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Nathan Goodyear

Coconut oil attenuates the effects of amylo... [J Alzheimers Dis. 2014] - PubMed - NCBI - 0 views

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    Coconut oil found to "rescue" neurons in vitro exposed to amyloid Beta.  It was also found to reduce/protect against mitochondrial damage from amyloid-beta.
Nathan Goodyear

1α,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate Amyloid... - 0 views

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    curcumin and vitamin D synergistic in beta-amyloid removal in Alzheimer's disease. 
Nathan Goodyear

Olive Component Oleuropein Promotes β-Cell Insulin Secretion and Protects β-C... - 0 views

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    Only abstract available here.  Study finds oleuropein, compound in olive oil, increases insulin secretion in response to glucose via unregulated ERK/MAPK signaling.  Oleuropein also blocked the cytotoxicity induced by amyloids i.e. beta amyloid plaques are well known hallmarks of Alzheimer's disease.
Nathan Goodyear

Progesterone enhances transthyretin expressio... [J Mol Neurosci. 2011] - PubMed - NCBI - 0 views

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    Postmenopausal cognitive decline is a common complaint.  Declining Estradiol and progesterone have been implicated, in part, to this cognitive decline.  This study finds that progesterone increases expression of Transthyretin, a protein that processes amyloid Beta protein.  This amyloid Beta protein is associated with damage found in Alzheimer's. 
Nathan Goodyear

Frontiers | Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of... - 0 views

  • lipopolysaccharides (LPS), either alone or in combination, have indicated that when compared, bacterial LPSs exhibit the strongest induction of pro-inflammatory signaling in human neuronal–glial cells in primary coculture of any single inducer, and different LPS extracts from different gastrointestinal (GI)-tract resident Gram-negative bacteria appeared to have different pro-inflammatory potential
  • powerful inducer of the NF-κB
  • In both neocortex and hippocampus, LPS has been detected to range from a ~7- to ~21-fold increase abundance in AD brain
  • ...15 more annotations...
  • Major Gram-negative bacilli of the human GI-tract, such as the abundant B. fragilis and Escherichia coli (E. coli), are capable of discharging a remarkably complex assortment of pro-inflammatory neurotoxins
  • (i) bacterial amyloids (10, 21); (ii) endotoxins and exotoxins (5, 12); (iii) LPS (12, 18); and (iv) small non-coding RNAs (sncRNAs)
  • integral components of the outer leaflet of the outer membrane of Gram-negative bacteria, LPS
  • LPS, the major molecular component of the outer membrane of Gram-negative bacteria normally serves as a physical barrier providing the bacteria protection from its surroundings
  • LPS is also recognized by the immune system as a marker for the detection of bacterial pathogen invasion and responsible for the development of inflammatory response is perhaps the most potent stimulator and trigger of inflammation known
  • AD-affected brains have remarkably large loads of bacterial-derived toxins compared to controls. The transfer of noxious, pro-inflammatory molecules from the GI-tract microbiome to the CNS may be increasingly important during the course of aging when both the GI-tract and blood–brain barriers become significantly more permeable
  • first evidence of a perinuclear association of LPS with AD brain cell nuclei
  • LPS-mediated stimulation of chronic inflammation, beta-amyloid accumulation, and episodic memory decline in murine models of AD (39, 40) and a biophysical association of LPS with amyloid deposits and blood vessels in human AD patients
  • Strong adherence of LPS to the nuclear periphery has recently been shown to inhibit nuclear maturation and function that may impair or block export of mRNA signals from brain cell nuclei, a highly active organelle with extremely high rates of transcription, mRNA processing, and export into the cytoplasm
  • LPS may be further injurious to the nuclear membrane just as LPS contributes to cerebrovascular endothelial cell membrane injury
  • high intake of dietary fiber is a strong inhibitor of B. fragilis abundance and proliferation in the intact human GI-tract and as such is a potent inhibitor of the neurotoxic B. fragilis-derived amyloids, LPS, enterotoxins, and sncRNAs.
  • GI-tract microbiome-derived LPS may be an important initiator and/or significant contributor to inflammatory degeneration in the AD CNS
  • LPS has been recently localized to the same anatomical regions involved in AD-type neuropathology
  • a known pro-inflammatory transcription factor complex that triggers the expression of pathogenic pathways involved in neurodegenerative inflammation
  • pro-inflammatory amyloids, endo- and exotoxins, LPSs, and sncRNAs but also serve as potent sources of membrane-disrupting agents
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    LPS links gut to inflammation in Alzheimer's disease
Nathan Goodyear

