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Nathan Goodyear

Triiodothyronine and breast cancer. [World J Clin Oncol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25114863

T3 thyroid triiodothyronine breast cancer E2

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    T3 may have effects similar to Estradiol in breast cell proliferation.  This may be, but what about the effects on increased metabolism and resultant fat loss which leads to reduce inflammation...I believe this is all about context of the environment in the individual and the importance of customizing therapy.
Nathan Goodyear

Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent ... - 0 views

ajp.amjpathol.org/...fulltext

dysbiosis inflammation diet nutrition gut flora gut bacteria

shared by Nathan Goodyear on 17 Jul 17 - No Cached
  • Nathan Goodyear on 17 Jul 17
     
    Western diet (high trans fats and sugar) linked to altered gut flora and resultant liver inflammation.  It would have been nice to have followed inflammatory biomarkers i.e. LPS.  This sounds just like metabolic syndrome.
Nathan Goodyear

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice: Cell Metabolism - 0 views

www.cell.com/...S1550-4131(17)30490-4

epigenitics diet nutrition ketogenic diet low carbohydrate diet low carb diet brain longevity

shared by Nathan Goodyear on 08 Sep 17 - No Cached
  • Nathan Goodyear on 08 Sep 17
     
    study of mice finds that high fat diet changes genetic expression, epigenetics, to increase lifespan of mice by 13%.
Nathan Goodyear

Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic... - 0 views

cancerandmetabolism.biomedcentral.com/...s40170-022-00288-7

melanoma malignant melanoma NRAS BRAF ketogenic diet

shared by Nathan Goodyear on 17 Apr 23 - No Cached
  • Nathan Goodyear on 17 Apr 23
     
    Ketogenic diet (low carb/high fats) slows malignant melanoma proliferation no matter the genomic mutations present. It matches with most BRAF+ as this points to increased GLUT1 expression.
Nathan Goodyear

Low-Fat High-Fiber Diet Decreased Serum and Urine Androgens in Men: The Journal of Clin... - 0 views

press.endocrine.org/...jc.2004-1530

diet nutrition Testosterone androgens men hormones male hormones

shared by Nathan Goodyear on 21 Sep 16 - No Cached
  • Nathan Goodyear on 21 Sep 16
     
    lower fat, higher fiber diets result in 12% reduction in circulating male hormones
Nathan Goodyear

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced d... - 0 views

dl-web.dropbox.com/...0DM%2C%20and%20endotoxemia.pdf

bifidobacterium flora LPS metabolic endotoxemia Diabetes DM type II obesity inflammation overweight weight-loss

shared by Nathan Goodyear on 20 Jan 12 - No Cached
  • Nathan Goodyear on 20 Jan 12
     
    decreased bifidobacterium gut flora results in increased absorption of LPS in high fat diets resulting in endotoxemia. This plays a significant role in diabetes
Nathan Goodyear

Expression and Subcellular Localization of Estrogen Receptors α and β in Huma... - 0 views

press.endocrine.org/...jc.2013-2017

ER ER alpha ER beta estrogen receptor fat

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    ER alpha and ER beta expressed on fetal fat cells.  The authors of this article propose that ER alpha plays the dominant in fetal adipocyte differentiation.
Nathan Goodyear

The Postprandial Rise in Plasma Cortisol in Men Is Mediated by Macronutrient-Specific S... - 0 views

press.endocrine.org/...jc.2013-2307

cortisol glucocorticoids macronutrients carbohydrates fats proteins nutrition

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Macronutrients provide some difference in cortisol production.  Carbs, in this study, were found to increase adrenal and extra-adrenal equally, whereas fats/proteins stimulated adrenal cortisol more than extra-adrenal.
Nathan Goodyear

Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with o... - 0 views

ajpendo.physiology.org/...E1188

ER alpha ER-alpha insulin male hormones hormone resistance overweight obese obesity HFD high fat diet over nutrition

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    Mouse study finds that estrogen signaling slows insulin resistance in animals fed High fat diet.  This mechanism of signaling occurs through the ER alpha pathway.
Nathan Goodyear

THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: result... - 0 views

www.eje-online.org/...EJE-15-0262.abstract

low T low Testosterone Testosterone fat muscle mass metabolism body composition cholesterol triglycerides HDL men male hormones

shared by Nathan Goodyear on 19 Nov 15 - No Cached
  • Nathan Goodyear on 19 Nov 15
     
    new study finds Testosterone therapy in men with low T significantly reduces fat, increases lean muscle mass, and reduces fasting glucose and insulin levels.  Improvements in total cholesterol, triglycerides and HDL was also seen.  Only abstract available currently.
Nathan Goodyear

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fa... - 0 views

diabetes.diabetesjournals.org/...1470.full.pdf

dysbiosis obesity endotoxemia diabetes gut metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    This article discusses how an imbalance gut bacteria balance leads to endotoxemia and resultant obesity and diabetes. So, the balance of gut bacteria plays a role in obesity. Really changes ones view of how the body interacts and how disease develops through dysfunction.
Nathan Goodyear

Endocrinology of the Aging Male - 0 views

www.ncbi.nlm.nih.gov/...PMC3073592

aging male hormone hormones

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • All steps beyond the formation of pregnenolone take place in the smooth endoplasmic reticulum
  • Cytochrome P450 enzyme, CYP11A is located on the inner mitochondrial membrane and catalyses the rate limiting step of pregnenolone synthesis
  • Estrogen and related steroids, thyroid hormone and insulin increase SHBG levels.
  • ...21 more annotations...
  • SHBG decreases in response to androgens, and in the presence of hypothyroidism, and insulin resistance.
  • Plasma SHBG levels tend to increase with increasing age
  • The apparent metabolic clearance rate of testosterone is decreased in elderly as compared to younger men
  • Testosterone circulates predominantly bound to the plasma proteins SHBG and albumin, with high and low affinity respectively
  • Testosterone is secreted in a pulsatile fashion
  • Current clinical guidelines suggest at least two measurements
  • In adult men, there is a well-documented diurnal variation (particularly in younger subjects) in testosterone levels, which are highest in the early morning and progressively decline throughout the day to a nadir in the evening
  • In older men, the diurnal variation is blunted
  • it is standard practice for samples to be obtained between 0800 and 1100 h.
  • Testosterone and DHEA decline, whereas LH, FSH, and SHBG rise
  • DHT remains constant despite the decline of its precursor testosterone
  • Longitudinal studies show an average annual decline of 1–2% total testosterone levels, with decline in free testosterone more rapid because of increases in SHBG with aging
  • Massachusetts Male Aging Study (MMAS) data show DHEA, DHEAS, and Ae declining at 2–3% per year
  • DHT showed no cross-sectional age trend
  • Androstanediol glucuronide (AAG) declined cross-sectionally with age in the MMAS sample, at 0.6% per year
  • The EMAS data show that, consistent with the longitudinal findings of MMAS (Figure 1), the core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total testosterone and progressively blunted free testosterone associated with higher LH
    • Nathan Goodyear
      Nathan Goodyear on 01 May 13
       
      This author proves the point in the review of these two studies, that TT may remain constant in aging men, however, FT drops.
  • obesity impairs hypothalamic/pituitary function
  • Androgen deprivation in men with prostate cancer has been associated with increased insulin resistance, worse glycemic control, and a significant increase in risk of incident diabetes
  • Low serum testosterone is associated with the development of metabolic syndrome 116, 117 and type 2 diabetes. 118 SHBG has been inversely correlated with type 2 diabetes
  • Improvement in insulin sensitivity with testosterone treatment has been reported in healthy 121 and diabetic 122 adult men
  • In studies conducted in men with central adiposity, testosterone has been shown to inhibit lipoprotein lipase activity in abdominal adipose tissue leading to decreased triglyceride uptake in central fat depots. 123
  • Nathan Goodyear on 30 Apr 13
     
    great review of hormone changes associated with aging in men.
Nathan Goodyear

Diabetology & Metabolic Syndrome | Full text | Visceral adiposity, insulin resistance a... - 0 views

www.dmsjournal.com/12

adipose tissue fat obesity cancer aromatase activity IR insulin resistance metabolic syndrome visceral

shared by Nathan Goodyear on 26 Oct 12 - No Cached
  • Nathan Goodyear on 26 Oct 12
     
    adipose tissue and it's biological activity contribution to cancer risk.  Good review of our current understanding on how adipose tissue increases the favorably of cancer.
Nathan Goodyear

