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Nathan Goodyear

C-Reactive Protein in Pneumonia - CHEST - 0 views

journal.chestnet.org/...fulltext

CRP pneumonia

shared by Nathan Goodyear on 11 Apr 20 - No Cached
  • Nathan Goodyear on 11 Apr 20
     
    CRP is useful in determining severity and following treatment of pneumonia
Nathan Goodyear

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Communit... - 0 views

www.hindawi.com/...426740

LPS lipopolysaccharides ROS TNF-alpha TNF tumor necrosis factor IL-6 inflammation pneumonia vitamin C

shared by Nathan Goodyear on 06 Dec 17 - No Cached
  • Nathan Goodyear on 06 Dec 17
     
    Cell culture study found that vitamin C inhibited LPS mediated increase in ROS, TNF-alpha, IL-6... The cells were taken from adults with pneumonia
Nathan Goodyear

Wiley Online Library: Book Abstract - 0 views

onlinelibrary.wiley.com/...247C94291EA55A4FED221D1.d03t02

flu vaccine vaccination

shared by Nathan Goodyear on 10 Sep 11 - No Cached
  • In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation, 4% of unvaccinated people versus 1% of vaccinated people developed influenza symptoms (risk difference (RD) 3%
  • The corresponding figures for poor vaccine matching were 2% and 1% (RD 1, 95% CI 0% to 3%).
  • Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates
  • ...1 more annotation...
  • Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost. There is no evidence that they affect complications, such as pneumonia, or transmission.
  • Nathan Goodyear on 10 Sep 11
     
    exhaustive review of the flu vaccine data reveals VERY poor matching of vaccine, poor prevention of flu symptoms, and only modest effect on reduction in hospital admission or complication rates.   Final conclusion: "There is no evidence that they affect complications, such as pneumonia, or TRANSMISSION.
Nathan Goodyear

Vaccines for preventing influenza... [Cochrane Database Syst Rev. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20614424

influenza vaccines flu adults prevention

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    Flu vaccines only found to have modest effect in adults.  Conclusion: "there is no evidence that they affect complications, such as pneumonia, or transmission".
Nathan Goodyear

Patients with Community Acquired Pneumonia Exhibit Depleted Vitamin C Status and Elevat... - 0 views

www.ncbi.nlm.nih.gov/...PMC7284353

pneumonia vitamin C

shared by Nathan Goodyear on 17 Aug 20 - No Cached
  • Nathan Goodyear on 17 Aug 20
     
    Patients with CAP found to be depleted of vitamin C...a metabolic scurvy if you will.
Nathan Goodyear

The effect of parenteral selenium on outcomes of mechanically ventilated patients follo... - 0 views

annalsofintensivecare.springeropen.com/...s13613-015-0071-y

selenium glutathione peroxidase glutathione sepsis

shared by Nathan Goodyear on 30 May 20 - No Cached
  • Nathan Goodyear on 30 May 20
     
    selenium IV in sepsis patients increased glutathione peroxidase and reduced ventilator associated pneumonia.
Nathan Goodyear

Update on the treatment of Pseudomonas aeruginosa pneumonia - 0 views

jac.oxfordjournals.org/...229.full

P aeuroginosa Pseudomas aeuroginosa Pseudomas aeuroginosa

shared by Nathan Goodyear on 22 Jul 14 - No Cached
  • Nathan Goodyear on 22 Jul 14
     
    pseudomonas aeruginosa is an opportunistic pathogen that requires treatment, especially in the immunocompromised.
Nathan Goodyear

Unintended effects of statins from observational studies in the general population: sys... - 0 views

www.ncbi.nlm.nih.gov/...PMC3998050

statin therapy statins myopathy cholesterol side effects diabetes liver liver enzymes

