the prostate
  • Behre et al. [22] demonstrated increased prostate volume and prostate-specific antigen (PSA) levels in hypogonadal men
  • Most studies, however, have shown no effect of exogenous androgens on PSA or prostate volume for older hypogonadal males
  • They argue that the prostate is relatively insensitive to changes in androgen concentration at normal levels or in mild hypogonadism because the AR is saturated by androgens and therefore maximal androgen-AR binding is achieved. Conversely, the prostate is very sensitive to changes in androgen levels when testosterone is low
  • saturation model
  • visceral obesity (one of the most significant components of metabolic syndrome) is associated with prostate volume and influences prostate growth during TRT.
  • This hypothesis of inflammation induced LUTS is also argued to be a mechanism for improvement of LUTS with PDE5I
  • The concept, therefore, that treatment with TRT of hypogonadal males with metabolic syndrome might lead to improvement/stabilization of their LUTS, appears to be confirmed in recent work by Francomano et al.
  • There was also an improvement in components of the patient's metabolic syndrome (such as BMI, waist circumference, hemoglobin A1c [HbA1c], insulin sensitivity, and lipid profile) as well as inflammatory markers and C-reactive protein.
  • They concluded that TRT was safe in this group of men, and hypothesize that TRT mitigates the pro-inflammatory factors associated with metabolic syndrome.
  • Nathan Goodyear on 01 Dec 14
     
    Authors review the literature behind Testosterone and BPH.  The authors highlight the 4 proposed theories behind BPH: Testosterone, Estrogen, inflammation, and metabolic.   The conclusion is mixed: pointing out that no high level of evidence exists on either side of the debate of Testosterone and BPH.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Lipoprotein-Associated Phospholipase A2, High-Sensitivity C-Reactive Protein, and Risk for Incident Ischemic Stroke in Middle-aged Men and Women in the Atherosclerosis Risk in Communities (ARIC) Study - 0 views

archinte.jamanetwork.com/article.aspx

LP-PLA2 lipoprotein-associated phospholipase A2 stroke CVD hsCRP

shared by Nathan Goodyear on 15 Apr 15 - No Cached
  • Nathan Goodyear on 15 Apr 15
     
    increased LP-PLA2 and hsCRP are associated with increased risk of ischemic stroke.
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