Skip to main content

Home/ Dr. Goodyear/ Group items tagged PR-B

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

ScienceDirect.com - The Journal of Steroid Biochemistry and Molecular Biology - Differe... - 0 views

www.sciencedirect.com/...S0960076097001192

progesterone receptor progesterone receptors PR-A PR-B progesterone receptor receptors hormone hormones

shared by Nathan Goodyear on 11 May 13 - No Cached
  • Nathan Goodyear on 11 May 13
     
    progesterone receptor status varies through a woman's menstrual cycle. PR-A dominates throughout, but the PR-A to PR-B ratio declines up to ovulation.
Nathan Goodyear

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. - 0 views

genesdev.cshlp.org/...2266.full.pdf+html

progesterone inflammation PR receptors PR-A PR-B

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    study shows that mice lacking PR-A and PR-B (progesterone receptors) have increased uterine inflammation.   Again, the inflammatory/pro-inflammatory effects of hormones may be regulated through receptors.  This may be the reason that different stages of life elicit a different response with the same hormone.
Nathan Goodyear

Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-... - 0 views

clincancerres.aacrjournals.org/...2751.full

progesterone receptor progesterone receptors A B PR-A PR-B breast cancer ER+ PR+ hormone hormones progesterone receptor receptors survival

shared by Nathan Goodyear on 26 Nov 12 - No Cached
  • Nathan Goodyear on 26 Nov 12
     
    Balance of progesterone receptor A and B shown to influence survival rates in ER+/PR+ breast cancer on hormonal therapy.
Nathan Goodyear

Mapping and Characterization of the Functional Domains Responsible for the Differential... - 0 views

www.jbc.org/...32889.long

progesterone receptor progesterone receptors PR-A PR-B progesterone receptor receptors

shared by Nathan Goodyear on 27 Nov 12 - No Cached
  • Nathan Goodyear on 27 Nov 12
     
    different functions of PR-A and PR-B.
Nathan Goodyear

Progesterone Receptor Inhibits Aromatase and Inflammatory Response Pathways in Breast C... - 0 views

mend.endojournals.org/...1812.long

progesterone receptor receptors PR breast cancer anti-inflammatory

shared by Nathan Goodyear on 12 Nov 12 - No Cached
  • Nathan Goodyear on 12 Nov 12
     
    Progesterone receptor (PR) shown to provide an important anti-inflammatory role in breast cancer in this study.  PR shown to increase NF-kappaB inhibitor IkBalpha, shown to inhibit aromatase activity, shown to inhibit COX-2 expression and shown to inhibit HER-2/neu expression.
Nathan Goodyear

An N-terminally truncated third p... [J Steroid Biochem Mol Biol. 1997] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9408082

progesterone receptor progesterone receptors PR-C C progesterone receptor receptors

shared by Nathan Goodyear on 26 Nov 12 - No Cached
  • Nathan Goodyear on 26 Nov 12
     
    progesterone receptor C is a shortened form of PR-A and PR-B.
Nathan Goodyear

Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform ... - 0 views

www.nursa.org/retrieveFile.cfm

progesterone receptor progesterone receptors A B PR-A PR-B progesterone receptor receptors

shared by Nathan Goodyear on 12 Nov 12 - No Cached
  • Nathan Goodyear on 12 Nov 12
     
    Good discussion of PR receptors. This article focus' on the different receptors, mainly A and B, and the nuclear transcriptional signaling.
Nathan Goodyear

Progesterone Receptor-A and -B Have Opposite Effects on Proinflammatory Gene Expression... - 0 views

jcem.endojournals.org/...E719.abstract

progesterone progesterone receptors PR A PR B pregnancy anti-inflammatory labor

shared by Nathan Goodyear on 25 May 12 - No Cached
  • Nathan Goodyear on 25 May 12
     
    Progesterone is known to have anti-inflammatory action.  This study looked at the anti-inflammatory action of progesterone on the myometrium of the uterus during pregnancy.  The anti-inflammatory effect, in this study, was through Progesterone Receptor B.  There was a change in the dominance to PR A late in pregnancy.  This would promote inflammatory signaling and thus contractions with the onset of labor.
Nathan Goodyear

5'-Heterogeneity in human progesterone recept... [Mol Endocrinol. 1990] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2082185

progesterone receptors PR PR-A PR-B PR-C human

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    article describes 3 progesterone receptors: A, B, and C.
Nathan Goodyear

Colocalization of progesterone receptors A and B by dual immunofluourescent histochemis... - 0 views

jcem.endojournals.org/...2963.full.pdf

progesterone receptor progesterone receptors PR-A PR-B progesterone receptor receptors

shared by Nathan Goodyear on 24 Nov 12 - No Cached
  • Nathan Goodyear on 24 Nov 12
     
