Group items tagged

study finds restoration of HPA in men with low T.  This was performed via clomid therapy at 25 to 50 mg daily for 4 months.  Increase in pulsatile LH, increase in serum Testosterone levels, and increase in sexual function was found.  Clomid restores HPA function that is suppressed from estrogen inhibition.  In this case, clomid is function as an estrogen antagonist.

small cohort with low serum Total Testosterone improved T:E2 ratio with clomid.  Clomid restores the HPA through inhibition of the negative feedback of Estradiol on the Hypothalamus and Pituitary in men.  This allows for an increase in gonadotropin production and thus increase in testosterone production.  Aromatase inhibition therapy would likely still prove beneficial in this situation.

HCG and clomid stimulation tests helpful in differentiating male hypogonadism

clomid used to reverse hypogonadism in male with prior anabolic abuse

Small study found that 2 months of clomid therapy increased LH, FSH, total Testosterone, and free Testosterone over placebo.  Improvement in ED was minimal and most in young men.  This is consistent with other studies that have found that less effects are seen in those with multiple comorbidities.

Case study finds clomid restores HPA function and normalizes Testosterone production in HPA suppressed endurance athlete.

very nice case review and discussion of the treatment of low T and low sperm count in men desiring preservation of fertility.  Clomid and HCG are viable options to increase endogenous Testosterone production, though both work via different mechanisms.

clomid beneficial in mean with hypogonadism

Enclomiphen, a clomid isomer, stimulates FSH and LH to preserve spermatogenesis and Testosterone production.

small study of men with low T and symptoms of hypogonadism found to improve with clomid.  Testosterone levels were found to increase by 115% and quality of life measures improved as well.