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Nathan Goodyear

Ubiquinone (coenzyme q10) and mitochondria in oxid... [Biol Signals Recept. 2001 May-Au... - 0 views

www.ncbi.nlm.nih.gov/...11351130

CoQ10 mitochondria oxidative stress Parkinson's neurodegenerative disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • Nathan Goodyear on 07 Feb 11
     
    Very good discussion on CoQ10, oxidative stress, and Parkinson's disease
Nathan Goodyear

Clinical experience with intravenous administration of ascorbic acid: achievable levels... - 0 views

www.ncbi.nlm.nih.gov/...PMC3751545

IV vitamin C dosing ascorbic acid inflammation disease cancer IV vitamin C intravenous vitamin C IV intravenous vitamin C vitamin C CRP therapy treatment alternative

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Patients with higher tumor markers are likely to have higher tumor burden, higher oxidative stress and, therefore, are more likely to have lower post IVC plasma levels.
  • Our data also showed that cancer patients with metastasis tend to have lower post-IVC vitamin C levels than those without metastasis
  • Lower peak plasma concentrations are obtained in cancer patients than in healthy subjects. Cancer patients who are deficient in vitamin C prior to therapy tend to achieve lower plasma levels post infusion.
  • ...25 more annotations...
  • Patients with higher inflammation or tumor burdens, as measured by CRP levels or tumor antigen levels, tend to show lower peak plasma ascorbate levels after IVC.
  • Patients with metastatic tumors tend to achieve lower post infusion plasma ascorbate levels than those with localized tumors.
  • Meta-analyses of clinical studies involving cancer and vitamins also conclude that antioxidant supplementation does not interfere with the efficacy of chemotherapeutic regiments
  • Most of the prostate cancer patients studied, 75±19% (95% confidence), showed reductions in PSA levels during the course of their IVC therapy
  • Laboratory studies suggest that, at high concentrations, ascorbate does not interfere with chemotherapy or irradiation and may enhance efficacy in some situations
  • Cameron and Pauling observed fourfold survival times in terminal cancer patients treated with intravenous ascorbate infusions followed by oral supplementation
  • The inflammatory microenvironment of cancer cells leads to increasing oxidative stress, which apparently depletes vitamin C, resulting in lower plasma ascorbate concentrations in blood samples post IVC infusion. Another explanation for this finding may be that cancers are themselves more metabolically active in their uptake of vitamin C, causing subjects to absorb more of the vitamin, and as a results show lower plasma ascorbate concentrations in blood post IVC infusion.
  • patients with severely elevated CRP levels attain plasma ascorbate concentrations after IVC infusions that are only 65% of those attained for subjects with normal CRP levels
  • The finding of decreased plasma ascorbate levels in cancer patients may relate to the molecular structure of ascorbic acid; in particular, the similarity of its oxidized form, dihydroascorbic acid, to glucose
  • Since tumor have increased requirement for glucose [67], transport of dehydroascorbate into the cancer cells via glucose transport molecules and ascorbate through sodium-dependent transporter may be elevated
  • Increased accumulation of ascorbic acid in the tumor site was supported by measurements of the level of ascorbic acid in tumors in animal experiments
  • patients with advanced malignancies may have lower level of ascorbic acid in tissue, creating a higher demand for the vitamin C
  • IVC therapy appears to reduce CRP levels in cancer patients.
  • CRP concentrations directly correlate with disease activity in many cases and can contribute to disease progression through a range of pro-inflammatory properties.
  • Being an exquisitely sensitive marker of systemic inflammation and tissue damage, CRP is very useful in screening for organic disease and monitoring treatment responses
  • ncreases in CRP concentrations have been associated with poorer prognosis of survival in cancer patients, particularly with advance disease independent of tumor stage
  • Regarding inflammation, 73±13% of subjects (95% confidence) showed a reduction in CRP levels during therapy. This was an even more dramatic 86±13% (95% confidence) in subjects who started therapy with CRP levels above 10 mg/L
  • patients treated by IVC with follow-up several year showed that suppression of inflammation in cancer patients by high-dose IVC is feasible and potentially beneficial
  • Inflammation is a marker of high cancer risk, and poor treatment outcome
  • The subjects with highly elevated CRP concentrations have a three-fold elevation “all-cause” mortality risk and a twenty-eight fold increase in cancer mortality risk
  • cancer patients may need higher doses to achieve a given plasma concentration.
  • patients with lower vitamin C levels may see more distribution of intravenously administered ascorbate into tissues and thus attain less in plasma.
  • When treating patients with IVC, the first treatment likely serves to replenish depleted tissue stores, if those subjects were vitamin C deficient at the beginning of the treatment. Then, in subsequent treatments, with increasing doses, higher plasma concentrations can be attained. On-going treatments serve to progressively reduce oxidative stress in cancer patients.
  • large doses given intravenously may result in maximum plasma concentrations of roughly 30 mM, a level that has been shown to be sufficient for preferential cytotoxicity against cancer cells
  • oral intake of vitamin C exceeded 200 mg administered once daily, it was difficult to increase plasma and tissue concentrations above roughly 200 μM.
  • Nathan Goodyear on 26 Aug 14
     
