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fnfdoc

Exactly How Bad Are Trans Fats | Your Health Our Priority - 0 views

www.fnfdoc.com/...bad-trans-fats

Heart Disease Obesity Saturated Fat Trans Fats

shared by fnfdoc on 03 May 18 - No Cached
  • fnfdoc on 03 May 18
     
    Are you worried you are getting heavier day by day? Well, it might be because of those fries you are addicted to. Deep fried foods are rich in trans fats which are directly related to obesity and heart failure. Trans fats build up the blood vessels, hindering the smooth flow of blood through them.
Nathan Goodyear

Trans fats-sources, health risks and alternative approach - A review - 0 views

www.ncbi.nlm.nih.gov/...PMC3551118

trans fats disease

shared by Nathan Goodyear on 19 Jul 17 - No Cached
  • Nathan Goodyear on 19 Jul 17
     
    trans fats and their associated health risks.
indiacardiacsurg

Dr. Ajay Kaul Offering Precision In Heart Care - 0 views

indiacardiacsurgery.wordpress.com/...fering-precision-in-heart-care

Dr. Ajay Kaul trans catheter aortic valve replacement in India cost of trans catheter aortic valve

shared by indiacardiacsurg on 27 Jul 22 - No Cached
  • indiacardiacsurg on 27 Jul 22
     
    The cost of trans catheter aortic valve replacement in India is cheaper than a majority of nations in the world. The country is particularly famous amongst international patients looking for cardiac treatments as they're certain to find the best possible treatment at an affordable cost.
indiacardiacsurg

India's Best TAVR Surgeons with Unique Delivering Optimal Results - 0 views

www.linkedin.com/...delivering-optimal-surgerysite

cost of trans catheter aortic valve replacement (Tavr) India India's Best TAVR surgeons Top 10 TAVR surgeons of India

shared by indiacardiacsurg on 15 Sep 21 - No Cached
  • indiacardiacsurg on 15 Sep 21
     
    By giving the highest quality of medical treatment at a cost of trans catheter aortic valve replacement (Tavr) India, India has established itself as one of the most popular hubs to get treatments from around the world. India Cardiac Surgery Service Please call +91-9370586696 Email id: enquiry@indiacardiacsurgerysite.com
Nathan Goodyear

Eggs and dietary cholesterol-dispelling the myth - 0 views

www.ovosbrasil.com.br/...l%20desvandendando%20mitos.pdf

Eggs CHD protein

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    Eggs are a great source of protein and nutrition. Eggs do not increase CHD. Diets high in saturated and trans fats do; not eggs.
Nathan Goodyear

Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse ... - 0 views

www.cell.com/...S1550-4131%2814%2900498-7

intermittent fasting nutrition diet obesity metabolism

shared by Nathan Goodyear on 03 Jul 15 - No Cached
  • Nathan Goodyear on 03 Jul 15
     
    Rat study finds intermittent fasting aids weight loss, improves insulin resistance, leptin signaling and blunts the effects of a high-fat (trans), high fructose, and high sugar diet.
Nathan Goodyear

Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspectiv... - 0 views

press.endocrine.org/...jc.2013-3092

toll like receptors toll-like receptors TLRs TLR-4 TLR4 inflammation metabolic syndrome MetS insulin resistance IR Diabetes obesity

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Only the abstract is available publicly.   Toll-like receptors, particularly TLR-4 has been shown to be associated with insulin resistance.  These TLRs have specific pathogen recognition sites.  TLRs are stimulated by fatty acids (FA) and endotoxemia from bacteria.  Thus, dietary intake of high trans fats, inflammation originating from the gut can be the source of insulin receptor dysfunction through TLRs.
Nathan Goodyear

Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent ... - 0 views

ajp.amjpathol.org/...fulltext

dysbiosis inflammation diet nutrition gut flora gut bacteria

shared by Nathan Goodyear on 17 Jul 17 - No Cached
  • Nathan Goodyear on 17 Jul 17
     
