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Rachel Renner

Saving A Relationship By Easing Snoring Issues - 1 views

I almost lost my long term partner because of my snoring problem. He used to have a bad sleep and stayed awake at night because of the irritating noise I produced. There was nothing I can do about ...

started by Rachel Renner on 20 Nov 12 no follow-up yet
Justin Tantrum

Perfect Body Building Supplements - 3 views

I can honestly recommend Body Workshop Supplements to anyone who is aiming for a high quality protein source supplement. I have taken their offered product immediately after my work-out and it prov...

supplements

started by Justin Tantrum on 28 Mar 12 no follow-up yet
Nathan Goodyear

The Complex Role of Estrogens in Inflammation - 0 views

edrv.endojournals.org/...521.full

estrogens inflammation

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • These studies suggest inflammation-dependent up-regulation of ERβ relative to ERα.
  • up-regulation of ERβ relative to ERα under hypoxic conditions, which might lead to a preponderance of signaling through ERβ pathways
  • it seems that E2 at periovulatory to pregnancy levels inhibited proinflammatory cytokines from PBMCs
  • ...26 more annotations...
  • it is clear that E2 can stimulate antibody production by B cells, probably by inhibiting T cell suppression of B cells
  • In cycling women, the largest quantities of Ig were detected before ovulation
  • In contrast, E2 at high concentrations leads to a suppression of B-lymphocyte lineage precursors
  • E2 at periovulatory to pregnancy serum levels is able to stimulate antibody secretion under healthy conditions but also in autoimmune diseases, whereas similar serum levels of E2 lead to a suppression of bone marrow B cell lineage precursors
  • In chronic inflammatory disorders, where B cells play a decisive role, E2 would promote the disease when autoaggressive B cells are already present, whereas chronically elevated E2 would inhibit initiation of an autoimmune disease when no such B cells are available. This might be a good reason why particularly B cell-dependent diseases such as SLE, mixed connective tissue disease (Sharp syndrome), IgA nephropathy, dermatitis herpetiformis, gluten sensitive enteropathy, myasthenia gravis, and thyroiditis appear in women in the reproductive years, predominantly, in the third or fourth decades of life
  • Th17 cells are thought to be the main responsible cells for chronic inflammatory tissue destruction in autoimmune diseases
  • IFN-γ, IL-12, and TNF were allocated to Th1 reactions
  • IL-4, IL-5, and IL-10 to Th2 responses
  • antiinflammatory T regulatory cells producing TGF-β and proinflammatory T helper type 17 cells (Th17) producing IL-17
  • no direct effects of estrogens on Th17 cells or IL-17 secretion have been described until now.
  • So-called Th17 cells producing IL-17 are the main T cells responsible for chronic inflammation.
  • Because IFN-γ has been allocated a Th17-inhibiting role (Fig. 1⇑), its increase by E2 at pregnancy doses and the E2-mediated inhibition of TNF must be viewed as a favorable effect in chronic inflammation
  • in humans and mice, E2 at periovulatory to pregnancy levels stimulates IL-4, IL-10, and IFN-γ but inhibits TNF from CD4+ T cells
  • In humans and mice, E3 and E2, respectively, at pregnancy levels inhibit T cell-dependent delayed type hypersensitivity
  • increased IL-4, IL-10, and IFN-γ in the presence of low TNF support an antiaggressive immune response
  • secretion of IL-1β is increased at periovulatory/proestrus to early pregnancy levels, whereas IL-1 secretion is inhibited at high pregnancy levels
  • The dichotomous effect of E2 on IL-1β and TNF at high and low concentrations is most probably due to inhibition of NF-κB at high concentrations
  • experiments with mouse and rat macroglial and microglial cells demonstrate that E2 at proestrus to pregnancy levels exerts neuroprotective effects by increasing TGF-β and by inhibiting iNOS and NO release, and reducing expression of proinflammatory cytokines and prostaglandin E2 production.
  • E2 at periovulatory to pregnancy levels inhibits NF-κB activation, which must be viewed as an antiinflammatory signal
  • It was shown that E2 concentrations equal to or above 10−10 m are necessary to inhibit NF-κB activation
  • important proinflammatory cytokines are typically inhibited at periovulatory (proestrus) to pregnancy levels of E2, which is evident for IL-6, IL-8, and TNF
  • low E2 concentrations were demonstrated to have no or even stimulatory effects
  • This renders a woman in the postmenopausal phase to a more proinflammatory situation
  • most in vitro studies demonstrated a stimulatory effect of E2 on secretion of IL-4, IL-10, and TGF-β typically at periovulatory to pregnancy levels
  • E2 at periovulatory to pregnancy levels has an ameliorating effect on chronic inflammatory diseases as long as B cell-dependent immunity or an overshooting fibrotic tissue repair process do not play a crucial pathogenic role. However, when the B cell plays an important role, E2 might even stimulate the disease process as substantiated by flare-ups in SLE during pregnancy
    • Nathan Goodyear
      Nathan Goodyear on 15 Aug 12
       
      SLE, mixed connective tissue disease (Sharp syndrome), IgA nephropathy, dermatitis herpetiformis, gluten sensitive enteropathy, myasthenia gravis, and thyroiditis
  • Short-term administration of E2 at pregnancy levels was shown to induce an inflammatory response specific to the lateral prostate of the castrated male rat
  • Nathan Goodyear on 14 Aug 12
     
    great review of the complex interaction between Estrogens and inflammation.  Reference here is in females.
Child Therapy

Child Therapy Works - 2 views

I have the chance of asking professional help for my kid who has been depressed for the past few weeks. We did not know what the reason was and so we asked help from NLP4Kids a reputed therapy orga...

