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Nathan Goodyear

Indole-3-carbinol disrupts estrogen rece... [Mol Cell Endocrinol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22835548

indole-3-carbinol I3C breast cancer cancer ER alpha

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    Indole-3-carbinol degrades ER alpha expression on breast cancer cells lines and down regulates ER alpha expression.  Not only does I3C degrade ER alpha expression it inhibits its expression as well.    Additionally, I3C interferes with signaling associated with ER alpha through IGF-1.
Nathan Goodyear

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition ... - 0 views

carcin.oxfordjournals.org/...1315.full

indole-3-carbinol I3C breast cancer ER alpha estrogen cancer

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    Indole-3-carbinol (I3C) inhibits breast cancer cell growth through, in part, down regulation of ER alpha signaling.
Nathan Goodyear

Dose-ranging study of indole-3-carbinol... [J Cell Biochem Suppl. 1997] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9589355

I3C indole-3-carbinol breast cancer dose dosing

shared by Nathan Goodyear on 04 Jan 13 - No Cached
  • Nathan Goodyear on 04 Jan 13
     
    Dosing information on I3C.  They found 300-400 mg to be tolerated well and an effective dose for breast cancer chemoprevention.
Nathan Goodyear

Cruciferous Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic Basis - 0 views

www.ncbi.nlm.nih.gov/...PMC2737735

DIM I3C indole-3-carbinol cruciferous vegetables vegetables cruciferous cancer

shared by Nathan Goodyear on 28 Mar 15 - No Cached
  • Nathan Goodyear on 28 Mar 15
     
    Cruciferous vegetables do appear to provide a means to attack Cancer risk.  In part through they are rich sources of DIM and I3C.
Nathan Goodyear

Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human ... - 0 views

www.jbc.org/...21136.full

DIM I3C PSA AR androgen receptor prostate cancer men male hormone hormones androgen

shared by Nathan Goodyear on 05 Nov 14 - No Cached
  • Inhibition of Endogenous PSA Expression by DIM
  • DIM strongly inhibited DHT induction of androgen-responsive genes by more than 50%
  • antiandrogenic activity of DIM
  • ...8 more annotations...
  • DIM suppresses DHT-induced cell growth and PSA expression and exhibits no AR agonist activity
  • DIM has a strong affinity for both the mutant AR inLNCaP cells and for recombinant wild-type human AR
  • nuclear translocation and foci formation of DHT-bound AR are inhibited by DIM
  • Our investigation, leads to the conclusion that DIM is a strong, pure androgen antagonist.
  • The down-regulation of PSA by DIM
  • PSA has been reported to promote the proliferation, migration, and metastasis of prostate cancer cells through several mechanisms, including cleavage of insulin-like growth factor-binding protein-3 and degradation of extracellular matrix proteins fibronectin and laminin
  • PSA expression is regulated by the AR and is thought to function as a growth factor in LNCaP cells
  • down-regulation of PSA expression may be important in the antiproliferative effects of DIM in LNCaP cells
  • Nathan Goodyear on 05 Nov 14
     
    DIM, from cruciferous veggies often used to aid estrogen metabolism, is found to decrease PSA transcription and function as an androgen receptor antagonist in prostate cancer cell lines.
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