    Western diet (high trans fats and sugar) linked to altered gut flora and resultant liver inflammation.  It would have been nice to have followed inflammatory biomarkers i.e. LPS.  This sounds just like metabolic syndrome.
Nathan Goodyear

Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic tra... - 0 views

science.sciencemag.org/...212

epigenetics

shared by Nathan Goodyear on 29 Sep 17 - No Cached
  • Nathan Goodyear on 29 Sep 17
     
    Epigenetics is trans-generational.
indiacardiacsurg

French Health Trip To India: Les meilleurs chirurgiens TAVR de l'Inde avec de... - 0 views

french-health-trip-2-india.blogspot.com/...elivering-optimal-results.html

TAVR de l'Inde chirurgiens TAVR de l'Inde Avantages de la chirurgie Tavi_Tavr

shared by indiacardiacsurg on 16 Oct 21 - No Cached
  • indiacardiacsurg on 16 Oct 21
     
    En offrant un traitement médical de la plus haute qualité au prix du remplacement de la valve aortique par cathéter trans (Tavr) Inde, l'Inde s'est imposée comme l'un des centres les plus populaires pour obtenir des traitements du monde entier. Pour un rendez-vous accéléré et une consultation avec notre consultant Veuillez appeler le +91-9370586696 ou vous pouvez nous envoyer un courrier Identifiant de l'e-mail : - enquiry@indiacardiacsurgerysite.com
indiacardiacsurg

Peyton Tremblay Renewed Her Life With Tavi/Tavr Procedure In India - 0 views

www.linkedin.com/...d-her-life-tavitavr-procedure-

Cost of Trans Catheter Aortic Valve Replacement (Tavr) India Low Cost Trans Aortic Valve Implantation (Tavi) India Top Hospitals for Tavi_Tavr Procedure India India's Best TAVR surgeons

shared by indiacardiacsurg on 30 Aug 21 - No Cached
  • indiacardiacsurg on 30 Aug 21
     
    My name is Peyton Tremblay My experience in Tavi/Tavr procedure in India was easy and hassle-free: without any complications and improved quality of life. I was able to walk without getting breathless, and that I had energy! India Cardiac Surgery Site Call us +91-9370586696 Email Id: enquiry@indiacardiacsurgerysite.com
indiacardiacsurg

India's Best TAVR Surgeons Achieving the Sustaining Improved Quality of Cardiac Surgery... - 0 views

indiacardiacsurgery.wordpress.com/...ty-of-cardiac-surgery-in-india

India's best TAVR surgeons best TAVR surgeons trans catheter aortic valve replacement cost of trans catheter aortic valve replacement (TAVR) in India

shared by indiacardiacsurg on 30 Apr 22 - No Cached
  • indiacardiacsurg on 30 Apr 22
     
    The risks of cardiac surgery can be zero if it's operated by India's best TAVR surgeons. In terms of cardiac surgery in India, patients can expect effective treatment and superior surgical treatment techniques from cardiologists or cardiac surgeons.
Nathan Goodyear

Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for t... - 0 views

www.ncbi.nlm.nih.gov/...PMC4918028

GELDING theory GELDING LPS gut gut health inflammation low T low Testosterone Testosterone hypogonadism obesity

shared by Nathan Goodyear on 30 Jun 16 - No Cached
  • GELDING theory (Gut Endotoxin Leading to a Decline IN Gonadal function)
  • trans-mucosal passage of bacterial lipopolysaccharide (LPS) from the gut lumen into the circulation is a key inflammatory trigger underlying male hypogonadism
  • Obesity and a high fat/high calorie diet are both reported to result in changes to gut bacteria and intestinal wall permeability, leading to the passage of bacterial endotoxin (lipopolysaccharide- LPS) from within the gut lumen into the circulation (metabolic endotoxaemia), where it initiates systemic inflammation.
  • ...1 more annotation...
  • Endotoxin is known to reduce testosterone production by the testis, both by direct inhibition of Leydig cell steroidogenic pathways and indirectly by reducing pituitary LH drive, thereby also leading to a decline in sperm production.
  • Nathan Goodyear on 30 Jun 16
     
