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Nathan Goodyear

Secondary causes of hyperlipidemia. [Med Clin North Am. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8283927

triglycerides hypertriglyceridemia aromatase activity estrogen glucocorticoids

shared by Nathan Goodyear on 23 Sep 13 - No Cached
  • Nathan Goodyear on 23 Sep 13
     
    Estrogen and Glucocorticoids increase triglyceride levels.
Nathan Goodyear

Fructose Consumption as a Risk Factor for Non-alcoholic Fatty Liver Disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2423467

fructose fructokinase triglyceride NAFLD non-alcoholic fatty liver fatty liver liver

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Fructose upregulates fructokinase activity and this increase liver triglyceride production increasing non-alcoholic fatty liver disease also known as NAFLD.
Nathan Goodyear

Uric acid induces hepatic steatosis by generatio... [J Biol Chem. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23035112

uric acid mitochondria non-alcoholic fatty liver fructose triglyceride oxidative stress fatty liver liver ATP

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Elevated uric acid levels up regulate fructose metabolism to triglycerides and fatty liver.  This study finds that liver mitochondrial oxidative stress is also evident.  This mitochondrial dysfunction also leads to compromised ATP production and fat accumulation specifically through inhibition of aconitase..
Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

www.jendocrinolinvest.it/...abstract.cfm

MetS metabolic syndrome vitamin D vitamin D triglycerides blood pressure

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Nathan Goodyear on 11 Dec 13
     
    low vitamin D associated with an increased odds ratio of elevated blood pressure and elevated triglycerides in post-menopausal women with metabolic syndrome.
Nathan Goodyear

Association of fructose consumption and components... [Nutrition. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24698343

metabolic syndrome fructose nutrition diet glucose triglycerides hypertension

shared by Nathan Goodyear on 07 Apr 14 - No Cached
  • Nathan Goodyear on 07 Apr 14
     
    Fructose intake associate with increased fasting blood sugar, elevated triglycerides, and elevated systolic blood pressure--all parameters of metabolic syndrome.
Nathan Goodyear

Long-Term Testosterone Treatment in Elderly Men wi... [J Sex Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24712761

low T Testosterone undecanoate metabolic syndrome cholesterol triglycerides glucose weight BMI men male hormone hormones hypogonadism

shared by Nathan Goodyear on 22 Apr 14 - No Cached
  • Nathan Goodyear on 22 Apr 14
     
    Testosterone therapy, undecanoate in this study, found to improve body weight, decrease waist circumference, BMI, lower Total Cholesterol, lower triglycerides, decrease fasting glucose, decrease HgbA1c, decrease blood pressure and increase HDL in men >59.  
Nathan Goodyear

Endocrine and metabolic effects of consuming bever... [Am J Clin Nutr. 2008] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...19064538

fructose HCFS sucrose metabolic syndrome triglyceride fat obesity overweight

shared by Nathan Goodyear on 20 Aug 11 - No Cached
  • Nathan Goodyear on 20 Aug 11
     
    fructose, HCFS, and sucrose increase triglyceride formation = fat
Nathan Goodyear

(n-3) Fatty Acids: Clinical Trials in People with Type 2 Diabetes - 0 views

advances.nutrition.org/...3.short

omega-3 trigylcerides hypertriglyceridemia

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • had varying effects on serum cholesterol, LDL cholesterol, and HDL cholesterol
  • (n-3) Fatty acids generally decreased serum triglycerides
  • Nathan Goodyear on 28 Apr 11
     
    Omega 3 review lowers triglycerides
Nathan Goodyear

Sex hormone-binding globulin is a major dete... [Atherosclerosis. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15777555

SHBG HDL triglycerides lipids cardiovascular disease cholesterol

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    SHBG positively associated with HDL and negatively associated with triglycerides.
Nathan Goodyear

Plasma testosterone, high density lipoprotein c... [Am J Cardiol. 1981] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7304438

testosterone lipids cholesterol HDL triglycerides VLDL male hormone hormones men

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    Free and total Testosterone in men found to be positively associated with HDL, but negatively associated with triglycerides and VLDL in this study.
Nathan Goodyear

Serum sex hormone-binding globulin and test... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24670886

SHBG CVD cardiovascular disease men male hormone hormones CRP cholesterol triglycerides Testosterone

shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    SHBG positively associated with lower CVD risk profile, CRP, blood pressure, TC, triglycerides..., in young men.  This was found independent of Testosterone.  This is similar to a lot of the research on Metabolic Syndrome as well.
Nathan Goodyear

Testosterone Supplementation Improves Carbohydrate and Lipid Metabolism in Some Older M... - 0 views

www.ncbi.nlm.nih.gov/...PMC4225803

Testosterone adipose obesity LDL triglycerides lipids metabolism insulin resistance insulin sensitivity men male hormone hormones

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    In some men, Testosterone therapy (10 mg transdermal) is associated with adipose tissue.  In those with a decrease in adipose tissue, a decrease in LDL, decrease in Triglycerides, increase in insulin sensitivity, and lower HDL were found.
Nathan Goodyear

