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Nathan Goodyear

Dietary intervention impact on gut microbial gene richness : Nature : Nature Publishing... - 0 views

www.nature.com/...nature12480.html

gut bacteria dysbiosis obesity overweight diet nutrition metabolism metabolic endotoxemia

shared by Nathan Goodyear on 29 Aug 13 - No Cached
  • Nathan Goodyear on 29 Aug 13
     
    Nutrition is a language.  Poor gut balance and as what the authors call "richness" contributes to metabolic dysfunction and obesity.  This study found that Nutrition can improve gut bacterial balance and "richness" that then will improve the metabolic impact of the nutrition. Complex and beautiful nutrition--gut--metabolism connection.
Nathan Goodyear

Richness of human gut microbiome correlates with metabolic markers. - 0 views

www.greenmedinfo.com/...e-correlates-metabolic-markers

dysbiosis gut microbiota bacteria inflammation obesity

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    Gut bacteria diversity, the authors of this study called it "richness" associated with decreased inflammation and obesity.  Lower gut diversity associated with increased inflammation and obesity.
fitspresso

https://www.sightcare-co.com/ - 0 views

www.sightcare-co.com

sight care sightcare group training nearsightedness food for eyesight carey codd vitasight vision how to cure bad eye tips fix improve your red light eyes diet improvement skincare malaysia costos de medicare indonesia singapore eyecare

shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Sight Care | Official Site sightcare-co.com · by Sight Care Sight Care Only $49/Bottle Limited Time Offer! Sight Care Special Deal + Special 67% Discount Save $600 + 180 Days Money Back Guarantee #1.The Sight Care vision supplement is a dietary supplement for helping you improve your vision and brain health. Sight Care eye supplements are formulated to provide a synergistic blend of vitamins, minerals, antioxidants, and other bioactive compounds that are essential for maintaining healthy vision Regular Price: 147/per bottle Only for: $49/per bottle What Is Sight Care? This powerful vision support supplement is made with a unique blend of natural ingredients and plant extracts that work together synergistically to deliver numerous benefits for your brain and eye health. With Sight Care, you can expect to experience increased energy levels, improved eyesight, and an overall revitalized sense of well-being. Taking care of your vision health is not just about seeing clearly; it's also about maintaining your overall brain health. As we age, our vision deteriorates, and our eyes and brain can experience a decline in function, but there are steps you can take to support your visual and cognitive health. Regular eye exams are crucial for detecting and treating vision problems early on, and making healthy choices such as eating a nutritious diet and exercising regularly can also help. However, with busy schedules, it can be difficult to find the time to devote to a healthy lifestyle. This is where the Sight Care supplement comes in. It's designed to support both vision and brain health with its blend of natural ingredients that have been shown to promote healthy vision and cognitive function You must not compromise your eye health for momentary exhilaration. If you are glued to digital screens day and night, you must take measures to prevent eye diseases like age-related macular degeneration. The SightCare vision supplement has been made using 100% natura
Nathan Goodyear

Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk - 0 views

jme.endocrinology-journals.org/...R51.full

metabolic endotoxemia obesity insulin resistance cardiovascular disease LPS inflammation

