Group items tagged disrupting - Dr. Goodyear

Circadian disruption in cancer: a neuroend... [Brain Behav Immun. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12946654

Cortisol saliva salivary hormone hormones test testing HPA cancer stress

shared by Nathan Goodyear on 28 Nov 11 - No Cached

Nathan Goodyear on 28 Nov 11

disrupted cortisol rhythm or pattern due to stress is a pathway to disease. A disrupted HPA axis is a disrupted immune system.

<div class="cArrow"> </div><div class="cContentInner">disrupted cortisol rhythm or pattern due to stress is a pathway to disease. A disrupted HPA axis is a disrupted immune system.</div>

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EHP - Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular... - 0 views

ehp.niehs.nih.gov/1205823

Bisphenol A estrogen E2 Estradiol xenoestrogens xenoestrogen hormone hormones BPA

shared by Nathan Goodyear on 19 Jun 13 - No Cached

Nathan Goodyear on 19 Jun 13

Bisphenol A shown to disrupt ovarian estrogen production from exposure in adults. The point of this that is important is that BPA, a xenoestrogen, can infact disrupt physiologic hormone production in adults, and contribute to ovarian failure. BPA, itself, is 1,000 fold weaker than E2, yet it disrupts ovarian function.

<div class="cArrow"> </div><div class="cContentInner">Bisphenol A shown to disrupt ovarian estrogen production from exposure in adults. The point of this that is important is that BPA, a xenoestrogen, can infact disrupt physiologic hormone production in adults, and contribute to ovarian failure. BPA, itself, is 1,000 fold weaker than E2, yet it disrupts ovarian function.</div>

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EHP - Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for t... - 0 views

ehp.niehs.nih.gov/1206198

polychlorinated biphenyls PCBs thyroid xenoestrogens hormone hormones

shared by Nathan Goodyear on 19 Jun 13 - No Cached

Nathan Goodyear on 19 Jun 13

Polychlorinated biphenyl (PCBs) shown to disrupt thyroid hormone function through disruption of the transthyretin binding sites. Not only is it a xenoestrogen, but it disrupts thyroid function too.

<div class="cArrow"> </div><div class="cContentInner">Polychlorinated biphenyl (PCBs) shown to disrupt thyroid hormone function through disruption of the transthyretin binding sites. Not only is it a xenoestrogen, but it disrupts thyroid function too.</div>

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Inflammation and cortisol response in coronary artery disease: Annals of Medicine: Vol ... - 0 views

www.tandfonline.com/...07853890802508934

HPA axis HPA inflammation hormones stress cortisol CAD coronary artery disease

shared by Nathan Goodyear on 12 Oct 16 - No Cached

Nathan Goodyear on 12 Oct 16

Inflammation disrupts HPA axis. This is no surprise as we Know that inflammation can disrupt Testosterone in men and progesterone production in women. This study suggests that this HPA axis disruption contributes to CAD.

<div class="cArrow"> </div><div class="cContentInner">Inflammation disrupts HPA axis. This is no surprise as we Know that inflammation can disrupt Testosterone in men and progesterone production in women. This study suggests that this HPA axis disruption contributes to CAD.</div>

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Roundup Disrupted Male Reproductive Func... [Free Radic Biol Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23820267

roundup infertility male glyphosate glutathione

shared by Nathan Goodyear on 04 Jul 13 - No Cached

Nathan Goodyear on 04 Jul 13

Glyphosate, component of Roundup is well known to be an endocrine disruptor. This rat study describes the mechanism of disruption of the Sertoli cells resulting in male infertility. In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification. If that is not enough, oxidative damage marker TBARS was elevated.

<div class="cArrow"> </div><div class="cContentInner">Glyphosate, component of Roundup is well known to be an endocrine disruptor. This rat study describes the mechanism of disruption of the Sertoli cells resulting in male infertility. In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification. If that is not enough, oxidative damage marker TBARS was elevated. </div>

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Disruption of the Nocturnal Testosterone Rhythm by Sleep Fragmentation in Normal Men - 0 views

jcem.endojournals.org/...1134.full.pdf

testosterone secretion rhythm

shared by Nathan Goodyear on 30 Apr 12 - No Cached

Nathan Goodyear on 30 Apr 12

Discusses normal testosterone rhythm and then what sleep disruption does to disrupt this rhythm.