Prevalence of Hyperuricemia and the Relationship between Serum Uric Acid and Metabolic ... - 0 views

www.jstage.jst.go.jp/..._article

uric acid metabolic syndrome triglycerides waist circumference hormones hormone inflammaiton

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    Waist circumference and triglycerides correlate with serum uric acid levels.  Men in this study had higher hyperuricemic rates compared to women.  Elevated uric acid levels were associated with increased MetS in both sexes and higher normal uric acid levels were also associated with a higher risk of MetS.
Nathan Goodyear

Testosterone and metabolic syndrome: a meta-analysis study. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20807333

Testosterone metabolic syndrome glucose HOMA triglycerides waist circumference HDL men male hormone hormones

shared by Nathan Goodyear on 03 Mar 15 - No Cached
  • Nathan Goodyear on 03 Mar 15
     
    Men with metabolic syndrome have lower Testosterone levels when compared to "healthy" individuals.  All men with MetS should have a full androgen analysis performed.  This meta-analysis of 20 studies found Testosterone therapy reduced fasting glucose, HOMA, triglycerides, waist circumference by Testosterone in men with MetS.  This study found that Testosterone therapy increased HDL as well.
Nathan Goodyear

Lipid-Lowering Effects of Curcumin in Patients... [Phytother Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25131839

metabolic syndrome curcumin tumeric HDL LDL triglycerides cholesterol natural alternative

shared by Nathan Goodyear on 19 Aug 14 - No Cached
  • Nathan Goodyear on 19 Aug 14
     
    Spice it up for cholesterol.  Study finds small, but significant, improvement in in HDL, LDL, and triglycerides with daily curcumin in those with metabolic syndrome.
Nathan Goodyear

THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: result... - 0 views

www.eje-online.org/...EJE-15-0262.abstract

low T low Testosterone Testosterone fat muscle mass metabolism body composition cholesterol triglycerides HDL men male hormones

shared by Nathan Goodyear on 19 Nov 15 - No Cached
  • Nathan Goodyear on 19 Nov 15
     
    new study finds Testosterone therapy in men with low T significantly reduces fat, increases lean muscle mass, and reduces fasting glucose and insulin levels.  Improvements in total cholesterol, triglycerides and HDL was also seen.  Only abstract available currently.
Nathan Goodyear

Oral spore-based probiotic supplementation was associated with reduced incidence of pos... - 0 views

www.wjgnet.com/...117.htm

probiotics spore probiotics LPS lipopolysaccharides IL-1beta inflammation gut gut bacteria gut flora gut health gut microbiome gut microbiota

shared by Nathan Goodyear on 05 Oct 17 - No Cached
  • Nathan Goodyear on 05 Oct 17
     
    Study finds spore probiotic for 30 days reduced LPS endotoxin by 42%, while the placebo group found a 36% increase.  As a result, and to no surprise, there was a significant drop in IL-beta.  Also, in the spore probiotic group, there was a 24% reduction in triglycerides.
Nathan Goodyear

Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss - 0 views

www.ncbi.nlm.nih.gov/...PMC1488852

ketogenic diet low carbohydrate diet diet nutrition atherosclerosis cholesterol HDL LDL Triglycerides

shared by Nathan Goodyear on 09 Feb 18 - No Cached
mamdouh_hfz liked it
  • Nathan Goodyear on 09 Feb 18
     
    low carb diet found to benefit atherosclerosis and lipid abnormalities (Triglycerides, HDL, and LDL particle size).  Interesting enough, no significant weight loss was seen.
Nathan Goodyear

Preventing Chronic Disease | Plasma Vitamin D and Biomarkers of Cardiometabolic Disease... - 0 views

www.cdc.gov/...12_0230.htm

vitamin D CRP cardiovascular disease CVD vitamin D

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    Higher vitamin D levels associated with lower cardio biomarkers: insulin, insulin resistance, triglycerides, TC, LDL and TC:HDL.  Not found to be associated: glucose, apoliporotein A1 and B, CRP, fibrinogen, and homocysteine.
Nathan Goodyear