shared by Nathan Goodyear on 04 Aug 14 - No Cached
  • Weight gain has been associated with a higher gut permeability
  • a high-fat diet promotes LPS absorption
  • higher concentrations of fatty acids impair intestinal barrier integrity
  • ...37 more annotations...
  • The starting point for innate immunity activation is the recognition of conserved structures of bacteria, viruses, and fungal components through pattern-recognition receptors
  • TLRs are PRRs that recognize microbe-associated molecular patterns
  • TLRs are transmembrane proteins containing extracellular domains rich in leucine repeat sequences and a cytosolic domain homologous to the IL1 receptor intracellular domain
  • The major proinflammatory mediators produced by the TLR4 activation in response to endotoxin (LPS) are TNFα, IL1β and IL6, which are also elevated in obese and insulin-resistant patients
  • Obesity, high-fat diet, diabetes, and NAFLD are associated with higher gut permeability leading to metabolic endotoxemia.
  • Probiotics, prebiotics, and antibiotic treatment can reduce LPS absorption
  • LPS promotes hepatic insulin resistance, hypertriglyceridemia, hepatic triglyceride accumulation, and secretion of pro-inflammatory cytokines promoting the progression of fatty liver disease.
  • In the endothelium, LPS induces the expression of pro-inflammatory, chemotactic, and adhesion molecules, which promotes atherosclerosis development and progression.
  • In the adipose tissue, LPS induces adipogenesis, insulin resistance, macrophage infiltration, oxidative stress, and release of pro-inflammatory cytokines and chemokines.
  • the gut microbiota has been recently proposed to be an environmental factor involved in the control of body weight and energy homeostasis by modulating plasma LPS levels
  • dietary fats alone might not be sufficient to cause overweight and obesity, suggesting that a bacterially related factor might be responsible for high-fat diet-induced obesity.
  • This was accompanied in high-fat-fed mice by a change in gut microbiota composition, with reduction in Bifidobacterium and Eubacterium spp.
  • n humans, it was also shown that meals with high-fat and high-carbohydrate content (fast-food style western diet) were able to decrease bifidobacteria levels and increase intestinal permeability and LPS concentrations
  • it was demonstrated that, more than the fat amount, its composition was a critical modulator of ME (Laugerette et al. 2012). Very recently, Mani et al. (2013) demonstrated that LPS concentration was increased by a meal rich in saturated fatty acids (SFA), while decreased after a meal rich in n-3 polyunsaturated fatty acids (n-3 PUFA).
  • this effect seems to be due to the fact that some SFA (e.g., lauric and mystiric acids) are part of the lipid-A component of LPS and also to n-3 PUFA's role on reducing LPS potency when substituting SFA in lipid-A
  • these experimental results suggest a pivotal role of CD14-mediated TLR4 activation in the development of LPS-mediated nutritional changes.
  • This suggests a link between gut microbiota, western diet, and obesity and indicates that gut microbiota manipulation can beneficially affect the host's weight and adiposity.
  • endotoxemia was independently associated with energy intake but not fat intake in a multivariate analysis
  • in vitro that endotoxemia activates pro-inflammatory cytokine/chemokine production via NFκB and MAPK signaling in preadipocytes and decreased peroxisome proliferator-activated receptor γ activity and insulin responsiveness in adipocytes.
  • T2DM patients have mean values of LPS that are 76% higher than healthy controls
  • LPS-induced release of glucagon, GH and cortisol, which inhibit glucose uptake, both peripheral and hepatic
  • LPSs also seem to induce ROS-mediated apoptosis in pancreatic cells
  • Recent evidence has been linking ME with dyslipidemia, increased intrahepatic triglycerides, development, and progression of alcoholic and nonalcoholic fatty liver disease
  • The hepatocytes, rather than hepatic macrophages, are the cells responsible for its clearance, being ultimately excreted in bile
  • All the subclasses of plasma lipoproteins can bind and neutralize the toxic effects of LPS, both in vitro (Eichbaum et al. 1991) and in vivo (Harris et al. 1990), and this phenomenon seems to be dependent on the number of phospholipids in the lipoprotein surface (Levels et al. 2001). LDL seems to be involved in LPS clearance, but this antiatherogenic effect is outweighed by its proatherogenic features
  • LPS produces hypertriglyceridemia by several mechanisms, depending on LPS concentration. In animal models, low-dose LPS increases hepatic lipoprotein (such as VLDL) synthesis, whereas high-dose LPS decreases lipoprotein catabolism
  • When a dose of LPS similar to that observed in ME was infused in humans, a 2.5-fold increase in endothelial lipase was observed, with consequent reduction in total and HDL. This mechanism may explain low HDL levels in ‘ME’ and other inflammatory conditions such as obesity and metabolic syndrome
  • It is known that the high-fat diet and the ‘ME’ increase intrahepatic triglyceride accumulation, thus synergistically contributing to the development and progression of alcoholic and NAFLD, from the initial stages characterized by intrahepatic triglyceride accumulation up to chronic inflammation (nonalcoholic steatohepatitis), fibrosis, and cirrhosis
  • On the other hand, LPS activates Kupffer cells leading to an increased production of ROS and pro-inflammatory cytokines like TNFα
  • high-fat diet mice presented with ME, which positively and significantly correlated with plasminogen activator inhibitor (PAI-1), IL1, TNFα, STAMP2, NADPHox, MCP-1, and F4/80 (a specific marker of mature macrophages) mRNAs
  • prebiotic administration reduces intestinal permeability to LPS in obese mice and is associated with decreased systemic inflammation when compared with controls
  • Cani et al. also found that high-fat diet mice presented with not only ME but also higher levels of inflammatory markers, oxidative stress, and macrophage infiltration markers
  • This suggests that important links between gut microbiota, ME, inflammation, and oxidative stress are implicated in a high-fat diet situation
  • high-fat feeding is associated with adipose tissue macrophage infiltration (F4/80-positive cells) and increased levels of chemokine MCP-1, suggesting a strong link between ME, proinflammatory status, oxidative stress, and, lately, increased CV risk
  • LPS has been shown to promote atherosclerosis
  • markers of systemic inflammation such as circulating bacterial endotoxin were elevated in patients with chronic infections and were strong predictors of increased atherosclerotic risk
  • As a TLR4 ligand, LPS has been suggested to induce atherosclerosis development and progression, via a TLR4-mediated inflammatory state.
  • Nathan Goodyear on 04 Aug 14
     
