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Nathan Goodyear

Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor path... - 0 views

ebm.rsmjournals.com/...1036.full

low dose naltrexone LND low dose naltrexone cancer cell proliferation opioid growth factor OGF

shared by Nathan Goodyear on 27 Nov 12 - No Cached
  • Nathan Goodyear on 27 Nov 12
     
    low-dose naltrexone (NLD) is shown to inhibit growth in vivo.  This is important as it has implications in cancer therapies.  This study found a greater benefit with LDN and exogenous opioid growth factor (OGF).
Nathan Goodyear

Neonatal abstinence syndrome and associated health care... [JAMA. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22546608

opioid opiates infants neonatal abstinence syndrome NAS pregnancy

shared by Nathan Goodyear on 14 Apr 14 - No Cached
  • Nathan Goodyear on 14 Apr 14
     
    Very disturbing trend.  Study finds that opioid addicted infants are on a dramatic risk in the US.  This study looked at Neionatal abstinence syndrome from 2000 to 2009.  This follows the significant increase in maternal opioid prescription use.  We physicians must do better.  Patients must demand better.  This study just focused on hospital costs directly associated with the Neonatal period.  No cost estimates are evaluated for long-term care.
Nathan Goodyear

Oxytrex Minimizes Physical Dependence While Providing Effective Analgesia: A Randomized... - 0 views

www.jpain.org/...abstract

naltrexone pain control opiates

shared by Nathan Goodyear on 19 May 11 - No Cached
  • Active treatment groups attained comparable analgesia despite significantly lower drug use
  • preclinical data also show a suppression of opioid tolerance and dependence
  • Previous clinical data have shown ultralow-dose naltrexone enhances and prolongs oxycodone analgesia,
  • ...1 more annotation...
  • A cellular mechanism of action has been demonstrated to be the prevention of aberrant G protein signaling by mu opioid receptors caused by chronic opioid administration
  • Nathan Goodyear on 19 May 11
     
    low dose naltrexone improves pain control and reduced opioid addiction
Nathan Goodyear

Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor path... - 0 views

ebm.sagepub.com/...1036.short

LDN low dose naltrexone opioid growth factor cancer

shared by Nathan Goodyear on 08 Sep 14 - No Cached
  • Nathan Goodyear on 08 Sep 14
     
    LDN inhibits cell proliferation through increased opioid growth factor and receptor translation.
Nathan Goodyear

National Institutes of Health Pathways to Prevention Workshop: The Role of Opioids in t... - 0 views

annals.org/article.aspx

NIH opioids chronic pain pain health

shared by Nathan Goodyear on 16 Jan 15 - No Cached
  • Nathan Goodyear on 16 Jan 15
     
    NIH panel review finds little empirical evidence to support the use of opioids in chronic pain.
Nathan Goodyear

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic... - 0 views

www.ncbi.nlm.nih.gov/...PMC3962576

microglia LDN low dose naltrexone pain inflammation

shared by Nathan Goodyear on 05 Jul 17 - No Cached
  • orally active competitive opioid receptor antagonist
  • 4.5 mg, though the dosage can vary a few milligrams below or above that common value
  • At the low dosage level, naltrexone exhibits paradoxical properties, including analgesia and anti-inflammatory actions
  • ...10 more annotations...
  • LDN may be an effective treatment for FM
  • In addition to the antagonist effect on mu-opioid and other opioid receptors, naltrexone simultaneously has an antagonist effect on non-opioid receptors (Toll-like receptor 4 or TLR4) that are found on macrophages such as microglia
  • It is via the non-opioid antagonist path that LDN is thought to exert its anti-inflammatory effects
  • Once activated, microglia produce inflammatory and excitatory factors that can cause sickness behaviors such as pain sensitivity, fatigue, cognitive disruption, sleep disorders, mood disorders, and general malaise
  • The neuroprotective action appears to result when microglia activation in the brain and spinal cord is inhibited
  • By suppressing microglia activation, naloxone reduces the production of reactive oxygen species and other potentially neuroexcitatory and neurotoxic chemicals
  • suppressed TNF-alpha, IL-6, MCP-1, and other inflammatory agents in peripheral macrophages
  • individuals with greater ESR at baseline experienced a greater drop in pain when taking LDN
  • LDN has been reported to reduce not only self-reported pain in that condition but also objective markers of inflammation and disease severity
  • Naltrexone has also shown some promise in improving disease severity in multiple sclerosis
  • Nathan Goodyear on 05 Jul 17
     
    LDN maybe useful in treating chronic pain via anti-inflammatory effects on microglia.
Nathan Goodyear

Testosterone suppression in opioid users: A systematic review and m... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25702934

Testosterone low T low Testosterone methadone opiates opioid narcotics men male hormone hormones

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Opioid use, despite type (including methadone), is associated with lower Testosterone in men.  This is not new information, but this meta-analysis reconfirms this relationship, particularly that methadone has the same effect.  This relationship was not found in women.  These physicians that regularly prescribe opiates  to men are doing them an incredible disservice.  A lower T in men is a significant negative health biomarker.
Nathan Goodyear

