We briefly described role of probiotics in maintaining gut health & how do probiotics work. What are natural sources & symptoms of unhealthy & healthy gut
Long-term DPs play a large role in determining the selective environment that the gut microbiota faces, ultimately influencing the composition and diversity of taxa maintained within the gut microbial community
Americans consuming unrestricted diets maintained less diverse fecal microbiota than those of individuals adhering to a plant-rich diet with restricted caloric intake
Experiments in mice have shown that multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” can lead to extirpation of specific bacterial lineages
Diet is the key to gut microbe diversity. Gut microbes are key to maintaining optimal cellular metabolism. Nutrition can be a prescription for improving and reprogramming gut bacteria.
he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of
multiple pathways in a variety of organ systems.
Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of
colonization
The colonization process stimulated
glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites
Expression and activity of major drug-metabolizing
enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans
it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
colonization of a germfree gut was rapid and remarkably stable, establishing within only
a week after first exposure
a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary
to obtain a stabilization and “normalization”
the microbiota status affects
the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver
and the kidney
Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis
Gut colonization alters bile acid metabolite profiles via modulation of hepatic Cyp8b1 expression
Bile acids are well-known contributors to glucose and lipid metabolism in the liver
GM is known to alter bile metabolism
GM is also known to exert a strong influence on the metabolism of xenobiotics
The effects of gut microbiome are not confined to the gut. They alter bile acid metabolism and thus lipid/glucose metabolism. They alter CYP450 activity. They effect metabolism. They effect the metabolism, and thus effects, of other drugs.
Gut bacteria brain connection: animal study finds antibiotics early in life alter gut flora which effects young brain and alters behavior; probiotics with Lactobacillus rhamnosus JB-1 appears to blunt the altered Gut bacteria brain connection.
A study by Bosi and colleagues suggested that the increased gut permeability preceded the clinical onset of T1D
gut permeability may be an important player in the development of T1D but, as yet, the findings in human studies have shown association but causation will be more difficult to prove.
Early childhood (≤ 3 month) introduction to cereals [10, 11] and cow's milk [48] were shown to promote beta cell autoimmunity
These findings suggest that prebiotics and probiotics could be potential therapeutic tools to improve gut integrity in various intestinal inflammatory and autoimmune diseases including T1D
Akkermansia muciniphila found to increase the integrity of the gut mucosal lining. Important in gut healing and likely a good biomarker of good/bad gut health and integrity.
New study finds that head injury alters gut bacteria. This destroys the isolated systems thinking of traditional medicine. This is the gut-grain connection, but in REVERSE.
LeanBiome™ (Official) | Get Save UpTo $540 Today Only!
usleanbiome.com
LeanBiome™
Hurry Up!
Offer Expires in:
00
HOUR
29
MINUTE
59
SECOND
LeanBiome
Attention! Get Special 84% Discount Today
Faster fat burning and weight loss
Healthy cholesterol and sugar levels
Higher energy levels
Regular price: $129
Only for: 39$
What Is LeanBiome?
LeanBiome Lean for Good is a weight loss dietary supplement derived from scientifically researched ingredients and comprehensively developed to help people achieve sustainable weight control. The formula comes in a capsule format that is easy to take and is made with natural ingredients from plants and other sources to achieve its goals. The main ingredient in LeanBiome is piperine, which has been found to affect the body's ability to absorb micronutrients and other compounds more effectively.
LeanBiome is a dietary supplement that claims to help weight management. It contains 100% natural ingredients that support healthy weight loss. It does not interfere with any natural process making it safe for use. It ranks among the top weight loss supplements that claim to provide a permanent solution.
LeanBiome is made by a company named Lean for Good. It is made with natural and research-backed ingredients that help you lose excess fat without hassles. It is sold in capsule form. The company assures the composition is GMO, gluten, and soy-free. As for manufacturing standards, you need not fret. The company makes the supplement in a facility certified by the FDA.
How Does LeanBiome Work?
The starting period of the LeanBiome program includes a detoxification process that effectively removes any accumulated ree radicals, toxins, fand oxidative stress. This cleansing enables improved blood circulation, setting the stage for the body to initiate its own fat-burning mechanisms. To enhance metabolic activity, introducing the lean bacteria contained in LeanBiome to your gut microbiome is a beneficial approach. This activation triggers r
Gut health the key to longevity? Or just and effect? Sorry, just abstract available. The authors found similarities in the gut commensal population of centurions in China and Italy.