Decreased Accumulation of Subcellular Amyloid-β with Improved Mitochondrial F... - 0 views

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    Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.
Nathan Goodyear

Neuronal membrane cholesterol loss enhances amyloid peptide generation - 0 views

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    low neuronal cholesterol increases risk of neurodegeneration.  Low Cholesterol in neurons increases B-amyloid protein formation.  Are we increasing Alzheimer's incidence by lowering cholesterol too much?  After all, the brain needs cholesterol!
Nathan Goodyear

Insulin increases CSF Abeta42 levels in normal old... [Neurology. 2003] - PubMed - NCBI - 0 views

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    elevated insulin, found in insulin resistance, associated with disordered Beta-amyloid metabolism.
Nathan Goodyear

Does insulin dysfunction play a role in... [Trends Pharmacol Sci. 2002] - PubMed - NCBI - 0 views

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    elevated insulin levels associated with disordered Beta-amyloid metabolism and hyperphosphorylation of tau proteins.  Free radicals also play a role as well.
Nathan Goodyear

A novel perspective for Alzheimer's disease... [J Alzheimers Dis. 2011] - PubMed - NCBI - 0 views

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    Alzheimer's model finds that amyloid-beta supresses vitamin D receptor.  This study found that vitamin D therapy protected neurons by up regulating vitamin D receptors.  This prevented cytotoxicity and cell death.
Nathan Goodyear

One year follow-up study of the association between chemical castration, sex hormones, ... - 0 views

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    Chemical castration as seen in androgen deprivation therapy resulted in precipitous decline in Testosterone and Estradiol in men.  Associated increased in beta-amylloid found.
Nathan Goodyear

Nutrition Journal | Full text | Diverse effects of a low dose supplement of lipidated c... - 0 views

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    liposomal curcumin reduces Triglycerides and serum beta-amyloid protein.
Nathan Goodyear

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged p... - 0 views

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    Curcumin found to provide benefit even in the healthy. This study, though small and very short, found improvement in Triglycerides, salivary amylase, reduced oxidative stress, reduced beta-amyloid protein, increased NO, and reduced liver enzymes.
Nathan Goodyear

NeuroSignals 2005, Vol. 14, No. 1-2 - Neuroprotective Effects of Huperzine A - FullText... - 0 views

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    Huperzine A is a great neuroprotector.  Huperzine A is a acetycholinesterase inhibitor. But, Huperzine A also reduces oxidative stress, reduces beta-Amyloid, protects mitochondria, antagonizes NMDA receptors and thus reduces excitotoxicity, and regulates apoptosis.
Nathan Goodyear

Alzheimer's disease--synergistic effects of ... [J Neural Transm. 1998] - PubMed - NCBI - 0 views

  • AGEs are protein modifications that contribute to the formation of the histopathological and biochemical hallmarks of AD: amyloid plaques, neurofibrillary tangles and activated microglia
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    good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.
Nathan Goodyear

Resolution of inflammation is altered in Alzheimer's disease - 0 views

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    Inflammation plays an important role in Alzheimers disease.  Likewise, the ability to resolve inflammation is altered, as this study shows.  This points to natural therapies i.e. omega-3, curcumin, vitamin D...
Nathan Goodyear

Taurine prevents the neurotoxicity of beta-amyloid... [FASEB J. 2004] - PubMed result - 0 views

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    Taurine, an amino acid, and melatonin, a hormone, both aid in decreasing excitotoxicity in Parkinson's disease
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