    Ever heard of the GELDING theory?  This involves the link between LPS endotoxin from the gut and low Testosterone in obese men.
Nathan Goodyear

Effect of germanium, poly-trans-[2-carboxyethyl] germasesquioxane on natural killer (NK... - 0 views

www.ncbi.nlm.nih.gov/...12237519

cancer germanium NK cells

shared by Nathan Goodyear on 30 May 18 - No Cached
  • Nathan Goodyear on 30 May 18
     
    Germanium found to augment NK cell activity both normal dogs and dogs with adenocarcinoma.
Nathan Goodyear

How is the Immune System Suppressed by Cancer - 1 views

www.cancertutor.com/ancer-suppresses-immune-system

iNOS cancer immune system

shared by Nathan Goodyear on 23 May 18 - No Cached
  • nitric oxide (NO) released by tumor cells
  • Excellent work by Prof de Groot of Essen, indicated by adding exogenous xanthine oxidase ( XO) in hepatoma cells, hydrogen peroxide was produced to destroy the hepatoma cells
  • NO from eNOS in cancer cells can travel through membranes and over long distances in the body
  • ...43 more annotations...
  • NO also is co linked to VEGF which in turn increases the antiapoptotic gene bcl-2
  • The other important influence of NO is in its inhibition of the proapoptoic caspases cascade. This in turn protects the cells from intracellular preprogrammed death.
  • nitric oxide in immune suppression in relation to oxygen radicals is its inhibitory effect on the binding of leukocytes (PMN) at the endothelial surface
  • Inhibition of inducible Nitric Oxide Synthase (iNOS)
  • NO from the tumor cells actually suppresses the iNOS, and in addition it reduces oxygen radicals to stop the formation of peroxynitrite in these cells. But NO is not the only inhibitor of iNOS in cancer.
  • Spermine and spermidine, from the rate limiting enzyme for DNA synthases, ODC, also inhibit iNOS
  • tolerance in the immune system that decreases the immune response to antigens on the tumors
  • Freund’s adjuvant
  • increase in kinases in these cells which phosphorylate serine, and tyrosine
  • responsible for activation of many growth factors and enzymes
  • phosphorylated amino acids suppress iNOS activity
  • Hexokinase II
  • Prostaglandin E2, released from tumor cells is also an inhibitor of iNOS, as well as suppressing the immune system
  • Th-1 subset of T-cells. These cells are responsible for anti-viral and anti-cancer activities, via their cytokine production including Interleukin-2, (IL-2), and Interleukin-12 which stimulates T-killer cell replication and further activation and release of tumor fighting cytokines.
    • Nathan Goodyear
      Nathan Goodyear on 23 May 18
       
      Th1 cells stimulate NK and other tumor fighting macrophages via IL-2 and IL-12; In contrast, Th2, which is stimulated in allergies and parasitic infections, produce IL-4 and IL-10.  IL-4 and IL-10 inhibit TH-1 activation and the histamine released from mast cell degranulation upregulates T suppressor cells to further immune suppression.
  • Th-2 subset of lymphocytes, on the other hand are activated in allergies and parasitic infections to release Interleukin-4 and Interleukin-10
  • These have respectively inhibitory effects on iNOS and lymphocyte Th-1 activation
  • Mast cells contain histamine which when released increases the T suppressor cells, to lower the immune system and also acts directly on many tumor Histamine receptors to stimulate tumor growth
  • Tumor cells release IL-10, and this is thought to be one of the important areas of Th-1 suppression in cancer patients
  • IL-10 is also increased in cancer causing viral diseases such as HIV, HBV, HCV, and EBV
  • IL-10 is also a central regulator of cyclooxygenase-2 expression and prostaglandin production in tumor cells stimulating their angiogenesis and NO production
  • nitric oxide in tumor cells even prevents the activation of caspases responsible for apoptosis
    • Nathan Goodyear
      Nathan Goodyear on 23 May 18
       