    PR-A and PR-B and regulation of the human menstural cycle.
Nathan Goodyear

Relative Expression of Progesterone Receptors A and B in Endometrioid Cancers of the En... - 0 views

cancerres.aacrjournals.org/...4576.long

progesterone receptor progesterone receptors A B PR-A PR-B endometrial cancer uterine progesterone receptor receptors

shared by Nathan Goodyear on 26 Nov 12 - No Cached
  • Nathan Goodyear on 26 Nov 12
     
    Balance of progesterone receptors A and B in the development of endometrial cancer.
Nathan Goodyear

Breast Cancer Research | Full text | Progesterone receptors - animal models and cell si... - 0 views

breast-cancer-research.com/...182

PR-A PR-B PR progesterone receptor progesterone receptors progesterone receptor

shared by Nathan Goodyear on 27 Nov 12 - No Cached
  • Nathan Goodyear on 27 Nov 12
     
    good discussion on progesterone receptors, coactivators, corepressors and their impact on breast cancer.  The question is, do these findings have applications to non-disease.
Nathan Goodyear

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform - 0 views

www.ncbi.nlm.nih.gov/...PMC187836

progesterone receptor B PR-B progesterone receptor B progesterone receptor breast

shared by Nathan Goodyear on 24 Nov 12 - No Cached
  • Nathan Goodyear on 24 Nov 12
     
    progesterone receptor B shown to be required for proper breast development
Nathan Goodyear

The dialectic role of progesterone. [Maturitas. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19171445

progesterone metabolite metabolites. hormone hormones receptor PR-A PR-B

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Nathan Goodyear on 30 Jan 14
     
    knowledge of progesterone and its metabolites are important in the use of hormones.  As the authors concluded here: "natural steroids should not be disparaged...an update on endocrinological knowledge and experience is rather mandatory for gynecologists".  There in lies the problem.  The IOM has shown that the average physician practices at a level of 17 years behind the current scientific knowledge and the environment created by medical governing bodies discourages questions, so as to protect the system.
Nathan Goodyear

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on g... - 0 views

www.ncbi.nlm.nih.gov/...PMC4741919

adenoid cystic carcinoma

shared by Nathan Goodyear on 03 Oct 18 - No Cached
  • Cisplatin and 5-FU or CAP (cisplatin, doxorubicin, and cyclophosphamide) regimens can be used for combination chemotherapy
  • patients with advanced salivary gland malignancy treated with the CAP regimen achieved partial response (PR) or stable disease (SD) rates of 67% (8 out of 12 patients)
  • Agents commonly given as monotherapy for treating ACC are cisplatin, mitoxantrone, epirubicin, vinorelbine, paclitaxel, and gemcitabine. However, few of these agents have shown efficacy
  • ...23 more annotations...
  • single agent mitoxantrone or vinorelbine were recommended as reasonable choices
  • ACC is subdivided into 3 histological groups based on solid components of the tumor including cribriform, tubular, and solid
  • Cribriform and tubular ACCs usually exhibit a more indolent course, whereas the solid subtype is associated with worse prognosis
  • ACC consists of two different cell types: inner luminal epithelial cells and outer myoepithelial cells
  • epithelial cells express c-kit, cox-2 and Bcl-2
  • myoepithelial cells express EGFR and MYB
  • a balanced translocation of the v-myb avian myeloblastosis viral oncogene homolog-nuclear factor I/B (MYB-NFIB) is considered to be a signature molecular event of ACC oncogenesis
  • As a transcription factor, MYB is known to modulate multiple genetic downstream targets involved in oncogenesis, such as cox-2, c-kit, Bcl-2 and BclX
  • Various signaling cascades are essential for cancer cells to survive and grow. The PI3K/Akt/mTOR pathway is one of them
  • This pathway regulates cell survival and growth and is upregulated in many cancers
  • Mutations in genes associated with DNA repair are frequently found in familial cancer syndromes, such as hereditary breast-ovarian cancer syndrome (HBOC), hereditary non-polyposis colorectal cancer (HNPCC, also called Lynch syndrome) and Li-Fraumeni syndrome [30, 31]. These mutations were also reported in non-hereditary cancers
  • 70% of ACC samples (58 of 84) were found to have genetic alterations in the MYB/MYC pathway, indicating that changes in this pathway are crucial in ACC pathogenesis
  • The second most frequently mutated pathway was involved in chromatin remodeling (epigenetic modification), a pathway that includes multiple histone related proteins, and was altered in 44% of samples
  • C-kit
  • VEGF, iNOS and NF-κB were noted to be highly expressed in ACC cells as compared to normal salivary gland cells
  • members of the SOX family, such as SOX 4 and SOX10, are overexpressed in ACC
  • FABP7 (Fatty acid binding protein 7) and AQP1 (Aquaporin 1) tend to be overexpressed in ACC cell lines
  • considerable variability in HER2 overexpression ranging from 0–58% in patients with ACC
  • the study with cetuximab and concurrent chemoradiation or chemotherapy showed the highest ORR (total 43%, 9.5% CR and 33% PR), but this regimen was only given to the EGFR positive patients
  • Cancer immunotherapy can be classified into 3 major groups. Active immunization using anti-tumor vaccines to induce and recruit T cells, passive immunization based on monoclonal antibodies, and adoptive cell transfer to expand tumor-reactive autologous T cells ex vivo and then reintroduce these cells into the same individual
  • LAK cells showed cytotoxicity against ACC cells
  • cytokine-induced cell apoptosis and the cytotoxic effect of the LAK cells contributed to tumor regression
  • molecular finding of the MYB-NFIB fusion gene has the greatest potential to target what appears to be a fundamental event in disease pathogenesis
  • Nathan Goodyear on 03 Oct 18
     