    Very nice updated review on Metabolic endotoxemia
Nathan Goodyear

Substituting whole grains for refined grains in a 6-wk randomized trial has a modest ef... - 0 views

ajcn.nutrition.org/...ajcn.116.146928.abstract

diet nutrition grains whole grains gut bacteria gut flora gut microbiota gut microbiome gut

shared by Nathan Goodyear on 06 Apr 17 - No Cached
  • Nathan Goodyear on 06 Apr 17
     
    small study finds diet rich in whole grains compared to refined grains improves gut bacteria balance and immune system.  Maybe the key to optimal gut health is the diet?
healthlineblog

Soursop Health Benefits | Benefits of Eating Soursop - 0 views

healthlineblog.com/lth-benefits-of-eating-soursop

Soursop Benefits

shared by healthlineblog on 13 Apr 17 - No Cached
  • healthlineblog on 13 Apr 17
     
    Rich in antioxidant properties, Soursop offers a plethora of health benefits apart from being very effective against cancer.
Nathan Goodyear

The combined effects of exercise and foods in preventing neurological and cognitive dis... - 0 views

www.ncbi.nlm.nih.gov/...PMC3258093

diet nutrition exercise BDNF omega-3 omega 3 n-3 brain derived neurotrophic factor curcumin polyphenols neuroplasticity memory sugar saturated fats

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • The most prevalent types of cognitive impairments include disturbances in attention and learning and memory function
  • An association between BDNF and learning and memory was found when measuring the performance of rats on the Morris water maze task
  • exercise and BDNF have been associated with reducing depression and promoting cognitive enhancement.
  • ...3 more annotations...
  • In addition to reducing oxidative stress and inflammation, DHA serves to improve neuronal function by supporting synaptic membrane fluidity
  • Curcumin has also been shown to protect the hippocampus and to counteract learning impairment
  • insufficient DHA in the brain can compromise neuronal function with subsequent effects on a broad range of neurological and behavioral faculties.
  • Nathan Goodyear on 01 Nov 13
     
    diet and exercise increases BDNF.  Diets rich in omega 3, curcumin, and polyphenols increase BDNF and thus increase neuroplasticity and associated cognition.   In contrast, sugar and saturated fats in crease oxidative stress and worsened spatial learning.  This study is a review.  
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

high protein diet Diabetes insulin resistance

shared by Nathan Goodyear on 22 Oct 13 - No Cached
  • Nathan Goodyear on 22 Oct 13
     
    High protein intake associated with increased type II Diabetes.  Many take in too much protein and actually need to increase fat and fiber rich carbs.
nucosmeticclinic

PRP Therapy - Non Surgical Hair Loss Treatment for Men and Women - 0 views

www.nuhairlosstreatments.co.uk/-surgical-hair-loss-treatments

PRP Therapy Platelet Rich Plasma Non-Surgical Hair Loss Treatment Fall Nu Cosmetic Clinic

shared by nucosmeticclinic on 21 Sep 15 - No Cached
  • nucosmeticclinic on 21 Sep 15
     
    PRP Therapy or Platelet Rich Plasma Therapy is an effective non-surgical hair loss treatment for men and women. PRP Therapy makes efficient utilization of a growth enhancing blood constituent called platelets, which when combined together with plasma, results in an unprecedented increase in the hair follicles across the treated areas.
Nathan Goodyear

