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Nathan Goodyear

Testosterone and Visceral Fat in Midlife Women: The Study of Women's Health Across the ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2866448

testosterone women obesity overweight SWAN post-menopausal SHBG Estradiol hormone hormones visceral fat

shared by Nathan Goodyear on 21 Jul 13 - No Cached
  • Nathan Goodyear on 21 Jul 13
     
    New study, SWAN study, finds that bioavailable Testosterone was "significantly positively related" to visceral fat.  As bioavailable Testosterone increases in post-menopausal women, visceral fat increases.  The authors conclude that Testosterone increases visceral fat accumulation.  This increased Testosterone is concluded to be from a decrease in SHBG as a result of falling Estradiol.
Nathan Goodyear

Bayesian meta-analysis of hormone therapy and morta... [Am J Med. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19854329

hormone hormones therapy post-menopausal women

shared by Nathan Goodyear on 14 Oct 13 - No Cached
  • Nathan Goodyear on 14 Oct 13
     
    Meta-analysis of 27 studies finds hormone therapy reduces mortality in post-menopausal women < 60.  A more recent 2013 study from Yale supports this conclusion.  This study found a 28% reduction in mortality.
Nathan Goodyear

The Benefits and Harms of Systemic T... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25279572

Testosterone women Postmenopause post-menopause female hormones hormone

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    Review of data of Testosterone in post-menopausal women is seriously lacking--especially long-term safety data and this is worrisome as other data points to increased CVD and cancer with increasing Testosterone levels in women.
Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

www.jendocrinolinvest.it/...abstract.cfm

estradiol testosterone hormone hormones post-menopausal women

shared by Nathan Goodyear on 28 Oct 13 - No Cached
  • Nathan Goodyear on 28 Oct 13
     
    endogenous, not supplemented, estradiol positively correlated with inflammation, weight, insulin resistance, and increased homocysteine.  Likewise Testosterone positively correlated with increased weight, insulin resistance, yet negatively with HDL and SHBG.  This study looked at post-menopausal women.  The conclusion of this study was that endogenous estradiol and Testosterone are biomarkers for CVD risk.  If they are positively associated with an increased risk, then adding in extra E2 without opposition of Progesterone and Testosterone, then CVD risk is increased.
Nathan Goodyear

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized tria... - 0 views

www.ajcn.org/...1586.full

vitamin D cancer women post menopause

shared by Nathan Goodyear on 03 Dec 10 - No Cached
  • Nathan Goodyear on 03 Dec 10
     
    Vitamin D reduces all Cancers in post-menopausal women
Nathan Goodyear

SHBG, Sex Hormones, and Inflammatory Markers in Older Women - 0 views

www.ncbi.nlm.nih.gov/...PMC3070258

inflammation SHBG CRP IL-6 cytokines Estradiol post menopause women hormone hormones

shared by Nathan Goodyear on 07 Apr 15 - No Cached
  • Nathan Goodyear on 07 Apr 15
     
    inflammation negatively associated with SHBG in post menopause women.  Interestingly, Estradiol was found to be positively associated.  The inflammatory cytokines evaluated were CRP and IL-6.
Nathan Goodyear

A cross-sectional study of different patterns of oral contraceptive use among premenopa... - 0 views

www.ncbi.nlm.nih.gov/...PMC3123282

birth control pills OCP contraception IGF-1 HGH pre-menopausal women human growth hormone

shared by Nathan Goodyear on 20 Feb 13 - No Cached
  • Nathan Goodyear on 20 Feb 13
     
    Birth control pills were found to reduce IGF-1 levels in the short term and long term.  Those that had used birth control pills had lower IGF-1 levels compared to those that had never used birth control pills.  This fits with the current knowledge that oral estrogen reduces HGH and IGF-1.  Those were in post-menopausal women, but this is in pre-menopaus women.  This has implications on health, weight, disease...
Nathan Goodyear

Endogenous androgen levels and cardiovascular risk profile i... : Menopause - 0 views

journals.lww.com/...and_cardiovascular_risk.7.aspx

CVD cardiovascular postmenopause CRP women hormone hormones Testosterone SHBG

shared by Nathan Goodyear on 25 Feb 14 - No Cached
  • Nathan Goodyear on 25 Feb 14
     
    Study finds low SHBG associated with increased CRP and CVD in post menopause women.  No significant association with androgens and CRP were found.
Nathan Goodyear

Androgens in relationship to cardiovascular risk factors in the menopausal transition, ... - 0 views

informahealthcare.com/...13697130802416640

cardiovascular risk disease women female hormone hormones androgens Testosterone CVD

shared by Nathan Goodyear on 20 Mar 14 - No Cached
  • Nathan Goodyear on 20 Mar 14
     