During the enterohepatic circulation (EC), bile salts are synthesized in the liver, concentrated in the gallbladder, and
function in the lumen of the small intestine to absorb dietary lipids and limit microbial growth at the site of nutrient uptake
Bile acid 7α/β-dehydroxylating bacteria are organisms capable of converting primary bile acids made by the host to harmful
secondary bile acids, deoxycholic acid, and lithocholic acid
These bacteria normally comprise a small proportion of the gut microbiota (∼103–104/g wet weight) and consist of species within the genus Clostridium
C. scindens and a small number of species belonging to the genus Clostridium are responsible for significant alterations in the human bile acid pool composition through bile acid 7α/β dehydroxylation
bile acids play an important role in maintaining intestinal barrier function as antimicrobial agents in the
small bowel (37, 38) and inducers of antimicrobial peptides
Perturbations in the biliary bile acid pool composition can be indicative of hepatogastrointestinal diseases such as fat
malabsorption (40), gallstones (3), gastrointestinal cancers (41), and possibly type II diabetes
Gut microbiota appears to be source of androgen production that originates from the gut. Who would have thought that the Gut as an androgen producing endocrine gland.
Sex difference of gut flora has different metabolic effects from the same diet. Could it all begin in the get? Are gut flora sexist? Of course not, but this study highlights the sex difference of the gut flora and the gender different effects.
Our work suggests that protein misfolding and immune activation in neurodegenerative disorders are triggered through cross-seeding by exposure to exogenous microbial amyloids in the nose, mouth and gut.
Streptococcus mutans, Staphlococcus aureus, Salmonella enterica, Mycobacterium tuberculosis and others
Gene homologs encoding curli were recently determined also in four phyla: Bacteroidetes, Proteobacteria, Firmicutes, and Thermodesulfobacteria
changes in the gut microbiota induced by antibiotics alter neuroinflammation and amyloid deposition in a mouse model of AD
Our data suggest that amyloid proteins in the microbiota are involved in the origination and maintenance of neurodegenerative disease.
exposure to bacteria producing a functional extracellular amyloid protein enhances aggregation of AS in brain neurons in aged rats and in muscle cells in nematodes
AS aggregates seed aggregation of tau
involvement of the vagus nerve in PD
microgliosis, astrogliosis and enhanced expression of IL-6, TLR2 and TNF in the brain following curli exposure suggest the occurrence of an enhanced local sterile inflammatory response to AS in the brain.
the immune system in both AD and PD have now been extensively established
TLR2 activation through exposure to bacterial amyloid is pathogenic
Gut bacteria may play crucial role in systemic inflammation that leads to Alzheimer's and Parkinson's disease. These amyloid production bacteria trigger systemic inflammation that leads to microglia activation and amyloid in the brain. More establishment of the gut-brain connection.
Only abstract available here: Gut bacteria, lactobacillus reuteri, could be the key to colon cancer prevention through inflammation control. What is fascinating is how the gut bacteria influenced epigenetic expression of histidine decarboxylase to increase histamine production.
small study finds diet rich in whole grains compared to refined grains improves gut bacteria balance and immune system. Maybe the key to optimal gut health is the diet?
The intra-testicular level of testosterone in GF mice was found to be significantly lower than in SPF and CBUT mice
This study establishes a novel role for the commensal gut microbiota in the regulation of testicular development and function
Absence of the normal microbiota influences the formation and the integrity of the BTB as well as the intra-testicular levels of testosterone and serum levels of LH and FSH.
Nutritional, socioeconomic, lifestyle and environmental factors (among others) are involved in the regulation of normal spermatogenesis.
he gut microbiota is one such potential source of environmental factors/products that has developed an intimate symbiotic relationship with host's physiology.
Manipulation of the gut microbiotia through dietary modification, pre- and probiotics can therefore be beneficial for the host's reproductive health.
In the current study, colonizing GF mice with CBUT resulted in an increased sperm production, suggesting that bacterial products, e.g. of fermentation, directly or indirectly, can affect the testis.
the absence of gut microbiota influenced testosterone levels
A recent study demonstrated that dietary supplementation of the probiotics Lactobacillus reuteri increased and restored testosterone levels in aging mice
bacterial metabolites such as butyrate have been shown to increase the levels of LH [43] and FSH
This suggests that butyrate most likely regulates testosterone production at the testicular level by stimulation of gene expression in Leydig cells and with little or no effect at the pituitary- hypothalamic levels.
Not that I am proposing gastric bypass for weight loss. IN my mind that is like a lobotomy for headache. But, this study shows the link between gut bacteria and obesity. This study documented an increase in the expression of certain bacteria types in the gut. This was associated with increase in white adipose tissue gene expression. Linking directly the gut and fat.