Skip to main content

Home/ Dr. Goodyear/ Group items tagged VEGF

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Broad targeting of angiogenesis for cancer prevention and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4737670

cancer curcumin VEGF EGCG green tea melatonin quercetin Resveratrol silymarin flavonoids HIF-1alpha

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), interleukin-8 (IL-8), placental growth factor (PlGF), transforming growth factor-beta (TGFbeta), platelet derived growth factor (PDGF), angiopoietins (Angs) and others (reviewed in [4])
  • The switch may also involve down-regulation of endogenous inhibitors of angiogenesis such as endostatin, angiostatin or thrombospondin (reviewed in [5]) and has thus been regarded as the result of tipping the net balance between positive and negative regulators
  • There is a complex interrelationship between tumor hypoxia and tumor angiogenesis
  • ...17 more annotations...
  • chronic hypoxia
  • acute hypoxia
  • Environmental stress as a result of low oxygen and proper nutrient deprivation, such as glucose deprivation, are capable of inducing VEGF mRNA stabilization resulting in increased levels of the secreted ligand and angiogenic growth
  • HIFalpha subunits accumulate in the cytoplasm where they bind HIFbeta to form a heterodimer that subsequently translocates to the nucleus to activate transcription of target genes, including genes important for various processes such as metabolism (glucose transporter (GLUT)-1, hexokinase (HK)-1), cell growth (cyclin (CCN)-D1 [23]) and also angiogenesis, such as erythropoietin, VEGF and PDGF [24] (summarized in Fig. 1)
  • When oxygen levels are low (hypoxia; red arrow) PHDs cannot hydroxylate HIFalphas thereby allowing them to escape pVHL-mediated degradation. HIFalpha subunits accumulate and bind to their heterodimeric partner, HIFbeta, translocate into the nucleus and activate a cascade of hypoxic signaling first by the transcription of various target genes including microRNAs that are important for tumor promoting pathways
  • c-Src is also capable of activating HIFs by indirectly inhibiting PHD activity via the NADPH oxidase/Rac pathway.
  • mTOR can also promote stabilization and HIF transcriptional activity
  • hypoxia inducible factors (HIFs), heterodimeric transcription factors composed from alpha and beta subunits, which can be rapidly stabilized to fluidly adapt to and overcome the effects of a hypoxic environment
  • Curcumin inhibits the expression of epidermal growth factor receptor (EGFR), VEGFR-1, VEGFR-2 and VEGFR-3, and the kinase activity of Src and FAK, which are responsible for the induction of angiogenic genes as well as endothelial cell polarity and migration
  • Curcumin also reduces the MMP-2 and MMP-9 expression, along with the suppression of growth and invasion potential of tumor cells in culture and xenograft experiments
  • The expression of angiogenic biomarkers COX-2 and serum levels of VEGF were significantly reduced in the curcumin-treated group
  • Resveratrol inhibits capillary endothelial cell growth and new blood vessel growth in animals
  • interrupting cell proliferation, inducing apoptosis
  • [155] and impeding angiogenesis by suppressing VEGF expression through down-regulation of HIF-1alpha
  • resveratrol was reported to inhibit cell proliferation of human ovarian cancer cells and human osteosarcoma cells by attenuating HIF-1alpha
  • prevents cytokine-induced vascular leakage and tumor metastasis
  • The underlying molecular mechanisms include: blocking VEGF- and FGF-receptor-mediated MAPK activation, inhibiting Akt- and MAPK-driven HIF-1alpha basal expression and its induction by IGF-1, stimulating the proteasomal degradation of HIF-1alpha, inhibiting phosphatidyl inositol (PI)-3K/Akt and Ras/mitogen/extracellular signal-regulated kinase (MEK)/ERK pathways, and activation of forkhead box (FOX)O transcription factors
  • Nathan Goodyear on 01 Jun 18
     
    natural compounds to attach cancer explained.
Nathan Goodyear

Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-de... - 0 views

www.ncbi.nlm.nih.gov/...PMC4637299

angiogenesis curcumin VEGF

shared by Nathan Goodyear on 27 Aug 20 - No Cached
  • Nathan Goodyear on 27 Aug 20
     
    Curcumin inhibits VEGF to inhibit angiogenesis.
Nathan Goodyear

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-M... - 0 views

www.sciencedirect.com/...S1535610810000826

prostate cancer 3-beta androstanediol male hormone hormones ER HIF-1alpha VEGF estrogen receptor receptors ER beta ER-beta

