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Nathan Goodyear

Cadmium - a metallohormone? - 0 views

www.ncbi.nlm.nih.gov/...PMC2709711

cadmium ER alpha ER-alpha ER estrogen receptors receptor androgen AR hormones endocrine disruptors endocrine disrupting chemicals EDC heavy

shared by Nathan Goodyear on 20 Jul 14 - No Cached
  • Nathan Goodyear on 20 Jul 14
     
    Great review article on the endocrine disrupting role of Cadmium.  Cadmium binds to the ER-alpha inducing an estrogen signal.  Cadmium also binds to the androgen receptor as well.  This study proposes a similar activation of ER-alpha and AR by Cadmium.
Nathan Goodyear

Molecular basis of cadmium toxicity. [Prog Food Nutr Sci. 1984] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...6385135

cadmium toxicity molecular basis

shared by Nathan Goodyear on 19 Apr 11 - Cached
  • Cadmium inhibits protein synthesis, carbohydrate metabolism and drug metabolizing enzymes in liver of animals.
  • Cadmium affects both humoral and cell mediated immune response in animals
  • cadmium nephropathy
  • ...3 more annotations...
  • produces hypertension
  • It causes an alterations of cellular functions in lungs
  • Cadmium is also toxic to central nervous system
  • Nathan Goodyear on 19 Apr 11
     
    for you biochemistry junkies, the molecular pathophysiology of cadmium oxicity
Nathan Goodyear

Associations between cadmium exposure and circulating levels of sex... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25173093

Testosterone Cadmium Estradiol menopause post menopause breast cancer women female hormone hormones

shared by Nathan Goodyear on 06 Feb 15 - No Cached
  • Nathan Goodyear on 06 Feb 15
     
    Cadmium levels found to be positively associated with serum Testosterone levels in women.  Cadmium inversely associated with E2 levels.  Cadmium has been associated with increased breast cancer risk in women.
Nathan Goodyear

Common environmental contaminant, cadmium, linked to rapid breast cancer cell growth - 0 views

www.sciencedaily.com/...120423184203.htm

cadmium breast cancer endocrine disruptor xenoestrogen estrogen environmental

shared by Nathan Goodyear on 16 May 12 - No Cached
  • Nathan Goodyear on 16 May 12
     
    cadmium increases growth potential of breast cancer.  No surprise, cadmium is a classic endocrine disruptor that mimics estrogen.
Nathan Goodyear

Cadmium a metalloestrogen: are we convinced? [J Appl Toxicol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22161274

Cadmium heavy metals metalloestrogen hormone hormones estrogen

shared by Nathan Goodyear on 21 Jul 14 - No Cached
  • Nathan Goodyear on 21 Jul 14
     
    Cadmium has estrogenic activity.  Many have coined the term "metalloestrogen" in a way to refer to the estrogenic activity of cadmium.
Nathan Goodyear

Effects of maternal dietary exposure to cadmium during pregnancy on mammary cancer risk... - 0 views

www.carcinogenesis.com/article.asp

Cadmium heavy metals pregnancy endocrine disrupting chemicals endocrine disruptors hormones puberty

shared by Nathan Goodyear on 20 Jul 14 - No Cached
  • Nathan Goodyear on 20 Jul 14
     
    Animal study finds that Cadmium is estrogenic.  This study found that not only was Cadmium an endocrine disruptor for the pregnant animals, but was also estrogenic in the mammary glands of the offspring.
Nathan Goodyear

Melatonin inhibits both ER alpha activation and... [J Pineal Res. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16635015

Cadmium CD estrogen receptor alpha estrogen receptor estrogen receptor melatonin hormones ER alpha

shared by Nathan Goodyear on 19 Jan 13 - No Cached
  • Nathan Goodyear on 19 Jan 13
     
    Several interesting points about this article.  Cadmium is a non-carcinogen.  Cadmium acts through estrogen receptors.  Cd acts as an estrogen.  Second, melatonin inhibits ER alpha, which promotes inflammation and growth signaling.
Nathan Goodyear

Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxi... - 0 views

het.sagepub.com/...0960327110369818

Cadmium EDTA glutathione chelation

shared by Nathan Goodyear on 07 Aug 13 - No Cached
  • Nathan Goodyear on 07 Aug 13
     
