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Nathan Goodyear

Evidence of estrogenic endocrine disruption in smallmouth and largemouth bass inhabitin... - 0 views

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    Is our effect on the environment and the environments, in turn, effect on us politics or science?  It is science that is manipulated by politicians for political gain/power.  In this study of male small/large mouth bass in NE America are found to have significant female characteristics  i.e. eggs where testes should exist...where none should exist.  The numbers were as high as 85% in the small mouth base compared to 27% for the large mouth bass.  Is there any wonder we have a low T epidemic in men?  The most likely cause are endocrine disruptors.  It is a concern that the authors did not look for endocrine disruptors in the water at the time of this study of the fish.
Nathan Goodyear

Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Ass... - 0 views

  • BPA promotes the development of TH2 cells in adulthood and both TH1 and TH2 cells in prenatal stages by reducing the number of regulatory T cells.
  • Bisphenol A (BPA), an estrogenic endocrine-disrupting chemical (EDC
  • BPA is one of the most widespread EDCs.
  • ...12 more annotations...
  • BPA antagonizes the actions of thyroid hormone
  • Prenatal exposure to BPA has been shown to alter a variety of reproductive endocrine parameters, such as testosterone and luteinizing hormone levels
  • arly onset of sexual maturation of female mice
  • imbalanced T-helper (TH)1/TH2 immune responses have been demonstrated on exposure to BPA
  • indicating that BPA exerted its effects by reducing the number of Treg cells.
  • Exposure to BPA by subcutaneous injection in adulthood significantly promoted antigen-stimulated production of IL-4, IL-10, and IL-13 in TH2-skewed
  • BPA can leak from the placenta and accumulate in the fetus
  • We showed that prenatal exposure to BPA increased the production of a TH1 cytokine, IFN-γ, and a TH2 cytokine, IL-4, after the offspring developed, suggesting that prenatal exposure to BPA can induce persistent immunologic effects lasting into adulthood.
  • These results are consistent with a previous report that fetal exposure to BPA augmented TH1 and TH2 immune responses
  • our results clearly demonstrate that the production of TH2 cytokines is promoted by BPA in adult mice and in offspring during developmental exposure.
  • The decrease of Treg cells would predispose to immune dysfunction in aged individuals, explaining their higher risk of immune-mediated diseases, cancer, and infections.
  • BPA might cause these diseases. Thus, avoiding exposure to or promoting the excretion of BPA and other EDCs would help in preventing diseases and adverse health effects.
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    BPA as endocrine disruptor and as immune disruptor
Nathan Goodyear

New aspects of cadmium as endocrine disruptor. [Environ Sci. 2006] - PubMed - NCBI - 0 views

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    Cadmium is an endocrine disruptor: binds to estrogen receptors and the androgen receptor. 
Nathan Goodyear

Effects of endocrine disruptors on obesity. [Int J Androl. 2008] - PubMed result - 0 views

  • Most recently, obesity has been proposed to be yet another adverse health effect of exposure to endocrine disrupting chemicals (EDCs) during critical stages of development. Obesity is quickly becoming a significant human health crisis
  • The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers.
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    Effects of endocrine disruptors on obesity.
Nathan Goodyear

Prepubertal exposure to commercial formulation ... [Arch Toxicol. 2010] - PubMed - NCBI - 0 views

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    Glyphosate found to lower Testosterone in rat study.  Glyphosate is a significant xenoestrogen which acts as an endocrine disruptor.
Nathan Goodyear

Male Reproductive Health and Environmental Xenoestrogens - 0 views

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    Good review of xenoestrogens and the impact these endocrine disruptors are having on men.
Nathan Goodyear

Reproductive Hormone Levels in Men Exposed to Persistent Organohalogen Pollutants: A St... - 0 views

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    Review finds endocrine disruption from Organocholrides, also called persistent organohalogen pollutants. Common POP, would be DDE, DDT... This is a review of several cohorts, but this follows the rest of the literature that these environmental toxicants are endocrine disruptors.
Nathan Goodyear

Do Parabens Have the Ability to Interfere with Steroidogenesis? - 0 views

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    There is growing evidence that some parabens have endocrine disrupting effects.  IN this study, they found that butyl paraben acted as an endocrine disruptor.
Nathan Goodyear

Common environmental contaminant, cadmium, linked to rapid breast cancer cell growth - 0 views

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    cadmium increases growth potential of breast cancer.  No surprise, cadmium is a classic endocrine disruptor that mimics estrogen.
Nathan Goodyear

BPA, BPA glucuronide, and BPA sulfate in... [Environ Sci Technol. 2013] - PubMed - NCBI - 0 views

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    Startling finding: 100% of all pregnancies in this study were found to have detectable BPA levels.  BPA is a known endocrine disruptor.
Nathan Goodyear

Bisphenol A and human health: A review of the... [Reprod Toxicol. 2013] - PubMed - NCBI - 0 views

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    Bisphenol A proving to be an significant endocrine disruptor in humans.
Nathan Goodyear

Effects of maternal dietary exposure to cadmium during pregnancy on mammary cancer risk... - 0 views

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    Animal study finds that Cadmium is estrogenic.  This study found that not only was Cadmium an endocrine disruptor for the pregnant animals, but was also estrogenic in the mammary glands of the offspring.
Nathan Goodyear

Endocrine Disruption: Historical Perspectives and Its Impact on the Future of Toxicolog... - 0 views

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    deep read on the environment and endocrine disruptors
Nathan Goodyear

Endocrine disruptors: can biological... [Regul Toxicol Pharmacol. 2002] - PubMed - NCBI - 0 views

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    Xenoestrogens disrupt hormones, despite being very weak compared to estradiol.
Nathan Goodyear

Roundup Disrupted Male Reproductive Func... [Free Radic Biol Med. 2013] - PubMed - NCBI - 0 views

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    Glyphosate, component of Roundup is well known to be an endocrine disruptor.  This rat study describes the mechanism  of disruption of the Sertoli cells resulting in male infertility.  In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification.  If that is not enough, oxidative damage marker TBARS was elevated.  
Nathan Goodyear

Endocrine Disruptors: From Endocrine to Metabolic Disruption - 0 views

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    Endocrine disruption starts early due to EDC and effects last life long.
Nathan Goodyear

n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases - 0 views

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    Omega 3 and inflammation.  Good review of the biochemistry of inflammation and the interaction of omega-3 as a disruptor of inflammation.
Nathan Goodyear

Taylor & Francis Online :: The microbiome as a target for endocrine disruptors: Novel c... - 0 views

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    EDCs are proposed to disrupted gut micro biome and thus effect androgen production and autoimmune risk.
Nathan Goodyear

Why pesticides could be a common cause of prostate... [Biomed Pharmacother. 2009] - Pub... - 0 views

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    Pesticides as endocrine disruptors and increasing incidence of prostate and breast Cancer
Nathan Goodyear

Effects of the herbicide Roundup on the epidi... [Reprod Toxicol. 2007] - PubMed - NCBI - 0 views

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    Glyphosate, component of Roundup shown to disrupt Testosterone production, aromatase activity, and the androgen receptors in this male in vivo model.
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