    Great review on the use of IV vitamin C in cancer and to reduce inflammation.  The article does a great job of discussing the mechanism of vitamin C therapy in cancer as well as the proposed reasons for low vitamin C in cancer patients.  The study also highlights the obstacles to rise in vitamin C levels post IV vitamin C in cancer patients.
Nathan Goodyear

Ibuprofen use during extreme exercise: effects on oxidative stress ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17596774

endurance athletes exercise athletesoxidative stress ibuprofen

shared by Nathan Goodyear on 10 Jan 15 - No Cached
  • Nathan Goodyear on 10 Jan 15
     
    ibuprofen associated with increased oxidative stress in extreme exercise.
Nathan Goodyear

Pesticide-induced decrease in rat tes... [Ecotoxicol Environ Saf. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23465731

Pesticides pesticide xenoestrogen xenoestrogens alpha lipoic acid ALA tocopherols

shared by Nathan Goodyear on 04 Jul 13 - No Cached
  • Nathan Goodyear on 04 Jul 13
     
    Pesticides disrupt the testicular function, in part, through oxidative damage.  This study found Alpha lipoic acid  to be a promising, effective mechanism to reduce the oxidative stress.  They also found tocopherols to be effect, but to a lesser extent.
Nathan Goodyear

Methylmercury induces oxidative injury, alterations in permeability and glutamine trans... - 0 views

www.ncbi.nlm.nih.gov/...PMC1847599

methylmercury mercury astrocytes glutamate mitochondria brain inflammation oxidative ROS

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    methylmercury mediates neurotoxicity via mitochondrial damage, inflammation, and oxidative stress.  Astrocytes accumulated the methyl mercury.  The destruction of the astrocytes will result in an increase in glutamate.  Methylmercury is synergistic with other toxins in the development of immunoexcitotoxicity.
Nathan Goodyear

Green Tea Reduced Inflammation, May Inhibit Prostate Cancer Tumor Growth - 0 views

www.aacr.org/...aacr-press-releases.aspx

prostate cancer inflammation NF-kapppB PSA oxidative stress damage green EGCG

shared by Nathan Goodyear on 28 Oct 12 - No Cached
  • Nathan Goodyear on 28 Oct 12
     
    Six cups of green tea daily in those men with prostate cancer found to reduce PSA, NK-KappB, and oxidative stress.  These levels were followed in men before and after surgery.
Nathan Goodyear

Anticonvulsant Mechanisms of the Ketogenic Diet - Bough - 2007 - Epilepsia - Wiley Onli... - 0 views

onlinelibrary.wiley.com/...full

ketogenic ketogenic diet seizures nutrition diet glucose mitochondria insulin ROS oxidative stress

shared by Nathan Goodyear on 16 Nov 16 - No Cached
  • The ketogenic diet (KD) is a high-fat, low-protein, low-carbohydrate diet that has been employed as a treatment for medically refractory epilepsy for 86 years
  • The hallmark feature of KD treatment is the production of ketone bodies by the liver
  • almost any diet that produces ketonemia and/or diminished blood glucose levels can induce an anticonvulsant effect.
  • Nathan Goodyear on 16 Nov 16
     
    ketogenic diet reduces seizures.  Proposed mechanisms: reduced insulin, reduced ROS, reduces oxidative stress, reduced inflammation, increased GABA/Gluatamate ratio.  In the end, it reduces inflammation and increases mitochondrial efficiency.
Nathan Goodyear

http://www.altmedrev.com/publications/16/4/355.pdf - 0 views

www.altmedrev.com/...355.pdf

astaxantin antioxidants oxidative stress inflammation CRP

shared by Nathan Goodyear on 31 May 16 - No Cached
  • Nathan Goodyear on 31 May 16
     
    astaxanthin reduces oxidative stress and inflammation.
Nathan Goodyear

Plasma coenzyme Q10 is increased during gestational diabetes. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21816499

CoQ10 pregnancy oxidative stress gestational diabetes

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    CoQ10 levels elevated in women with gestational diabetes.  The authors proposed that this was an adaptation to increased oxidative stress.
Nathan Goodyear

