Skip to main content

Home/ Dr. Goodyear/ Group items tagged fructokinase

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Developmen... - 0 views

www.ncbi.nlm.nih.gov/...PMC3480441

non-alcoholic fatty liver fatty liver fructose uric acid

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Vicious cycle.  High fructose intake increases uric acid production.  Hyperuricemia then leads to further Fructose metabolism.  This study finds that hyperuricemia upregulates the fructokinase enzyme that is the first step in fructose metabolism.  This upregulation will increase fructose metabolism and increase fat accumulation in the liver.
Nathan Goodyear

Fructose Consumption as a Risk Factor for Non-alcoholic Fatty Liver Disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2423467

fructose fructokinase triglyceride NAFLD non-alcoholic fatty liver fatty liver liver

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Fructose upregulates fructokinase activity and this increase liver triglyceride production increasing non-alcoholic fatty liver disease also known as NAFLD.
Nathan Goodyear

Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension - 0 views

www.hindawi.com/...682673

fructose uric acid metabolic syndrome sugar

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • HFCS consists of fructose and glucose mixed in a variety of concentrations, but most commonly as 55% fructose and 45% glucose
  • In the United States, HFCS and sucrose are the major sources of fructose in the diet, and HFCS is a major ingredient in soft drinks, pastries, desserts, and various processed foods
  • fructose and glucose are metabolized in completely different ways and utilize different GLUT transporters
  • ...9 more annotations...
  • In the liver, fructose bypasses the two highly regulated steps of glycolysis, catalyzed by glucokinase/hexokinase and phosphofructokinase both of which are inhibited by increasing concentrations of their byproducts. Instead, fructose enters the pathway at a level that is not regulated and is metabolized to fructose-1-phosphate primarily by fructokinase or ketohexokinase
  • Fructokinase has no negative feedback system, and ATP is used for the phosphorylation process. As a result, continued fructose metabolism results in intracellular phosphate depletion, activation of AMP deaminase, and uric acid generation which is harmful at the cellular level
  • Uric acid, a byproduct of fructose degradation,
  • Uric acid inhibits endothelial NO both in vivo and in vitro, [15] and directly induces adipocyte dysfunction
  • Serum uric acid increases rapidly after ingestion of fructose, resulting in increases as high as 2 mg/dL within 1 hour
  • Uncontrolled fructose metabolism leads to postprandial hypertriglyceridemia, which increases visceral adipose deposition. Visceral adiposity contributes to hepatic triglyceride accumulation, protein kinase C activation, and hepatic insulin resistance by increasing the portal delivery of free fatty acids to the liver
  • Several reviews have concluded that intake of both fructose and HFCS by children and adults was associated with an increased risk of obesity and metabolic syndrome
  • Sucrose is a disaccharide that is comprised of fructose and glucose
  • Figure 2
  • Nathan Goodyear on 24 Aug 14
     
    great read and review of the role of fructose in metabolic syndrome.
1 - 3 of 3
Showing 20▼ items per page