Skip to main content

Home/ Dr. Goodyear/ Group items tagged attacks

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis o... - 0 views

www.ncbi.nlm.nih.gov/...PMC4306416

NAC N-acetylcysteine PCOS infertility women women's health female hormone hormones

shared by Nathan Goodyear on 23 Feb 15 - No Cached
  • compared effects of NAC with placebo or metformin in women with PCOS
  • NAC significantly improved rates of live births and spontaneous ovulation compared to placebo in women with PCOS
  • we found no evidence of effects of NAC on improving menstrual regularity, acne, hirsutism, BMI, fasting insulin, fasting glucose, or HOMA-IR
  • ...3 more annotations...
  • NAC was not associated with greater benefits to metformin for improving pregnancy rate, spontaneous ovulations, and menstrual regularity
  • Metformin also improved the BMI, total testosterone, insulin level, and lipid levels compared to NAC
  • All the studies were of short duration (three months)
  • Nathan Goodyear on 23 Feb 15
     
    Data review finds NAC improves pregnancy rates and ovulation rates in women with PCOS against placebo.  Meta-analysis revealed limited studies on the topic.  When compared to metformin, there was no difference found.  Though, one wonders if attacking insulin resistance through proper diet and additional neutraceutical approach would negate that.  The reason?  NAC and metformin are working in different biochemical pathways.  The authors here seem to not realize this. It appears that they think NAC and metormin are both working in the same manner, but they don't.  The fact that there is still benefit found compared to placebo, despited the authors lack of understanding of what NAC is and does is a positive.
Nathan Goodyear

Cruciferous Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic Basis - 0 views

www.ncbi.nlm.nih.gov/...PMC2737735

DIM I3C indole-3-carbinol cruciferous vegetables vegetables cruciferous cancer

shared by Nathan Goodyear on 28 Mar 15 - No Cached
  • Nathan Goodyear on 28 Mar 15
     
    Cruciferous vegetables do appear to provide a means to attack Cancer risk.  In part through they are rich sources of DIM and I3C.
Nathan Goodyear

Randomized trial of vitamin D supplementation to prevent seasonal influenza A in school... - 0 views

ajcn.nutrition.org/...1255.long

vitamin d influenza flu vitamin d3 asthma

shared by Nathan Goodyear on 20 Sep 17 - No Cached
  • Nathan Goodyear on 20 Sep 17
     
    Nice study from a few years ago found that a low dose vitamin D3 (1200 IU) significantly reduced the relative risk of the flu in school age children.  Also of note, a significant reduction in asthma attacks in those children with asthma were significantly reduced in the vitamin D3 treated group.  One interesting thing about this study was that they did not check prior or during the study if vitamin D deficiency was even present.  This study was conducted in Japan
Nathan Goodyear

IL-2: The First Effective Immunotherapy for Human Cancer | The Journal of Immunology - 0 views

www.jimmunol.org/...5451

cancer IL-2 Treg immune system immunology

shared by Nathan Goodyear on 17 Apr 18 - No Cached
  • IL-2 is a 15.5-kDa cytokine secreted predominately by Ag-simulated CD4+ T cells, but it can also be produced by CD8+ cells, NK cells, and activated dendritic cells
  • IL-2 is the predominant factor responsible for the maintenance of CD4+ regulatory T cells
  • A generalized capillary leak syndrome was induced by IL-2 in vivo that resulted in interstitial pulmonary infiltrates and substantial weight gain in patients
  • ...4 more annotations...
  • The side effects were transient and returned to baseline following treatment
  • Tumors do not express IL-2 receptors and thus the antitumor activity was the result of IL-2 stimulation of immune cell
  • Patients with metastatic melanoma or metastatic renal cell cancer were uniquely responsive to high-dose IL-2 administration, and except for patients with advanced non-Hodgkin’s lymphomas (35) only rare responses were seen in patients with other tumor types
  • The underlying toxicity of IL-2 results from a capillary leak that leads to fluid extravasation into visceral organs that can compromise their function
  • Nathan Goodyear on 17 Apr 18
     