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • A markedly increased risk of myopathy was observed
  • One cohort study (Women’s Health Initiative) of higher quality and larger sample size found stronger evidence of an increased risk of self-reported T2DM (OR=1.47; 95% CI 1.32 to 1.64) for the groups of women who reported statin use at baseline and three years later
  • Hippisley-Cox et al. found an increased risk of liver enzyme changes
  • ...5 more annotations...
  • weak evidence of an increased risk of type 2 diabetes mellitus (T2DM) was observed
  • Smeeth et al. found an increased risk of incident liver disease in the first year after the index date
  • The cumulative incidence of T2DM after three years of statin treatment was 6.25%, corresponding to an excess risk of 2.25%
  • We found no increased risk of peripheral neuropathy, depression, common eye diseases, renal disorders or arthritis associated with taking statins. Studies of higher quality did not show previously reported protective effects of statins on fractures, venous thrombo-embolism or pneumonia
  • There was evidence of an increase in myopathy, raised liver enzymes and diabetes.
  • Nathan Goodyear on 19 Mar 15
     
    Statin use associated with increased myopathy, liver dysfunction, and type II Diabetes.  The authors conclude that the absolute risk is very low, yet OR was 1.47 for type II Diabetes (translated 47% increased odds of developing Diabetes as a result of statins) and OR of 2.63 in risk of myopathy (translated 163% increased odds of developing myopathy as a result of statins).  Seems the authors "low risk" statement is just applies to those without symptoms/side effects.  Physicians need to do a better job of understanding risks and customizing therapies.
wheelchairindia9

Tynor Rib Belt - 0 views

www.wheelchairindia.com/...Tynor-Rib-Belt

How to Effectively use a Rib Belt most common injuries to the chest rib cage is a protective organ flat chest bone called the sternum toning up abdominal muscles after surgery reduction of waist size compression belt to support

shared by wheelchairindia9 on 31 Mar 16 - No Cached
  • wheelchairindia9 on 31 Mar 16
     
    Tynor Rib Belt Rib belt is applied to the thoracic and upper abdominal region to compress and bind the rib cage during rib fractures and postoperative care, while allowing sufficient flexibility for comfortable breathing. Extra porous. With splinting pad. No buckling or rolling over. Controlled compression. Tynor Rib Belt Features Light weight and thin construction, does not peep through the clothes improves patient compliance. Extra porous webbing improves ventilation and comfort of the patient. Broad hook and loop tape panel offers better holding and size adjust ability. Optimal compression, tones up abdominal muscles following surgery, CS or delivery. Special nylon reeves prevent rolling over of belt. Tynor Rib Belt Measurements Measure circumference around the chest.
Nathan Goodyear

Relationship between rheumatoid arthritis and Mycoplasma pneumoniae: a case-control stu... - 0 views

academic.oup.com/...keh630

RA rheumatoid arthritis arthritis mycoplasma

shared by Nathan Goodyear on 17 Jul 17 - No Cached
  • Nathan Goodyear on 17 Jul 17
     
    mycoplasma as a potential causative factor in RA.
Nathan Goodyear

The definition and risks of Cytokine Release Syndrome-Like in 11 COVID-19-Infected Pneu... - 0 views

www.medrxiv.org/...2020.02.26.20026989v1

cytokine storm

shared by Nathan Goodyear on 22 Apr 20 - No Cached
  • Nathan Goodyear on 22 Apr 20
     