Increased Salivary Cortisol Reliably Induced by a Protein-Rich Midday Meal -- Gibson et... - 0 views

www.psychosomaticmedicine.org/...214

salivary saliva cortisol testing hormones hormone

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • The measurement of free cortisol in saliva provides a psychologically stress-free and reliable technique to assess the cortisol response to a standard protein-rich meal, ie, a physiological challenge to the HPA axis in men and women that could be investigated in naturalistic settings outside the laboratory.
  • Nathan Goodyear on 22 Nov 10
     
    saliva testing and cortisol
Nathan Goodyear

Cruciferous Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic Basis - 0 views

www.ncbi.nlm.nih.gov/...PMC2737735

DIM I3C indole-3-carbinol cruciferous vegetables vegetables cruciferous cancer

shared by Nathan Goodyear on 28 Mar 15 - No Cached
  • Nathan Goodyear on 28 Mar 15
     
    Cruciferous vegetables do appear to provide a means to attack Cancer risk.  In part through they are rich sources of DIM and I3C.
fnfdoc

Exactly How Bad Are Trans Fats | Your Health Our Priority - 0 views

www.fnfdoc.com/...bad-trans-fats

Heart Disease Obesity Saturated Fat Trans Fats

shared by fnfdoc on 03 May 18 - No Cached
  • fnfdoc on 03 May 18
     
    Are you worried you are getting heavier day by day? Well, it might be because of those fries you are addicted to. Deep fried foods are rich in trans fats which are directly related to obesity and heart failure. Trans fats build up the blood vessels, hindering the smooth flow of blood through them.
curetick

Walnut Benefits and Side Effects | How to Eat Walnuts - 0 views

curetick.com/lnut-benefits-and-side-effects

walnut_for_weight_loss walnut_health_benefits walnut_oil_during_pregnancy walnut_oil_for_skin

shared by curetick on 22 Feb 18 - No Cached
  • curetick on 22 Feb 18
     
    The walnut benefits can also be useful for weight loss purpose. The containing omega-3 inside the walnut have fatty acids with other substances into it. The 2.5 grams of 'ALA' per serving is found rich beneficial sources as the fatty acid. From studies among the women's observed that having a walnut at diet can be helpful for reducing the weight loss with greater efficiency. It also lowers the 'bad' levels of LDL cholesterol from the body. And the higher levels of 'HDL' cholesterol in a good manner as suggested by the doctors.
Nathan Goodyear

Immune responses to malignancies - 0 views

www.ncbi.nlm.nih.gov/...PMC3721350

cancer immune system

shared by Nathan Goodyear on 18 Apr 18 - No Cached
  • increased densities of T-cell infiltrates with a high proportion of CD8+ T cells within primary colorectal carcinomas were associated with a significant protection against tumor recurrence
  • coexpression of genes mediating cytotoxicity and TH1 adaptive immune responses accurately predicted survival in patients with colorectal carcinoma independently of the metastatic status.
  • tumor-specific cytolytic T lymphocytes (CTLs)
  • ...10 more annotations...
  • tumor-associated antigens (TAs)
  • Proinflammatory cytokines secreted by inflammatory cells can contribute to tumor progression, and soluble factors produced by the tumor in response to nonspecific or tumor-specific signals, such as prostaglandin E2 (PGE2), adenosine, or TGF-β, downregulate functions of immune cells
  • they are largely ineffective in arresting tumor growth, although they can proliferate and mediate antitumor cytotoxicity on their removal from the tumor bed and ex vivo IL-2 activation.42
  • DCs (HLA-DR+CD86+CD80+CD14−) are nature’s best APCs
  • They are a common component of tumor immune infiltrates and are responsible for the uptake, processing, and cross-presentation of TAs to naive or memory T cells, thus playing a crucial role in the generation of tumor-specific effector T cells
  • DCs control the induction of Treg cells. In patients with cancer, cellular interactions between antigen-presenting DCs and T cells lead to expansion and accumulation of Treg cells at the tumor site and in the periphery
  • NK cells (CD3−CD56+CD16+), which mediate innate immunity and contain both perforin-rich and granzyme-rich granules, are well equipped to mediate lysis of tumor cells
  • B cells (CD19+, CD20+) are also rare in most human tumors, with the exception of breast cancer and melanoma
  • The initial acute inflammation involving the recruitment and influx of antitumor effector cells is replaced by chronic inflammation in later stages of tumor progression
  • Tissue hypoxia plays a major role in shaping the nature of immune infiltrates in tumors
  • Nathan Goodyear on 18 Apr 18
     
    Another great review of the immune system during different stages of carcinogenesis; how the cancer manipulates the immue system to cloak itself from the immune system.
Nathan Goodyear