    Great review of the history of IL-2 in the treatment of cancer.  IL-2 stimulates the immune system to attack cancer.  Don't reinvent the wheel; use what is already present and available.
Nathan Goodyear

First results on survival from a large Phase 3 clinical trial of an autologous dendriti... - 0 views

translational-medicine.biomedcentral.com/...s12967-018-1507-6

dendritic cells cancer glioblastoma multiforme glioblastoma brain cancer

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Dendritic therapy, I think the use of vaccine is completely inappropriate here, found to extend life in those with methylated MGMT.  This phase III trial is still on going, but this is a very positive future therapy in the immunotherapy attack against cancer.
Nathan Goodyear

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde... - 0 views

www.hindawi.com/...360438

MDA malondialdehyde peroxidation oxidative stress free radicals

shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Hydroxyl radicals cause oxidative damage to cells because they unspecifically attack biomolecules [22] located less than a few nanometres from its site of generation and are involved in cellular disorders such as neurodegeneration [23, 24], cardiovascular disease [25], and cancer [26, 27].
  • It is generally assumed that in biological systems is formed through redox cycling by Fenton reaction, where free iron (Fe2+) reacts with hydrogen peroxide (H2O2) and the Haber-Weiss reaction that results in the production of Fe2+ when superoxide reacts with ferric iron (Fe3+)
  • other transition-metal including Cu, Ni, Co, and V can be responsible for formation in living cells
  • ...20 more annotations...
  • The hydroperoxyl radical () plays an important role in the chemistry of lipid peroxidation
  • The is a much stronger oxidant than superoxide anion-radical
  • Lipid peroxidation can be described generally as a process under which oxidants such as free radicals or nonradical species attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs) that involve hydrogen abstraction from a carbon, with oxygen insertion resulting in lipid peroxyl radicals and hydroperoxides as described previously
  • under medium or high lipid peroxidation rates (toxic conditions) the extent of oxidative damage overwhelms repair capacity, and the cells induce apoptosis or necrosis programmed cell death
  • The overall process of lipid peroxidation consists of three steps: initiation, propagation, and termination
  • Once lipid peroxidation is initiated, a propagation of chain reactions will take place until termination products are produced.
  • The main primary products of lipid peroxidation are lipid hydroperoxides (LOOH)
  • Among the many different aldehydes which can be formed as secondary products during lipid peroxidation, malondialdehyde (MDA), propanal, hexanal, and 4-hydroxynonenal (4-HNE) have been extensively studied
  • MDA has been widely used for many years as a convenient biomarker for lipid peroxidation of omega-3 and omega-6 fatty acids because of its facile reaction with thiobarbituric acid (TBA)
  • MDA is one of the most popular and reliable markers that determine oxidative stress in clinical situations [53], and due to MDA’s high reactivity and toxicity underlying the fact that this molecule is very relevant to biomedical research community
  • 4-HNE is considered as “second toxic messengers of free radicals,” and also as “one of the most physiologically active lipid peroxides,” “one of major generators of oxidative stress,” “a chemotactic aldehydic end-product of lipid peroxidation,” and a “major lipid peroxidation product”
  • MDA is an end-product generated by decomposition of arachidonic acid and larger PUFAs
  • Identifying in vivo MDA production and its role in biology is important as indicated by the extensive literature on the compound (over 15 800 articles in the PubMed database using the keyword “malondialdehyde lipid peroxidation” in December 2013)
  • MDA reactivity is pH-dependent
  • When pH decreases MDA exists as beta-hydroxyacrolein and its reactivity increases
  • MAA adducts are shown to be highly immunogenic [177–181]. MDA adducts are biologically important because they can participate in secondary deleterious reactions (e.g., crosslinking) by promoting intramolecular or intermolecular protein/DNA crosslinking that may induce profound alteration in the biochemical properties of biomolecules and accumulate during aging and in chronic diseases
  • MDA is an important contributor to DNA damage and mutation
  • This MDA-induced DNA alteration may contribute significantly to cancer and other genetic diseases.
  • Dietary intake of certain antioxidants such as vitamins was associated with reduced levels of markers of DNA oxidation (M1dG and 8-oxodG) measured in peripheral white blood cells of healthy subjects, which could contribute to the protective role of vitamins on cancer risk
  • 4-HNE is an extraordinarily reactive compound
  • Nathan Goodyear on 05 Dec 17
     
