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3 year study finds improvement in classic menopausal symptoms for women in perimenopause and menopause with improvement in other parameters: fasting glucose, cholesterol, MMP-9, CRP, fibrinogen and other clotting factors.  This study used bioidentical Bi-est, progesterone, and in some DHEA and Testosterone.

study shows that smoking cessation, physical inactivity, menopause, hysterectomy and energy intake associated with the perimenopause weight gain.  What is interesting about it is the energy imbalance is small that results in a big weight gain over time.  We need to look closely and be more frank with out clients about the risk that a hysterectomy poses for her health post surgery.

Pycnogenol useful in vasomotor symptoms in those women in the peri-menopausal years.

Cochrane review for Testosterone therapy for women points to lacking data.  The lengths of study reached a maximum of 2 years with the average at 6 months.  Improvement in sexual function was found in post-menopausal women, but safety and long-term data is lacking.

Progesterone is the primary hormone issue in perimenopause for women.