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Nathan Goodyear

Testosterone Concentrations In Young Pubertal And Post-Pubertal Obese Males - Mogri - C... - 0 views

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    obese boys/young men between ages of 14-20 have 50% less testosterone than normal weight boys/young men.
Nathan Goodyear

ROUND-UP: Predicting depression in boys (PNAS*) - an expert responds - AusSMC - Austral... - 0 views

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    Elevated salivary am cortisol predicts increased risk of depression in boys.  
Nathan Goodyear

Glyphosate impairs male offspring reproductive ... [Arch Toxicol. 2012] - PubMed - NCBI - 0 views

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    Probably one of the more disturbing aspects of glyphosate exposure. In utero exposure, lowers Testosterone levels and effects the masculinization process of the young boy.  Very disturbing.  Our boys are being altered before they are even born.
Nathan Goodyear

Hepatitis B Vaccination of Male Neonates and Autism - 0 views

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    boys receiving HBV had 2.94 greater incidence of Autism Spectrum Disorder vs later or unvaccinated boys
Nathan Goodyear

Testosterone Concentrations In Young P... [Clin Endocrinol (Oxf). 2012] - PubMed - NCBI - 0 views

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    New study shows that obese boys/young men pre and post puberty have up to 50% lower testosterone levels than comparative normal BMI counterparts.  Also of note, estradiol levels were not associated with the low testosterone levels.
Nathan Goodyear

Salivary cortisol and testosterone responses to resistance and plyometric exercise in 1... - 0 views

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    Study of 12-14 y/o boys found increased Testosterone after resistance training and plyometric exercise.  Cortisol did increase after plyometric, but not resistance exercise.
Nathan Goodyear

Prenatal Exposure to Phthalates is Associated with Reduced Masculine Behavior in Boys - 0 views

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    phthalate exposure associated with reduced masculinity of boys
Nathan Goodyear

Letrozole Significantly Improves Growth Potential in a Pubertal Boy With Growth Hormone... - 0 views

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    Letrazole improves growth potential in boys with HGH deficiency through aromatase inhibition and delayed closure of the growth plates
trungtamnamkhoa

Foreskin Sign Of What Disease? Treatment - 0 views

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    Causes of itching For men, the cause of the itch can be divided into three groups: * The "little boy" hygiene is not right: Men - especially young people - often do not focus or "lazy" to clean the boy. This bad habit has gradually created an environment for the growth of genital fungi, causing an itching sensation. Besides, the selection of inappropriate cleaning solutions is also the reason that may be encountered in men. Some men reported using feminine cleaning solutions or shower gels to "bath" their "boy". This makes the itching condition more and more because the nature of the feminine hygiene solution is not suitable for his small skin, so it can easily lead to skin irritation, even leading to a disorder of the skin and creating favorable conditions for mushroom growth.
Nathan Goodyear

A Cohort Effect on Serum Testosterone Levels in Finnish Men - 0 views

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    Finnish study of 3,271 men found that there was a decline in serum free testosterone levels in recently born boys compared to previous generations.  Additionally, they found inappropriate HPA response to this decline in testicular testosterone.
Nathan Goodyear

Organophosphate Pesticide Exposure and Attention in Young Mexican-American Children: Th... - 1 views

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    In utero organophosphate exposure linked to ADHD, especially in boys.
Nathan Goodyear

Salivary testosterone diurnal variation and psychopathology in adolescent males and fem... - 0 views

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    low testosterone in boys associated with anxiety/depression and attention problems.  Disruptive behavior found in girls with low testosterone.  All determined by salivary testing.
Nathan Goodyear

Highly efficient ketone body treatment in multiple acyl-CoA dehydrogenase deficiency-re... - 0 views

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    case study of a young boy with MADD treated with ketones. Significant improvement/resolution after 5 months of therapy with ketone therapy.  There was even improvement in brain MRI.
Nathan Goodyear

Effects of weight loss on leptin, sex hormones, and measures of adiposity in obese chil... - 0 views

