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Nathan Goodyear

The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older Eur... - 0 views

jcem.endojournals.org/...E1577.abstract

testosterone T low estradiol sexual function men

shared by Nathan Goodyear on 31 Oct 11 - No Cached
  • Nathan Goodyear on 31 Oct 11
     
    Testosterone, estradiol and sexual function in men
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-3818 - 0 views

press.endocrine.org/...jc.2014-3818

low T low Testosterone ED Estradiol SHBG erectile dysfunction libido men male hormone hormones

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Nathan Goodyear on 27 Jan 15
     
    Study finds that low free T and low Total T were associated with decline in desire, ED and activity versus none with Estradiol and SHBG in older men.  The difficult issue is the threshold of "low T".  The definition of "low T" is not uniform and varies with age.  Thus baseline evaluations and correlation with symptoms, metabolic dysfunction must be done.
Nathan Goodyear

Evidence for hypogonadism in massively obese ... [Horm Metab Res. 1981] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7198085

obesity obese overweight low T low T testosterone low testosterone aromatase SHBG estradiol men male hyogonadism

shared by Nathan Goodyear on 19 Nov 12 - No Cached
  • Nathan Goodyear on 19 Nov 12
     
    In obese men, low T is the result of increased estradiol formation from aromatase activity.  Low SHBG is no enough to offset the decrease in free T levels.
Nathan Goodyear

Testosterone Concentrations In Young P... [Clin Endocrinol (Oxf). 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22970699

obesity overweight men males boys low T low Testosterone low T testosterone estradiol hormone hormones insulin resistance

shared by Nathan Goodyear on 17 Nov 12 - No Cached
  • Nathan Goodyear on 17 Nov 12
     
    New study shows that obese boys/young men pre and post puberty have up to 50% lower testosterone levels than comparative normal BMI counterparts.  Also of note, estradiol levels were not associated with the low testosterone levels.
Nathan Goodyear

Relations between sex hormone levels and sexu... [Arch Sex Behav. 1986] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3789906

men male libido orgasm estradiol estrogen aromatase testosterone hormone hormones

shared by Nathan Goodyear on 08 Jun 13 - No Cached
  • Nathan Goodyear on 08 Jun 13
     
    Estradiol levels significantly negatively correlated libido and orgasm frequency in men.  Conversely, free levels of testosterone positively correlated with libido and orgasm frequency.
Nathan Goodyear

The effect of short-term treatment with micronize... [Endocr Res. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11019903

estradiol SHBG testosterone male men hormone hormones

shared by Nathan Goodyear on 08 Jun 13 - No Cached
  • Nathan Goodyear on 08 Jun 13
     
    Estradiol increases SHBG in men.  This will lower the effective free levels of testosterone.  This study looked at the effect on bone turnover.
Nathan Goodyear

Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Ath... - 0 views

www.ncbi.nlm.nih.gov/...28041602

vitamin d hormones Testosterone estradiol SHBG

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • Nathan Goodyear on 09 Jan 17
     
    cross sectional study finds low vitamin D associated with a decrease in SHBG and an increase in free Testosterone;  a decrease in estradiol and an increase in DHEA was seen in women.  No association with total Testosterone was found.  There are studies that show a direct decrease in testicular Testosterone production in men with low vitamin D and decrease in AR function.
Nathan Goodyear

Differential Regulation of Gonadotropin Secretion by Testosterone in the Human Male: Ab... - 0 views

jcem.endojournals.org/...53.long

Testosterone men T E2 estradiol FSH LH HPA male hormone regulation

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    In men, Testosterone is shown to provide negative feedback on LH; but FSH is primarily regulated by estradiol.
Nathan Goodyear

Estrogen Receptor {beta}: Switching to a New Partner and Escaping from Estrogen -- Leun... - 0 views

stke.sciencemag.org/...pe19

estrogen estradiol estrone E2 E1 ER-alpha ER-beta BPH prostate cancer inflammation apoptosis men male receptors

shared by Nathan Goodyear on 18 Sep 12 - No Cached
  • Nathan Goodyear on 18 Sep 12
     
    Study shows that estradiol decreases ER beta in the prostate. ER beta is anti-inflammatory, inhibits growth, and promotes cell death: all of which would decrease risk of prostate growth and/or cancer.   We know that men increase estrogen production through increased aromatase activity, which according to this study, will decrease ER beta and the prostate associated benefits.
Nathan Goodyear

One year follow-up study of the association between chemical castration, sex hormones, ... - 0 views

www.sciencedirect.com/...S0306453003002208

hormone hormones depression memory beta-amyloid Testosterone Estradiol

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Chemical castration as seen in androgen deprivation therapy resulted in precipitous decline in Testosterone and Estradiol in men.  Associated increased in beta-amylloid found.
Nathan Goodyear