Child therapist Therapy for children

started by Child Therapy on 24 Feb 12 no follow-up yet
Justin Stone

Effective Stretch Mark Remedy - 4 views

I gave birth six months ago. What bothers me are these stretch marks that are found in my belly. I could not wear my swim wear attire whenever my family would decide to stay at the beach to swim. I...

skin care stretch mark cream

started by Justin Stone on 28 Feb 12 no follow-up yet
felipp windsor

Thank You The Dental Co. - 1 views

I was deeply worried when I noticed that my 9 year-old daughter got some problems with her teeth. I then brought her to a nearby dentist, but I found out that she was not that capable of answering ...

started by felipp windsor on 30 Sep 13 no follow-up yet
Wallis Tavern

Great Place For A Great Ceremony - 1 views

started by Wallis Tavern on 23 Nov 12 no follow-up yet
Stanley Bishop

Save Me From Snoring - 1 views

started by Stanley Bishop on 16 Jan 13 no follow-up yet
Rachel Renner

You Can Stop Snoring Now! - 1 views

I have been looking for the best solution on How to Stop Snoring. In fact I have tried a number of anti-snoring products that all claimed to be effective yet, nothing happened. But when I tried Noi...

started by Rachel Renner on 18 Dec 12 no follow-up yet
Barbara Smith

Effective Chiropractic Solution - 1 views

I had the worst back pain ever. I already tried all types of painkillers and back pain remedies but none of them worked for me. I was about to give up when a friend told me about The Chiropractic D...

started by Barbara Smith on 08 Jan 13 no follow-up yet
Wallis Tavern

A Magical Wedding Venue - 1 views

started by Wallis Tavern on 27 Jan 13 no follow-up yet
Stanley Bishop

The Reliable Sleep Apnea Home Test - 1 views

Because I used to snore hard, my wife insisted that I should see a doctor to make sure that this snoring problem will not lead to a more serious health concern. However, going to a doctor is the la...

started by Stanley Bishop on 17 Oct 12 no follow-up yet
Nathan Goodyear

Vitamin B for treating peripheral... [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18646107

B vitamins peripheral neuropathy neuropathy Vitamin B vitamins B

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Cochrane review did show that B vitamins improve peripheral neuropathy; though less than alpha lipoic acid.  And B vitamins are well tolerated.
Stretch Marks

Prevention Cream For Stretch Marks - 1 views

I was really afraid to get pregnant because I knew then that my skin will be prone to stretch marks. That is why I have researched on How to get rid of stretch marks to prevent it from appearing o...

skin care how to get rid of stretch marks

started by Stretch Marks on 28 Feb 12 no follow-up yet
Stretch Marks

Prevention Cream For Stretch Marks - 1 views

I was really afraid to get pregnant because I knew then that my skin will be prone to stretch marks. That is why I have researched on How to get rid of stretch marks to prevent it from appearing o...

how to get rid of stretch marks skin care

started by Stretch Marks on 29 Feb 12 no follow-up yet
Justin Stone

Effective Stretch Mark Remedy - 1 views

I gave birth six months ago. What bothers me are these stretch marks that are found in my belly. I could not wear my swim wear attire whenever my family would decide to stay at the beach to swim. I...

stretch mark cream

started by Justin Stone on 29 Feb 12 no follow-up yet
Justin Stone

Effective Stretch Mark Remedy - 3 views

I gave birth six months ago. What bothers me are these stretch marks that are found in my belly. I could not wear my swim wear attire whenever my family would decide to stay at the beach to swim. I...

stretch mark cream treatment skin care

started by Justin Stone on 07 Mar 12 no follow-up yet
Day Spa Adelaide

I went to Shantai and I was Rebourned - 1 views

Nothing can be as good as relieving oneself from the daily pressures of life than treating yourself to a rejuvenating and satisfying facial treatment. Such is what I did when I felt that my stress...

Day Spa Adelaide

started by Day Spa Adelaide on 25 Nov 11 no follow-up yet
becomea paramedic

I Passed The Paramedic Recruitment Process on My First Attempt - 1 views

I really wanted to become a paramedic in the UK. That is why I went online and sought out the help of HowToBecomeAParamedic. They gave me useful insider tips, advice and products (which I bought,...

become a paramedic

started by becomea paramedic on 29 Sep 11 no follow-up yet
Willow O'Donnell

Refurbished B. Braun Horizon NXT Infusion IV Pump | willowmed | Buzznet - 0 views

willowmed.buzznet.com/...efurbished-b-braun-horizon-nxt

We purchase your infusion pumps Buy IV pumps Purchase infusion pumps

shared by Willow O'Donnell on 24 Nov 14 - No Cached
  • Willow O'Donnell on 24 Nov 14
     
    Refurbished B. Braun Horizon NXT Infusion IV Pump The Refurbished B. Braun Horizon NXT Infusion IV Pump is intended for use with B. Braun Horizon I.V. sets to regulate the flow of primary and secondary fluids when positive pressure is required. The infusion system features the capability of delivering fluid from a negative head height, and provides volumetric accuracy for all standard I.V. fluids, including blood, lipids and TPN.
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