    good review of adenoid cystic carcinoma
Nathan Goodyear

Communication between genomic and non-genomic signaling events coordinate steroid hormo... - 0 views

www.ncbi.nlm.nih.gov/...PMC5864526

genomic signaling cancer hormones non-genomic signaling

shared by Nathan Goodyear on 10 Apr 21 - No Cached
  • steroid hormones typically interact with their cognate receptor in the cytoplasm for AR, glucocorticoid receptor (GR) and PR, but may also bind receptor in the nucleus as appears to often be the case for ERα and ERβ
  • This ligand binding results in a conformational change in the cytoplasmic NRs that leads to the dissociation of HSPs, translocation of the ligand-bound receptor to the nucleus
  • In the nucleus, the ligand-bound receptor dimerizes and then binds to DNA at specific HREs to regulate gene transcription
  • ...25 more annotations...
  • some steroid hormone-induced nuclear events can occur in minutes
  • the genomic effects of steroid hormones take longer, with changes in gene expression occurring on the timescale of hours
  • Classical steroid hormone signaling occurs when hormone binds nuclear receptors (NR) in the cytoplasm, setting off a chain of genomic events that results in, among other changes, dimerization and translocation to the nucleus where the ligand-bound receptor forms a complex with coregulators to modulate gene transcription through direct interactions with a hormone response element (HRE)
  • NRs have been found at the plasma membrane of cells, where they can propagate signal transduction often through kinase pathways
  • Membrane-localized ER, PR and AR have been reported to modulate the activity of MAPK/ERK, phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), nitric oxide (NO), PKC, calcium flux and increase inositol triphosphate (IP3) levels to promote cell processes including autophagy, proliferation, apoptosis, survival, differentiation, and vasodilation
  • ERα36, a 36kDa truncated form of ERα that lacks the transcriptional activation domains of the full-length protein. Membrane-localized ERα36 can activate pathways including protein kinase C (PKC) and/or mitogen activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) to promote the progression of various cancers
  • G protein-coupled receptor 30 (GPR30), also referred to as G protein-coupled estrogen receptor (GPER), is a membrane-localized receptor that has been observed to respond to estrogen to activate rapid signaling
  • hormone-responsive G protein coupled receptor is Zip9, which androgens can activate
  • GPRC6A is another G protein-coupled membrane receptor that is responsive to androgen
  • androgen-mediated non-genomic signaling through this GPCR can modulate male fertility, hormone secretion and prostate cancer progression
  • non-NR proteins located at the cell surface can bind to steroid hormones and respond by eliciting rapid signaling events
  • Estrogens have been shown to induce rapid (i.e. seconds) calcium flux via membrane-localized ER (mER)
  • ER-calcium dynamics lead to activation of kinase pathways such as MAPK/ERK which can result in cellular effects like migration and proliferation
  • 17β-estradiol (E2) has been reported to promote angiogenesis through the activation of GPER
  • Membrane NRs may also mediate rapid signaling through crosstalk with growth factor receptors (GFR)
  • A similar crosstalk occurs between the receptor tyrosine kinase insulin-related growth factor-1 receptor (IGF-IR) and ERα. Not only does IGF-IR activate ERα, but inhibition of IGF-IR downregulates estrogen-mediated ERα activity, suggesting that IGF-IR is essential for maximal ERα signaling
    • Nathan Goodyear
      Nathan Goodyear on 10 Apr 21
       
      This is a bombshell that shatters the current right brain approach to ER. It completely shatters the concept of eat sugar, whatever you want, with cancer treatment in ER+ or hormonally responsive cancer!
  • Further, ER activates IGF-IR pathways including MAPK
  • GPER is involved in the transactivation of the EGFR independent of classical ER
  • tight interconnection between genomic and non-genomic effects of NRs.
  • non-genomic pathways can also lead to genomic effects
  • androgen-bound AR associates with the kinase Src at the plasma membrane, activating Src which then leads to a signaling cascade through MAPK/ERK
  • However, Src can also increase the expression of AR target genes by the ligand-independent transactivation of AR
  • extranuclear steroid hormone actions can potentially reprogram nuclear NR events
  • estrogen modulated the expression of several genes including endothelial nitric oxide synthase (eNOS) via rapid signaling pathways
  • epigenetic changes can then mediate genomic events in uterine tissue and breast cancer cells
1 - 17 of 17
Showing 20▼ items per page