17β-Estradiolid Ca influx rapid Ca2+ prostate cancer cells - 0 views

www.eje-online.org/...367

prostate cancer cells Estradiol hormone hormones men male

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Nathan Goodyear on 21 Aug 13
     
    Estradiol in men shown to increase Prostate cancer cell line growth.  The link is through calcium influx through membrane calcium channels.
Nathan Goodyear

Aromatase and regulating the estr... [J Steroid Biochem Mol Biol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19896534

prostate disease cancer estrogen receptors ER Testosterone Estradiol estrogen hormone hormones men

shared by Nathan Goodyear on 16 Sep 13 - No Cached
  • Nathan Goodyear on 16 Sep 13
     
    Balance of Testosterone and Estradiol plays role in prostate disease.   With age in men comes declining Testosterone, yet estrogen productions stay the same to increase.  This significantly alters the estrogen receptors and prostate disease risk.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2008-0940 - 0 views

press.endocrine.org/...jc.2008-0940

estradiol estrogen men male hormones hormone inflammation IL-6 cytokines

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    Estradiol found to be associated with increased IL-6 in older men. This after, the adjustments to exclude variables.  Other inflammatory markers were not associated.
Nathan Goodyear

Informa Healthcare - The Aging Male - 5(2):98 - Summary - 0 views

informahealthcare.com/...tam.5.2.98.102

Estradiol Testosterone men elderly aging

shared by Nathan Goodyear on 11 Oct 11 - No Cached
  • Nathan Goodyear on 11 Oct 11
     
    Estradiol from Testosterone in elderly men.  
Nathan Goodyear

Longitudinal relationships of circul... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24628559

Testosterone low T free Estradiol Estrone muscle mass strength elderly men male hormone hormones men's health

shared by Nathan Goodyear on 24 Mar 14 - No Cached
  • Nathan Goodyear on 24 Mar 14
     
    Declining Testosterone, calculated free Testosterone, Estradiol, and Estrone levels appear to be associated with muscle mass/strength decline in elderly men.  This points to a global decrease in HPA function rather than an individual, specific hormone deficiency.
Nathan Goodyear

Clomiphene citrate effects on testosterone/estroge... [J Sex Med. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16422830

clomid HPA low T testosterone estrogen estradiol hypogonadism men male hormone hormones

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    small cohort with low serum Total Testosterone improved T:E2 ratio with clomid.  Clomid restores the HPA through inhibition of the negative feedback of Estradiol on the Hypothalamus and Pituitary in men.  This allows for an increase in gonadotropin production and thus increase in testosterone production.  Aromatase inhibition therapy would likely still prove beneficial in this situation.
Nathan Goodyear

Higher serum testosterone and dihydrotestosterone, but not estradio... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25660119

Testosterone DHT dihydrotestosterone Estradiol male men hormone hormones FEV1 FVC pulmonary function

shared by Nathan Goodyear on 16 Feb 15 - No Cached
  • Nathan Goodyear on 16 Feb 15
     
    Higher Testosterone and DHT levels in men was found to be positively associated with FEV1 and FVC; Estradiol was not.  The question here is cause or effect.   Also interesting is the fact that smokers had higher Testosterone levels compared to non-smokers.
Nathan Goodyear

Lowered testosterone in male obesity: Mechanisms, morbidity and management Tang Fui MN,... - 0 views

