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Nathan Goodyear

Will testosterone replacement therapy become a new treatment of chronic heart failure? ... - 0 views

  • TRT could improve significantly the exercise capacity of patients, compared with placebo
  • it could be seen that the effect of TRT on SBP and DBP was controversial
  • in men with congestive heart failure, testosterone reduced the Q-Td, whereas placebo had no effects
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  • The MVC and PTmax were significantly improved in TRT patients but remained unchanged in the placebo group
  • handgrip strength improved significantly with testosterone treatment
  • According to EF assessed by echocardiography, no differences were observed between the patients who were prescribed testosterone and those who received placebo
  • There were no differences between the groups in circulating levels of NT pro-BNP, and inflammatory markers were unchanged, except for a decrease in TNF-α from baseline in the placebo group
  • Testosterone supplementation therapy appeared to be safe, and the subjects who accepted testosterone treatment did not appear any obvious adverse reactions.
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    Testosterone therapy in men with CHF found to increase exercise capacity, reduced the Q-T interval in men, improved muscle strength in men, and was found to be safe in meta-analysis.
Nathan Goodyear

Therapeutic effect of taurine in congestive heart failure: a double-blind crossover tri... - 0 views

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    Taurine an effective adjuvant in treatment of CHF.  Also shown to be safe.
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Tynor Compression Stocking Below Knee - 0 views

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    Tynor Compression Stocking Below Knee Compression Stockings provide controlled compression to the legs to squeeze away abnormal back flow of blood into the superficial veins that lie just beneath the surface of the skin from the perforating veins. It is used in all forms of venous disease including blood pools or congests in legs. Severe varicose veins and discoloration to sores, ulcers and potentially life-threatening blood clots. Light weight. Four way stretch. Freely breathable. Soft and comfortable. Tynor Compression Stocking Below Knee Features Made from soft nylon yarn and spandex Strong and durable. Dermophillic. Optimal compression. Excellent aesthetics. Excellent Color fastness. Four-way stretchability Offers optimal compression. Snug fitting. Double layered Retains body heat effectively. Provides therapeutic warmth. Quicker healing. Strong and durable. Tapered shape and Controlled compression Uniform compression even on uneven limb surface. Offers graded compression high to low from toe upwards. Effective blood evacuation. Open toe design Reduces wear and tear. Easy to wear. Compatible to toe rings or other jewelry items. Tynor Compression Stocking Below Knee Measurements
Nathan Goodyear

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis - 0 views

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    Meta-analysis shows that coQ10 "may" improve heart function in those with CHF.
Nathan Goodyear

The potential health benefits of taurine in cardiovascular disease - 0 views

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    Taurine safe and effect in CHF.
Nathan Goodyear

Thyroid Hormone Treatment to Mend a Broken Heart - 0 views

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    free T3 is critical in the heart healing post MI.  Hypothyroidism and CHF share many hemodynamic and cardiovascular similarities.
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

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    IV T3 was given to patients with chronic heart failure.  What the study found may surprise you: improved heart function (ventricular), improved BNP, decrease heart rate, no side effects.  T3 has been shown to be more predictive of cardiac death in those with cardiac disease, than elevated lipids or decreased ejection fraction.
Nathan Goodyear

Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive H... - 0 views

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    Patients with CHF often have low T3 levels.  In this study, IV T3 was shown to be safe and well tolerated
Nathan Goodyear

Testosterone: a natural tonic for the failing heart? - 0 views

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    This early in the evaluation: but testosterone therapy in those men with CHF is of considerable benefit.  This would improve the catabolic:anabolic state, reduce inflammation, improve strength/endurance and reduce CVD risk
Nathan Goodyear

Testosterone level and mortality in elderly men with systolic chronic heart failure - 0 views

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    Good article.  Heart failure in men associated with lower Total Testosterone and estimated Free Testosterone. The severity of disease was associated with lower Testosterone levels.   I wish they would have measured free levels not estimated them.   Increased SHBG concentrations was associated increased CHF as well. This study found no association with mortality.
Ciara Usher

Quality Bed that Contributes to Healthy Living - 1 views

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started by Ciara Usher on 20 May 11 no follow-up yet
Nathan Goodyear

Reverse T3 as a parameter of myocardial function impairment in heart failure. - 0 views

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    reverse T3 and the free T3:rT3 can be used to assess prognosis of those with CHF.
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
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  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
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    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Nathan Goodyear

Testosterone Supplementation in Heart Failure - 0 views

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    Review of 4 studies found that Testosterone therapy improved exercise capacity in those patients with heart failure.
Nathan Goodyear

Testosterone and pro-inflammatory cytokines in men with chronic heart failure - 0 views

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    Low bioavailable Testosterone associated with increased IL-1beta and TNF-alpha in men with CHF.
Nathan Goodyear

Beneficial effects of testosterone therapy on... [Biomed Res Int. 2014] - PubMed - NCBI - 0 views

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    Testosterone in men with CHF found to improve diastolic function and exercise distance versus placebo.  
Nathan Goodyear

Role of dopamine in congestive heart failure: a contemporary appraisal. - PubMed - NCBI - 0 views

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    dopamine has benefit in CHF.  Actually, use to be a therapy employed.
Nathan Goodyear

The role of dopamine receptors in the treatment of congestive heart failure. - PubMed -... - 0 views

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    Dopamine improves chronic CHF via its interactions with the dopamine receptors.
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