    EDTA and glutathione for chelation of Cadmium
Nathan Goodyear

PLOS ONE: Towards Prenatal Biomonitoring in North Carolina: Assessing Arsenic, Cadmium,... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0031354

heavy metals Mercury Arsenic Lead Pb Hg As Cadmium Cd pregnancy

shared by Nathan Goodyear on 30 Sep 13 - No Cached
  • Nathan Goodyear on 30 Sep 13
     
    study finds women living in North Carolina exposed to Cadmium, Mercury, Arsenic, and Lead in the prenatal period.  These levels exceed that considered "safe".
Nathan Goodyear

New aspects of cadmium as endocrine disruptor. [Environ Sci. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16788562

cadmium heavy metals hormones estrogen receptors androgen endocrine disrupting chemicals endocrine disruptors puberty

shared by Nathan Goodyear on 20 Jul 14 - No Cached
  • Nathan Goodyear on 20 Jul 14
     
    Cadmium is an endocrine disruptor: binds to estrogen receptors and the androgen receptor. 
Nathan Goodyear

EHP - Determinants and Within-Person Variability of Urinary Cadmium Concentrations amon... - 0 views

ehp.niehs.nih.gov/1205524

cadmium Cd heavy metals toxins

shared by Nathan Goodyear on 19 Jun 13 - No Cached
  • Nathan Goodyear on 19 Jun 13
     
    one time 24 hour urinary Cadmium level was not reflective of body burden.  This study did not look at those challenged with chelation.
Nathan Goodyear

Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium... - 0 views

cat.inist.fr/?aModele=afficheN&cpsidt=14869409

antioxidants toxic metals arsenic cadmium

shared by Nathan Goodyear on 19 Apr 11 - No Cached
  • Nathan Goodyear on 19 Apr 11
     
    antioxidants aid in cadmium and arsenic chelation
Nathan Goodyear

Glutathione, a first line of defense against cadmium toxicity - 0 views

www.fasebj.org/...220.short

glutathione cadmium toxicity

shared by Nathan Goodyear on 19 Apr 11 - No Cached
  • Nathan Goodyear on 19 Apr 11
     
    glutathione provides protection against cadmium toxicity
Nathan Goodyear

Cadmium toxicity among wildlife in the Colorado Rocky Mountains : Abstract : Nature - 0 views

www.nature.com/...406181a0.html

cadmium toxicity

shared by Nathan Goodyear on 19 Apr 11 - No Cached
  • Nathan Goodyear on 19 Apr 11
     
    cadmium toxicity in the Colorado Rocky Mountain wildlife
Nathan Goodyear

Testicular toxicity induced by dietary cadmium is ... [Biometals. 2004] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15689104

testicular toxicity cadmium

shared by Nathan Goodyear on 19 Apr 11 - No Cached
  • Nathan Goodyear on 19 Apr 11
     
    cadmium toxicity induces Testicular damage
Nathan Goodyear

ATSDR - Substances Map Results Page - 0 views

www.atsdr.cdc.gov/...SubstanceMapResults.asp

cadmium Louisiana maps heavy metals

shared by Nathan Goodyear on 16 May 12 - No Cached
  • Nathan Goodyear on 16 May 12
     
    documented cadmium sites in Louisiana
Nathan Goodyear

Estrogen signaling and disruption of androgen metab... [Prostate. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17075824

cadmium prostate cancer AR androgen receptors ER male hormone hormones men

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    Cadmium exposure/toxicity promotes prostate tumor growth and it does this via a AR independent process.  The authors propose that it is via estrogen receptors and estrogen signaling from DHT metabolites.
Nathan Goodyear

Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls - 0 views

www.ncbi.nlm.nih.gov/...PMC3002200

heavy metals hormones girls puberty

shared by Nathan Goodyear on 20 Jul 14 - No Cached
  • Nathan Goodyear on 20 Jul 14
     
    Study finds higher Pb levels in young girls is associated with delayed puberty onset.  This occurs through an inverse relationship with inhibin B and follicular development.  This relationship was also found with Cadmium.  Both of these heavy metals are toxic to the ovaries.
Nathan Goodyear

darbre2006.pdf - 0 views

estrogen metalloestrogens xenoestrogens heavy metals

shared by Nathan Goodyear on 22 Apr 19 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 22 Apr 19
     
    Heavy metals shown to be estrogenic with Cadmium being one of the biggest culprits.
Nathan Goodyear

The role of mercury and cadmi... [Altern Ther Health Med. 2007 Mar-Apr] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17405690

Mercury Hg Cadmium Cd CVD hypertension cardiovascular disease COMT

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Heavy metals play a role in the development of CVD.  Hg and Cd in particular play a role in hypertension.
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