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Nathan Goodyear

PLOS ONE: Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Incre... - 0 views

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    calorie restriction, though not malnutrition, is associated with longevity as determined by increased telomerase reverse transcriptase and a reduction in aged related diseases.  Granted this was a mouse model.
Nathan Goodyear

Gut microbiota signatures of longevity - 0 views

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    Gut health the key to longevity?  Or just and effect?  Sorry, just abstract available.  The authors found similarities in the gut commensal population of centurions in China and Italy.
Nathan Goodyear

Telomerase at the intersection of cancer and aging - 0 views

  • The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
  • Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
  • increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
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  • mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
  • In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
  • Although recent findings strongly support the idea that short telomeres drive several age-related diseases 38 we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
  • the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
  • telomerase activation can be an early event in cancer, it is not necessary for cancer initiation
  • telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
  • Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
  • recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
  • Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
  • telomerase activation is a potential therapeutic strategy for the treatment of age-related diseases
  • telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
  • These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
  • humans almost completely lose telomerase activity from somatic tissues in the adulthood
  • a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
  • Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
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    Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
Nathan Goodyear

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in ... - 0 views

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    epidemiological study finds that telomere length inversely correlated with longevity, especially in those > 75.  The sex differences was significant beyond the age of 50, with women having longer telomere lengths.
Nathan Goodyear

The Role of Androgens and Estrogens on Healthy Aging and Longevity - 0 views

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    Customized hormone therapy benefits muscle and bone loss in men and women.  This is abstract only.
Nathan Goodyear

Serum progesterone and prognosis in operable breast cancer. - 0 views

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    progesterone levels at the time of surgery predict outcome.  Higher progesterone levels associated with increased longevity.  progesterone > 4 ng/ml associated with 65% survival at 18 years versus 35% with those women and low progesterone.
Nathan Goodyear

Muscle Mass Index As a Predictor of Longevity in Older Adults - The American Journal of... - 0 views

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    Higher muscle mass associated with lower mortality in older adults.  so many focus on cardio and forget about resistance training.
Nathan Goodyear

Mitochondrial-nuclear epistasis: Implications for ... [Ageing Res Rev. 2010] - PubMed r... - 0 views

  • There is substantial evidence that mitochondria are involved in the aging process
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    Mitochondrial-nuclear epistasis: Implications for human aging and longevity.
Nathan Goodyear

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice: Cell Metabolism - 0 views

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    study of mice finds that high fat diet changes genetic expression, epigenetics, to increase lifespan of mice by 13%.
umar111

Computer Science: Computer hardware - 0 views

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    Computer Science Tuesday, April 25, 2023 Computer hardware Computer hardware is the physical components that make up a computer system. It includes everything from the central processing unit (CPU) to the monitor, keyboard, and mouse. Understanding the different types of hardware and how they work together is essential for anyone who works with computers. In this article, we will explore the various components of computer hardware, including internal and external components, and the peripherals that connect to them. We will also discuss the importance of hardware maintenance, the latest advancements in computer technology, and factors to consider when choosing the right hardware for your needs. Whether you are a computer technician, a gamer, or simply someone who uses a computer for everyday tasks, this article will help you better understand the world of computer hardware. Introduction to Computer Hardware Computer hardware refers to the physical components that make up a computer system. It includes everything from the processor and memory to input/output devices such as the keyboard and monitor. In this article, we will explore the different types of computer hardware and their functions. What is Computer Hardware Computer hardware refers to the physical components of a computer system. It includes all the components that can be touched, seen, and used to interact with a computer, such as the monitor, keyboard, and mouse. Hardware is different from computer software, which refers to the programs and applications that run on a computer system. History of Computer Hardware The history of computer hardware dates back to the 1820s when Charles Babbage, an English mathematician, and inventor, designed the first analytical engine, which was considered to be the first mechanical computer. With time, more complex electronic computers were developed, including the first Intel microprocessor in 1971. Since then, computer hardware has continued to evolve, becoming
spineneuro

Gamma Knife Radiosurgery in India Improves Quality of Life and Longevity - Sp... - 0 views

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    Top hospitals for gamma knife India have current medical centers and global class infrastructure. Gamma knife surgery in India has been achieved at top hospitals for gamma knife India and is backed by the exclusive professionals, consisting of neurosurgeons, oncologists, and specialized nurses.
umar111