11beta-hydroxysteroid dehydrogenase type 1 an... [Front Horm Res. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18230901

11-betaHSD1 fat adipose tissue adipoxytes liver metabolic syndrome insulin resistance dyslipidemia hypertension fatty

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • Adipose-selective 11beta -HSD1 transgenic mice exhibited elevated intra-adipose and portal, but not systemic corticosterone levels, abdominal obesity, hyperglycaemia, insulin resistance, dyslipidaemia and hypertension
  • transgenic overexpression of 11beta -HSD1 in liver yielded an attenuated metabolic syndrome with mild insulin resistance, dyslipidaemia, hypertension and fatty liver, but not obesity or glucose intolerance
  • Nathan Goodyear on 14 Mar 12
     
    11-betaHSD1 expression and effect is site specific.
Nathan Goodyear

Body Fat Distribution and Cortisol Metabolism in Healthy Men: Enhanced 5β-Red... - 0 views

jcem.endojournals.org/...4924.long

cortisone cortisol obesity overweight men 11-betaHSD type 1 5-alpha reductase metabolism

shared by Nathan Goodyear on 13 Mar 12 - No Cached
  • Nathan Goodyear on 13 Mar 12
     
    increased 11-betaHSD type 1 and increased 5-alpha reductase activity found to be associated with generalized obesity in men.  Both indicate increased cortisone to cortisol production.  
Nathan Goodyear

Web of Knowledge [v.5.3] - Web of Science - 0 views

cel.webofknowledge.com/full_record.do

DHEA DHEA-S adipose tissue obesity overweight fat

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    human study: revealed a decrease in saturated fatty acids, omega-6 in those supplemented with DHEA-S.  DHEA-S was found to improve the metabolic profile of adipose tissue
Nathan Goodyear

Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possib... - 0 views

www.ajcn.org/...45

Capsaicin weight-loss overweight obesity metabolism capsiate

shared by Nathan Goodyear on 10 Feb 12 - No Cached
  • Nathan Goodyear on 10 Feb 12
     
    Capsaicin shown to aid weight loss.
Nathan Goodyear

Effects of Hypo- and Hyperthyroidism on Noradrenergic Activity and Glycerol Concentrati... - 0 views

press.endocrine.org/...jc.2003-030576

thyroid hormone adipose tissue adipose fat obesity metabolism noradrenaline norepinephrine

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Thyroid hormone increased localized norepinephrine production and liposlys resulting in decreases SQ adipose tissue compared to hypothyroid.  This study showed a localized effect of adipose tissue by thyroid hormone. 
Nathan Goodyear

LeptiPro - Intelligent Weight Control - 0 views

www.leptinresearch.org

Leptin resistance obese overweight weight loss

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • "leptin resistance."
  • In order for leptin to control body weight and metabolism, it must do so from the hypothalamic centers in the brain,
  • When brain levels of leptin are low due to "leptin resistance" - even if there are high circulating blood levels of leptin - food cravings and weight gain occur because the body believes that it is hungry and goes into a state of continued fat storage.
  • ...2 more annotations...
  • By reversing "leptin resistance," through the blocking of PTP1 B, the function of the protein hormone leptin is restored so that the hypothalamic center can normally and effectively modulate body weight and metabolism.
  • Published studies demonstrate that the botanically derived phytochemical, isolated and purified single-peak Isoquinoline Alkaloid Berberine Hel, specifically and potently inhibits human Protein Tyrosine Phosphates 1B (PTP1 B).
  • Nathan Goodyear on 08 Mar 11
     
    Obese or struggling with weight?  look to Leptin
Nathan Goodyear

The major green tea polyphenol, (-)-epigallocatech... [J Nutr. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18716169

green tea extract weight loss

shared by Nathan Goodyear on 05 May 11 - No Cached
  • Our results indicate that long-term EGCG treatment attenuated the development of obesity, symptoms associated with the metabolic syndrome, and fatty liver. Short-term EGCG treatment appeared to reverse preexisting high-fat-induced metabolic pathologies in obese mice. These effects may be mediated by decreased lipid absorption, decreased inflammation, and other mechanisms.
  • Nathan Goodyear on 05 May 11
     
    Green tea extract results in weight loss, both short-term and long-term
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