<div class="cArrow"> </div><div class="cContentInner">Discusses normal testosterone rhythm and then what sleep disruption does to disrupt this rhythm.</div>

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Growth Inhibition of Ovarian Tumor-Initiating Cells by Niclosamide | Molecular Cancer T... - 0 views

mct.aacrjournals.org/...1703.long

Niclosamide Tumor-initiation cells TIC ovarian cancer cancer CSC cancer stem cells

shared by Nathan Goodyear on 16 Apr 18 - No Cached

Ovarian cancer is the most lethal gynecologic malignancy and the fifth-most cause of overall cancer death of women in developed countries
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An increasingly accepted cancer stem cell hypothesis regards tumors as caricatures of normal organs, possessing a hierarchy of cell types, at various stages of aberrant differentiation, descended from precursor tumor-initiating cells (TIC) cells that are highly resistant to conventional cytotoxics
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Significant changes of gene expression in 2,928 genes were identified after niclosamide treatment for different time periods
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...14 more annotations...
uncoupling of mitochondrial oxidative phosphorylation is believed to be its anti-helminthic mechanism of action
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we hypothesized that niclosamides antagonistic effects on OTICs could, in part, be due to its disruption of metabolism
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Our results showed that genes participating in protein complexes of oxidative phosphorylation were downregulated
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niclosamide treatment resulted in a more than 20% increase in reactive oxygen species (ROS) in cultured OTICs
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niclosamide, which has proved to be safe and effective for the past 2 decades against numerous parasites, inhibited OTIC growth both in vitro and in vivo
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niclosamide represses metabolic enzymes responsible for bioenergetics, biosynthesis, and redox regulation specifically in OTICs, presumably leading to mitochondrial intrinsic apoptosis pathways, loss of tumor stemness, and growth inhibition
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Niclosamide is believed to inhibit mitochondrial oxidative phosphorylation
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Niclosamide was reported to inactivate NF-κB, causing mitochondrial damage and the generation of ROS, leading to apoptosis of leukemic stem cells
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niclosamide were identified in a screen for mTOR-signaling inhibitors
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mTOR was reported to maintain stemness properties of HSCs by inhibiting mitochondrial biogenesis and ROS levels (39), implying that mTOR inhibitors (such as niclosamide) may interfere with mitochondria and various metabolic pathways in TICs via disruption of antioxidant responses
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We observed Wnt hyperactivity in OTICs, in agreement with previous hypotheses of Wnt inhibitor effectiveness as an ovarian cancer therapy
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niclosamide has now been independently identified in screens for Wnt inhibitors
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downregulation of the Wnt/β-catenin target oncogenes survivin and c-Myc
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ovarian carcinogenesis, the cell-to-cell signaling pathway Notch (8), were also suppressed by niclosamide (data not shown). These results agree with another recent niclosamide study in leukemia (49), and it has been widely hypothesized that disruption of Notch signaling may represent a highly effective therapy for ovarian and other solid tumors, via its essentiality to maintaining TIC stemness
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Nathan Goodyear on 16 Apr 18

Niclosamide, common anti-parasitic medication, inhibits cellular metabolism and increases ROS; both of which provide powerful anti-proliferative, anti-cancer treatment mechanism in TICs. Powerful target therapy for cancer stem cells. Also shown to inhibit Wnt stimulated oncogenes survivin and c-Myc, disrupts Notch signaling, inactivates NF-kappaBeta, and inhibits mTOR-signaling. This has been found in in vitro and in vivo studies.

<div class="cArrow"> </div><div class="cContentInner">Niclosamide, common anti-parasitic medication, inhibits cellular metabolism and increases ROS; both of which provide powerful anti-proliferative, anti-cancer treatment mechanism in TICs. Powerful target therapy for cancer stem cells. Also shown to inhibit Wnt stimulated oncogenes survivin and c-Myc, disrupts Notch signaling, inactivates NF-kappaBeta, and inhibits mTOR-signaling. This has been found in in vitro and in vivo studies.</div>

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A relationship in adrenal androgen levels between mothers and their children from a dio... - 0 views

www.sciencedirect.com/...S0048969717316911

EDC endocrine disrupting chemicals hormones endocrine disruptors agent orange DHEA androstenedione

shared by Nathan Goodyear on 04 Oct 17 - No Cached

Nathan Goodyear on 04 Oct 17

Endocrine Disrupting Chemicals from 1970 still disrupting hormones today. Three fold increase in DHEA in 3 year old children via saliva and androstenedione in mothers compared to controls.