Testosterone: a metabolic hormone in health and disease - 0 views

joe.endocrinology-journals.org/...R25.full

male hormone hormones testosterone hypogonadal-obesity-adipocytokine hypothesis

shared by Nathan Goodyear on 08 May 13 - No Cached
  • E2 and the inflammatory adipocytokines tumour necrosis factor α (TNFα) and interleukin 6 (IL6) inhibit hypothalamic production of GNRH and subsequent release of LH and FSH from the pituitary
  • Leptin, an adipose-derived hormone with a well-known role in regulation of body weight and food intake, also induces LH release under normal conditions via stimulation of hypothalamic GNRH neurons
  • In human obesity, whereby adipocytes are producing elevated amounts of leptin, the hypothalamic–pituitary axis becomes leptin resistant
  • ...39 more annotations...
  • there is evidence from animal studies that leptin resistance, inflammation and oestrogens inhibit neuronal release of kisspeptin
  • Beyond hypothalamic action, leptin also directly inhibits the stimulatory action of gonadotrophins on the Leydig cells of the testis to decrease testosterone production; therefore, elevated leptin levels in obesity may further diminish androgen status
  • Prostate cancer patients with pre-existing T2DM show a further deterioration of insulin resistance and worsening of diabetic control following ADT
  • ADT for the treatment of prostatic carcinoma in some large epidemiological studies has been shown to be associated with an increased risk of developing MetS and T2DM
  • Non-diabetic men undergoing androgen ablation show increased occurrence of new-onset diabetes and demonstrate elevated insulin levels and worsening glycaemic control
  • increasing insulin resistance assessed by glucose tolerence test and hypoglycemic clamp was shown to be associated with a decrease in Leydig cell testosterone secretion in men
  • The response to testosterone replacement of insulin sensitivity is in part dependent on the androgen receptor (AR)
  • Low levels of testosterone have been associated with an atherogenic lipoprotein profile, characterised by high LDL and triglyceride levels
  • a positive correlation between serum testosterone and HDL has been reported in both healthy and diabetic men
  • up to 70% of the body's insulin sensitivity is accounted for by muscle
  • Testosterone deficiency is associated with a decrease in lean body mass
  • relative muscle mass is inversely associated with insulin resistance and pre-diabetes
  • GLUT4 and IRS1 were up-regulated in cultured adipocytes and skeletal muscle cells following testosterone treatment at low dose and short-time incubations
  • local conversion of testosterone to DHT and activation of AR may be important for glucose uptake
  • inverse correlation between testosterone levels and adverse mitochondrial function
  • orchidectomy of male Wistar rats and associated testosterone deficiency induced increased absorption of glucose from the intestine
  • (Kelley & Mandarino 2000). Frederiksen et al. (2012a) recently demonstrated that testosterone may influence components of metabolic flexibility as 6 months of transdermal testosterone treatment in aging men with low–normal bioavailable testosterone levels increased lipid oxidation and decreased glucose oxidation during the fasting state.
  • Decreased lipid oxidation coupled with diet-induced chronic FA elevation is linked to increased accumulation of myocellular lipid, in particular diacylglycerol and/or ceramide in myocytes
  • In the Chang human adult liver cell line, insulin receptor mRNA expression was significantly increased following exposure to testosterone
  • Testosterone deprivation via castration of male rats led to decreased expression of Glut4 in liver tissue, as well as adipose and muscle
  • oestrogen was found to increase the expression of insulin receptors in insulin-resistant HepG2 human liver cell line
  • FFA decrease hepatic insulin binding and extraction, increase hepatic gluconeogenesis and increase hepatic insulin resistance.
  • Only one, albeit large-scale, population-based cross-sectional study reports an association between low serum testosterone concentrations and hepatic steatosis in men (Völzke et al. 2010)
  • This suggests that testosterone may confer some of its beneficial effects on hepatic lipid metabolism via conversion to E2 and subsequent activation of ERα.
  • hypogonadal men exhibiting a reduced lean body mass and an increased fat mass, abdominal or central obesity
  • visceral adipose tissue was inversely correlated with bioavailable testosterone
  • there was no change in visceral fat mass in aged men with low testosterone levels following 6 months of transdermal TRT, yet subcutaneous fat mass was significantly reduced in both the thigh and the abdominal areas when analysed by MRI (Frederiksen et al. 2012b)
  • ADT of prostate cancer patients increased both visceral and subcutaneous abdominal fat in a 12-month prospective observational study (Hamilton et al. 2011)
  • Catecholamines are the major lipolysis regulating hormones in man and regulate adipocyte lipolysis through activation of adenylate cyclase to produce cAMP
  • deficiency of androgen action decreases lipolysis and is primarily responsible for the induction of obesity (Yanase et al. 2008)
  • may be some regional differences in the action of testosterone on subcutaneous and visceral adipose function
  • proinflammatory adipocytokines IL1, IL6 and TNFα are increased in obesity with a downstream effect that stimulates liver production of CRP
  • observational evidence suggests that IL1β, IL6, TNFα and CRP are inversely associated with serum testosterone levels in patients
  • TRT has been reported to significantly reduce these proinflammatory mediators
  • This suggests a role for AR in the metabolic actions of testosterone on fat accumulation and adipose tissue inflammatory response
  • testosterone treatment may have beneficial effects on preventing the pathogenesis of obesity by inhibiting adipogenesis, decreasing triglyceride uptake and storage, increasing lipolysis, influencing lipoprotein content and function and may directly reduce fat mass and increase muscle mass
  • Early interventional studies suggest that TRT in hypogonadal men with T2DM and/or MetS has beneficial effects on lipids, adiposity and parameters of insulin sensitivity and glucose control
  • Evidence that whole-body insulin sensitivity is reduced in testosterone deficiency and increases with testosterone replacement supports a key role of this hormone in glucose and lipid metabolism
  • Impaired insulin sensitivity in these three tissues is characterised by defects in insulin-stimulated glucose transport activity, in particular into skeletal muscle, impaired insulin-mediated inhibition of hepatic glucose production and stimulation of glycogen synthesis in liver, and a reduced ability of insulin to inhibit lipolysis in adipose tissue
  • Nathan Goodyear on 08 May 13
     
    Great review of the Hypogonadal-obesity-adipocytokine hypothesis.
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