www.ajandrology.com/article.asp

Testosterone male obesity overweight men hormone hormones low T Low T

shared by Nathan Goodyear on 15 Jan 14 - No Cached
  • The number of overweight people is expected to increase from 937 million in 2005 to 1.35 billion in 2030
  • Similarly the number of obese people is projected to increase from 396 million in 2005 to 573 million in 2030
  • By 2030, China alone is predicted to have more overweight men and women than the traditional market economies combined
  • ...37 more annotations...
  • diacylglycerol O-acyltransferase 2 (DGAT2), mechanistically implicated in this differential storage, [10] is regulated by dihydrotestosterone, [11] suggesting a potential role for androgens to influence the genetic predisposition to either the MHO or MONW phenotype.
  • bariatric surgery achieves 10%-30% long-term weight loss in controlled studies
  • The fact that obese men have lower testosterone compared to lean men has been recognized for more than 30 years
  • Reductions in testosterone levels correlate with the severity of obesity and men
  • epidemiological data suggest that the single most powerful predictor of low testosterone is obesity, and that obesity is a major contributor of the age-associated decline in testosterone levels.
  • healthy ageing by itself is uncommonly associated with marked reductions in testosterone levels
  • obesity blunts this LH rise, obesity leads to hypothalamic-pituitary suppression irrespective of age which cannot be compensated for by physiological mechanisms
  • Reductions in total testosterone levels are largely a consequence of reductions in sex hormone binding globulin (SHBG) due to obesity-associated hyperinsulinemia
  • although controversial, measurement of free testosterone levels may provide a more accurate assessment of androgen status than the (usually preferred) measurement of total testosterone in situations where SHBG levels are outside the reference range
  • SHBG increases with age
  • marked obesity however is associated with an unequivocal reduction of free testosterone levels, where LH and follicle stimulating hormone (FSH) levels are usually low or inappropriately normal, suggesting that the dominant suppression occurs at the hypothalamic-pituitary level
  • adipose tissue, especially when in the inflamed, insulin-resistant state, expresses aromatase which converts testosterone to estradiol (E 2 ). Adipose E 2 in turn may feedback negatively to decrease pituitary gonadotropin secretion
  • diabetic obesity is associated with decreases in circulatory E 2
  • In addition to E 2 , increased visceral fat also releases increased amounts of pro-inflammatory cytokines, insulin and leptin; all of which may inhibit the activity of the HPT axis at multiple levels
  • In the prospective Massachusetts Male Aging Study (MMAS), moving from a non-obese to an obese state resulted in a decline of testosterone levels
  • weight loss, whether by diet or surgery, increases testosterone levels proportional to the amount of weight lost
  • fat is androgen-responsive
  • low testosterone may augment the effects of a hypercaloric diet
  • In human male ex vivo adipose tissue, testosterone decreased adipocyte differentiation by 50%.
  • Testosterone enhances catecholamine-induced lipolysis in vitro and reduces lipoprotein lipase activity and triglyceride uptake in human abdominal adipose tissue in vivo
  • in men with prostate cancer receiving 12 months of androgen deprivation therapy, fat mass increased by 3.4 kg and abdominal VAT by 22%, with the majority of these changes established within 6 months
  • severe sex steroid deficiency can increase fat mass rapidly
  • bidirectional relationship between testosterone and obesity
  • increasing body fat suppresses the HPT axis by multiple mechanisms [30] via increased secretion of pro-inflammatory cytokines, insulin resistance and diabetes; [19],[44] while on the other hand low testosterone promotes further accumulation of total and visceral fat mass, thereby exacerbating the gonadotropin inhibition
  • androgens may play a more significant role in VAT than SAT
  • men undergoing androgen depletion for prostate cancer show more marked increases in visceral compared to subcutaneous fat following treatment
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      Interesting: low T increases VAT, yet T therapy does not reduce VAT, yet T therapy reduces SAT.
  • irisin, derived from muscle, induces brown fat-like properties in rodent white fat
  • androgens can act via the PPARg-pathway [37] which is implicated in the differentiation of precursor fat cells to the energy-consuming phenotype
  • low testosterone may compound the effect of increasing fat mass by making it more difficult for obese men to lose weight via exercise
  • pro-inflammatory cytokines released by adipose tissue may contribute to loss of muscle mass and function, leading to inactivity and further weight gain in a vicious cycle
  • Sarcopenic obesity, a phenotype recapitulated in men receiving ADT for prostate cancer, [55] may not only be associated with functional limitations, but also aggravate the metabolic risks of obesity;
  • observational evidence associating higher endogenous testosterone with reduced loss of muscle mass and crude measures of muscle function in men losing weight
  • genuine reactivation of the HPT axis in obese men requires more substantial weight-loss
  • A number of intervention studies have confirmed that both diet- and surgically-induced weight losses are associated with increased testosterone, with the rise in testosterone generally proportional to the amount of weight lost
  • men, regardless of obesity level, can benefit from the effect of weight loss.
  • inconsistent effect of testosterone on VAT
  • Nathan Goodyear on 15 Jan 14
     
    to be read
Nathan Goodyear

Salivary Sex Hormone Measurement in a National, Population-Based Study of Older Adults - 0 views

www.ncbi.nlm.nih.gov/...PMC2763516

hormone hormones saliva salivary estradiol progesterone testosterone DHEA testing

shared by Nathan Goodyear on 16 Oct 12 - No Cached
  • Nathan Goodyear on 16 Oct 12
     
    Another study supports saliva hormone testing.  This study involved 2,722 individuals and tested estradiol, progesterone, DHEA and testosterone in men and women.  All of these are sex hormones.  Someone needs to tell the insurance companies that the overwhelming evidence supports saliva hormone testing.  But, that would mean they are even interested in the science.
Nathan Goodyear

New roles for estrogens in rheumatoid arthritis. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14740444

RA rheumatoid arthritis estradiol inflammation NF-kapppB

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    Estradiol appears to be pro-inflammatory in the synovial fluids of men/women with RA.  This appears to be mediated through NF-KappaB.
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