Selenium and L-carnitine reduce oxidative stress in the heart of rat induced by 2.45-GH... - 0 views

www.ncbi.nlm.nih.gov/...21360060

carnitine selenium heart health cardiovascular disease

shared by Nathan Goodyear on 11 Apr 17 - No Cached
  • Nathan Goodyear on 11 Apr 17
     
    animal study finds high dose Carnitine plus selenium protects against oxidative stress of the heart.
Nathan Goodyear

Redox imbalance in Parkinson's disease. [Biochim Biophys Acta. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18358848

Parkinson's disease ROS oxidative stress dopamine

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    oxidative stress and Parkinson's disease
Nathan Goodyear

Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardi... - 0 views

content.onlinejacc.org/...249

glucose inflammation dietary cardiovascular health inflammatory markers saturated fats oxidative stress triglycerides anti-inflammatory diet

shared by Nathan Goodyear on 20 Dec 11 - No Cached
  • Nathan Goodyear on 20 Dec 11
     
    Diet can be a direct cause of inflammation.  A anti-inflammatory diet is a must in those with chronic, inflammatory diseases.    In this study, triglycerides, oxidative stress, and inflammation was found immediately after a single meal of saturated fat.
Nathan Goodyear

Dash diet - 0 views

dl-web.dropbox.com/...Dash%20diet.pdf

DASH diet lifestyle changes intervention hypertension HTN blood pressure obesity overweight oxidative stress inflammation insulin resistance IR

shared by Nathan Goodyear on 14 Jan 12 - No Cached
  • Nathan Goodyear on 14 Jan 12
     
    For those interested in learning the DASH diet. The dash diet has been shown to reduce blood pressure, weight, oxidative stress, inflammation, and insulin resistance.
Nathan Goodyear

Glutathione metabolism in brain metabolic inte... [Eur J Biochem. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10931173

glutathione oxidative stress brain neurodegenerative disease

shared by Nathan Goodyear on 11 Nov 11 - No Cached
  • Nathan Goodyear on 11 Nov 11
     
    glutathione and oxidative stress in the brain
Nathan Goodyear

Imbalance between Lipid Peroxidation and Antioxidant Status in Preeclampsia - 0 views

content.karger.com/...produkte.asp

preeclampsia HELLP PIH glutathione vitamin C oxidative stress

shared by Nathan Goodyear on 11 Nov 11 - No Cached
  • Nathan Goodyear on 11 Nov 11
     
    preeclampsia associated with oxidative stress.  Low levels of glutathione, vitamin C found in placentas of those with preeclampsia.  Implications for therapy?
Nathan Goodyear

The effect of leg hyperthermia using far in... [Acta Med Okayama. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20424670

IR sauna DM diabetes TYpe II oxidative stress

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IR sauna over short 2 week study shown to improve oxidative stress in patients with type 2 DM
Nathan Goodyear

The Effect of Glutathione and N-Acetylcysteine on Lipoperoxidative Damage in Patients w... - 0 views

171.66.122.149/...1907

IV glutathione NAC therapy treatment septic shock oxidative stress

shared by Nathan Goodyear on 10 Nov 11 - No Cached
  • Nathan Goodyear on 10 Nov 11
     
    IV glutathione and NAC shown to reduce oxidative stress markers associated with septic shock
Nathan Goodyear

Altered placental glutathione peroxidase mRNA expre... [Placenta. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21145108

glutathione pregnancy placenta perioxidase oxidative stress pre-eclampsia

shared by Nathan Goodyear on 01 Mar 12 - No Cached
  • Nathan Goodyear on 01 Mar 12
     
    decrease placental glutathione perioxidase and increased oxidative stress found in the placenta of women with pre-eclampsia.
Nathan Goodyear

Alzheimer's disease--synergistic effects of ... [J Neural Transm. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9720973

AD AGE advanced glycation end products Alzheimer's disease neurofibrillary tangles Beta-amyloid protein microglia brain neurology oxidative stress alzheimer

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • AGEs are protein modifications that contribute to the formation of the histopathological and biochemical hallmarks of AD: amyloid plaques, neurofibrillary tangles and activated microglia
  • Nathan Goodyear on 11 Jun 12
     
    good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.
Nathan Goodyear

ESTROGEN SIGNALING AND NEUROPROTECTION IN CEREBRAL ISCHEMIA - 0 views

www.ncbi.nlm.nih.gov/...PMC3324183

estrogen estradiol cerebral ischemia neuordegeneration brain protection ROS oxidative stress

shared by Nathan Goodyear on 10 Mar 14 - No Cached
  • Nathan Goodyear on 10 Mar 14
     
    estradiol plays an important role in neuropreservation following cerebral ischemia.  The mechanism is through ER alpha stimulation.  The result is a reduction of ROS and oxidative stress.  This occurs through the classic intranuclear and the rapid membrane receptors as well.
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