Group items tagged

Study finds non-hormonal therapy to manage hot flashes in postmenopausal women--drug them.  The authors of this study, looked to gabapentin, also known as neurontin to treat hot flashes.  Instead of looking at the causes: hormone imbalance, stress... these authors looked to a sedating drug.  The dosing of neurontin was 900 mg.   Most can't stand at this dose.  This study points to the lunacy in the research today.  Very soon, there will be the walking dead among us.  They will be the walking doped instead of dead.

Cadmium levels found to be positively associated with serum Testosterone levels in women.  Cadmium inversely associated with E2 levels.  Cadmium has been associated with increased breast cancer risk in women.

Current protein recommendations for women > 65 are inadequate.  New study finds daily requirements range from 0.96 g/kg and 1.29 g/kg per day for women > 65.  What does the RDA get right?

Low Hormones, post-ovary removal, linked to low libido

Testosterone therapy in women post-hysterectomy, with low total and low free Testosterone, provides no benefit in cognitive function.

Different progesterone metabolites shown to have different tumor effects.  Implications are that, just as estrogen metabolism effects cancer risk, so does progesterone metabolism.

Increasing free androgen index associated with increasing vascular endothelial inflammation and dysfunction.

Older study finds weak synthetic androgen improves weight loss in obese postmenopausal women.  This study compared nandrolone decanoate to spironolactone--an androgen receptor antagonist.  No change in glucose or insulin was seen.  Hard to draw a strong conclusion from this study due to the comparison of a synthetic androgen versus an anti-androgen.  This comparison could have exaggerated the benefit of androgen in these women.

Study finds that estradiol combined with synthetic progestin increased CRP.  No surprise.

study finds prolonged exposure to estrogen associated with increased colorectal cancer risk in postmenopausal women. So many unanswered questions. What was the ER status of these patients? What was the weight of these patients? One cannot simply compare estrogen exposure to colorectal cancer risk and say aha! What is the environment of the individual(s)?!

Premarin increases the risk of stroke in postmenopausal women.  The risk of hip fracture was reduced and no change in Coronary Heart disease was found.

Estrogen improves vascular function in postmenopausal women.  The mechanism of action is through the increased nitric oxide production with estrogen therapy.  This increase in nitric oxide reduces endothelial dysfunction.

can the pathway of estrogen metabolism help to predict postmenopausal breast cancer?  according to this study, yes.

Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.

Study of 110 women finds metabolic syndrome prevalence at 39%.  The women with metabolic syndrome had statistically higher Testosterone levels and statistically lower SHBG.  This stands in start contrast to metabolic syndrome in men.