Body Luxuries Miracle Perfume for Ladies - 0 views

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    Body Luxuries Miracle Perfume for Ladies The Scent That Will Make You Feel Divine. Perfume is an essential part of every woman's beauty regimen. The right scent can lift your mood, boost your confidence, and make you feel divine. But finding the perfect perfume can be a challenge with so many options available in the market. This is where Body Luxuries Miracle Perfume comes in, a fragrance that promises to make you feel like a goddess. What is Body Luxuries Miracle Perfume? Body Luxuries Miracle Perfume is a luxury fragrance designed for women who want to feel confident, alluring, and sophisticated. This fragrance is made from high-quality ingredients, making it long-lasting and ideal for everyday wear. Its unique blend of floral and fruity notes creates a delightful aroma that is sure to turn heads. What makes Body Luxuries Miracle Perfume so special? The scent of Body Luxuries Miracle Perfume is both sensual and captivating. It has a top note of juicy pear and luscious peach that gives it a fruity aroma. The heart notes are a blend of floral scents such as jasmine, lily-of-the-valley, and peony, which give it a feminine touch. The base notes of vanilla, musk, and cedarwood create a warm and inviting aroma, making it perfect for any occasion. The fragrance is long-lasting, so you can wear it all day without having to reapply. This makes it ideal for women who want to smell great throughout the day. Additionally, Body Luxuries Miracle Perfume is affordable, making it accessible to women from all walks of life. How to use Body Luxuries Miracle Perfume To get the best out of Body Luxuries Miracle Perfume, you need to apply it correctly. Start by taking a shower and moisturizing your skin. This will help the fragrance to last longer. Next, spray the perfume onto your pulse points, such as your wrists, neck, and behind the ears. These areas are warmer than other parts of your body, which helps the fragrance to diffuse better. Conclusion Original Body Luxuries Miracle P
umar111

Body Luxuries Intense Perfume - 0 views

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    Unique blend of floral, woody, and fruity notes create a bold and intense scent. Long-lasting fragrance that can last for up to 12 hours. Affordable price point makes it accessible to a wide range of consumers. Sleek and elegant packaging adds a luxurious touch to any perfume collection. Cons: The bold and intense scent may not be suitable for those who prefer more subtle fragrances. Some people may find the scent too overpowering for everyday wear. The longevity of the fragrance may vary depending on individual body chemistry. Limited availability in some regions may make it difficult to purchase for some consumers.
wheelchairindia9

Karma S-Ergo 105 Manual Wheelchair - 0 views

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    Ergonomic chairs are designed to confirm to a person's physical dimensions, allowing them to sit naturally and comfortably for long periods of time, while reducing the risk of pressure ulcers. Ergonomic system (Intelligent s-shaped ergonomic seating) provides efficient pressure relief by spreading weight over a greater area, at the same time provides stabilization and reduced sliding. With their lightweight frames and seats designed to reduce or prevent pressure points, ergonomic wheelchairs provide a comfortable option for mobility impaired users who have the upper body strength to propel themselves, or a caregiver strong enough to do so. Karma Ergo Lite 2501 Wheelchair: The extremely lightweight Ergo Lite 2501 Transport Wheelchair weighs only 8.16 kg. and features an ergonomically-designed seat and backrest, making it one of the most comfortable transport chairs on the market. The folding seat and backrest make the S-Ergo ideal for storage or travel, and the built in AEGIS anti-bacterial cushion provides added comfort and support. Despite its light weight, the S-Ergo features a 115 kg. weight capacity along with large, 14" flat-free polyurethane rear tires. Karma Ergo Lite 2501 Wheelchair Features: Lightest transporter on the market! Patented S-Style Ergonomic Seat Frame 6061 T-6 Aircraft-grade Aluminum Only 18 lb . (w/ footrests) Built in Silver Aegis Anti-bacterial Cushion Fixed Armrests w/Concaved Armpads Pocket Behind Backrest & Small Carry Pouch on Each Armrest 6" x 1" Polyurethane Front Casters 16" x 17" or 18" x 17" Seat Width S-Style Ergonomic Seat 14" Rear Polyurethane, High Tread, Flat Free Wheels 3-Stage handle brake: allows light to firm grip for lock Folding Backrest/ Folding Seat for Transporting in Vehicle or Travel Fixed Footrests w/ Extra Wide Footplates Frame Color: Pearl Silver Weight Capacity of 100 kg Ergonomic Transporter w/ handle brakes Karma Ergo Lite 2501 Wheelchair Measurements: Seat Width 16 inch., 18
Nathan Goodyear

Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation,... - 0 views

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    prolonged calorie restriction results in loss of muscle mass, which results in decreased metabolism
brandnew12

Home Remedies: Longevity Tips - Kindle edition by John Okeniyi. Health, Fitness & D... - 0 views