    To be read
Nathan Goodyear

NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC8924116

cancer NETosis SARS-CoV-2 COVID COVID-19 COVID19 platelets

shared by Nathan Goodyear on 18 Apr 23 - No Cached
  • Pneumonia is a typical symptom of COVID-19 infection, while acute respiratory distress syndrome (ARDS) and multiple organ failure are common in severe COVID-19 patients
  • NETs are important for preventing pathogen invasion, their excessive formation can result in a slew of negative consequences, such as autoimmune inflammation and tissue damage
  • SARS-CoV-2 infection has also been linked to increased neutrophil-to-lymphocyte ratios, which is associated with disease severity and clinical prognosis
  • ...40 more annotations...
  • NETosis is a special form of programmed cell death in neutrophils, which is characterized by the extrusion of DNA, histones, and antimicrobial proteins in a web-like structure known as neutrophil extracellular traps (NETs)
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Definition
  • increased generation of reactive oxygen species (ROS) is a crucial intracellular process that causes NETosis
  • Another indirect route of SARS-CoV-2-induced NET production is platelet activation
  • When NETs are activated in the circulation, they can also induce hypercoagulability and thrombosis
  • In COVID-19, major NET protein cargos of NETs (i.e., NE, MPO, and histones) are significantly elevated.
  • SARS-CoV-2 can also infect host cells through noncanonical receptors such as C-type lectin receptors
  • Immunopathological manifestations, including cytokine storms and impaired adaptive immunity, are the primary drivers behind COVID-19, with neutrophil infiltration being suggested as a significant cause
  • NETosis and NETs are increasingly recognized as causes of vascular injury
  • SARS-CoV-2 and its components (e.g., spike proteins and viral RNA) attach to platelets and increase their activation and aggregation in COVID-19, resulting in vascular injury and thrombosis, both of which are linked to NET formation
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Connects SARS-CoV-2 to TLR on Platelets to NETosis to metastasis.
  • NET formation may be caused by activated platelets rather than SARS-CoV-2 itself
  • NETosis, leading to aberrant immunity such as cytokine storms, autoimmune disorders, and immunosuppression.
  • early bacterial coinfections were more prevalent in COVID-19 patients than those infected with other viruses
  • NETosis and NETs may also have a role in the development of post COVID-19 syndromes, including lung fibrosis, neurological disorders, tumor growth, and worsening of concomitant disease
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      NETosis-> tumor growth
  • NETs and other by-products of NETosis have been shown to act as direct inflammation amplifiers. Hyperinflammation
  • “cytokine storm”
  • SARS-CoV-2 drives NETosis and NET formation to allow for the release of free DNA and by-products (e.g., elastases and histones). This may trigger surrounding macrophages and endothelial cells to secrete excessive proinflammatory cytokines and chemokines, which, in turn, enhance NET formation and form a positive feedback of cytokine storms in COVID-19
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Cycle of hyperinflammation
  • NET release enables self-antigen exposure and autoantibody production, thereby increasing the autoinflammatory response
  • patients with COVID-19 who have higher anti-NET antibodies are more likely to be detected with positive autoantibodies [e.g., antinuclear antibodies (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA)]
  • COVID-19 NETs may act as potential inducers for autoimmune responses
  • have weakened adaptive immunity as well as a high level of inflammation
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Immunomodulation
  • tumor-associated NETosis and NETs promote an immunosuppressive environment in which anti-tumor immunity is compromised
  • NETs have also been shown to enhance macrophage pyroptosis in sepsis
  • facilitating an immunosuppressive microenvironment
  • persistent immunosuppression may result in bacterial co-infection or secondary infection
  • can enhance this process by interacting with neutrophils through toll-like receptor 4 (TLR4), platelet factor 4 (PF4), and extracellular vesicle-dependent processes
  • NET-induced immunosuppression in COVID-19 in the context of co-existing bacterial infection
  • Following initial onset of COVID-19, an estimated 50% or more of COVID-19 survivors may develop multi-organ problems (e.g., pulmonary dysfunction and neurologic impairment) or have worsening concomitant chronic illness
  • NETs in the bronchoalveolar lavage fluid of severe COVID-19 patients cause EMT in lung epithelial cells
  • decreased E-cadherin (an epithelial marker) expression
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Leads to emt
  • COVID-19 also has a long-term influence on tumor progression
  • Patients with tumors have been shown to be more vulnerable to SARS-CoV-2 infection and subsequent development of severe COVID-19
  • patients who have recovered from COVID-19 may have an increased risk of developing cancer or of cancer progression and metastasis
  • awaken cancer cells
  • NETs have been shown to change the tumor microenvironment
  • enhance tumor progression and metastasis
  • vitamin C has been tested in phase 2 clinical trials aimed at reducing COVID-19-associated mortality by reducing excessive activation of the inflammatory response
  • vitamin C is an antioxidant that significantly attenuates PMA-induced NETosis in healthy neutrophils by scavenging ROS
  • vitamin C may also inhibit NETosis and NET production in COVID-19
  • Metformin
  • Vitamin C
  • Nathan Goodyear on 18 Apr 23
     
    NETosis intimately involved in progressive COVID, long COVID, autoimmunity, and cancer
Nathan Goodyear

Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneu... - 0 views

www.ncbi.nlm.nih.gov/...PMC8112281

COVID-19 ascorbic acid COVID SARS-CoV-2 vitamin C COVID19

shared by Nathan Goodyear on 12 Jul 22 - No Cached
  • Nathan Goodyear on 12 Jul 22
     
    At 2 grams per day, this study was designed to fail…and they did not even evaluate plasma AA levels.
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