    Great review of lipid peroxidation
Nathan Goodyear

Oncotarget | NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Id... - 0 views

www.oncotarget.com/index.php

vitamin C IV vitamin C cancer cancer stem cells milk thistle silymarin ascorbic acid bee propolis CAPE glycolytic inhibitor natural

shared by Nathan Goodyear on 08 Dec 17 - No Cached
  • Vitamin C was ~10 times more potent than 2-DG for the targeting of CSCs
  • Cancer stem-like cells (CSCs) are thought to be the root cause of chemotherapy-resistance and radio-resistance
  • ultimately leading to treatment failure in patients with advanced disease [1-3]. They have been directly implicated mechanistically in tumor recurrence and metastasis, resulting in poor patient survival
  • ...26 more annotations...
  • mitochondrial biogenesis may be a key driver of the CSC phenotype
  • Our results indicate that increased mitochondrial oxidative stress and high NADH levels are both key characteristics of the CSC metabolic phenotype
  • high levels of NAD(P)H auto-fluorescence are known to be a surrogate marker for mitochondrial “power”, high OXPHOS capacity and increased ATP production
  • CSCs may be strictly dependent on NAD(P)H to maintain their enhanced mitochondrial function
  • an intact NAD+ salvage pathway is strictly required for mammosphere formation, supporting our results using NAD(P)H auto-fluorescence, which enriched CSC activity by more than 5-fold.
  • Since glycolysis is especially critical for maintaining the TCA cycle, OXPHOS and overall mitochondrial function, we next assessed the effects of known glycolytic inhibitors
  • we show that two other natural products that function as effective glycolysis inhibitors, also inhibited mammosphere formation. More specifically, vitamin C (ascorbic acid), which induces oxidative stress and inhibits the activity of GAPDH (a key glycolytic enzyme) [17], also inhibited mammosphere formation, with an IC-50 of 1 mM (Figure 7B). Therefore, vitamin C was ~10 times more potent than 2-DG at targeting CSC propagation
  • silibinin (the major active constituent of silymarin, an extract of milk thistle seeds) [18], which specifically functions as an inhibitor of glucose uptake, blocked mammosphere formation, with an IC-50 between 200 and 400 µM
  • caffeic acid phenyl ester (CAPE), a key component of honey-bee propolis, has potent anti-cancer properties
  • Propolis has a strong history of medicinal use, dating back more than 2,000 years
  • Because of it aromatic ring structure (Figure 8), we speculated that CAPE might function as a potent inhibitor of oxidative mitochondrial metabolism
  • CAPE quantitatively inhibits the mitochondrial oxygen consumption rate (OCR) and, in turn, induces the onset of aerobic glycolysis (ECAR)
  • CAPE shows a clear selectivity for targeting CSCs and adherent cancer cells, relative to normal fibroblasts.
  • CAPE functions as a “natural” mitochondrial OXPHOS inhibitor, that preferentially targets the CSC sub-population. This could explain CAPE’s known anti-cancer properties
  • Our data directly shows that a small fraction of the total cell population, characterized by increased PGC1α activity, high mitochondrial ROS/H2O2 and high NADH levels, has the ability to survive and grow under anchorage-independent conditions, driving mammosphere formation
  • We highlight the utility of certain natural products, such as Silibinin, Vitamin C and CAPE, that could be used to therapeutically target CSCs. Silibinin is the major active component of silymarin, which is an extract prepared from milk thistle seeds.
  • high NADH is a property that is conserved between normal and cancerous stem cells
  • Previous studies have also shown that when non-CSCs and CSCs are both fed mitochondrial fuels (such as L-lactate or ketone bodies), that CSCs quantitatively produce more NADH in response to this stimulus
  • CSCs may be strictly dependent on NADH to maintain their enhanced mitochondrial function
  • The Noble Prize winner, Linus Pauling, was among the first to describe and clinically test the efficacy of Vitamin C, as a relatively non-toxic anti-cancer agent
  • Vitamin C has two mechanisms of action. First, it is a potent pro-oxidant, that actively depletes the reduced glutathione pool, leading to cellular oxidative stress and apoptosis in cancer cells. Moreover, it also behaves as an inhibitor of glycolysis, by targeting the activity of GAPDH, a key glycolytic enzyme.
  • Here, we show that Vitamin C can also be used to target the CSC population, as it is an inhibitor of energy metabolism that feeds into the mitochondrial TCA cycle and OXPHOS
  • Vitamin C may prove to be promising agent for new clinical trials, aimed at testing its ability to reduce CSC activity in cancer patients, as an add-on to more conventional therapies, to prevent tumor recurrence, further disease progression and metastasis
  • Interestingly, a breast cancer based clinical study has already shown that the use of Vitamin C, concurrent with or within 6 months of chemotherapy, significantly reduces both tumor recurrence and patient mortality
  • CAPE quantitatively reduces mitochondrial oxygen consumption (OCR), while inducing a reactive increase in glycolysis (ECAR). As such, it potently inhibits mammosphere formation with an IC-50 of ~2.5 µM. Similarly, it also significantly inhibits cell migration
  • we also demonstrate that 7 different inhibitors of key energetic pathways can be used to effectively block CSC propagation, including three natural products (silibinin, ascorbic acid and CAPE). Future studies will be necessary to test their potential for clinical benefit in cancer patients.
  • Nathan Goodyear on 08 Dec 17
     