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    Are you struggling with the fact that you really don't know anything about how to get into shape? If you're busy living in yesterday's errors, many of your decisions will be founded on guilt and shame instead of what you really want (and need) to accomplish to achieve your goals. Real change comes from day-to-day choices and becoming mindful and basing your choices on what you need now (rather than what you did or didn't do yesterday) will make your exercise life much more passable. What if I can offer you a solution that will help you to attain greatness, to become a success and learn about the best ways to get in shape? In this book, you will learn about: - Navigate the Astral Plane - MIRROR MADNESS - The Health Zen - Vitamin Vitality - Native American Healing - Boost your Health with Gua Sha - Beautiful Body Essential - Secret of Food Combination - Lose Weight Fasting - Child Diet - many other useful things!
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    Are you struggling with the fact that you really don't know anything about how to get into shape? If you're busy living in yesterday's errors, many of your decisions will be founded on guilt and shame instead of what you really want (and need) to accomplish to achieve your goals. Real change comes from day-to-day choices and becoming mindful and basing your choices on what you need now (rather than what you did or didn't do yesterday) will make your exercise life much more passable. What if I can offer you a solution that will help you to attain greatness, to become a success and learn about the best ways to get in shape? In this book, you will learn about: - Navigate the Astral Plane - MIRROR MADNESS - The Health Zen - Vitamin Vitality - Native American Healing - Boost your Health with Gua Sha - Beautiful Body Essential - Secret of Food Combination - Lose Weight Fasting - Child Diet - many other useful things!
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    Are you struggling with the fact that you really don't know anything about how to get into shape? If you're busy living in yesterday's errors, many of your decisions will be founded on guilt and shame instead of what you really want (and need) to accomplish to achieve your goals. Real change comes from day-to-day choices and becoming mindful and basing your choices on what you need now (rather than what you did or didn't do yesterday) will make your exercise life much more passable. What if I can offer you a solution that will help you to attain greatness, to become a success and learn about the best ways to get in shape? In this book, you will learn about: - Navigate the Astral Plane - MIRROR MADNESS - The Health Zen - Vitamin Vitality - Native American Healing - Boost your Health with Gua Sha - Beautiful Body Essential - Secret of Food Combination - Lose Weight Fasting - Child Diet - many other useful things!
Nathan Goodyear

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? - 0 views

  • Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
  • HIF-1α is the principal mediator of cellular hypoxia adaptations
  • activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
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  • The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
  • Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
  • McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
  • The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
  • Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
  • To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
  • HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
  • Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
  • Hormesis
  • process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
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    great review of hbot, brain injury, neuroplasticity and neurogenesis.
spineneuro

French to India Medical Travel: La radiochirurgie Gamma Knife en Inde amélior... - 0 views

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    Le taux de réussite de la radiochirurgie au couteau gamma en Inde est plus élevé. Il existe un certain nombre des meilleurs hôpitaux pour la radiochirurgie au couteau gamma en Inde, capables et correctement préparés avec la technologie la plus avancée utilisée pour offrir le meilleur traitement au patient de partout dans le monde.
spineneuro

বাংলাদেশ স্বাস্থ্য নিউজ আপডেট - সংবাদ মাধ্যম: ভারতে গামা ছুরি রেডিওসার্জারি জ... - 0 views

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    প্রতি বছর ভারতে মার্কিন রোগীদের সংখ্যা বাড়ছে; গামা ছুরি ভারতের জন্য শীর্ষ হাসপাতালে এবং অন্যান্য মানের যত্ন পরিষেবা এবং উচ্চ সাফল্যের হার সহ। গামা ছুরির জন্য ভারতের শীর্ষ হাসপাতালগুলি হল একটি বড় কারণ যার কারণে বিশ্বজুড়ে অনেক আন্তর্জাতিক রোগী তাদের চিকিত্সার জন্য ভারতে ভ্রমণ করার সিদ্ধান্ত নেয়৷ আমাদের কল করুন: +91-9325887033 ইমেল আইডি: enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

تعمل الجراحة الإشعاعية باستخدام سكين جاما في الهند على تحسين جودة الحياة وطول... - 0 views

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    تعد الجراحة الإشعاعية باستخدام سكين جاما في الهند أكثر منطقية مما هي عليه في البلدان الأخرى. يأتي المرضى من البلدان النامية ، ولا سيما البلدان الأفريقية ، لإجراء الجراحة الإشعاعية باستخدام سكين جاما في الهند بسبب نقص العروض السريرية المناسبة في مكانهم.
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