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Nathan Goodyear

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition ... - 0 views

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    Indole-3-carbinol (I3C) inhibits breast cancer cell growth through, in part, down regulation of ER alpha signaling.
Nathan Goodyear

Indole-3-carbinol disrupts estrogen rece... [Mol Cell Endocrinol. 2012] - PubMed - NCBI - 0 views

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    Indole-3-carbinol degrades ER alpha expression on breast cancer cells lines and down regulates ER alpha expression.  Not only does I3C degrade ER alpha expression it inhibits its expression as well.    Additionally, I3C interferes with signaling associated with ER alpha through IGF-1.
Nathan Goodyear

Dose-ranging study of indole-3-carbinol... [J Cell Biochem Suppl. 1997] - PubMed - NCBI - 0 views

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    Dosing information on I3C.  They found 300-400 mg to be tolerated well and an effective dose for breast cancer chemoprevention.
Nathan Goodyear

Cruciferous Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic Basis - 0 views

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    Cruciferous vegetables do appear to provide a means to attack Cancer risk.  In part through they are rich sources of DIM and I3C.
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