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Nathan Goodyear

Activation of CNS Inflammatory Pathways by Interferon-alpha: Relationship to Monoamines... - 0 views

www.ncbi.nlm.nih.gov/...PMC2655138

IFN-alpha Interferon-alpha IL-6 CNS inflammation inflammatory depression serotonin 5-hydroxyindoleacetate

shared by Nathan Goodyear on 14 Sep 11 - No Cached
  • Nathan Goodyear on 14 Sep 11
     
    mechanism of peripheral inflammation , via IFN-alpha and IL-6, contribution to depression
Nathan Goodyear

IOS Press - Journal Article - 0 views

iospress.metapress.com/...vux3g01201610607

neuroinflammation excitotoxicity inflammation air pollution air pollution Alzheimer's disease IL-6 IL-1 TNF-alpha IFN-gamma

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    neuroinflammaiton, also described as excitotoxicity, found in the brains of children/young adults that lived in high air pollution areas.  Neuroinflammation (IL-6, IL-1, TNF-alpha, IFN-gamma...) found in the brains of these children and young adults.  This is the same process found in Alzheimers and other excitotoxicity disease states.  Addtionally, it is also involved in most chronic diseases of aging.
Nathan Goodyear

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyel... - 0 views

www.jimmunol.org/...7094.long

MS multiple Sclerosis DHEA dehydroepiandrosterone inflammation TNF-alpha IFN-gamma

shared by Nathan Goodyear on 30 Jul 13 - No Cached
  • Nathan Goodyear on 30 Jul 13
     
    DHEA found to decrease IFN-gamma, IL-12, and TNF-alpha through inhibition of NF-kappaB in animal model of MS.
Nathan Goodyear

Interferon-[alpha] reduces the density of monoaminergic axon... : NeuroReport - 0 views

journals.lww.com/..._reduces_the_density_of.7.aspx

depression inflammation IFN-gamma 5-HT serotnin noradrenergic neurotransmitter

shared by Nathan Goodyear on 14 Sep 11 - No Cached
  • Nathan Goodyear on 14 Sep 11
     
    inflammation, IFN-gamma, shown to lead to 5-HT and noradrenergic axon degeneration.  This reveals another inflammatory contribution to depression
Nathan Goodyear

Thymosin alpha 1: A comprehensive review of the literature - 0 views

www.ncbi.nlm.nih.gov/...PMC7747025

peptides cancer thymosin alpha-1 TA-1

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    Awesome review article on TA-1 and its broad immunomodulatory effects, i.e. increase IL-1, IFN-gamma, increase dendritic cell activity, inhibition of tumor growth…
Nathan Goodyear

Immune Modulation in Multiple Sclerosis Patients Treated with the Pregnancy Hormone Est... - 0 views

www.jimmunol.org/...6267.long

MS RA rheumatoid arthritis psoriasis multiple sclerosis Estriol autoimmune disease inflammation hormone hormones E3

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • A beneficial effect of pregnancy on clinical symptoms has been observed in MS and other Th1-mediated autoimmune diseases, including rheumatoid arthritis (RA), psoriasis, uveitis, and thyroiditis
  • In general, Th1 lymphocytes secrete proinflammatory cytokines (e.g., IL-2, IL-12, IFN-γ, and TNF-α) that promote cellular immunity, while Th2 lymphocytes produce anti-inflammatory cytokines (e.g., IL-4, IL-5, IL-6, and IL-10) that promote humoral immunity
  • Th2 cytokines are associated with the down-regulation of Th1 cytokines and may confer protection from Th1-mediated autoimmune diseases
  • ...1 more annotation...
  • During pregnancy, there is a shift from Th1 to Th2 that occurs both locally, at the fetal maternal interface, (23, 24, 25), and systemically
  • Nathan Goodyear on 19 Mar 14
     
    MS is in part a Th1 autoimmune disease.  Estriol therapy induces a shift to Th2 through increase in Th10.  Estriol also decreases TNF-alpha cytokine production.
Nathan Goodyear

N-acetylcysteine improves antitumoural response of Interferon alpha by NF-kB downregula... - 0 views

www.ncbi.nlm.nih.gov/...PMC3539937

IFN-alpha N-acetylcysteine hepatocellular cancer liver cancer NAC hepatocellular carcinoma

shared by Nathan Goodyear on 03 Mar 21 - No Cached
  • Nathan Goodyear on 03 Mar 21
     
    NAC for treatment of hepatocellular cancer.
Nathan Goodyear

Cytokines sing the blues: inflammation and th... [Trends Immunol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16316783

depression inflammation IL-6 IFN-alpha

shared by Nathan Goodyear on 14 Sep 11 - No Cached
  • Nathan Goodyear on 14 Sep 11
     
    cause and effect.  Is it depression or is the depression really the result of inflammation.
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