    The future of cancer therapy is cancer stem cells.  Study finds that Vitamin C, silymarin, and bee propolis blocks mitochondrial energy pathways in cancer stem cells.  Vitamin C is a known glycolytic inhbitor. Vitamin C was found to inhibit glycolysis via GAPDH targeting to inhibit the energy pathways of the mitochondria in CSCs.  The authors propse that Vitamin C can be used as add on therapies for conventional therapies to specifically attack the CSCs and their contribution to recrurence, treatment resistance, and metastasis potential all in addition to the ability of vitamin C to reduce the side effects of chemotherapy.
Nathan Goodyear

Aging | Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for... - 0 views

www.aging-us.com/...text

cancer stem cells cancer azithromycin IV vitamin C vitamin C doxycycline CSC

shared by Nathan Goodyear on 21 May 19 - No Cached
  • Nathan Goodyear on 21 May 19
     
    Triple attack on cancer stem cells. Doxy and Azithromycin with vitamin C found to significantly inhibit CSC mitochondrial activity.
Nathan Goodyear

Reduction of Chronic Hyperinsulinemia (Insulin Resistance) for the Prevention and Treat... - 0 views

fasting calorie restriction insulin resistance hyperinsulinemia cancer

shared by Nathan Goodyear on 10 Jan 21 - No Cached
  • Nathan Goodyear on 10 Jan 21
     
    Fasting and calorie restriction are a means to attack hyperinsulinemia and insulin resistance.
Nathan Goodyear

Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4542825

immunogenic chemoimmunomodulation low-dose cancer ultra metronomic chemotherapy low-dose chemotherapy chemotherapy

shared by Nathan Goodyear on 03 Jul 20 - No Cached
  • Nathan Goodyear on 03 Jul 20
     
    Low dose and ultra-low dose chemo stimulate the immune system to attack cancer
indiacardiacsurg

