Exercise reduces Gestational Diabetes risk in Obese pregnant women. The amount of exercise was quite limited: 30 minutes cycling for 3 days/week only. No increased risk of preterm delivery as well.
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Here is my problems with "statistics". The statement "No significant difference in the report of sexual ideation was found..." If you are the one women that had decreased sexual function after having your ovaries removed: isn't it comforting to know you are not statistically significant. Come on. Some did, and that is enough and should be considered significant. This is a permanent change to these woman's lives and marriage.
vitamin D associated with increased Pre term delivery in twin pregnancies. This is a cohort, so not the most reliable of study designs, but known that vitamin D inhibits inflammation and that this plays a role in labor...logic makes sense.
Exercise is not only safe in pregnancy, it is good for the pregnancy and the baby. This idea that pregnancy is a disease or a condition has got to stop; science continues to prove that is not the case.
analysis of 3 clinical trials found that up to 40% of 447 women that were treated with antidepressant therapy found no benefit. Physical symptoms were provided little, if any benefit.
A study to evaluate serum and urinary hormone levels following short and long term administration of two regimens of progesterone cream in postmenopausal women
Sufficient favorable clinical experience over the last 10 years suggests that PN is a relatively safe and effective method for reversing maternal malnutrition and promoting normal fetal growth and development.
glutathione low in pregnancies complicated by PIH and HELLP syndrome. Every woman should have her detoxification capacity evaluated prior to pregnancy.
M1 macrophages are characterized by the secretion of reactive oxygen species and proinflammatory cytokines and chemokines and can be identified via the cell surface marker CD86
M2 macrophages secrete growth factors and antiinflammatory immune modulators and can be identified by the cell surface marker CD206
an overzealous M2 response can also lead to excess tissue deposition and fibrosis
Studies of similar meshes that are used in hernia repair have demonstrated that all polypropylene meshes induce a prolonged inflammatory response at the site of implantation
the long-term presence of activated inflammatory cells, such as macrophages at the mesh tissue interface, can impact negatively the ability of the mesh to function as intended.
All M1 proinflammatory and M2 proremodeling cytokines and chemokines were increased in mesh explants as compared with nonmesh tissue (Table 3Table 3), which indicated a robust, active, and ongoing host response to polypropylene long after implantation
Comparison of the ratio of the M2 proremodeling cytokines (IL-10+IL-4) with the M1 proinflammatory cytokines (TNF-α+IL-12p70) revealed a decrease in mesh explants as compared with controls (P = .003), which indicated a shift towards a proinflammatory profile.
Mesh explants contained a higher number of total cells/×200 field when compared with controls (682.46 ± 142.61 cells vs 441.63 ± 126.13 cells; P < .001) and a lower ratio of M2:M1 macrophages (0.260 ± 0.161 cells vs 1.772 ± 1.919; P = .001), which supported an ongoing proinflammatory response.
the host response was proportional to the amount of material in contact with the host
A persistent foreign body response was observed in mesh-tissue complexes that were excised from women who required surgical excision of mesh months to years after mesh implantation
The host response was characterized by a predominance of macrophages with an increase in both proinflammatory and proremodeling cytokines/chemokines along with increased tissue degradation, as evidenced by increased MMP-2 and -9
Mesh-tissue complexes removed for mesh exposure had increased pro–MMP-9 that indicated a proinflammatory and tissue destruction–type response
The presence of macrophages, elevated cytokines, chemokines, and MMPs in tissue-mesh complexes that were excised from patients with exposure or pain suggests that polypropylene mesh elicits an ongoing host inflammatory response
In the presence of a permanent foreign body, the implant is surrounded with a fibrotic capsule because it cannot be degraded
For hernia meshes, if the fibers are too close (<1 mm), the fibrotic response to neighboring fibers overlaps, or “bridges,” and results in “bridging fibrosis” or encapsulation of the mesh
Gynemesh PS has a highly unstable geometry when loaded that resulted in pore collapse and increasing stiffness of the product
mesh shrinkage (50-70%) has been described to occur after transvaginal insertion of prolapse meshes
Study finds that early (defined as 1-2 weeks after diagnosis) surgery after diagnosis of uterine cancer is associated with increased complications including death. This compared to lower postoperative death rates in delay out to 3-4 weeks.