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Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tis... - 0 views

www.cell.com/...S1097-2765(16)30670-0 epigenetics diet nutrition SCFA gut gut bacteria gut flora gut microbiome gut microbiota
shared by Nathan Goodyear on 28 Nov 16 - No Cached
  • SCFAs play a dual role both as substrates for metabolism and as signaling molecules
  • SCFAs can be either directly converted (acetate) or oxidized (propionate and butyrate) to acetyl-Co
  • Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner
  • ...1 more annotation...
  • complex functional interactions between diet, gut microbiota, and host health.
  • Nathan Goodyear on 28 Nov 16
     
    diet changes gut microbiota, which changes genetic expression--it is called epigenetics.  This is an animal study.
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Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic... - 0 views

www.jleukbio.org/...275.abstract SCFA fiber diet nutrition inflammation gout gut bacteria gut gut flora gut microbiome gut microbiota
shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • Nathan Goodyear on 09 Jan 17
     
    new animal study finds that high fiber diet intake increases gut flora SCFA production that reduces inflammation in gout
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Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 cha... - 0 views

www.fasebj.org/...3024.full Boswellia Frankincense anxiety depression essential oils brain
shared by Nathan Goodyear on 11 Apr 12 - No Cached
  • Nathan Goodyear on 11 Apr 12
     
    Boswellia shown to have potential anti-anxiety and anti-depressive properties.
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Effects of tibolone and combined 17β-estradiol and norethisterone acetate on ... - 0 views

humrep.oxfordjournals.org/...2748.full estradiol progestin hormone hormones HRT CRP women
shared by Nathan Goodyear on 17 Nov 13 - No Cached
  • Nathan Goodyear on 17 Nov 13
     
    Study finds that estradiol combined with synthetic progestin increased CRP.  No surprise.
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Prostate Cancer and Prostatic Diseases - Androgen dynamics and serum PSA in patients tr... - 0 views

www.nature.com/...pcan20148a.html ADT androgen deprivation therapy male hormone hormones prostate cancer PSA disease
shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    ADT therapy with abiraterone inhibits androgen production from both testicular and adrenal origins.  This study finds that a decrease in androgen production through ADT did not always equal a decrease in PSA, indicating other mechanisms of prostate cancer profession.
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Lead acetate may cause erectile dysfunctio... [Cell Biol Toxicol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23979109 ED erectile dysfunction NO Pb lead
shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    In rat model, Pb reduced NO and contributed to ED.  Of interest, arginine masked the effects of Pb on NO synthase and vitamin C reversed it all together.
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Normal Flora - Medical Microbiology - NCBI Bookshelf - 0 views

www.ncbi.nlm.nih.gov/...NBK7617 flora gut flora gut microbiome gut microbiota
shared by Nathan Goodyear on 05 May 15 - No Cached
  • Concentrations of 109 to 1011 bacteria/g of contents are frequently found in human colon
  • more than 400 species have been identified
  • 95 to 99 percent belong to anaerobic genera such as Bacteroides, Bifidobacterium, Eubacterium, Peptostreptococcus, and Clostridium
  • ...2 more annotations...
  • hese genera proliferate, occupy most available niches, and produce metabolic waste products such as acetic, butyric, and lactic acids
  • Anaerobic bacteria can then deconjugate bile acids in this region and bind available vitamin B12 so that the vitamin and fats are malabsorbed
  • Nathan Goodyear on 05 May 15
     
    normal flora of the body
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Metabolic Effects of Dietary Fiber Consumption and Prevention of Diabetes - 0 views

jn.nutrition.org/...439.long soluble insoluble fiber dietary diet nutrition diabetes
shared by Nathan Goodyear on 22 Oct 13 - No Cached
  • DF are highly complex substances that can be described as any nondigestible carbohydrates and lignins not degraded in the upper gut
  • Commonly, DF are classified according to their solubility in water, even though grading according to viscosity, gel-forming capabilities, or fermentation rate by the gut microbiota might be physiologically more relevant
  • Main sources of soluble DF are fruits and vegetables
  • ...8 more annotations...
  • n increased intake of total DF was inversely associated with markers of insulin resistance in several studies
  • consumption of insoluble DF increased whole body glucose disposal independent of changes in body weight in both short-term and more prolonged studies
  • Short-chain fatty acids (SCFA) such as acetate, propionate, and butyrate are produced by bacterial fermentation of indigestible DF polysaccharides in the colon
  • increased production of SCFA is assumed to be beneficial by reducing hepatic glucose output and improving lipid homeostasis
  • a high DF diet (oligofructose) reduced gram-negative bacterial content and body weight, whereas a high fat diet increased the proportion of a gram-negative bacterial lipopolysaccharides (LPS) containing microbiota in humans
  • Prospective cohort studies indicate that diets high in insoluble cereal DF and whole grains might reduce diabetes risk
  • soluble DF (i.e., pectin, inulin, and β-glucans)
  • cereal DF (i.e., cellulose and hemicelluloses)
  • Nathan Goodyear on 22 Oct 13
     
    Good discussion of dietary fiber intake and Diabetes.  
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ScienceDirect - European Journal of Cancer and Clinical Oncology : Actions of a progest... - 0 views

www.sciencedirect.com/science breast cancer Provera Medroxyprogesterone acetate MPA HRT and
shared by Nathan Goodyear on 05 Nov 10 - No Cached
  • at both progestogen and glucocorticoid receptors may mediate the effects of high-dose MPA therapy in breast cancer. The possible stimulation of the growth of some cell types by MPA requires further investigation.
  • Nathan Goodyear on 05 Nov 10
     
    Provera provides stimulation of breast issue; likely increasing risk of breast cancer
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Effect of Medroxyprogesterone Acetate on Endothelium-Dependent Vasodilation in Postmeno... - 0 views

circ.ahajournals.org/...1773 MPA synthetic progestins heart cardiac medroxyprogesterone
shared by Nathan Goodyear on 18 Nov 10 - No Cached
  • Nathan Goodyear on 18 Nov 10
     
    synthetic progestin (MPA) off sets beneficial estrogen heart benefits
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Comparison of regimens containing oral micronized ... [J Womens Health Gend Based Med. ... - 0 views

www.ncbi.nlm.nih.gov/...10868610 biodentical progesterone depression medroxyprogesterone acetate provera women hormone hormones
shared by Nathan Goodyear on 30 Mar 11 - No Cached
  • Approximately 80% of women reported overall satisfaction with the micronized progesterone-containing regimen. A micronized progesterone-containing HRT regimen offers the potential for improved QOL as measured by improvement of menopause-associated symptoms.
  • Nathan Goodyear on 30 Mar 11
     
    watch out!  bioidentical progesterone provides improved symptom control versus synthetic progestin MPA
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