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Dr. Jennifer Martinick

Dr Jennifer Martinick - Experienced Hair Transplant Surgeon - 0 views

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    Dr Jennifer Martinick reviews the cases of many Hair Loss patients everyday. She has also spread knowledge on factors that causes negative impact on hairs. Read this complete article to know why an experienced Hair Restoration Surgeon is preferred.
Nathan Goodyear

Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metas... - 0 views

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    New insight to new therapy for Pancreatic cancer.  This article/study does a great job of reviewing the biochemistry by which Graviola works against pancreatic cancer.  Graviola was shown to downregulate HIF-1alpha, NF-kappaB, GLUT1, GLUT4, HKII, and LDHA.  Complex 1 of the electron transport was also inhibited.
Nathan Goodyear

Testosterone level and mortality in elderly men with systolic chronic heart failure - 0 views

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    Good article.  Heart failure in men associated with lower Total Testosterone and estimated Free Testosterone. The severity of disease was associated with lower Testosterone levels.   I wish they would have measured free levels not estimated them.   Increased SHBG concentrations was associated increased CHF as well. This study found no association with mortality.
Nathan Goodyear

Polychlorinated Biphenyls, Lead, and Mercury Are Associated with Liver Disease in Ameri... - 0 views

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    full article that revealed PCBs, Lead, and Mercury associated with elevated liver enzymes and NAFLD.
Nathan Goodyear

Natural Products for Cancer Prevention - 0 views

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    Review article that looked at "natural" therapies for cancer therapy.  I have to read this--unread at this point.
Nathan Goodyear

Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regul... - 0 views

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    Another mark for cucumin in the battle against cancer.  This article looked at the mechanism behind the inhibition of cell proliferation by curcumin.  The proposed mechanism is via Nrf2 induction in the MCF-7 cell culture lines.
Nathan Goodyear

The dialectic role of progesterone - 0 views

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    Just the abstract available here.  Article states the complexity of hormones found in hormone metabolism.  I love the authors quote, "As steroid hormones are known to be converted to many other steroids occupying different receptors and thereby exerting various different effects..."  Doesn't fit into the "know your numbers" marketing deception does it?
Nathan Goodyear

Revisiting Financial Conflicts of Interest in FDA Advisory Committees - 0 views

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    Article highlights the conflicts of interest by advisors on the advisory board to the FDA.  This boarders on the illegal.
Nathan Goodyear

JNK Expression by Macrophages Promotes Obesity-induced Insulin Resistance and Inflammation - 0 views

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    JNK pathway plays important role in inflammation signaling.  In this article, JNK activation plays role in insulin resistance, obesity, and metabolic dysfunction.
Nathan Goodyear

Cadmium - a metallohormone? - 0 views

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    Great review article on the endocrine disrupting role of Cadmium.  Cadmium binds to the ER-alpha inducing an estrogen signal.  Cadmium also binds to the androgen receptor as well.  This study proposes a similar activation of ER-alpha and AR by Cadmium.
Nathan Goodyear

Vitamin D for Cancer Prevention: Global Perspective - 0 views

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    Only abstract available here.  The authors of the this epidemiologic article estimate that 58,000 cases of breast cancer and 49,000 cases of colorectal cancer can be prevented annually by raising levels to 40-60.  The study also points to a new cancer model that Vitamin D has a positive effect at each step.  The acronym is DINOMIT and this stands for disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition.
Nathan Goodyear

The impact of vitamin D in breast cancer: genomics, pathways, metabolism - 0 views

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    Good review article of how vitamin D interacts with the biochemistry of breast cancer.
Nathan Goodyear

Review article: biofilm formation by Helicobacter pylori as a target for eradication of... - 0 views

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    good discussion of biofilms and H.pylori.  This article reviews the literature behind some of the natural and traditional therapies to reduce biofilms.
Nathan Goodyear

Testosterone: More Than Having the Guts to Win the Tour de France - 0 views

  • female adult mice have microbiomes similar to those of prepubescent mice of both sexes;
  • the commensal microbial community in adult male mice significantly deviates from this shared initial pool.
  • the microbiome in castrated adult males clearly shifts away from that of normal adult males and is closer to the microbiome of females
  • ...10 more annotations...
  • The incidence of T1D in these mice is positively correlated with the “femaleness” of the microbiota
  • These results support the hypothesis that the host androgen level is influential in determining the composition of the microbiota, which in turn affects T1D initiation and progression
  • a high testosterone level enriches the microbiota for specific organisms such as segmented filamentous bacteria (SFB) and Escherichia coli or Shigella–like (SECS) strains.
  • A minimum level of testosterone and specific male-enriched microbes working together upregulate M2 macrophage and IFN-γ producing T cells in pancreatic lymph nodes. Microarray data show that both the IFN-γ and IL-1β pathways are also stimulated.
  • These microbes also upregulate host testosterone
  • In four independent experiments, the authors found no universal unique “male microbiome”
  • they did find that four distinct combinations of microbial groupings (with an interesting lack of overlap at the individual family level in the four experiments) were enhanced by androgen
  • one species consists of the segmented filamentous bacteria (SFB) and belongs to the Firmicutes, whereas the other is an Escherichia coli or Shigella–like (SECS) strain belonging to the Proteobacteria
  • colonization with protective microbiomes—e.g., SPF microbiota, SFB, and SECS—is positively correlated with high blood testosterone levels in male mice
  • A direct implication of this study is that probiotic administration or fecal transplantation is a theoretically possible approach to protection against T1D
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    nice summary of article on the relationship between Testosteorne and gut microbiome in autoimmune disease.
Nathan Goodyear

New Frontiers in Androgen Biosynthesis and Metabolism - 0 views

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    great article on androgen metabolism in the diseased prostate.
Nathan Goodyear

Global burden of cancer attributable to high body-mass index in 2012: a population-base... - 0 views

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    Worldwide increase in BMI is associated with increase in Cancer.  This article, abstract only available here, found that up to 6% of new cancer cases is associated with a high BMI.
Nathan Goodyear

Brain foods: the effects of nutrients on brain function - 0 views

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    Just a great article on the interaction between food, gut and the brain.
Nathan Goodyear

A PERSPECTIVE ON THE ROLE OF ESTROGEN IN HORMONE-INDUCED PROSTATE CARCINOGENESIS - 0 views

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    review article points to the concept that it is not Testosterone, but Estrogen that is involved with carcinogenesis of the prostate.
Nathan Goodyear

PLoS ONE: Antidepressants and Breast and Ovarian Cancer Risk: A Review of the Literatur... - 0 views

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    Antidepressants shown to increase Breast and Ovarian Cancer risk in review of 61 articles. Clear relationship found, but exact risk still needs further research.  Interestingly, the pharmaceutical industry's research, showed no risk.
Nathan Goodyear

High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fat... - 0 views

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    BCBS says that there is not enough evidence to support apolipoprotein testing?!  Somehow they missed this 2001 article
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