In the group of patients with PIH, reduced glutathione concentration significantly decreased
CONCLUSIONS: Obtained results of the research allowed us to conclude that the pregnancy-induced hypertension is associated with the overproduction of lipid peroxides and impaired antioxidant defence.
We concluded that both extracellular and intracellular antioxidant buffering levels were decreased in patients with PIH, especially in those with proteinuria
glutathione low in pregnancies complicated by PIH and HELLP syndrome. Every woman should have her detoxification capacity evaluated prior to pregnancy.
Interesting, yet not surprising. TNF-alpha has strong correlation with IR in pregnancy. This follows metabolic endotoxemia pathophysiology. I believe this could be used to assess risk for PIH...
Many studies have been published on Selenium deficiency and decreased reproduction and pregnancy complications. This study provides a nice review of Selenium and reproduction. This is a just the abstract and will post the full article when it become available
preeclampsia associated with oxidative stress. Low levels of glutathione, vitamin C found in placentas of those with preeclampsia. Implications for therapy?