The emerging role of nutrition in Parkinson's disease - 0 views

www.ncbi.nlm.nih.gov/...PMC3945400

nutrition disease Parkinson's disease Parkinson's

shared by Nathan Goodyear on 18 Oct 17 - No Cached
  • Nathan Goodyear on 18 Oct 17
     
    Good review of the current data on the role of nutrition in Parkinson's disease.  Take home, a lot of data is conflicting.  But the figure at the end does well to summarize: diet rich in polyphenols in fruits/veggies, carotenoids, resveratrol, Vitamin C, D, E, and MUFA and PUFA are neuroprotective compared to dairy being neurodegenerative.
snfilms

How To Make Your Life Purple! - 0 views

#snfilms #productionHouseHooghly #filmInstituteHooghly #flowersPhotography #roadsideFlowers #actingSchoolHooghly #singingSchoolHooghly

shared by snfilms on 12 Aug 20 - No Cached
  • snfilms on 12 Aug 20
     
    Purple represents #ambition, #royalty and #richness. Only day dreaming doesn't offer you purple. You need to learn and nurture your skills to fulfil your dream. Join our online/classroom #acting #singing #spokenEnglish #personalityDevelopmentclasses at #SNFPA Chandannagar, Hooghly to be the #PURPLE. https://youtu.be/eOJyG_hGa4o Faculty: Sanjib Nath Debasmita Chattopadhyay
harshitatyagi

Dr. Sweta Gupta - Infertility, IVF, IUI Specialist in Noida - 0 views

slashdot.org/...ty-ivf-iui-specialist-in-noida

Dr. Sweta Gupta IVF Specialists in Noida Infertility Doctors

shared by harshitatyagi on 20 Aug 22 - No Cached
  • harshitatyagi on 20 Aug 22
     
    Being one of the infertility specialists in Noida, Dr. Sweta is a medical director of Crysta IVF, having rich experience of more than 25 years. She believes in providing the best infertility treatments to all patients with her expertise in handling more than 12000 IVF cycles in her entire medical journey. Additionally, she believes in ensuring a higher success rate with the latest medical advances for her patients with enough empathy and compassion Thus to regain the ability to become the parent of a child, It is significant to Visit Crysta IVF to get your treatment done by a prominent IVF specialist in Noida.
umar111

Colour Me Black Perfume - 0 views

plazzapk.blogspot.com/...colour-me-black-perfume.html

Best PerfumesColour MeLadies Perfum

shared by umar111 on 31 Mar 23 - No Cached
  • umar111 on 31 Mar 23
     
    If you're looking for a new fragrance that can transform your personality, then you must try Colour Me Black perfume. This captivating fragrance has been designed to evoke a sense of sensuality and confidence, and is perfect for those who want to make a bold statement. With its unique blend of exotic and alluring notes, Colour Me Black is a perfume that is sure to turn heads. The Fragrance of Colour me Black Perfume Original Colour Me Black perfume is a seductive fragrance that combines rich and spicy notes to create an alluring aroma. The top notes of this fragrance are made up of bergamot, lavender, and pineapple, which provide a fresh and invigorating scent. The heart notes include jasmine, geranium, and nutmeg, which add a spicy and exotic twist to the fragrance. The base notes of Colour Me Black are made up of cedarwood, musk, and amber, which provide a warm and sensual finish.
Nathan Goodyear

Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-... - 0 views

clincancerres.aacrjournals.org/...2751.full

progesterone receptor progesterone receptors A B PR-A PR-B breast cancer ER+ PR+ hormone hormones progesterone receptor receptors survival

shared by Nathan Goodyear on 26 Nov 12 - No Cached
  • Nathan Goodyear on 26 Nov 12
     
    Balance of progesterone receptor A and B shown to influence survival rates in ER+/PR+ breast cancer on hormonal therapy.
Nathan Goodyear

Gut microbiota after gastric bypass in human obesity: increased richness and associatio... - 0 views

ajcn.nutrition.org/...16.abstract

gastric bypass obesity gut microbiota microbiota inflammation WAT white adipose tissue dysbiosis gut

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    Not that I am proposing gastric bypass for weight loss.  IN my mind that is like a lobotomy for headache.  But, this study shows the link between gut bacteria and obesity.  This study documented an increase in the expression of certain bacteria types in the gut.   This was associated with increase in white adipose tissue gene expression.  Linking directly the gut and fat.
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