<div class="cArrow"> </div><div class="cContentInner">Endocrine Disrupting Chemicals from 1970 still disrupting hormones today. Three fold increase in DHEA in 3 year old children via saliva and androstenedione in mothers compared to controls.</div>

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Effect of a phase advance and phase delay of ... [Am J Clin Nutr. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22914550

circadian rhythm sleep insulin glucose metabolism

shared by Nathan Goodyear on 06 Sep 12 - No Cached

Nathan Goodyear on 06 Sep 12

small study. But it showed that disruption in circadian rhythm results in disruption of insulin/glucose metabolism.

<div class="cArrow"> </div><div class="cContentInner">small study. But it showed that disruption in circadian rhythm results in disruption of insulin/glucose metabolism.</div>

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Vagal Regulation, Cortisol, and Sleep Disruption in Women with Metastatic Breast Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC2576311

saliva salivary cortisol test testing evaluation hormone hormones sleep breast cancer metastatic BHRT

shared by Nathan Goodyear on 28 Nov 11 - No Cached

an association between disrupted nocturnal sleep and flattened diurnal cortisol rhythm in women with metastatic breast cancer
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They suggest that the stress-buffering effects of sleep may be associated with improved parasympathetic tone and normalized cortisol patterns during the day.
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Nathan Goodyear on 28 Nov 11

women with metastatic breast cancer shown to have more disruption in cortisol pattern and thus dysfunctional sleep. This has implications on survival.

<div class="cArrow"> </div><div class="cContentInner">women with metastatic breast cancer shown to have more disruption in cortisol pattern and thus dysfunctional sleep. This has implications on survival.</div>

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Tight Junctions, Intestinal Permeability, and Autoimmunity Celiac Disease and Type 1 Di... - 0 views

www.ncbi.nlm.nih.gov/...PMC2886850

gut flora microbiota bacteroides bifidobacterium lactobacillus dysbiosis leaky celiac disease diabetes

shared by Nathan Goodyear on 29 Feb 12 - No Cached

Nathan Goodyear on 29 Feb 12

this study from 2009 showed how disrupted/imbalanced gut flora leads to leaky gut. This case, high bacteroides relative to bifidobacterium and lactobacillus resulted in disruption of the zonulin pathway and thus lncreased intestinal permeability.

<div class="cArrow"> </div><div class="cContentInner">this study from 2009 showed how disrupted/imbalanced gut flora leads to leaky gut. This case, high bacteroides relative to bifidobacterium and lactobacillus resulted in disruption of the zonulin pathway and thus lncreased intestinal permeability.</div>

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The relationship between sleep disorders and testosterone in men Wittert G - Asian J An... - 0 views

www.ajandrology.com/article.asp

sleep disorders testosterone men male hormone hormones

shared by Nathan Goodyear on 03 Feb 14 - No Cached

Nathan Goodyear on 03 Feb 14

Low Testosterone found to disrupt restful sleep in men. However, in contrast, Testosterone doping leads to sleep disruption as well. I love how the authors describe it: ...in supra therapeutic doses, or in the context abuse."

<div class="cArrow"> </div><div class="cContentInner">Low Testosterone found to disrupt restful sleep in men. However, in contrast, Testosterone doping leads to sleep disruption as well. I love how the authors describe it: ...in supra therapeutic doses, or in the context abuse."</div>

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Actions of Estrogens and Endocrine Disrupting Chemicals on Human Prostate Stem/Progenit... - 0 views

www.ncbi.nlm.nih.gov/...PMC3249013

prostate cancer EDC xenoestrogens endocrine disrupting chemicals estrogen men male hormone hormones

shared by Nathan Goodyear on 06 Feb 14 - No Cached

Nathan Goodyear on 06 Feb 14

Endocrine Disrupting chemicals, xenoestrogens, alter the hormone receptors very early. Increased estrogenic load with the change in ER increase prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">Endocrine Disrupting chemicals, xenoestrogens, alter the hormone receptors very early. Increased estrogenic load with the change in ER increase prostate cancer.</div>

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Exposure to DEHP and MEHP from hatching to adu... [Aquat Toxicol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24292025

pthalates toxins endocrine disruptors hormones xenoestrogens

shared by Nathan Goodyear on 04 Dec 13 - No Cached

Nathan Goodyear on 04 Dec 13

endocrine disrupting pthalates disrupt marine animal hormones. This effect was more prevalent in males than females.