    Increasing androgens, male hormones, may be associated with the increased risk of CVD found in post menopausal women.  Other variables also need to be included ie. fat, insulin resistance...
Nathan Goodyear

Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measureme... - 0 views

www.ncbi.nlm.nih.gov/...PMC2291491

metabolic syndrome PCOS menopause postmenopause women Testosterone hormone hormones

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    Post menopause women with PCOS have high CVD.  PCOS is essentially metabolic syndrome separated by age.  Both PCOS and MetS in women is associated with an increase in Testosterone levels.
Nathan Goodyear

Relationship between endogenous testosterone and ... [Metabolism. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18555838

Testosterone women postmenopause hormone hormones CRP CVD menopause

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    Post menopause transition associated with increase in Testosterone levels in women.  This is associated with an increase in CRP and CVD.
Nathan Goodyear

Sex Hormone-Binding Globulin and the Free Androgen Index Are Related to Cardiovascular ... - 0 views

circ.ahajournals.org/...1242.long

metabolic syndrome SHBG Testosterone women hormone hormones menopause CVD cardiovascular disease

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    A decrease in the SHBG in post menopause women is associated with increase in free Testosterone, which is associated with increase in MetS and CVD
Nathan Goodyear

Low Sex-Hormone Binding Globulin is Associated with the Metabolic Syndrome in Postmenop... - 0 views

www.ncbi.nlm.nih.gov/...PMC1633722

metabolic syndrome Menopause SHBG Testosterone MetS women hormone hormones

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    Post menopause associated with lower SHBG, increase in free Testosterone and increase in metabolic syndrome.
Nathan Goodyear

PLOS ONE: Metabolic Syndrome and Breast Cancer Risk: A Case-Cohort Study Nested in a Mu... - 0 views

journals.plos.org/...article

metabolic syndrome breast cancer cancer menopause women

shared by Nathan Goodyear on 03 Jun 15 - No Cached
  • Nathan Goodyear on 03 Jun 15
     
    new study finds increased post menopause breast cancer in women with Metabolic syndrome.
Nathan Goodyear

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial - 0 views

ajcn.nutrition.org/...1586.abstract

vitamin d vitamin vitamins cancer post-menopause women calcium menopause post-menopausal

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    Study finds that optimization of vitamin D and Calcium levels reduces all-cancer risk in postmenopausal women.
Nathan Goodyear

The Benefits and Harms of Systemic Testosterone Therapy in Postmenopausal Women With No... - 0 views

press.endocrine.org/...jc.2014-2262

Testosterone women female hormone hormones menopause

shared by Nathan Goodyear on 06 Feb 15 - No Cached
  • Nathan Goodyear on 06 Feb 15
     
    Only abstract available.  Meta-analysis of Testosterone therapy in post-menopausal women finds significant bias, some improvement in sexual function and cholesterol levels, yet safety and long-term data is significantly lacking.  Take this with studies on endogenous Testosterone in women, significant caution needs to be followed with Testosterone in women. Only abstract available here.
Nathan Goodyear

Cardiovascular Fat, Menopause, and Sex Hormones in Women: The SWAN Cardiovascular Fat A... - 1 views

press.endocrine.org/...JC.2015-2110

women hormones estrogen estradiol cardiovascular disease cardiovascular disease fat menopause post menopause metabolism

shared by Nathan Goodyear on 28 Sep 15 - No Cached
  • Nathan Goodyear on 28 Sep 15
     
    declining serum Estradiol associated with increased cardiovascular fat in postmenopausal women.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

content.onlinejacc.org/article.aspx

mitochondria oxidative stress heart failure heart

shared by Nathan Goodyear on 19 Mar 13 - No Cached
  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
  • ...10 more annotations...
  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
      Nathan Goodyear on 19 Mar 13
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
  • Nathan Goodyear on 19 Mar 13
     
    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
Nathan Goodyear

Neuroprotection of Sex Steroids - 0 views

www.ncbi.nlm.nih.gov/...PMC3036837

hormones estrogen progesterone testosterone sex hormones brain neurology neuroprotection neuroprotective hormones hormone

shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    great article on sex hormones and neuroprotection.  This article summarizes the research on estrogen, progesterone, and aromatase activity in in vitro and in vivo studies.  Additionally, the study reviews the androgenic neuroprotection in men.  Who has said that hormones are not needed post menopausal again?  Maybe, that is the sign that they need the neuroprotective effect of hormones.
Nathan Goodyear

Sex Hormones and Age: A Cross-sectional Study of Testosterone and Estradiol and Their B... - 0 views

aje.oxfordjournals.org/...750.short

hormone hormones men male Estradiol Estrogen testosterone

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Older men have Estradiol levels that are 3 x that of a post-menopausal women.  The bioavailable levels of Testosterone and Estradiol showed the greatest precipitous decline.
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