Interesting: study finds no association between tryptophan and serotonin levels and depression. The study found no difference between 44 "depressed" perimenopausal women and 19 "without depression". Serotonin therapy of depression?? However, poor sleep and hot flashes did.
The opposite effect strikes again: elevated free androgen index is associated with CV risk in perimenopause women across 5 ethnic groups. Low SHBG was associated with increased CVD.
Study results demonstrate there is adequate evidence to support use of saliva testing as an effective clinical tool for measuring hormone status in perimenopausal and menopausal women
2007 review states: "there is adequate evidence to support use of saliva testing as an effective clinical tool for measuring hormone status in perimenopausal and menopausal women". Pretty definitive statement. This was a worldwide analysis
great review of the menopause transition and the effect of weight and hormones. For example, muscle loss is found in menopause vs perimenopause. Increased estrogen production occurs from non-ovary sites i.e. visceral and SQ fat.
study shows that smoking cessation, physical inactivity, menopause, hysterectomy and energy intake associated with the perimenopause weight gain. What is interesting about it is the energy imbalance is small that results in a big weight gain over time. We need to look closely and be more frank with out clients about the risk that a hysterectomy poses for her health post surgery.
3 year study finds improvement in classic menopausal symptoms for women in perimenopause and menopause with improvement in other parameters: fasting glucose, cholesterol, MMP-9, CRP, fibrinogen and other clotting factors. This study used bioidentical Bi-est, progesterone, and in some DHEA and Testosterone.
Women
who have an oophorectomy before the normal age at menopause show an increased risk for cognitive impairment or dementia later
in life unless they are treated with estrogen until the normal age at menopause
SIRT1 has been implicated in the disruption of mitochondrial bioenergenetics in Alzheimer's
disease and mild cognitive impairment
the increase in dementia observed with CEE/MPA rather than CEE alone suggests potential deleterious effects of
MPA on brain function in older women
Early estrogen therapy in perimenopause and early menopause, with Estradiol, provides more health benefits than later therapy. This article looked at Estrogen's effects on a woman's brain. This likely has its origins in the change in estrogen receptors. The signal is not changing, but the reception of that signal is. How else can one explain a different response to the same hormone dosage?