      NO produced by cancer cells inhibits proapoptotic pathways such as the caspases.
  • early stages of carcinogenesis, which we call tumor promotion, one needs a strong immune system, and fewer oxygen radicals to prevent mutations but still enough to destroy the tumor cells should they develop
  • later stages of cancer development, the oxygen radicals are decreased around the tumors and in the tumor cells themselves, and the entire cancer fighting Th-1 cell replication and movement are suppressed. The results are a decrease in direct toxicity and apoptosis, which is prevented by NO, a suppression of the macrophage and leukocyte toxicity and finally, a suppression of the T-cell induced tumor toxicity
  • cGMP is increased by NO
  • NO in cancer is its ability to increase platelet-tumor cell aggregates, which enhances metastases
  • the greater the malignancies and the greater the metastatic potential of these tumors
  • The greater the NO production in many types of tumors,
  • gynecological
  • elevated lactic acid which neutralizes the toxicity and activity of Lymphocyte immune response and mobility
  • The lactic acid is also feeding fungi around tumors and that leads to elevated histamine which increases T-suppressor cells.  Histamine alone stimulates many tumor cells.
    • Nathan Goodyear
      Nathan Goodyear on 23 May 18
       
      The warburg effect in cancer cells results in the increase in local lactic acid production which suppresses lymphocyte activity and toxicity as well as stimulates histamine production with further stimulates tumor cell growth.
  • T-regulatory cells (formerly,T suppressor cells) down regulate the activity of Natural killer cells
  • last but not least, the Lactic acid from tumor cells and acidic diets shifts the lymphocyte activity to reduce its efficacy against cancer cells and pathogens in addition to altering the bacteria of the intestinal tract.
  • intestinal tract bacteria in cancer cells release sterols that suppress the immune system and down regulate anticancer activity from lymphocytes.
  • In addition to the lactic acid, adenosine is also released from tumors. Through IL-10, adenosine and other molecules secreted by regulatory T cells, the CD8+ cells can be inactivated to an anergic state
  • Adenosine up regulates the PD1 receptor in T-1 Lymphocytes and inhibits their activity
  • Adenosine is a purine nucleoside found within the interstitial fluid of solid tumors at concentrations that are able to inhibit cell-mediated immune responses to tumor cells
  • Adenosine appears to up-regulate the PD1 receptor in T-1 Lymphocytes and inhibits the immune system further
  • Mast cells with their release of histamine lower the immune system and also stimulate tumor growth and activate the metalloproteinases involved in angiogenesis and metastases
  • COX 2 inhibitors or all trans-retinoic acid
  • Cimetidine, an antihistamine has been actually shown to increase in apoptosis in MDSC via a separate mechanism than the antihistamine effect
    • Nathan Goodyear
      Nathan Goodyear on 23 May 18
       
      cimetidine is an H2 blocker
  • interleukin-8 (IL-8), a chemokine related to invasion and angiogenesis
  • In vitro analyses revealed a striking induction of IL-8 expression in CAFs and LFs by tumor necrosis factor-alpha (TNF-alpha)
  • these data raise the possibility that the majority of CAFs in CLM originate from resident LFs. TNF-alpha-induced up-regulation of IL-8 via nuclear factor-kappaB in CAFs is an inflammatory pathway, potentially permissive for cancer invasion that may represent a novel therapeutic target
  • Nathan Goodyear on 23 May 18
     
    Great review of the immunosuppression in cancer driven by the likes of NO.
Nathan Goodyear

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II ... - 0 views

journals.plos.org/...article

spike protein spike proteins IL-6 inflammation cytokine storm SARS-CoV-2

shared by Nathan Goodyear on 17 Dec 21 - No Cached
  • Nathan Goodyear on 17 Dec 21
     
    SARS-CoV-2 induces increase in IL-6; can anyone say cytokine storm which causes metastasis.
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