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Interferon therapy in men with hepatitis C was found to decrease total Testosterone and Free Androgen index at the level of the gonads; this was independent of the HPA in this study.

mechanism of peripheral inflammation , via IFN-alpha and IL-6, contribution to depression

Exercise is not just for calories out.  Exercise increases growth hormone, IGF-1, glucagon-like peptide 1, IL-6, and IL-1ra.  The effect is to GH increases beta islet cell mass and protects beta cell lines against IL-1beta, Interferon-gamma and TNF-alhpa induced apoptosis.  IL-6 increased production increases GLP-1 and IL-1ra which counters IL-1beta.  Interleukin-1beta induces islet cell apoptosis and thus IL-1ra counters this pro-inflammatory signal.

EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis.  Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.

hepatitis associated with a decline in total Testosterone.  This was a positive correlation with worsening hepatitis.  Free Testosterone was not effected.  Interesting, SHBG increased.

NAC for treatment of hepatocellular cancer.

People with chronic hepatitis C have low growth hormone production.  HGH therapy did not increase IGF-1 due to liver disease.

inflammation, IFN-gamma, shown to lead to 5-HT and noradrenergic axon degeneration.  This reveals another inflammatory contribution to depression

paroxetine, SSRI, shown to improve depressive symptoms without altering kynurenine levels.  Revealing underlying issue of depression in many individuals is disordered tryptophan metabolism due to inflammation

Elevated prolactin found statistically elevated in melanoma versus dysplastice nevi.