neuroinflammaiton, also described as excitotoxicity, found in the brains of children/young adults that lived in high air pollution areas. Neuroinflammation (IL-6, IL-1, TNF-alpha, IFN-gamma...) found in the brains of these children and young adults. This is the same process found in Alzheimers and other excitotoxicity disease states. Addtionally, it is also involved in most chronic diseases of aging.
Awesome review article on TA-1 and its broad immunomodulatory effects, i.e. increase IL-1, IFN-gamma, increase dendritic cell activity, inhibition of tumor growth…
A beneficial effect of pregnancy on clinical
symptoms has been observed in MS and other Th1-mediated autoimmune diseases, including rheumatoid arthritis (RA), psoriasis,
uveitis, and thyroiditis
In general, Th1 lymphocytes secrete proinflammatory cytokines (e.g., IL-2, IL-12, IFN-γ, and TNF-α) that promote cellular
immunity, while Th2 lymphocytes produce anti-inflammatory cytokines (e.g., IL-4, IL-5, IL-6, and IL-10) that promote humoral
immunity
Th2 cytokines are associated with the down-regulation of Th1 cytokines and may confer protection from Th1-mediated
autoimmune diseases
MS is in part a Th1 autoimmune disease. Estriol therapy induces a shift to Th2 through increase in Th10. Estriol also decreases TNF-alpha cytokine production.