Increased Physical Activity after Lowest Price for ICD Implantation India Linked to Les... - 0 views

www.briefingwire.com/...on-india-linked-to-less-expiry

ICD treatment centers in India ICD implantation in India lowest price for ICD implantation in India Cost of ICD Implantation India

shared by indiacardiacsurg on 11 Nov 21 - No Cached
  • indiacardiacsurg on 11 Nov 21
     
    The lowest price for ICD implantation in India is also endorsed for heart attack survivors and sufferers who've currently had percutaneous coronary intervention or passed surgical procedures. ICD treatment centers in India to increase access to cardiac and pulmonary rehabilitation programs. International Helpline Number : +91-9370586696 Email id: enquiry@indiacardiacsurgerysite.com
Nathan Goodyear

ESC | Congresses | HEART FAILURE 2013 | Scientific Programme - 0 views

spo.escardio.org/SessionDetails.aspx

CoQ10 heart attack MI heart failure cardiovascular cardiovascular death heart failure

shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    CoQ10 in those with prior MIs, found to have reduced hospital readmission, less heart failure, and lower cardiovascular death.  Enough said.
Nathan Goodyear

Homocysteine and MTHFR Mutations - 0 views

circ.ahajournals.org/...e289.full

homocysteine MTHFR CVD cardiovascular death CAD c677T A1298c

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • The most common MTHFR mutation is called the MTHFR C677T mutation
  • Another common mutation is called MTHFR A1298C
  • Having only one mutation, ie, being heterozygous, is, from a medical perspective, irrelevant. Even when 2 MTHFR mutations are present (eg, 2 C677T mutations, or one C677T mutation and one A1298C mutation)
  • ...4 more annotations...
  • Although these mutations do impair the regulation of homocysteine, adequate folate levels essentially “cancel out” this defect.
  • Regardless of whether you have an MTHFR mutation in both genes or not, the treatment for elevated homocysteine is the same—dietary intervention and supplementation with folic acid and vitamins B6 and B12
  • Overall, evidence from these studies indicates that, so long as the homocysteine level is normal, MTHFR mutations do not significantly increase the risk of heart attack or stroke
  • Studies investigating the association of MTHFR mutations and venous blood clots have been inconsistent, with some studies showing a slight association, but most studies have not shown any association
  • Nathan Goodyear on 02 Feb 15
     
    Good review of MTHFR and homocysteine.
Nathan Goodyear

Low serum testosterone, arterial stiffness and mortality in male haemodialysis patients - 0 views

ndt.oxfordjournals.org/...2971.abstract

low testosterone CVD mortality men male cardiovascular disease MI heart attack stroke

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    low testosterone increases CVD and all-cause mortality in me.
Nathan Goodyear

Myocardial infarction is inversely associate... [Int J Epidemiol. 1990] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2262248

CAD CVD vitamin D) 25 OH MI heart attack

shared by Nathan Goodyear on 29 Jun 12 - No Cached
  • Nathan Goodyear on 29 Jun 12
     
    Vitamin D (25 OH) below 34 ng/ml associated with double risk of MI.
Nathan Goodyear

Rebuilding the post-infarcted myocardium by a... [Heart Fail Rev. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18773293

thyroid MI myocardial infarction heart attack hormone hormones post-MI heart cardiac remodeling

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    Wow, thyroid hormones play a significant role in cardiac remodeling post MI.  Thyroid hormones, "promotes tissue growth and differentiation and favorably remodels cardiac cell while increases cellular survival..."  How many people post-MI are having their thyroid evaluated, let alone correctly evaluated?
Nathan Goodyear

Stat Update Splash Page - 0 views

circ.ahajournals.org/...StatUpdate.xhtml

CVD cardiovascular disease data stroke MI heart attack

shared by Nathan Goodyear on 05 Feb 12 - No Cached
  • Nathan Goodyear on 05 Feb 12
     