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Loss of ERβ1 expression also resulted in a significant increase in migration and invasion (Figure 2F), functions characteristic of an EMT
  • we hypothesized that ERβ functions as a “gatekeeper” of the epithelial phenotype
  • breast and prostate are different with respect to ER expression and function
  • Nathan Goodyear on 21 Jan 14
     
    The process of androgen deprivation therapy needs to be re-evaluated.  Why?  First, the CVD side effects associated with the androgen depletion.  Second, the depletion of 3 beta androstanediol that has been shown to bind to ER beta and inhibit growth.  As in this study that finds that ER beta activity slows prostate cancer through destabilizing of HIF-1 alpha and by inhibiting VEGF.
Nathan Goodyear

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumo... - 0 views

www.nature.com/...nature10525

cancer stem cells VEGF angiogenesis stem

shared by Nathan Goodyear on 23 Apr 21 - No Cached
  • Nathan Goodyear on 23 Apr 21
     
    Not specifically focused on CSC, but anti-angiogenic therapies via blockade of VEGF inhibit stem ness.
Nathan Goodyear

VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3294103

low-dose chemotherapy glioblastoma multiforme VEGF glioblastoma cancer metronomic chemotherapy

shared by Nathan Goodyear on 11 Nov 20 - No Cached
  • Nathan Goodyear on 11 Nov 20
     
    CPA administered on an intermittent, every 6-day metronomic schedule stimulates tumor recruitment of macrophages, natural killer (NK) cells, and dendritic cells with regression of large established tumors, as seen in several implanted glioma models; also of note, VEGF inhibition inhibited this effect.
Nathan Goodyear

Thymosin alpha-1 blocks the accumulation of myeloid suppressor cells in NSCLC by inhibi... - 0 views

pubmed.ncbi.nlm.nih.gov/32942159

MDSC TME TA-1 VEGF tumor microenvironment myeloid-derived suppressor cells thymosin alpha-1

shared by Nathan Goodyear on 16 Aug 21 - No Cached
  • Nathan Goodyear on 16 Aug 21
     
    TA-1 alters tumor microenvironment via VEGF induced decrease in MDSC.
Nathan Goodyear

Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overwei... - 0 views

cancerres.aacrjournals.org/...4226

overweight obese inflammation exercise weight loss cancer diet nutrition VEGF PEDF PAI-1

shared by Nathan Goodyear on 19 Jul 16 - No Cached
  • Nathan Goodyear on 19 Jul 16
     
    only abstract available here.  Weight loss, through diet and exercise, decreased proteins important to tumor angiogenesis; thus weight loss associated with a reduction in VEGF, PEDF, and PAI-1 may reduce cancer risk, particularly in the overweight and obese. This is all the result of inflammation originating from obesity.
Nathan Goodyear

Increased estradiol levels in venous... [Int J Impot Res. 2005 May-Jun] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15578040

estradiol estrogen ED erectile dysfunction men male hormone hormones NO VEGF

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Nathan Goodyear on 05 Feb 14
     
    Study finds a link between Estradiol, venous insufficiency, and ED in men.  The signaling is through VEGF and NO.
Nathan Goodyear

Cyclooxygenase-2 Induces EP1- and HER-2/Neu-Dependent Vascular Endothelial Growth Facto... - 0 views

cancerres.aacrjournals.org/...554

COX-2 cancer HER-2 Celebrex VEGF metastasis prostate cancer lung cancer colorectal cancer

shared by Nathan Goodyear on 07 Aug 18 - No Cached
  • Nathan Goodyear on 07 Aug 18
     
    COX-2 is overexpressed in a variety of human cancers i.e. colorectal, prostate, lung adenocarcinoma.  This study hightlights the increased tumor metastatic potential via upregulation of VEGF-C via EP1 and HER-2 dependent pathways.  This upregulation was correlated with survival and mets.
Nathan Goodyear

In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines - 0 views

file.scirp.org/...5-2500510_47691.htm

CBD medical marijuana THC prostate BPH male men VEGF hormone hormones cancer PSA CSC cancer stem cells

shared by Nathan Goodyear on 13 Feb 19 - No Cached
  • Nathan Goodyear on 13 Feb 19
     
    High CBD downregulates prostate CBD1, CBD2, chemosensitizes CSCs, suppressed cancer cell formation, down regulated IL-6 and IL-8, decreased PSA, and VEGF.
Nathan Goodyear

Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U9... - 0 views

www.ncbi.nlm.nih.gov/...PMC4686121

quercetin cancer HSP heat shock proteins mTOR VEGF apoptosis

shared by Nathan Goodyear on 23 Feb 19 - No Cached
  • Nathan Goodyear on 23 Feb 19
     
    Quercetin effects in cancer i.e. decreased VEGF, apoptosis inhibition, mTOR inhibition... are augmented via HSP27 suppression
Nathan Goodyear

The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Ske... - 0 views

www.hindawi.com/...418340

VEGF prostate cancer vascular endothelial growth factor

shared by Nathan Goodyear on 23 Jun 19 - No Cached
  • Nathan Goodyear on 23 Jun 19
     
    VEGF plays role in prostate cancer spread and its particular spread to and growth in bone.
Nathan Goodyear

Lipopolysaccharide induces inflammation and facilitates lung metastasis in a ... - 0 views

www.ncbi.nlm.nih.gov/...25625500

LPS breast cancer angiogenesis VEGF

shared by Nathan Goodyear on 16 Aug 19 - No Cached
  • Nathan Goodyear on 16 Aug 19
     
    LPS found to increase breast cancer metastasis via increase in VEGF. It also increases NF-kappaB.
Nathan Goodyear

Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellul... - 0 views

www.sciencedirect.com/...S0891584906007611

VEGF cancer GLUT Hypoxia-inducible Factor 1 vitamin C HIF-1alpha HIF-1

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    "Induction of HIF-1α by hypoxia (1% O2) or by CoCl2 was markedly inhibited by ascorbate and loading with physiological levels resulted in almost complete reversal of HIF-1α stabilisation. Gene expression was similarly affected, with VEGF mRNA and GLUT-1 up-regulation being inhibited by ascorbate"
Nathan Goodyear

Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in P... - 0 views

www.ncbi.nlm.nih.gov/...PMC7830882

VEGF IV vitamin C vitamin C colon cancer hypoxia HIF-1alpha cancer HIF-1 GLUT

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Very interesting study. They gave IV vitamin C up to 75 grams to increase tumor delivery and found there was correlation between plasma and tumor levels post resection. This correlation was to a point-saturation curve. Also, there was a reduction in VEGF and hypoxia scores.
Nathan Goodyear

Curcumin blocks brain tumor formation - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/19368804

brain tumor curcumin NF-kappaB VEGF Akt brain cancer

shared by Nathan Goodyear on 16 Apr 21 - No Cached
  • Nathan Goodyear on 16 Apr 21
     
    Curcumin crosses blood brain barrier and suppresses cyclin D1, NF-kappaB BCLxl, Akt, and VEGF.
Nathan Goodyear

Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor... - 0 views

pubmed.ncbi.nlm.nih.gov/15930297

VEGF Topotecan HIF-1alpha IGF-1

shared by Nathan Goodyear on 14 Jan 21 - No Cached
  • Nathan Goodyear on 14 Jan 21
     
    The chemo agent Topotecan inhibits IGF-1 stimulated VEGF and HIF-1alpha.
Nathan Goodyear

Anti-angiogenic action of hyperthermia by suppressing gene expression and production of... - 0 views

www.ncbi.nlm.nih.gov/...PMC2746582

angiogenesis vasculogenesis VEGF hyperthermia cancer

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Hyperthermia inhibits VEGF and thus angiogenesis and vasculogenesis
Nathan Goodyear

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience - 0 views

www.ncbi.nlm.nih.gov/...PMC6446118

cancer therapy HIF-1alpha metastasis CSC metronomic chemotherapy cancer stem cells cancer treatment VEGF angiogenesis

shared by Nathan Goodyear on 06 Aug 20 - No Cached
  • Nathan Goodyear on 06 Aug 20
     
    Awesome article on how metronomic, low-dose chemotherapy reduces angiogenesis via decrease in HIF-1alpha and VEGF. Many other effects.
Nathan Goodyear

Curcumin is an in vivo inhibitor of angiogenesis. - 0 views

www.ncbi.nlm.nih.gov/...PMC2230271

curcumin VEGF angiogenesis

shared by Nathan Goodyear on 26 Aug 20 - No Cached
  • Nathan Goodyear on 26 Aug 20
     
    Curcumin inhibits angiogenesis via VEGF inhibition.
1 - 20 of 59 Next › Last »
Showing 20▼ items per page