Antagonism of antinociception in mice by glucose and fructose: comparison of subcutaneo... - 0 views

www.ncbi.nlm.nih.gov/...3371404

fructose glucose opioid receptors

shared by Nathan Goodyear on 09 Sep 12 - No Cached
  • Nathan Goodyear on 09 Sep 12
     
    Glucose, and especially fructose shown to antagonize opioid receptors. This negatively effects pain control. Novel concept: pain control requires dietary fructose restriction.
Nathan Goodyear

Opioid growth factor and the treatment of human pancreatic cancer: A review - 0 views

www.ncbi.nlm.nih.gov/...PMC3942827

peptides peptide therapy cancer

shared by Nathan Goodyear on 04 Jul 20 - No Cached
  • Nathan Goodyear on 04 Jul 20
     
    Review of Opioid Growth Factor inhibition of cancer growth via inhibition in cell cycle.
Nathan Goodyear

The role of opioids in cancer response to immunotherapy | Journal of Translational Medi... - 0 views

translational-medicine.biomedcentral.com/...s12967-021-02784-8

immunotherapy immunosuppression morphine Opiates immun

shared by Nathan Goodyear on 13 Nov 22 - No Cached
  • Nathan Goodyear on 13 Nov 22
     
    opioids use during immunotherapy is associated with early progression, potentially representing a predictive factor for PFS and negatively influencing OS as well.
Nathan Goodyear

Low-dose naltrexone (LDN): Tricking the body to heal itself - 0 views

www.sciencedaily.com/...110902133047.htm

low dose naltrexone LND opioid growth factor OGF inflammation cancer low dose naltrexone opioid growth factor

shared by Nathan Goodyear on 27 Nov 12 - No Cached
  • Nathan Goodyear on 27 Nov 12
     
    synopsis of a previously posted article on LDN and OGF in the potential use in cancer.
Nathan Goodyear

Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial - 0 views

www.ncbi.nlm.nih.gov/...PMC2657183

LDN low dose naltrexone naltrexone opiates opioids

shared by Nathan Goodyear on 20 Dec 16 - No Cached
  • Nathan Goodyear on 20 Dec 16
     
    LDN found to help reduce opiod withdrawal symptoms.
Nathan Goodyear

Effect of Opioids on Testosterone Levels: Cross-Sectional Study using NHANES. - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...26177122

low T low Testosterone opiates opioids Testosterone men hormone hormones

shared by Nathan Goodyear on 21 Jul 15 - No Cached
  • Nathan Goodyear on 21 Jul 15
     
    opiate use increases odds of low Testosterone; however, this is just one piece. 
Nathan Goodyear

Hospitalizations for Poisoning by Prescription Opioids, Sedatives, and Tranquilizers - 0 views

www.ajpmonline.org/...abstract

prescription medications side effects opioids sedatives tranquilizers Hospitals

shared by Nathan Goodyear on 02 Oct 11 - No Cached
  • Nathan Goodyear on 02 Oct 11
     
    Prescription medications are one of the leading causes of death today.
Nathan Goodyear

Opioid growth factor - opioid growth factor receptor axis inhibits proliferation of tri... - 0 views

journals.sagepub.com/...1535370213489492

peptide therapy cancer peptides TNBC breast cancer

shared by Nathan Goodyear on 05 Jul 20 - No Cached
  • Nathan Goodyear on 05 Jul 20
     
    Peptide therapy effective in inhibits proliferation in TNBC.
Nathan Goodyear

Methionine enkephalin (MENK) mounts antitumor effect via regulating dendritic cells (DC... - 0 views

pubmed.ncbi.nlm.nih.gov/28088065

MET-enkephalin MET-5 dendritic cell cancer

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    MET-enkephalins provides anti-tumor activity via opioid receptors on Dendritic cells.
Nathan Goodyear

Testosterone replacement therapy outcomes among opioid users: The Testim Registry in th... - 0 views

www.medaus.com/index00a3-0012.html

low T low T low testosterone opiates narcotics replacement therapy men male hormone hormones

shared by Nathan Goodyear on 17 Nov 12 - No Cached
  • Nathan Goodyear on 17 Nov 12
     
    opiates are a common cause of low testosterone.  So, by physicians increasing the addiction rate, what are we really doing here?  We are lowering their testosterone levels and increasing their mortality rates per numerous other studies.
Nathan Goodyear

Methadone induces testosterone suppression in patients with opioid addiction : Scientif... - 0 views

www.nature.com/srep06189

methadone Testosterone male hormones

shared by Nathan Goodyear on 15 May 16 - No Cached
  • Nathan Goodyear on 15 May 16
     
    Methadone suppresses Testosterone in men.
Nathan Goodyear

Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus ... - 0 views

www.ane.pl/7020.pdf

vaccination ASD autism vaccinations

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    vaccinations as given between 1994 and 1999 were administered to rhesus macaque monkeys. The challenge group showed altered brain development versus the control group of saline. This was a small pilot study, but well designed.
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