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    weight loss decreases leptin in boys and the result is an increase in Testosterone
Nathan Goodyear

Male pubertal development: are endocrine-disrupting compounds shifting the norms? - 0 views

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    Study supports the mechanism behind endocrine disruption of xenoestrogens in the pubertal development of young boys.
Nathan Goodyear

Patches of Disorganization in the Neocortex of Children with Autism - NEJM - 0 views

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    New study suggests that intra-uterine exposure effects prefrontal cortex development that leads to autism.  This study was conducted of postmortem samples of children with autism ranging from 2 to 15. Intra-pregnancy exposure of what?  That is the question.  Environmental toxins: whether it is all the xenoestrogens (autism at rate of 5:1 in boys), PCBs, heavy metals, and yes (lead author) preservatives, metals (Al and thermeresol) in vaccines--particularly the flu vaccine which ACOG is almost mandating during pregnancy.
Nathan Goodyear

Use of Aromatase Inhibitors in Large... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

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    aromatase inhibition therapy shown to reduce and/or eliminate man boobs in young boys with sertoli cell tumors.
Nathan Goodyear

Endocrine actions of pesticides m... [Environ Sci Pollut Res Int. 2014] - PubMed - NCBI - 0 views

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    low dose pesticide (organophosphates) exposure associated with delayed sexual development in boys and girls.  In addition, there was an inverse correlation with free T4 and a positive correlation with TSH.  
Nathan Goodyear

Urinary Phthalate Metabolites Are Associated With Decreased Serum Testosterone in Men, ... - 0 views

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    Phthalate exposure is a cause of low Testosterone in men, women, and children.   In boys 6-12, exposure was associated with a 24-34% reduction in Testosterone.
Nathan Goodyear

The implication of neuroactive steroids in Tourette syndrome pathogenesis: a ... - 0 views

  • The typical onset of TS occurs at 6–7 years of age and is characterized by the appearance of simple, recurrent motor tics, followed by the manifestation of phonic tics after several months [12]. In most children, TS symptoms undergo a progressive exacerbation, which reaches its zenith at the beginning of puberty (11–12 years of age), and is then followed by a gradual remission in the majority of patients
  • 30–40% of TS-affected children retain their symptoms in adulthood
  • Multiple neurotransmitters have been implicated in TS, including dopamine (DA), serotonin, norepinephrine, acetylcholine, glutamate and γ-amino-butyric acid (GABA)
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  • female gender may predict greater tic severity in adulthood
  • male gender is a major risk factor for TS (with a male:female prevalence ratio estimated at ~4:1)
  • the typical age of onset coincides with adrenarche (6–7 years old); symptoms increase in severity until the beginning of puberty (12 years old) and then undergo a spontaneous amelioration, which becomes apparent with the end of puberty (at 18–19 years of age)
  • TS is diagnosed later in females than males
  • ample evidence supports the involvement of DAergic dysfunctions in TS
  • a number of clinical observations showed that tics in TS patients could be exacerbated by anabolic androgens
  • steroidogenic enzymes and androgen receptors may serve as putative therapeutic targets for this disorder
  • Unlike males, tic severity is typically increased after puberty in females
  • 26% of females were found to experience exacerbation of tics in the estrogenic phase of the menstrual cycle, and this phenomenon was found to be correlated with increased tic severity at menarche
  • biochemical hallmark of adrenarche is the acquisition of 17,20 lyase activity by cytochrome P450 C17 (CYP17A1)
  • increased synthesis of dehydroepiandrosterone (DHEA) and androstenedione, which leads to the growth of axillary and pubic hair as well as enhancement in the oiliness of the skin
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    interesting read on hormones and tourette's.. Proposed that 5 alpha reductase activity is involved in worsening of tics.  This makes sense as Testosterone in men with low T is known to increase dopamine and dopaminergic dysfunction is known to play a role in tourette's;  the clinical presentation of girls vs boys is very different.  The authors of this article propose that 5 alpha reductase activity controls a back door method where by progesterone is converted to androgens.
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