<div class="cArrow"> </div><div class="cContentInner">endocrine disrupting pthalates disrupt marine animal hormones. This effect was more prevalent in males than females.</div>

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Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvi... - 0 views

www.sciencemag.org/...967

antibiotics chemotherapy cancer gut microbiota bacteria

shared by Nathan Goodyear on 04 Dec 13 - No Cached

Nathan Goodyear on 04 Dec 13

Animal model finds that disruption of the gut microbiota by antibiotics disrupts the effects of chemotherapy.

<div class="cArrow"> </div><div class="cContentInner">Animal model finds that disruption of the gut microbiota by antibiotics disrupts the effects of chemotherapy.</div>

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Artificial sweeteners induce glucose intolerance by altering the gut microbiota : Natur... - 0 views

www.nature.com/...nature13793.html

gut flora microbiota bacteria diabetes glucose artificial sweetners nutrition health

shared by Nathan Goodyear on 18 Sep 14 - No Cached

Nathan Goodyear on 18 Sep 14

Artificial sweeteners disrupt glucose metabolism through disruption of health gut bacteria balance.

<div class="cArrow"> </div><div class="cContentInner">Artificial sweeteners disrupt glucose metabolism through disruption of health gut bacteria balance.</div>

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Taylor & Francis Online :: The microbiome as a target for endocrine disruptors: Novel c... - 0 views

www.tandfonline.com/...23273739.2014.964539

EDC endocrine disrupting chemicals gut flora gut microbiome gut microbiota Testosterone autoimmune disease

shared by Nathan Goodyear on 30 Apr 15 - No Cached

Nathan Goodyear on 30 Apr 15

EDCs are proposed to disrupted gut micro biome and thus effect androgen production and autoimmune risk.

<div class="cArrow"> </div><div class="cContentInner">EDCs are proposed to disrupted gut micro biome and thus effect androgen production and autoimmune risk.</div>

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Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased A... - 0 views

diabetes.diabetesjournals.org/...2674

high protein diet dietary insulin resistance

shared by Nathan Goodyear on 21 Oct 13 - No Cached

Nathan Goodyear on 21 Oct 13

High protein intake can lead to insulin resistance. Glucose regulation by insulin and skeletal muscle removal of glucose is disrupted by high amino acid intake through disruption of secondary insulin signaling.

<div class="cArrow"> </div><div class="cContentInner">High protein intake can lead to insulin resistance. Glucose regulation by insulin and skeletal muscle removal of glucose is disrupted by high amino acid intake through disruption of secondary insulin signaling.</div>

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Endocrine-Disrupting Chemicals: Associated Disorders and Mechanisms of Action - 0 views

www.ncbi.nlm.nih.gov/...PMC3443608

xenoestrogens environmental toxins

shared by Nathan Goodyear on 11 Mar 13 - No Cached

Nathan Goodyear on 11 Mar 13

good review of current knowledge on endocrine disrupting chemicals, more commonly known as xenoestrogens.

<div class="cArrow"> </div><div class="cContentInner">good review of current knowledge on endocrine disrupting chemicals, more commonly known as xenoestrogens.</div>

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ScienceDirect - Cancer Letters : The glutathione-related detoxification pathway in the ... - 0 views

www.sciencedirect.com/...S030438350000481X

glutathione breast cancer

shared by Nathan Goodyear on 11 Nov 11 - No Cached

Nathan Goodyear on 11 Nov 11

glutathione disruption is a component of breast cancer development

<div class="cArrow"> </div><div class="cContentInner">glutathione disruption is a component of breast cancer development</div>

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Group items tagged