    2012 Cardiovascular disease data.
Nathan Goodyear

Journal of General Internal Medicine, Online First™ - SpringerLink - 0 views

www.springerlink.com/...b042807u865853t7

diet soda coke cardiovascular events stroke heart attack MI

shared by Nathan Goodyear on 10 Feb 12 - No Cached
  • Nathan Goodyear on 10 Feb 12
     
    diet soda a day increases the risk of cardiovascular events.   This proved to be a 43% increase.
Nathan Goodyear

JAMA Network | JAMA: The Journal of the American Medical Association | Low-Fat Dietary ... - 0 views

jama.jamanetwork.com/article.aspx

low fat diet CVD CHD cardiovascular disease risk stroke MI heart attack health

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    large study of 50,000 postmenopausal women found no significant reduction in CVD with a low fat diet.  The mean dietary time period was 8 years.
Nathan Goodyear

Sex steroids and cardiovascular disease Yeap BB - Asian J Androl - 0 views

www.ajandrology.com/article.asp

cardiovascular disease CVD sex estradiol carotid intima-media thickness hormones hormone men Testosterone estrogen

shared by Nathan Goodyear on 15 Jan 14 - No Cached
  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases.
  • calculations based on mass action equations may not reflect precisely free T measured using a reference method
  • free T declines more steeply with age than total T in both cross-sectional [35] and longitudinal studies, [36] as does free E2 in comparison to total E2
  • ...22 more annotations...
  • T may slow development of or progression of atherosclerosis by modulating effects on insulin resistance, inflammation, endothelial function, preclinical atherosclerosis or the vasculature.
  • these cross-sectional and longitudinal studies support a relationship between low circulating T with CIMT and higher E2 with its progression
  • lower levels of T are biomarkers for aortic vascular disease
  • circulating free T was negatively associated with the presence of AAA
  • luteinizing hormone (LH) was positively associated.
  • low levels of total or bioavailable T were associated with aortic atherosclerosis manifested as calcified deposits detected by radiography
  • Men with total or free T in the lowest quartile had increased adjusted ORs for PAD defined as ABI <0.90, as did men with free E2 in the highest quartile of values
  • The apparent association of SHBG with intermittent claudication reflects the correlation of total T with SHBG, while the contribution of E2 to risk of PAD remains unclear
  • men with total T in the lowest quartile of values (<11.7 nmol l−1 ) experienced an increased incidence of stroke or transient ischemic attack
  • lower total T with increased incidence of CVD events
  • cohort studies in mostly older men have supported the association of lower androgen levels with higher mortality
  • lower total or free T levels were associated with mortality in older men, but with discordant results for cause-specific mortality and for associations of E2
  • several large studies identifying lower endogenous levels of total or free T as independent predictors of all-cause or CVD-related deaths in middle-aged and older men
  • T exhibits anti-inflammatory effects, enhances flow-mediated brachial artery reactivity, and reduces arterial stiffness
  • Short-term T therapy had a beneficial effect on exercise-induced myocardial ischemia in middle-aged men with coronary artery disease or chronic stable angina, [95],[96],[97] and reduced angina frequency in older men with diabetes and coronary artery disease
  • T therapy resulted in an increase in treadmill test duration and time to ST segment depression
  • there are interventional studies supporting a protective effect of exogenous T against myocardial ischemia in men with coronary artery disease
  • employ conservative doses
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      This dosing is 100 fold higher then peak production of a  young man at 20-22.
  • Observational studies indicate that lower levels of endogenous T in older men are associated with the presence of carotid atherosclerosis, aortic and peripheral vascular disease, and incidence of CVD events and mortality
  • Interventional studies have shown beneficial effects of exogenous T on vascular function and on exercise-induced myocardial ischemia in men with coronary artery disease
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      the therapies employed in these studies were massively overdosed.
  • Nathan Goodyear on 15 Jan 14
     
    Nice review of all the sex hormones and their relationship to CVD in men.  
‹ Previous 21 - 40 of 56 Next ›
Showing 20▼ items per page